专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07247736B2 Method of identifying inhibitors of DHODH 有权
标题翻译：鉴定DHODH抑制剂的方法
公开(公告)号：US07247736B2
公开(公告)日：2007-07-24
申请号：US10736739
申请日：2004-11-10
申请人： Johann Leban , Bernd Kramer , Roland Baumgartner , Katharina Aulinger-Fuchs , Stefan Tasler
发明人： Johann Leban , Bernd Kramer , Roland Baumgartner , Katharina Aulinger-Fuchs , Stefan Tasler
IPC分类号： C07D333/10 , C07C235/84
CPC分类号： A61K31/401 , A61K31/44 , C07C233/60 , C07C2601/10 , C07D333/24 , Y02A50/411
摘要： The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH. Furthermore, the present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains an aromatic ring system as a core structure, a group capable of interacting with residues His 56 and/or Tyr 356 of subsite 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH.
摘要翻译：本发明提供能够结合DHODH的泛素结合位点的化合物，其含有非芳香族环系统作为核心结构，能够与DHODH的泛素结合位点的亚位点2或3的结构元件相互作用的基团和能够与DHODH的泛醌结合位点的亚位点1的结构元件疏水相互作用的基团。此外，本发明提供能够结合含有芳环系统作为核心结构的DHODH的泛素结合位点的化合物，能够与泛醌结合的亚位点3的残基His 56和/或Tyr 356相互作用的基团 DHODH的位点和能够与DHODH的泛素结合位点的亚位点1的结构元件疏水相互作用的基团。

2. 发明申请

US20070224672A1 Method of Identifying Inhibitors of DHODH 审中-公开
标题翻译：鉴定DHODH抑制剂的方法
公开(公告)号：US20070224672A1
公开(公告)日：2007-09-27
申请号：US11626140
申请日：2007-01-23
申请人： Johann Leban , Bernd Kramer , Roland Baumgartner , Katharina Aulinger-Fuchs , Stefan Tasler
发明人： Johann Leban , Bernd Kramer , Roland Baumgartner , Katharina Aulinger-Fuchs , Stefan Tasler
IPC分类号： C12N9/02 , G06F19/00
CPC分类号： A61K31/401 , A61K31/44 , C07C233/60 , C07C2601/10 , C07D333/24 , Y02A50/411
摘要： The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH. Furthermore, the present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains an aromatic ring system as a core structure, a group capable of interacting with residues His 56 and/or Tyr 356 of subsite 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH.
摘要翻译：本发明提供能够结合DHODH的泛素结合位点的化合物，其含有非芳香族环系统作为核心结构，能够与DHODH的泛素结合位点的亚位点2或3的结构元件相互作用的基团和能够与DHODH的泛醌结合位点的亚位点1的结构元件疏水相互作用的基团。此外，本发明提供能够结合含有芳环系统作为核心结构的DHODH的泛素结合位点的化合物，能够与泛醌结合的亚位点3的残基His 56和/或Tyr 356相互作用的基团 DHODH的位点和能够与DHODH的泛素结合位点的亚位点1的结构元件疏水相互作用的基团。

3. 发明授权

US08592456B2 IL17 and IFN-gamma inhibition for the treatment of autoimmune inflammation 有权
公开(公告)号：US08592456B2
公开(公告)日：2013-11-26
申请号：US13360050
申请日：2012-01-27
申请人： Johann Leban , Stefan Tasler , Roland Baumgartner , Wael Saeb , Carine Chevrier
发明人： Johann Leban , Stefan Tasler , Roland Baumgartner , Wael Saeb , Carine Chevrier
IPC分类号： A61K31/454 , A61K31/444 , A61K31/4439 , A61K31/422 , C07D401/14 , C07D405/14 , C07D405/04
CPC分类号： C07D413/04
摘要： The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salt or solvate thereof, as anti-inflammatory and immunomodulatory agents.

4. 发明授权

US08354433B2 Anti-inflammatory agents as virostatic compounds 有权
标题翻译：抗炎剂作为静脉药物
公开(公告)号：US08354433B2
公开(公告)日：2013-01-15
申请号：US12772470
申请日：2010-05-03
申请人： Daniel Vitt , Manfred Groeppel , Roland Baumgartner , Johann Leban
发明人： Daniel Vitt , Manfred Groeppel , Roland Baumgartner , Johann Leban
IPC分类号： A61K31/44
CPC分类号： A61K31/196 , A61K31/341 , A61K31/381 , A61K31/44 , C07D213/78 , C07D307/68 , C07D333/38 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/397 , Y02A50/467
摘要： The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, for the use as a medicament.
摘要翻译：本发明涉及用作药物的通式（I）的化合物及其盐和生理功能衍生物。

5. 发明申请

US20070110594A1 CONTROLLABLE DRIVE FOR A MOTOR VEHICLE, IN PARTICULAR FOR A COOLANT PUMP 有权
标题翻译：适用于汽车的可控驱动，特别适用于冷却液泵
公开(公告)号：US20070110594A1
公开(公告)日：2007-05-17
申请号：US11555937
申请日：2006-11-02
申请人： Roland Baumgartner , Ralf Maus
发明人： Roland Baumgartner , Ralf Maus
IPC分类号： F04B9/00
CPC分类号： F16D35/024 , F01P5/12 , F04D13/022
摘要： A controllable drive (1) suitable for a motor vehicle coolant pump (2) comprises a rotatably mounted shaft (5), a driven member (7) which is rotationally fixedly mounted on the shaft (5), a driving member (9) which is mounted so as to be rotatable relative to the shaft (5), and a coupling region (7/8) which is arranged between the driving and driven members (9, 7) and holds a viscous fluid. At least one first flow path and at least one second flow path connect a fluid reservoir to the coupling region (7/8), and an actuation device (11a, 11b, 12, 13, 14) changes at least one passage opening of at least one flow path. A coupling housing (8, 8a, 8b) is connected to the driving member (9), and the actuator (14) is arranged within the coupling housing (8, 8a, 8b).
摘要翻译：适用于机动车辆冷却剂泵（2）的可控驱动器（1）包括可旋转地安装的轴（5），被旋转地固定地安装在轴（5）上的从动构件（7），驱动构件（9）安装成能够相对于轴（5）旋转，以及联接区域（7/8），其布置在驱动构件和被驱动构件（9,7）之间并保持粘性流体。至少一个第一流动路径和至少一个第二流动路径将流体储存器连接到联接区域（7/8），并且致动装置（11a，11b，12,13,14）改变至少一个通道开口的至少一个流动路径。联接壳体（8,8a，8b）连接到驱动构件（9），并且致动器（14）布置在联接壳体（8,8a，8b）内。

6. 发明授权

US07828529B2 Regulatable drive for a motor vehicle component 有权
标题翻译：机动车部件的可调节驱动
公开(公告)号：US07828529B2
公开(公告)日：2010-11-09
申请号：US11062754
申请日：2005-02-23
申请人： Roland Baumgartner , Ralf Maus , Gerold Schultheiss
发明人： Roland Baumgartner , Ralf Maus , Gerold Schultheiss
IPC分类号： F04B49/00 , F04B17/00
CPC分类号： F01P5/12 , F01P7/042 , F01P7/162 , F01P7/164 , F16D35/024
摘要： A regulatable drive for a motor vehicle, in particular for a water pump in a motor vehicle, has a rotatably mounted shaft, on which is located a rotatably mounted drive member and a rotationally fixed driven member. Between the drive member and driven member, a coupling region is defined, which can receive a viscous fluid for selectively coupling the drive member and driven member. The regulatable drive includes at least one first and at least one second flow path, which connect a fluid storage space to the coupling region, and it has a device which can be varied in its position by means of at least one actuator and which varies at least one passage orifice of at least one of the flow paths.
摘要翻译：用于机动车辆，特别是机动车辆中的水泵的可调节驱动器具有可旋转地安装的轴，其上设置有可旋转地安装的驱动构件和旋转固定的从动构件。在驱动构件和从动构件之间限定了联接区域，其可以容纳用于选择性地联接驱动构件和被驱动构件的粘性流体。可调节驱动器包括至少一个第一和至少一个第二流动路径，其将流体存储空间连接到联接区域，并且其具有可以通过至少一个致动器在其位置变化的装置，并且其在至少一个流路的至少一个通道孔。

7. 发明申请

US20070020973A1 Connector plug and mating plug 失效
公开(公告)号：US20070020973A1
公开(公告)日：2007-01-25
申请号：US11488125
申请日：2006-07-18
申请人： Fred Sattele , Roland Baumgartner
发明人： Fred Sattele , Roland Baumgartner
IPC分类号： H01R13/648
CPC分类号： H01R24/40 , H01R13/627 , H01R13/6277 , H01R2103/00
摘要： The invention concerns a coaxial connector plug and mating plug in which the connector plug has a connector housing that is open at the front end for plugging in the mating plug and contains a canal holding an insulated internal conductor contact, with a clamp sleeve and a sliding sleeve that can be moved axially to mechanically connect the connector housing with the mating plug, wherein the sliding sleeve surrounds the clamp sleeve in the operating position and exerts on it a force directed radially inward in the operating position, and wherein the clamp sleeve can be made to rest against the mating plug at a clamp surface, and wherein an outer conductor contact surface of the mating plug can be clamped axially against an outer conductor contact surface of the connector plug. The purpose of the invention is to create a connector plug of the sort described above, where an outer conductor contact surface of the mating plug can be axially clamped against an outer conductor contact surface of the connector plug, independent of the shape of the clamp surface, in other words, even if the clamp surface is perpendicular to the longitudinal axis of the mating plug. This purpose is achieved in that the clamp sleeve (8) has an end section (15) with a part (15a) extending diagonally outward followed by a part (15b) extending diagonally inward and backward, wherein an axial force component (Fa) is exerted in the operating position by the clamp sleeve (8) on the clamp surface (13) via the part (15b) extending backward and in that the clamp sleeve (8) has a widening part (12) between the connector plug and the end section (15) followed by a narrowing part (12a).

8. 发明授权

US06846206B2 Electrical plug connector 失效
标题翻译：电插头连接器
公开(公告)号：US06846206B2
公开(公告)日：2005-01-25
申请号：US10362015
申请日：2002-04-16
申请人： Martin Kling , Thomas Kotlarski , Josef Hierl , Jiri Legat , Michal Trnka , Roland Baumgartner , Ivan Feranec , Karel Rybak
发明人： Martin Kling , Thomas Kotlarski , Josef Hierl , Jiri Legat , Michal Trnka , Roland Baumgartner , Ivan Feranec , Karel Rybak
IPC分类号： H01R11/11 , H01R13/04 , H01R13/05 , H01R9/24
CPC分类号： H01R13/055
摘要： An electrical plug connector has a flat insertion pin and a flat insertion sheath into which the flat insertion pin can be inserted. The flat insertion pin, in its end region pointing in the insertion direction, has a widened portion embodied in the shape of a hammerhead.
摘要翻译：电插头连接器具有扁平插入销和扁平插入护套，扁平插入销可插入该插入插头。平面插入销在其指向插入方向的端部区域中具有以锤头形状体现的加宽部分。

9. 发明授权

US07914264B2 Controllable drive for a motor vehicle, in particular for a coolant pump 有权
标题翻译：机动车辆的可控制驱动装置，特别是冷却液泵
公开(公告)号：US07914264B2
公开(公告)日：2011-03-29
申请号：US11555937
申请日：2006-11-02
申请人： Roland Baumgartner , Ralf Maus
发明人： Roland Baumgartner , Ralf Maus
IPC分类号： F04B49/03 , F04B9/00 , F16D31/00
CPC分类号： F16D35/024 , F01P5/12 , F04D13/022
摘要： A controllable drive (1) suitable for a motor vehicle coolant pump (2) comprises a rotatably mounted shaft (5), a driven member (7) which is rotationally fixedly mounted on the shaft (5), a driving member (9) which is mounted so as to be rotatable relative to the shaft (5), and a coupling region (7/8) which is arranged between the driving and driven members (9, 7) and holds a viscous fluid. At least one first flow path and at least one second flow path connect a fluid reservoir to the coupling region (7/8), and an actuation device (11a, 11b, 12, 13, 14) changes at least one passage opening of at least one flow path. A coupling housing (8, 8a, 8b) is connected to the driving member (9), and the actuator (14) is arranged within the coupling housing (8, 8a, 8b).
摘要翻译：适用于机动车辆冷却剂泵（2）的可控驱动器（1）包括可旋转地安装的轴（5），被旋转地固定地安装在轴（5）上的从动构件（7），驱动构件（9）安装成能够相对于轴（5）旋转，以及联接区域（7/8），其布置在驱动构件和被驱动构件（9,7）之间并保持粘性流体。至少一个第一流动路径和至少一个第二流动路径将流体储存器连接到联接区域（7/8），并且致动装置（11a，11b，12,13,14）改变至少一个通道开口至少一个流路。联接壳体（8,8a，8b）连接到驱动构件（9），并且致动器（14）布置在联接壳体（8,8a，8b）内。

10. 发明申请

US20060099853A1 Coaxial plug connector and mating connector 有权
标题翻译：同轴插头连接器和配对连接器
公开(公告)号：US20060099853A1
公开(公告)日：2006-05-11
申请号：US11037822
申请日：2005-01-18
申请人： Fred Sattele , Roland Baumgartner
发明人： Fred Sattele , Roland Baumgartner
IPC分类号： H01R9/05
CPC分类号： H01R24/40 , H01R13/62 , H01R13/6277 , H01R13/639 , H01R2103/00
摘要： A connector includes a plug connector and a mating connector. The plug connector includes a housing with an open front end, an insulated inner conductor disposed within the housing, a clamping sleeve and an axially movable sliding sleeve disposed radially outside the clamping sleeve. The sliding sleeve can be positioned in a working position where it surrounds the clamping sleeve and exerts a radially inward-directed force. The mating connector, which is receivable within the housing, includes a clamping surface. A force Fr introduced radially from the sliding sleeve toward the clamping sleeve when the sliding sleeve is in the working position is redirected by the clamping sleeve into an axial force component Fa which is introduced from the clamping sleeve toward the clamping surface.
摘要翻译：连接器包括插头连接器和配合连接器。插头连接器包括具有开放前端的壳体，设置在壳体内的绝缘内部导体，夹紧套筒和径向位于夹紧套筒外侧的可轴向移动的滑动套筒。滑动套筒可以被定位在其围绕夹紧套筒并施加径向向内的力的工作位置。可接收在壳体内的配合连接器包括夹紧表面。当滑动套筒处于工作位置时，从滑动套筒径向引导到夹紧套筒的力F R 1被夹紧套筒重新定位成轴向力分量F a，其从夹紧套筒向夹紧表面引入。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式