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    • 8. 发明申请
    • Inhibitors of cancer cell, T-cell and keratinocyte proliferation
    • 癌细胞抑制剂,T细胞和角化细胞增殖
    • US20070037753A1
    • 2007-02-15
    • US11501722
    • 2006-08-10
    • Johann LebanMartin Kralik
    • Johann LebanMartin Kralik
    • A61K38/05A61K38/04C07K5/04C07D403/02
    • C07D233/72A61K38/00C07D403/12C07D405/12C07D409/12C07D417/14C07K5/0205C07K5/06078C07K5/06191Y02A50/409
    • The invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein Y is —NRaRb, —NRcC═ONRaRb, —NRcC═SNRaRb, —NRcC═NRdNaRb, heterocycle, —C═ONRaRb, heterocycle, or aryl; n is 0 to 8; m is 0, or 1; r is 0 to 3; t is 0 to 3; X is O or N; Z is CH2, C═O, C═S or a single bond; Z1 is CO—R2, CS—R2, (CH2)t—R2 or the side-chain of a naturally occuring amino acid;, Z2 is CO—R2, CS—R2 or (CH2)t—R3 or the side-chain of a naturally occuring amino acid; Z3 is CO—R2, CS—R2 or (CH2)t—R4 or the side-chain of a naturally occuring amino acid; Z4 is H, alkyl, alkoxy, or cycloalkyl; R1, R2, R3, and R4 are independently from each other H, OH, SH, NH2, CN, NO2, alkyl, cycloalkyl, heterocycloalkyl, haloalkyl, alkylthio, haloalkyloxy, hydroxyalkyl, hydroxyalkylamino, alkylamino, alkylaryl, alkylsulfinyl, alkylsulfonyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, alkoxyalkyl, alkoxy, aryloxy, heteroaryl, aryl, or halogen.
    • 本发明涉及通式(I)的化合物及其盐和生理功能衍生物,其中Y是-NR a,R b, C-ON< b> b<<< C> C-SNR< b> b C 1 -C 6卤代烷基,杂环基,C 1 -C 6 - 杂环或芳基;杂环或芳基; n为0〜8; m为0或1; r为0〜3; t为0〜3; X是O或N; Z是CH 2,C-O,C-S或单键; Z 1是CO-R 2,CS-R 2,(CH 2)2, / SUB> -R 2或天然存在的氨基酸的侧链; Z 2是CO-R 2,CS- R 2或(CH 2)2 -TH 3或天然存在的氨基酸的侧链 ; Z 3是CO-R 2,CS-R 2或(CH 2 CH 2) / SUB→4或天然存在的氨基酸的侧链; Z 4是H,烷基,烷氧基或环烷基; R 1,R 2,R 3和R 4彼此独立地为H,OH,SH ,NH 2,CN,NO 2,烷基,环烷基,杂环烷基,卤代烷基,烷硫基,卤代烷氧基,羟烷基,羟烷基氨基,烷基氨基,烷基芳基,烷基亚磺酰基,烷基磺酰基,烷硫基烷基,烷基亚磺酰基烷基 烷基磺酰基烷基,烷氧基烷基,烷氧基,芳氧基,杂芳基,芳基或卤素。