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    • 5. 发明授权
    • HIV integrase inhibitors
    • HIV整合酶抑制剂
    • US06245806B1
    • 2001-06-12
    • US09625246
    • 2000-07-25
    • Anne DombrowskiSheo SinghDeborah L. ZinkAna TeranFernando PelaezDaria Hazuda
    • Anne DombrowskiSheo SinghDeborah L. ZinkAna TeranFernando PelaezDaria Hazuda
    • A61K31335
    • C07D493/08A61K31/352A61K45/06C12P17/181C12R1/645A61K2300/00
    • Novel tetracyclic aromatic ketones are natural product compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. Further, the novel fungal cultures MF6388 (ATCC 74478), Sterile Fungus, and MF6591 (ATCC 74477), Ascochyta sp. are also disclosed. Further, the cultures Sterile Fungus MF6388 (ATCC 74478) and Ascochyta sp. MF6591 (ATCC 74477) are also disclosed, as well as processes for making compounds of the present invention employing the cultures.
    • 新型四环芳族酮是用于抑制HIV整合酶,预防或治疗艾滋病毒感染和治疗艾滋病的天然产物化合物,作为化合物,药学上可接受的盐,药物组合物成分,无论是否与其他抗病毒药物组合 ,免疫调节剂,抗生素或疫苗。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。 此外,新型真菌培养物MF6388(ATCC 74478),无菌真菌和MF6591(ATCC 74477),Ascochyta sp。 也被披露。 此外,培养无菌真菌MF6388(ATCC 74478)和Ascochyta sp。 还公开了MF6591(ATCC 74477),以及使用培养物制备本发明化合物的方法。