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1. 发明授权

US06245806B1 HIV integrase inhibitors 失效
标题翻译： HIV整合酶抑制剂
公开(公告)号：US06245806B1
公开(公告)日：2001-06-12
申请号：US09625246
申请日：2000-07-25
申请人： Anne Dombrowski , Sheo Singh , Deborah L. Zink , Ana Teran , Fernando Pelaez , Daria Hazuda
发明人： Anne Dombrowski , Sheo Singh , Deborah L. Zink , Ana Teran , Fernando Pelaez , Daria Hazuda
IPC分类号： A61K31335
CPC分类号： C07D493/08 , A61K31/352 , A61K45/06 , C12P17/181 , C12R1/645 , A61K2300/00
摘要： Novel tetracyclic aromatic ketones are natural product compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. Further, the novel fungal cultures MF6388 (ATCC 74478), Sterile Fungus, and MF6591 (ATCC 74477), Ascochyta sp. are also disclosed. Further, the cultures Sterile Fungus MF6388 (ATCC 74478) and Ascochyta sp. MF6591 (ATCC 74477) are also disclosed, as well as processes for making compounds of the present invention employing the cultures.
摘要翻译：新型四环芳族酮是用于抑制HIV整合酶，预防或治疗艾滋病毒感染和治疗艾滋病的天然产物化合物，作为化合物，药学上可接受的盐，药物组合物成分，无论是否与其他抗病毒药物组合，免疫调节剂，抗生素或疫苗。还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。此外，新型真菌培养物MF6388（ATCC 74478），无菌真菌和MF6591（ATCC 74477），Ascochyta sp。也被披露。此外，培养无菌真菌MF6388（ATCC 74478）和Ascochyta sp。还公开了MF6591（ATCC 74477），以及使用培养物制备本发明化合物的方法。

2. 发明授权

US06395743B1 HIV integrase inhibitors 失效
标题翻译： HIV整合酶抑制剂
公开(公告)号：US06395743B1
公开(公告)日：2002-05-28
申请号：US09689174
申请日：2000-10-12
申请人： Brian Heimbuch , Sheo Singh , Deborah L. Zink , Magda Gagliardi , Olga Genilloud , Ana Teran
发明人： Brian Heimbuch , Sheo Singh , Deborah L. Zink , Magda Gagliardi , Olga Genilloud , Ana Teran
IPC分类号： A61K3144
CPC分类号： C07D493/10 , A61K31/4025 , A61K31/4425 , A61K45/06 , C12P17/18 , C12R1/045
摘要： Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The culture Actinoplanes sp. MA7220 (ATCC 202188) is also disclosed, as well as processes for making compounds of the present invention employing the culture.
摘要翻译：可用于抑制HIV整合酶，预防或治疗艾滋病毒感染和治疗艾滋病的化合物，无论是否与其他抗病毒药，免疫调节剂，抗生素或疫苗结合使用，化合物，药学上可接受的盐，药物组合物成分均为描述。还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。文化动植物还公开了MA7220（ATCC 202188），以及使用培养物制备本发明化合物的方法。

3. 发明授权

US5994412A Bis-aryl ethers, compositions containing such compounds and methods of treatment 失效
标题翻译：双芳基醚，含有这些化合物的组合物和处理方法
公开(公告)号：US5994412A
公开(公告)日：1999-11-30
申请号：US110006
申请日：1998-07-02
申请人： Seok H. Lee , Maria T. Diez , Fernando Pelaez , Marina Mojena Sanchez , M. Dolores Vilella Amils , Hans E. Huber , Denis R. Patrick , Otto D. Hensens , Rosalind G. Jenkins , Leeyuan Huang , Annie Z. Zhao , Deborah L. Zink , Anne Dombrowski , Gerald F. Bills
发明人： Seok H. Lee , Maria T. Diez , Fernando Pelaez , Marina Mojena Sanchez , M. Dolores Vilella Amils , Hans E. Huber , Denis R. Patrick , Otto D. Hensens , Rosalind G. Jenkins , Leeyuan Huang , Annie Z. Zhao , Deborah L. Zink , Anne Dombrowski , Gerald F. Bills
IPC分类号： C12P7/22 , A01N31/14
CPC分类号： C12R1/645 , C12P7/22
摘要： A compound represented by the formula I is disclosed: ##STR1## or a pharmaceutically acceptable salt or hydrate thereof. The compound has inhibitory activity against the oncoprotein Raf.Also included are pharmaceutical compositions, methods of treating cancer, cultures of the producing fungal microorganism and methods of fermentative production of the compound.
摘要翻译：公开了由式I表示的化合物：或其药学上可接受的盐或水合物。该化合物对癌蛋白Raf具有抑制活性。还包括药物组合物，治疗癌症的方法，产生真菌微生物的培养物和化合物发酵生产的方法。

4. 发明授权

US6124327A HIV integrase inhibitors 失效
标题翻译： HIV整合酶抑制剂
公开(公告)号：US6124327A
公开(公告)日：2000-09-26
申请号：US123180
申请日：1998-07-27
申请人： Keith C. Silverman , Russell B. Lingham , Sheo Bux Singh , Deborah L. Zink , Ana Teran
发明人： Keith C. Silverman , Russell B. Lingham , Sheo Bux Singh , Deborah L. Zink , Ana Teran
IPC分类号： C07C69/88 , C12P7/62 , C07C69/84 , A61K31/235
CPC分类号： C07C69/88 , C12P7/62
摘要： Natural products such as certain dimerized hydroxyphenylundecanes are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
摘要翻译：描述了某些二聚羟基苯基十一烷等天然产物。这些化合物可用作抑制HIV整合酶，预防或治疗HIV感染和治疗AIDS，作为化合物，药学上可接受的盐，药物组合物成分，无论是否与其他抗病毒药，免疫调节剂，抗生素或其他抗生素组合使用疫苗。还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。

5. 发明授权

US5801172A Antifungal agent from sporomiella minimoides 失效
标题翻译：来自孢子虫的抗真菌剂
公开(公告)号：US5801172A
公开(公告)日：1998-09-01
申请号：US890772
申请日：1997-07-11
申请人： Wendy H. Clapp-Shapiro , Bruce W. Burgess , Robert A. Giacobbe , Guy H. Harris , Suzanne Mandala , Jon Polishook , Mark Rattray , Rosemary A. Thornton , Deborah L. Zink , Angeles Cabello , Maria Teresa Diez , Isabel Martin , Fernando Pelaez
发明人： Wendy H. Clapp-Shapiro , Bruce W. Burgess , Robert A. Giacobbe , Guy H. Harris , Suzanne Mandala , Jon Polishook , Mark Rattray , Rosemary A. Thornton , Deborah L. Zink , Angeles Cabello , Maria Teresa Diez , Isabel Martin , Fernando Pelaez
IPC分类号： A01N43/90 , A01N63/04 , C07K5/097 , C07D471/00 , A01N43/58
CPC分类号： C07K5/0821 , A01N43/90 , A01N63/04
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译：公开了具有抗真菌活性的具有式（I）＆lt; IMAGE＆gt;的式的新化合物。

6. 发明授权

US5756472A Antifungal agent obtained from hormonema 失效
标题翻译：从激素水解获得的抗真菌剂
公开(公告)号：US5756472A
公开(公告)日：1998-05-26
申请号：US789349
申请日：1997-01-27
申请人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Sandra A. Morris , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Wendy S. Horn , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
发明人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Sandra A. Morris , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Wendy S. Horn , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
IPC分类号： C07H15/24 , A61K31/70 , C07D315/00 , C12N1/14
CPC分类号： C07H15/24 , Y10S435/911
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译：公开了具有抗真菌活性的具有式（I）＆lt; IMAGE＆gt;的式的新化合物。

7. 发明授权

US5712151A Antifungal agent 失效
标题翻译：抗真菌剂
公开(公告)号：US5712151A
公开(公告)日：1998-01-27
申请号：US734702
申请日：1996-10-21
申请人： Sandra A. Morris , Gerald F. Bills , James E. Curotto , Sarah J. Dreikorn , Angela Basilio , Maria Teresa Diez , Fernando Pelaez , Francisca Vicente , Bruce W. Burgess , Stanley L. Streicher , Deborah L. Zink , John R. Thompson
发明人： Sandra A. Morris , Gerald F. Bills , James E. Curotto , Sarah J. Dreikorn , Angela Basilio , Maria Teresa Diez , Fernando Pelaez , Francisca Vicente , Bruce W. Burgess , Stanley L. Streicher , Deborah L. Zink , John R. Thompson
IPC分类号： A01N37/42 , C07D207/44 , C07D207/448 , C12P17/10 , C12N5/00 , C12N5/02
CPC分类号： C07D207/448 , A01N37/42 , C12P17/10 , C12R1/645
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译：公开了具有抗真菌活性的具有式（I）的化合物。

8. 发明授权

US5703067A Inhibitors of farnesyl-protein transferase 失效
标题翻译：法呢基蛋白转移酶抑制剂
公开(公告)号：US5703067A
公开(公告)日：1997-12-30
申请号：US435047
申请日：1995-05-08
申请人： Hiranthi Jayasuriya , Russell B. Lingham , Fernando Pelaez , Manuel Sanchez , Keith C. Silverman , Sheo Bux Singh , Deborah L. Zink
发明人： Hiranthi Jayasuriya , Russell B. Lingham , Fernando Pelaez , Manuel Sanchez , Keith C. Silverman , Sheo Bux Singh , Deborah L. Zink
IPC分类号： A61K31/575 , C07J9/00 , C07J17/00
CPC分类号： A61K31/573 , A61K31/575 , C07J17/00 , C07J9/00
摘要： The present invention is directed to steroidal or terpenoidal compounds which inhibit farnesyl-protein transferase (FPTase). The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer. The compounds of this invention have the following structure: ##STR1##
摘要翻译：本发明涉及抑制法呢基蛋白转移酶（FPTase）的甾族化合物或萜类化合物。本发明进一步涉及含有本发明化合物的化疗组合物和抑制法呢基蛋白转移酶和治疗癌症的方法。本发明的化合物具有以下结构：

9. 发明授权

US5543431A Anti-fungal agents 失效
公开(公告)号：US5543431A
公开(公告)日：1996-08-06
申请号：US449622
申请日：1995-05-24
申请人： Evon A. Bolessa , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez Perez , Angeles Cabello Arroyo , Teresa Diez Matas , Isabel Martin Fernandez , Francisca Vicente Perez , Suzanne M. Mandala , Deborah L. Zink , Rosemary Thornton , John R. Thompson , James E. Curotto
发明人： Evon A. Bolessa , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez Perez , Angeles Cabello Arroyo , Teresa Diez Matas , Isabel Martin Fernandez , Francisca Vicente Perez , Suzanne M. Mandala , Deborah L. Zink , Rosemary Thornton , John R. Thompson , James E. Curotto
IPC分类号： C07D207/12 , C07C233/09 , A61K31/16 , A61K31/695 , C07C233/20
CPC分类号： C07D207/12
摘要： A compound having the formula ##STR1## which is an anti-fungal agent is described. The producing organism Colletotricum accutatum is also described, along with a method of production.

10. 发明授权

US5789438A Inhibitors of farnesyl-protein transferase 失效
标题翻译：法呢基蛋白转移酶抑制剂
公开(公告)号：US5789438A
公开(公告)日：1998-08-04
申请号：US924557
申请日：1997-09-05
申请人： Sheo B. Singh , Russell B. Lingham , Keith C. Silverman , Deborah L. Zink , Isabel Martin , Fernando Pelaez , Manuel Sanchez
发明人： Sheo B. Singh , Russell B. Lingham , Keith C. Silverman , Deborah L. Zink , Isabel Martin , Fernando Pelaez , Manuel Sanchez
IPC分类号： C07D311/78 , C07D493/04 , A61K31/365 , C07D493/06
CPC分类号： C07D493/04 , C07D311/78
摘要： The present invention is directed to steroidal or terpenoidal compounds which inhibit farnesyl-protein transferase (FPTase). The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer.
摘要翻译：本发明涉及抑制法呢基蛋白转移酶（FPTase）的甾族化合物或萜类化合物。本发明进一步涉及含有本发明化合物的化疗组合物和抑制法呢基蛋白转移酶和治疗癌症的方法。

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