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1. 发明申请

US20120065718A1 CATHETER BALLOON AND METHOD FOR FORMING SAME 有权
标题翻译：导管气泡及其形成方法
公开(公告)号：US20120065718A1
公开(公告)日：2012-03-15
申请号：US12881733
申请日：2010-09-14
申请人： John A. Simpson , Sarah A. Nelson , Jonathan P. Durcan
发明人： John A. Simpson , Sarah A. Nelson , Jonathan P. Durcan
IPC分类号： A61F2/84 , A61L29/04 , B29C49/04 , A61M25/10
CPC分类号： A61M25/1029 , A61F2/958 , A61L29/04 , A61L29/06 , A61L29/14 , A61L2420/08 , A61M25/0009 , A61M25/10 , A61M25/1027 , A61M25/104 , A61M2025/1075 , B29C49/04 , B29C49/185 , B29C49/22 , B29L2031/7543 , Y10T428/1334 , Y10T428/1352 , Y10T428/1386 , Y10T428/1393
摘要： A catheter balloon and method involves extruded tubing with multiple layers of different durometer values, selected such that the blow up ratio (BUR) at the balloon's inner surface is increased. In one method a two stage blow mold process uses a small radius initial stage where radial growth is limited, followed by a second stage to a final dimension. A single stage blow mold process is also disclosed where the materials and processing are selected to approach the elongation to failure limit of the material. The single stage approach is preferably followed by a modified post-expansion heat set treatment to promote greater axial strength, leading to a preferred failure mode in the axial rather than radial direction.
摘要翻译：导管球囊和方法包括具有多层不同硬度值的挤出管，其选择为使得球囊内表面处的吹胀比（BUR）增加。在一种方法中，两级吹塑工艺使用径向生长受限的小半径初始阶段，随后是第二阶段到最终尺寸。还公开了单级吹塑工艺，其中选择材料和加工以接近材料的伸长率到破坏极限。单阶段方法优选地是经过改进的后膨胀热定形处理以促进更大的轴向强度，导致在轴向而不是径向方向上优选的破坏模式。

2. 发明授权

US08703260B2 Catheter balloon and method for forming same 有权
标题翻译：导管气球及其形成方法
公开(公告)号：US08703260B2
公开(公告)日：2014-04-22
申请号：US12881733
申请日：2010-09-14
申请人： John A. Simpson , Sarah A. Nelson , Jonathan P. Durcan
发明人： John A. Simpson , Sarah A. Nelson , Jonathan P. Durcan
IPC分类号： B32B1/00 , B32B1/08 , A61M29/00 , A61M31/00 , B29C71/00 , B29C49/00 , B29C47/00 , B29C45/14 , B29C35/02
CPC分类号： A61M25/1029 , A61F2/958 , A61L29/04 , A61L29/06 , A61L29/14 , A61L2420/08 , A61M25/0009 , A61M25/10 , A61M25/1027 , A61M25/104 , A61M2025/1075 , B29C49/04 , B29C49/185 , B29C49/22 , B29L2031/7543 , Y10T428/1334 , Y10T428/1352 , Y10T428/1386 , Y10T428/1393
摘要： A catheter balloon and method involves extruded tubing with multiple layers of different durometer values, selected such that the blow up ratio (BUR) at the balloon's inner surface is increased. In one method a two stage blow mold process uses a small radius initial stage where radial growth is limited, followed by a second stage to a final dimension. A single stage blow mold process is also disclosed where the materials and processing are selected to approach the elongation to failure limit of the material. The single stage approach is preferably followed by a modified post-expansion heat set treatment to promote greater axial strength, leading to a preferred failure mode in the axial rather than radial direction.
摘要翻译：导管球囊和方法包括具有多层不同硬度值的挤出管，其选择为使得球囊内表面处的吹胀比（BUR）增加。在一种方法中，两级吹塑工艺使用径向生长受限的小半径初始阶段，随后是第二阶段到最终尺寸。还公开了单级吹塑工艺，其中选择材料和加工以接近材料的伸长率到破坏极限。单阶段方法优选地是经过改进的后膨胀热定形处理以促进更大的轴向强度，导致在轴向而不是径向方向上优选的破坏模式。

3. 发明授权

US07906066B2 Method of making a balloon catheter shaft having high strength and flexibility 有权
标题翻译：制造具有高强度和柔韧性的球囊导管轴的方法
公开(公告)号：US07906066B2
公开(公告)日：2011-03-15
申请号：US11480143
申请日：2006-06-30
申请人： Bruce M. Wilson , Jonathan P. Durcan , John A. Simpson
发明人： Bruce M. Wilson , Jonathan P. Durcan , John A. Simpson
IPC分类号： B29C39/02 , B29C35/02 , B29C43/02 , B29C49/00 , B29C71/00 , B29C45/00 , B29C47/00 , B29C49/08 , B29C67/00 , B29D22/00 , A61M29/00
CPC分类号： A61M25/10 , A61M25/0009 , B29B2911/14586 , B29C49/0073 , B29C49/04 , B29C49/10 , B29C55/26 , B29C65/02 , B29C65/48 , B29C66/5344 , B29K2101/12 , B29K2995/0053 , B29L2022/022 , B29L2031/7542 , Y10S264/90 , Y10S264/903 , Y10S264/904
摘要： A catheter having an elongated shaft with a tubular member which forms at least a portion of the shaft and which is formed of a biaxially oriented thermoplastic polymeric material, and a method of forming the catheter shaft by radially and longitudinally expanding the tubular member to biaxially orient the polymeric material. A catheter of the invention has an improved combination of low bending stiffness, high rupture pressure, and high tensile strength, for improved catheter performance.
摘要翻译：一种具有细长轴的导管，其具有管状构件，其形成所述轴的至少一部分并且由双轴取向的热塑性聚合物材料形成，以及通过径向和纵向地将所述管状构件膨胀成双轴取向形成所述导管轴的方法聚合材料。本发明的导管具有改进的低弯曲刚度，高断裂压力和高拉伸强度的组合，以改善导管性能。

4. 发明申请

US20080125707A1 Balloon catheter shaft having high strength and flexibility and method of making same 有权
标题翻译：气球导管轴具有高强度和灵活性，并且制作方法
公开(公告)号：US20080125707A1
公开(公告)日：2008-05-29
申请号：US11480143
申请日：2006-06-30
申请人： Bruce M. Wilson , Jonathan P. Durcan , John A. Simpson
发明人： Bruce M. Wilson , Jonathan P. Durcan , John A. Simpson
IPC分类号： A61M25/10 , B29C65/00 , B29C49/02
CPC分类号： A61M25/10 , A61M25/0009 , B29B2911/14586 , B29C49/0073 , B29C49/04 , B29C49/10 , B29C55/26 , B29C65/02 , B29C65/48 , B29C66/5344 , B29K2101/12 , B29K2995/0053 , B29L2022/022 , B29L2031/7542 , Y10S264/90 , Y10S264/903 , Y10S264/904
摘要： A catheter having an elongated shaft with a tubular member which forms at least a portion of the shaft and which is formed of a biaxially oriented thermoplastic polymeric material, and a method of forming the catheter shaft by radially and longitudinally expanding the tubular member to biaxially orient the polymeric material. A catheter of the invention has an improved combination of low bending stiffness, high rupture pressure, and high tensile strength, for improved catheter performance.
摘要翻译：一种具有细长轴的导管，其具有管状构件，其形成所述轴的至少一部分并且由双轴取向的热塑性聚合物材料形成，以及通过径向和纵向地将所述管状构件膨胀成双轴取向形成所述导管轴的方法聚合材料。本发明的导管具有改进的低弯曲刚度，高断裂压力和高拉伸强度的组合，以改善导管性能。

5. 发明授权

US08382738B2 Balloon catheter tapered shaft having high strength and flexibility and method of making same 有权
标题翻译：气球导管锥形轴具有高强度和灵活性及其制造方法
公开(公告)号：US08382738B2
公开(公告)日：2013-02-26
申请号：US11763623
申请日：2007-06-15
申请人： John A. Simpson , Jonathan P. Durcan , Bruce M. Wilson
发明人： John A. Simpson , Jonathan P. Durcan , Bruce M. Wilson
IPC分类号： A61M29/00 , A61M31/00 , A61M37/00 , A61M25/00
CPC分类号： A61L29/06 , A61M25/00 , A61M25/0009 , A61M25/0021 , A61M25/0054 , A61M25/10 , A61M25/1006 , A61M25/1029 , A61M25/1034 , A61M25/1036 , A61M25/104 , A61M2025/018 , A61M2025/0183 , A61M2025/1031 , B29C47/0023 , B29C47/0026 , B29C47/0028 , B29C47/0033 , B29C47/0038 , B29C47/0057 , B29C49/00 , B29C49/04 , B29C49/08 , B29C49/18 , B29C49/64 , B29C55/26 , B29C65/02 , B29C65/48 , B29C66/1122 , B29C66/24221 , B29C66/53241 , B29C66/534 , B29C66/73711 , B29C66/73713 , B29C2049/0089 , B29C2791/001 , B29D23/001 , B29K2105/258 , B29L2022/022 , B29L2031/7542
摘要： A catheter having an elongated shaft with a tubular member which forms at least a portion of the shaft and which is formed of a biaxially oriented thermoplastic polymeric material, and a method of forming the catheter shaft by radially and longitudinally expanding the tubular member to biaxially orient the polymeric material, and, in one embodiment, tapering the tubular member to form a bending stiffness transition. A catheter of the invention has an improved combination of low bending stiffness, high rupture pressure, and high tensile strength, for improved catheter performance.
摘要翻译：一种具有细长轴的导管，其具有管状构件，其形成所述轴的至少一部分并且由双轴取向的热塑性聚合物材料形成，以及通过径向和纵向地将所述管状构件膨胀成双轴取向形成所述导管轴的方法聚合物材料，并且在一个实施例中，使管状构件逐渐变细以形成弯曲刚度过渡。本发明的导管具有改进的低弯曲刚度，高断裂压力和高拉伸强度的组合，以改善导管性能。

6. 发明申请

US20120143129A1 BALLOON CATHETER SHAFT HAVING HIGH STRENGTH AND FLEXIBILITY 有权
标题翻译：具有高强度和灵活性的气缸导管轴
公开(公告)号：US20120143129A1
公开(公告)日：2012-06-07
申请号：US13398178
申请日：2012-02-16
申请人： John A. Simpson , Jonathan P. Durcan , Bruce M. Wilson
发明人： John A. Simpson , Jonathan P. Durcan , Bruce M. Wilson
IPC分类号： A61M25/10 , B29C65/00
CPC分类号： A61L29/06 , A61M25/00 , A61M25/0009 , A61M25/0021 , A61M25/0054 , A61M25/10 , A61M25/1006 , A61M25/1029 , A61M25/1034 , A61M25/1036 , A61M25/104 , A61M2025/018 , A61M2025/0183 , A61M2025/1031 , B29C47/0023 , B29C47/0026 , B29C47/0028 , B29C47/0033 , B29C47/0038 , B29C47/0057 , B29C49/00 , B29C49/04 , B29C49/08 , B29C49/18 , B29C49/64 , B29C55/26 , B29C65/02 , B29C65/48 , B29C66/1122 , B29C66/24221 , B29C66/53241 , B29C66/534 , B29C66/73711 , B29C66/73713 , B29C2049/0089 , B29C2791/001 , B29D23/001 , B29K2105/258 , B29L2022/022 , B29L2031/7542
摘要： Balloon catheter comprises an elongated shaft having a proximal end, a distal end, an inflation lumen extending therein, and a biaxially oriented nonporous thermoplastic polymer tubular member having a Shore durometer hardness of less than about 75D and having the inflation lumen therein. The balloon catheter also comprises a balloon sealing secured proximate the distal end of the shaft and having an interior in fluid communication with the inflation lumen.
摘要翻译：气球导管包括细长轴，其具有近端，远端，在其中延伸的充气腔，以及双轴取向的无孔热塑性聚合物管状构件，其具有小于约75D的肖氏硬度计硬度并且其中具有充气腔。球囊导管还包括靠近轴的远端固定并具有与膨胀腔流体连通的内部的气囊密封件。

7. 发明申请

US20080045928A1 BALLOON CATHETER TAPERED SHAFT HAVING HIGH STRENGTH AND FLEXIBILITY AND METHOD OF MAKING SAME 有权
标题翻译：具有高强度和柔韧性的气泡导管片及其制造方法
公开(公告)号：US20080045928A1
公开(公告)日：2008-02-21
申请号：US11763623
申请日：2007-06-15
申请人： John A. Simpson , Jonathan P. Durcan , Bruce M. Wilson
发明人： John A. Simpson , Jonathan P. Durcan , Bruce M. Wilson
IPC分类号： A61M25/10
CPC分类号： A61L29/06 , A61M25/00 , A61M25/0009 , A61M25/0021 , A61M25/0054 , A61M25/10 , A61M25/1006 , A61M25/1029 , A61M25/1034 , A61M25/1036 , A61M25/104 , A61M2025/018 , A61M2025/0183 , A61M2025/1031 , B29C47/0023 , B29C47/0026 , B29C47/0028 , B29C47/0033 , B29C47/0038 , B29C47/0057 , B29C49/00 , B29C49/04 , B29C49/08 , B29C49/18 , B29C49/64 , B29C55/26 , B29C65/02 , B29C65/48 , B29C66/1122 , B29C66/24221 , B29C66/53241 , B29C66/534 , B29C66/73711 , B29C66/73713 , B29C2049/0089 , B29C2791/001 , B29D23/001 , B29K2105/258 , B29L2022/022 , B29L2031/7542
摘要： A catheter having an elongated shaft with a tubular member which forms at least a portion of the shaft and which is formed of a biaxially oriented thermoplastic polymeric material, and a method of forming the catheter shaft by radially and longitudinally expanding the tubular member to biaxially orient the polymeric material, and, in one embodiment, tapering the tubular member to form a bending stiffness transition. A catheter of the invention has an improved combination of low bending stiffness, high rupture pressure, and high tensile strength, for improved catheter performance.
摘要翻译：一种具有细长轴的导管，其具有管状构件，其形成所述轴的至少一部分并且由双轴取向的热塑性聚合物材料形成，以及通过径向和纵向地将所述管状构件膨胀成双轴取向形成所述导管轴的方法聚合物材料，并且在一个实施例中，使管状构件逐渐变细以形成弯曲刚度过渡。本发明的导管具有改进的低弯曲刚度，高断裂压力和高拉伸强度的组合，以改善导管性能。

8. 发明授权

US08388602B2 Balloon catheter shaft having high strength and flexibility 有权
标题翻译：气球导管轴具有高强度和柔韧性
公开(公告)号：US08388602B2
公开(公告)日：2013-03-05
申请号：US13398178
申请日：2012-02-16
申请人： Bruce M. Wilson , Jonathan P. Durcan , John A. Simpson
发明人： Bruce M. Wilson , Jonathan P. Durcan , John A. Simpson
IPC分类号： A61M29/00 , A61M31/00 , A61M37/00 , A61M25/00
CPC分类号： A61L29/06 , A61M25/00 , A61M25/0009 , A61M25/0021 , A61M25/0054 , A61M25/10 , A61M25/1006 , A61M25/1029 , A61M25/1034 , A61M25/1036 , A61M25/104 , A61M2025/018 , A61M2025/0183 , A61M2025/1031 , B29C47/0023 , B29C47/0026 , B29C47/0028 , B29C47/0033 , B29C47/0038 , B29C47/0057 , B29C49/00 , B29C49/04 , B29C49/08 , B29C49/18 , B29C49/64 , B29C55/26 , B29C65/02 , B29C65/48 , B29C66/1122 , B29C66/24221 , B29C66/53241 , B29C66/534 , B29C66/73711 , B29C66/73713 , B29C2049/0089 , B29C2791/001 , B29D23/001 , B29K2105/258 , B29L2022/022 , B29L2031/7542
摘要： Balloon catheter comprises an elongated shaft having a proximal end, a distal end, an inflation lumen extending therein, and a biaxially oriented nonporous thermoplastic polymer tubular member having a Shore durometer hardness of less than about 75D and having the inflation lumen therein. The balloon catheter also comprises a balloon sealing secured proximate the distal end of the shaft and having an interior in fluid communication with the inflation lumen.
摘要翻译：气球导管包括细长轴，其具有近端，远端，在其中延伸的充气腔，以及双轴取向的无孔热塑性聚合物管状构件，其具有小于约75D的肖氏硬度计硬度并且其中具有充气腔。球囊导管还包括靠近轴的远端固定并具有与膨胀腔流体连通的内部的气囊密封件。

9. 发明授权

US08535596B2 Non-compliant multilayered balloon for a catheter 有权
标题翻译：用于导管的不符合标准的多层气囊
公开(公告)号：US08535596B2
公开(公告)日：2013-09-17
申请号：US13397140
申请日：2012-02-15
申请人： Jonathan P. Durcan
发明人： Jonathan P. Durcan
IPC分类号： B29C49/22
CPC分类号： A61M25/1029 , A61F2/958 , A61F2250/0018 , A61F2250/0063 , A61L29/06 , A61M25/10 , A61M25/104 , A61M2025/1075 , A61M2025/1084 , B29C67/0014 , C08L77/00
摘要： Method of making a multilayer balloon for a catheter having a nominal working diameter comprises forming a tube having at least a first layer and a second layer having a combined wall thickness. The first layer is made of a first polymer material having a first maximum blow-up-ratio and the second layer is made of a second polymer material having a second maximum blow-up-ratio greater than the first maximum blow-up-ratio. The second layer is an inner layer relative to the first layer. The method also comprises forming the multilayer balloon from the tube in a balloon mold having an inner diameter corresponding to the balloon's nominal working diameter. The at least first and second layers of the multilayer balloon define a compliance less than that of a single layer balloon made of the first polymer material with a wall thickness equal to the combined wall thickness.
摘要翻译：制造具有标称工作直径的导管的多层气囊的方法包括形成具有至少第一层的管和具有组合的壁厚度的第二层。第一层由具有第一最大吹胀比的第一聚合物材料制成，并且第二层由具有大于第一最大吹胀比的第二最大吹胀比的第二聚合物材料制成。第二层是相对于第一层的内层。该方法还包括在具有对应于球囊的标称工作直径的内径的球囊模具中从管形成多层气囊。所述多层气囊的至少第一层和第二层限定了比由第一聚合物材料制成的单层球囊的顺应性小的壁厚度，其厚度等于组合的壁厚度。

10. 发明授权

US07060218B2 Adjustable length mold assemblies 有权
公开(公告)号：US07060218B2
公开(公告)日：2006-06-13
申请号：US10990046
申请日：2004-11-16
申请人： Johann J. Skinner , Kerry J. Williams , Jonathan P. Durcan
发明人： Johann J. Skinner , Kerry J. Williams , Jonathan P. Durcan
IPC分类号： B29C49/48 , B29D23/00
CPC分类号： A61M25/1029 , A61F2/958 , A61M25/1002 , A61M25/1038 , A61M2025/1004 , B29C35/045 , B29C49/48 , B29C49/64 , B29C51/225 , B29C51/424 , B29C2035/1658 , B29C2049/481 , B29L2022/022 , B29L2031/7542
摘要： The invention is directed to adjustable length mold assemblies for forming inflatable members and methods for using adjustable length mold assemblies for forming inflatable members, such as, for example, balloons for use with balloon catheters and stent delivery systems. The adjustable length mold assemblies comprise at least two mold pieces adapted to fit together, one mold piece having a surface configured to be slidably received by a bore of the other mold piece, the placement of one piece within the other defining a chamber of variable length which forms the mold. Each adjustable length mold assembly of the present invention is effective to form balloons, where if desired different balloons formed by a single mold may have different lengths. The adjustable length mold assemblies may also comprise a positioner to put a mold piece in a desired position relative to the other, and a locking mechanism to secure a mold piece in a desired position.

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