专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4064256A Benzopyranyltetrazoles as antiasthma agents 失效
标题翻译：苯并吡喃基四唑作为抗哮喘药
公开(公告)号：US4064256A
公开(公告)日：1977-12-20
申请号：US539437
申请日：1975-01-03
申请人： Joachim Augstein , Hugh Cairns , Dennis Hunter , John King
发明人： Joachim Augstein , Hugh Cairns , Dennis Hunter , John King
IPC分类号： A61K31/41 , C07D311/24 , C07D335/06 , C07F1/00
CPC分类号： C07D335/06 , C07C321/00 , C07C323/00 , C07D311/24 , C07F1/005 , Y10S514/826
摘要： There are described compounds of formula I, ##STR1## in which R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, are hydrogen, alkyl C2 to 6, alkoxy C2 to 8, hydroxy-alkoxy C3 to 8, and R.sub.5 may be hydroxy, provided that one or two of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are other than hydrogen, and pharmaceutically acceptable derivatives thereof. The compounds of formula I are indicated for use in the treatment of asthma, and pharmaceutical compositions containing them and processes for their preparation are also described.
摘要翻译：描述了式I的化合物，其中R 5，R 6，R 7和R 8可以相同或不同，为氢，烷基C2至6，烷氧基C2至8，羟基 - 烷氧基C3至8，并且R 5可以是羟基，条件是R 5，R 6，R 7和R 8中的一个或两个不是氢，及其药学上可接受的衍生物。式I化合物用于治疗哮喘，还描述了含有它们的药物组合物及其制备方法。

2. 发明授权

US4029802A The treatment of asthma, hay fever or urticaria 失效
标题翻译：治疗哮喘，花粉症或荨麻疹
公开(公告)号：US4029802A
公开(公告)日：1977-06-14
申请号：US463180
申请日：1974-04-22
申请人： Joachim Augstein , Hugh Cairns , Dennis Hunter , John King
发明人： Joachim Augstein , Hugh Cairns , Dennis Hunter , John King
IPC分类号： C07D311/24 , A61K31/41
CPC分类号： C07D311/24
摘要： There are described compounds of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are the same or are different and each is a hydrogen or halogen atom or an alkyl, hydroxy, alkoxy, or substituted alkyl or alkoxy group, (for example a hydroxy-alkoxy, alkoxyalkoxy or carboxyalkoxy group), and X is a saturated or unsaturated, substituted or unsubstituted, straight or branched hydrocarbon chain which may be interrupted by a carbocyclic or heterocyclic ring, or by one or more oxygen atoms or carbonyl groups. There are also described processes for making the compounds and pharmaceutical compositions, for the treatment of asthma, containing the compounds.
摘要翻译：描述了式I，其中R 1，R 2，R 3，R 4，R 5和R 6相同或不同并且各自为氢或卤素原子的式I化合物，其中R 1，R 2，R 3，R 4，R 5和R 6相同或不同，或烷基，羟基，烷氧基或取代的烷基或烷氧基，（例如羟基 - 烷氧基，烷氧基烷氧基或羧基烷氧基），X是可被中断的饱和或不饱和的，取代或未取代的直链或支链烃链通过碳环或杂环，或由一个或多个氧原子或羰基组成。还描述了制备用于治疗含有化合物的哮喘的化合物和药物组合物的方法。

3. 发明授权

US3933844A Benzopyranyltetrazoles 失效
标题翻译：苯并吡喃基四唑
公开(公告)号：US3933844A
公开(公告)日：1976-01-20
申请号：US175394
申请日：1971-08-26
申请人： Joachim Augstein , Hugh Cairns , Dennis Hunter , John King
发明人： Joachim Augstein , Hugh Cairns , Dennis Hunter , John King
IPC分类号： C07D311/22 , C07D311/24 , C07D335/06 , C07D405/04 , C07D409/04 , C07F1/00 , C07D405/14 , C07D409/14
CPC分类号： C07D335/06 , C07C321/00 , C07C323/00 , C07D311/24 , C07F1/005 , Y10S514/826
摘要： There are described compounds of formula I, ##SPC1##in whichR.sub.5, r.sub.6, r.sub.7 and R.sub.8, which may be the same or different, are hydrogen, alkyl, halogen, hydroxy, alkenyl, phenyl, alkenyloxy, aralkyl, acyloxy or alkoxy; the alkoxy optionally being substituted by alkoxy, hydroxy, or a heterocyclic ring containing carbon and oxygen; the alkyl, alkenyl and alkoxy groups containing from 1 to 8 carbon atoms, andW is oxygen or sulphur,And pharmaceutically acceptable derivatives thereof.Certain of the compounds in which W is oxygen are excluded. The compounds of formula I are indicated for use in the treatment of asthma, and pharmaceutical compositions containing them and processes for their preparation are also described.
摘要翻译：描述式I化合物，其中可以相同或不同的R 5，R 6，R 7和R 8是氢，烷基，卤素，羟基，烯基，苯基，烯氧基，芳烷基，酰氧基或烷氧基; 任选被烷氧基，羟基或含有碳和氧的杂环取代的烷氧基; 含有1至8个碳原子的烷基，烯基和烷氧基，W是氧或硫，以及其药学上可接受的衍生物。

4. 发明授权

US3933845A Benzopyranyltetrazoles 失效
标题翻译：苯并吡喃基四唑
公开(公告)号：US3933845A
公开(公告)日：1976-01-20
申请号：US175392
申请日：1971-08-26
申请人： Joachim Augstein , Hugh Cairns , Dennis Hunter , John King
发明人： Joachim Augstein , Hugh Cairns , Dennis Hunter , John King
IPC分类号： C07D311/22 , C07D311/24 , C07D335/06 , C07D405/04 , C07D409/04 , C07F1/00 , C07D405/14 , C07D413/14
CPC分类号： C07D335/06 , C07C321/00 , C07C323/00 , C07D311/24 , C07F1/005 , Y10S514/826
摘要： There are described compounds of formula I, ##SPC1##in which R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, are hydrogen, alkyl C2 to 6, alkoxy C2 to 8, hydroxy-alkoxy C3 to 8, and R.sub.5 may be hydroxy, provided that one or two of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are other than hydrogen,And pharmaceutically acceptable derivatives thereof. The compounds of formula I are indicated for use in the treatment of asthma, and pharmaceutical compositions containing them and processes for their preparation are also described.
摘要翻译：描述了式I的化合物，其中可以相同或不同的R 5，R 6，R 7和R 8是氢，C 2-6烷基，烷氧基C 2至8，羟基 - 烷氧基C 3至8和R 5可以是羟基，条件是R 5，R 6，R 7和R 8中的一个或两个不是氢，并且其药学上可接受的衍生物。式I化合物用于治疗哮喘，还描述了含有它们的药物组合物及其制备方法。

5. 发明授权

US4085115A Carboxamido tetrazoles 失效
标题翻译：卡巴酰胺四唑
公开(公告)号：US4085115A
公开(公告)日：1978-04-18
申请号：US674732
申请日：1976-04-06
申请人： Joachim Augstein , Hugh Cairns , Norman Harold Rogers
发明人： Joachim Augstein , Hugh Cairns , Norman Harold Rogers
IPC分类号： C07D493/04 , C07D257/04 , A61K31/41
CPC分类号： C07D493/04
摘要： There are described compounds of formula Ix, ##STR1## IN WHICH ONE OR MORE ADJACENT PAIRS OF P, Q, R and T represent a chain of formula XX, ##STR2## or a group of formula X, ##STR3## in which Ba and Bb represent the pair of groups:- a carbon-carbon bond and --CRa.dbd.CRb--; or an adjacent pair of P, Q, R and T represent a group of formula XI, ##STR4## Ra and Rb and those of P, Q, R and T which do not form a chain of formula XX or a group of formula X or XI may be the same or different and each represents hydrogen; alkyl; alkoxy; alkenyl; alkenyloxy; alkyl or alkoxy, substituted by a hydroxy, alkoxy, aryl or halo group; amino; mono- or di-lower alkylamino; aminoalkoxy; aminoalkoxy substituted by a lower alkyl group; nitro; hydroxy; halogen; acyl; or aryloxy.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing them.
摘要翻译：描述了式Ix的化合物，其中P，Q，R和T的一个或多个相邻对表示式XX的链， XX或一组式X， X在其中Ba和Bb代表一对基团： - 碳 - 碳键和-CRa = CRb-; 或相邻的一对P，Q，R和T表示式XI，XIAa和Rb的基团，以及不形成式XX链或式 X或XI可以相同或不同，各自表示氢; 烷基; 烷氧基烯基; 链烯氧基被羟基，烷氧基，芳基或卤代基取代的烷基或烷氧基; 氨基; 单 - 或二 - 低级烷基氨基; 氨基烷氧基被低级烷基取代的氨基烷氧基; 硝基羟基; 卤素; 酰基; 或芳氧基。

6. 发明授权

US4335048A 5-(2-Hydroxypropoxy)-8-propyl-4H-1-benzopyran-4-one-2-carboxylic acid 失效
标题翻译： 5-（2-羟基丙氧基）-8-丙基-4H-1-苯并吡喃-4-酮-2-羧酸
公开(公告)号：US4335048A
公开(公告)日：1982-06-15
申请号：US122284
申请日：1980-02-19
申请人： Hugh Cairns , Richard Hazard , John King , Thomas B. Lee
发明人： Hugh Cairns , Richard Hazard , John King , Thomas B. Lee
IPC分类号： C07D311/24
CPC分类号： C07D311/24 , Y10S514/826
摘要： There is described the compound of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. Processes for making the compound and pharmaceutical, e.g. anti-asthmatic, compositions containing it are also described.
摘要翻译：描述了式I化合物及其药学上可接受的衍生物。制备化合物和药物的方法，例如还描述了抗哮喘药，含有它的组合物。

7. 发明申请

US20060253236A1 Method of detecting vehicle speed sensor failure 有权
标题翻译：检测车速传感器故障的方法
公开(公告)号：US20060253236A1
公开(公告)日：2006-11-09
申请号：US11121829
申请日：2005-05-04
申请人： Jeffery Hawkins , Hugh Cairns
发明人： Jeffery Hawkins , Hugh Cairns
IPC分类号： G01M17/00
CPC分类号： G01P21/02 , G07C5/0816
摘要： A method of detecting vehicle speed sensor failures is disclosed. The method is intended to prevent or discourage tampering with a vehicle's speed limiting system. The method includes the steps of determining whether the transmission is in neutral or whether the transmission is in its converter mode to prevent false indications of speed sensor failure under certain circumstances.
摘要翻译：公开了一种检测车速传感器故障的方法。该方法旨在防止或阻止篡改车辆限速系统。该方法包括以下步骤：确定传输是否处于中立状态，或者传输是否处于其转换器模式，以防止在某些情况下速度传感器故障的错误指示。

8. 发明授权

US4228173A Thiopyrano-benzopyrans, compositions and method of use thereof 失效
标题翻译：噻喃 - 苯并吡喃，组合物及其使用方法
公开(公告)号：US4228173A
公开(公告)日：1980-10-14
申请号：US58609
申请日：1979-07-18
申请人： Hugh Cairns , Anthony H. Ingall
发明人： Hugh Cairns , Anthony H. Ingall
IPC分类号： A61K31/38 , A61K31/382 , A61K31/41 , A61P11/00 , A61P27/00 , A61P37/08 , C07D335/06 , C07D495/02 , C07D495/04 , A61K31/28 , C07D497/04
CPC分类号： C07D495/04 , C07C323/00 , C07D335/06
摘要： There are described compounds of formula I, ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.CE--O--, and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, hydroxy, alkyl, halogen, alkenyl, alkoxy, or --NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2, which are the same or different, are each hydrogen or alkyl, andE is --COOH, a 5-tetrazolyl group or an (N-tetrazol-5-yl) carboxamido group,and pharmaceutically acceptable derivatives thereof.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing them.
摘要翻译：描述了式I的化合物，其中相邻的一对R 5，R 6，R 7和R 8形成链-COCH = CE-O-，其余的R5，R6，R7和R8，其可以是相同或不同，各自表示氢，羟基，烷基，卤素，烯基，烷氧基或-NR 1 R 2，其中相同或不同的R 1和R 2各自为氢或烷基，并且E为-COOH，a 5 - 四唑基或（N-四唑-5-基）甲酰胺基及其药学上可接受的衍生物。还描述了制备化合物和药物的方法，例如。抗过敏，含有它们的组合物。

9. 发明授权

US4419352A Pyranoquinolinones and analogs thereof 失效
标题翻译：吡喃喹啉酮及其类似物
公开(公告)号：US4419352A
公开(公告)日：1983-12-06
申请号：US236329
申请日：1981-02-20
申请人： David Cox , Hugh Cairns , Nigel Chadwick , John L. Suschitzky
发明人： David Cox , Hugh Cairns , Nigel Chadwick , John L. Suschitzky
IPC分类号： A61K31/435 , A61K31/495 , A61P11/06 , A61P37/08 , C07D215/00 , C07D215/48 , C07D239/72 , C07D239/90 , C07D311/24 , C07D335/06 , C07D491/04 , C07D491/052 , C07D495/04 , A61K31/47 , A61K31/535 , C07D413/14
CPC分类号： C07D491/04 , C07D215/48 , C07D239/90 , C07D311/24 , C07D335/06 , C07D495/04 , Y10S514/826 , Y10S514/914 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/934
摘要： There are described compounds of formula I, ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --CZC(G.sub.1).dbd.(G.sub.2)--Z--,R.sub.4, R.sub.9 and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, alkyl, halogen, alkenyl, --NO.sub.2, --NR.sub.1 R.sub.2, --OR.sub.3, --S(O).sub.n R.sub.3 ; or alkyl substituted by hydroxy, amino, alkoxy or carbonyl oxygen,n is 0, 1 or 2,R.sub.1 and R.sub.2, which may be the same or different, each represent hydrogen, alkyl, --CONHR.sub.3, phenyl or phenyl substituted by alkyl or halogen, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5 or 6 membered heterocyclic ring,R.sub.3 represents hydrogen, alkyl, alkenyl or phenyl,one of G.sub.1 and G.sub.2 is hydrogen and the other is a group E,each E, which may be the same or different, is --COOH, a 5-tetrazolyl group, or a carboxamidotetrazole group,each Z, which may be the same or different, is oxygen or sulphur, andone or two of the atoms, a, b, c and d are nitrogen atoms and the remainder are carbon atoms, R.sup.9 having no significance when two of a, b, c and d are nitrogen,(with certain exclusions)and pharmaceutically acceptable derivatives thereof.There are also described methods for making the compounds and pharmaceutical, e.g. anti-allergic, compositions and mixtures containing them.
摘要翻译：描述了式I，其中相邻的一对R 5，R 6，R 7和R 8形成链-CZC（G1）=（G2）-Z-，R4，R9和R5的其余部分的式I化合物， R 6，R 7和R 8可以相同或不同，各自表示氢，烷基，卤素，烯基，-NO 2，-NR 1 R 2，-OR 3，-S（O）n R 3; 或被羟基，氨基，烷氧基或羰基氧取代的烷基，n为0,1或2，可以相同或不同的R 1和R 2各自表示氢，烷基，-CONHR 3，苯基或被烷基或卤素取代的苯基，或R1和R2与它们所连接的氮原子一起形成5或6元杂环，R 3表示氢，烷基，链烯基或苯基，G1和G2之一是氢，另一个是基团E，每个 E可以相同或不同，为-COOH，5-四唑基或羧酰胺基四唑基，各Z可以相同或不同，为氧或硫，一个或两个原子为 b，c和d为氮原子，其余为碳原子，当a，b，c和d中的两个为氮时，R 9为无意义（具有某些排除）及其药学上可接受的衍生物。还描述了制备化合物和药物的方法。抗过敏剂，组合物和含有它们的混合物。

10. 发明授权

US4055654A 6,8-Di-t-butyl-4-oxo-4H-1-benzopyran-2-carboxylic acid and derivative for the prevention of asthmatic symptoms 失效
标题翻译： 6,8-二叔丁基-4-氧代-4H-1-苯并吡喃-2-羧酸及其用于预防哮喘症状的衍生物
公开(公告)号：US4055654A
公开(公告)日：1977-10-25
申请号：US646025
申请日：1976-01-02
申请人： Hugh Cairns , Albert Chambers , Thomas Brian Lee
发明人： Hugh Cairns , Albert Chambers , Thomas Brian Lee
IPC分类号： C07D307/12 , A61K31/35
CPC分类号： C07C45/67 , C07C45/46 , C07C45/71 , C07D307/12 , Y10S514/826
摘要： There are described certain mono-chromone-2-carboxylic acids of formula, ##STR1## having one substituent in the 5 or 6 position or having 2 or more substituents in the 5,6,7 or 8 positions. There are also described processes for making the compounds and pharmaceutical compositions, for the treatment of asthma, containing the compounds.
摘要翻译：描述了具有5或6位具有一个取代基或在5,6,7或8位具有2个以上取代基的式的某些单色酮-2-羧酸。还描述了制备用于治疗含有化合物的哮喘的化合物和药物组合物的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式