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1. 发明授权

US09132281B2 Focused radiation for augmenting immune-based therapies against neoplasms 有权
标题翻译：聚焦放射线用于增强基于免疫的治疗肿瘤的疗法
公开(公告)号：US09132281B2
公开(公告)日：2015-09-15
申请号：US14127597
申请日：2012-06-19
申请人： Jing Zeng , Charles George Drake , Drew M. Pardoll , Michael Lim
发明人： Jing Zeng , Charles George Drake , Drew M. Pardoll , Michael Lim
IPC分类号： G21K5/04 , A61N5/10 , A61K41/00 , C07K16/24 , C07K16/28 , A61K45/06 , A61K39/395 , A61K39/00
CPC分类号： A61N5/1001 , A61K39/39558 , A61K41/00 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2300/00 , A61N5/1042 , C07K16/24 , C07K16/2818 , C07K16/2878
摘要： An approach combining immune-based therapies with focused radiation, including stereotactic radiation, to treat cancers is disclosed. The use of focused radiation primes the immune system in a similar manner to vaccines to augment immune-based therapies and can counteract the suppressive effects of a tumor. The combination of focused radiation and immune-based therapies, including administration of at least one immunotherapeutic agent, improves survival compared to each therapy alone and can, in some cases, lead to a durable cure. Accordingly, focused radiation can be an adjuvant for immune-based therapies for treating cancers.
摘要翻译：公开了一种将基于免疫的疗法与聚焦辐射（包括立体定向辐射）结合治疗癌症的方法。使用聚焦辐射以与疫苗相似的方式对免疫系统进行补充，以增强基于免疫的疗法，并且可以抵消肿瘤的抑制作用。聚焦辐射和基于免疫的疗法的组合，包括施用至少一种免疫治疗剂，与单独的每种治疗相比，改善了存活，并且在一些情况下可以导致持久的治愈。因此，聚焦辐射可以是用于治疗癌症的基于免疫的疗法的佐剂。

2. 发明申请

US20140155678A1 FOCUSED RADIATION FOR AUGMENTING IMMUNE-BASED THERAPIES AGAINST NEOPLASMS 有权
标题翻译：用于补充基于免疫反应的治疗方法的聚焦辐射
公开(公告)号：US20140155678A1
公开(公告)日：2014-06-05
申请号：US14127597
申请日：2012-06-19
申请人： Jing Zeng , Charles George Drake , Drew M. Pardoll , Michael Lim
发明人： Jing Zeng , Charles George Drake , Drew M. Pardoll , Michael Lim
IPC分类号： A61N5/10 , A61K45/06 , A61K39/395
CPC分类号： A61N5/1001 , A61K39/39558 , A61K41/00 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2300/00 , A61N5/1042 , C07K16/24 , C07K16/2818 , C07K16/2878
摘要： An approach combining immune-based therapies with focused radiation, including stereotactic radiation, to treat cancers is disclosed. The use of focused radiation primes the immune system in a similar manner to vaccines to augment immune-based therapies and can counteract the suppressive effects of a tumor. The combination of focused radiation and immune-based therapies, including administration of at least one immunotherapeutic agent, improves survival compared to each therapy alone and can, in some cases, lead to a durable cure. Accordingly, focused radiation can be an adjuvant for immune-based therapies for treating cancers.
摘要翻译：公开了一种将基于免疫的疗法与聚焦辐射（包括立体定向辐射）结合治疗癌症的方法。使用聚焦辐射以与疫苗相似的方式对免疫系统进行补充，以增强基于免疫的疗法，并且可以抵消肿瘤的抑制作用。聚焦辐射和基于免疫的疗法的组合，包括施用至少一种免疫治疗剂，与单独的每种治疗相比，改善了存活，并且在一些情况下可以导致持久的治愈。因此，聚焦辐射可以是用于治疗癌症的基于免疫的疗法的佐剂。

3. 发明授权

US07460483B2 System and method for managing performance of communication lines of a communication network 有权
标题翻译：用于管理通信网络的通信线路的性能的系统和方法
公开(公告)号：US07460483B2
公开(公告)日：2008-12-02
申请号：US11388874
申请日：2006-03-24
申请人： Baofeng Jiang , Michael Lim , Mo Katibeh , Robert Michetich , Juan G. Flores
发明人： Baofeng Jiang , Michael Lim , Mo Katibeh , Robert Michetich , Juan G. Flores
IPC分类号： G06F11/00 , H04B7/00
CPC分类号： H04L12/2856 , H04L1/24 , H04L41/0253 , H04L41/06 , H04L41/5009 , H04L41/5035 , H04L41/507 , H04L41/5074 , H04M3/306 , H04W4/18 , H04W8/26 , H04W24/00
摘要： A method and system for managing performance data of communication lines, such as digital subscriber lines, is disclosed. The method includes receiving from a remote user device an identifier for a particular communications line at a web server; initiating a real-time performance analysis of the line at a network end of the line; receiving real-time performance data and converting the real time performance data to analyzed data; receiving field performance data from the user device; and converting at least one of the field performance data and the real-time performance data from a web-based format to a mainframe format; and sending the converted data to a mainframe for storage corresponding to a file associated with the identifier.
摘要翻译：公开了一种用于管理诸如数字用户线路的通信线路的性能数据的方法和系统。该方法包括从远程用户设备接收web服务器上特定通信线路的标识符; 在线路的网络端启动线路的实时性能分析; 接收实时性能数据并将实时性能数据转换为分析数据; 从用户设备接收现场演奏数据; 以及将所述现场演奏数据和所述实时演奏数据中的至少一个从基于网络的格式转换为大型机格式; 并将转换的数据发送到与该标识符相关联的文件相对应的主机。

4. 发明授权

US07391059B2 Isotropic collimation devices and related methods 有权
标题翻译：各向同性准直装置及相关方法
公开(公告)号：US07391059B2
公开(公告)日：2008-06-24
申请号：US11370395
申请日：2006-03-07
申请人： Alexei A. Erchak , Elefterios Lidorikis , Michael Lim , Nikolay I. Nemchuk , Jo A. Venezia
发明人： Alexei A. Erchak , Elefterios Lidorikis , Michael Lim , Nikolay I. Nemchuk , Jo A. Venezia
IPC分类号： H01L33/00
CPC分类号： H01L33/20 , B82Y20/00 , H01L2933/0083 , Y10S977/95
摘要： Devices, such as light-emitting devices (e.g., LEDs), and methods associated with such devices are provided. A light-emitting device may include an interface through which emitted light passes therethrough. The interface having a dielectric function that varies spatially according to a pattern, wherein the pattern is arranged to provide light emission that has a substantially isotropic emission pattern and is more collimated than a Lambertian distribution of light.
摘要翻译：提供诸如发光装置（例如，LED）的装置以及与这种装置相关联的方法。发光装置可以包括发射的光从其中通过的界面。所述界面具有根据图案在空间上变化的介电功能，其中所述图案被布置成提供具有基本上各向同性的发射图案并且比朗伯分布更准确的发光。

5. 发明申请

US20080128728A1 Polarized light-emitting devices and methods 审中-公开
标题翻译：极化发光器件和方法
公开(公告)号：US20080128728A1
公开(公告)日：2008-06-05
申请号：US11804209
申请日：2007-05-17
申请人： Nikolay I. Nemchuk , Alexander L. Pokrovskiy , Michael Lim , Alexei A. Erchak
发明人： Nikolay I. Nemchuk , Alexander L. Pokrovskiy , Michael Lim , Alexei A. Erchak
IPC分类号： H01L33/00
CPC分类号： H01L33/44 , G02F1/133603 , G02F1/13362 , H01L33/10 , H01L33/20 , H01L33/22 , H01L33/24 , H01L33/46 , H01L51/5262 , H01L51/5268 , H01L51/5293 , H01L2933/0083
摘要： Light-emitting devices and/or systems are described. In one embodiment, a light-emitting device comprises a light-emitting material stack including a light-generating region and a light emission surface, and a polarizer configured to receive at least some light emitted from the light emission surface of the light-emitting material stack, wherein the polarizer comprises first reflective regions at a first height and second reflective regions separated from the first metal regions and at a second height different from the first height.
摘要翻译：描述发光器件和/或系统。在一个实施例中，发光装置包括包括发光区域和发光表面的发光材料堆叠，以及偏振器，被配置为接收从发光材料的发光表面发射的至少一些光堆叠，其中所述偏振器包括在第一高度处的第一反射区域和与所述第一金属区域分开的第二反射区域和与所述第一高度不同的第二高度。

6. 发明申请

US20080067533A1 FLEXIBLE CIRCUIT LIGHT-EMITTING STRUCTURES 有权
标题翻译：柔性电路发光结构
公开(公告)号：US20080067533A1
公开(公告)日：2008-03-20
申请号：US11855597
申请日：2007-09-14
申请人： Michael Lim , Mark Czoschke , Alexei Erchak
发明人： Michael Lim , Mark Czoschke , Alexei Erchak
IPC分类号： H01L33/00
CPC分类号： H01L33/486 , F21K9/00 , H01L2224/48091 , H01L2224/49175 , H01L2924/16195 , H05K1/0203 , H05K1/184 , H05K1/189 , H01L2924/00014
摘要： Light-emitting structures, and related components, systems, and methods associated therewith are provided. In one embodiment, a light-emitting structure includes at least one LED, a contact bond pad supported by the at least one LED, and a flexible circuit member bonded to the contact bond pad.
摘要翻译：提供发光结构以及与之相关的组件，系统和方法。在一个实施例中，发光结构包括至少一个LED，由所述至少一个LED支撑的接触焊盘和与所述接触焊盘接合的柔性电路部件。

7. 发明授权

US07341880B2 Light emitting device processes 有权
标题翻译：发光器件工艺
公开(公告)号：US07341880B2
公开(公告)日：2008-03-11
申请号：US10896435
申请日：2004-07-22
申请人： Alexei A. Erchak , Michael Lim , Scott Duncan , John Graff , Milan Minsky , Matthew Weig
发明人： Alexei A. Erchak , Michael Lim , Scott Duncan , John Graff , Milan Minsky , Matthew Weig
IPC分类号： H01L33/00
CPC分类号： H01L33/0079 , H01L27/156 , H01L33/20 , H01L2224/49111 , H01L2224/73265 , H01L2933/0083 , H04N9/315
摘要： Light-emitting devices, and related components, processes, systems and methods are disclosed.
摘要翻译：公开了发光器件及相关部件，工艺，系统和方法。

8. 发明申请

US20070295981A1 Patterned light-emitting devices 审中-公开
标题翻译：图案化的发光装置
公开(公告)号：US20070295981A1
公开(公告)日：2007-12-27
申请号：US11704892
申请日：2007-02-09
申请人： Alexei Erchak , Michael Lim , Elefterios Lidorikis , Jo Venezia , Robert Karlicek , Nikolay Nemchuk
发明人： Alexei Erchak , Michael Lim , Elefterios Lidorikis , Jo Venezia , Robert Karlicek , Nikolay Nemchuk
IPC分类号： H01L33/00
CPC分类号： H01L33/22 , H01L33/20 , H01L33/24 , H01L2924/12041 , H01L2933/0083
摘要： Light-emitting devices (e.g., LEDs) and methods associated with such devices are provided. The devices may include a first pattern and a second pattern which are formed at one or more interfaces of the device (e.g., the emission surface). The patterns may be positioned such that light generated by the device passes through the interfaces of the patterns when being emitted. The patterns can be defined by a series of features (e.g., vias, posts) having certain characteristics (e.g., feature size, depth, periodicity, nearest neighbor distance, etc.) which may be controlled to influence properties of the light emitted from the device, including improving extraction and/or collimation of the emitted light.
摘要翻译：提供了与这种装置相关联的发光装置（例如，LED）和方法。器件可以包括在器件的一个或多个界面（例如，发射表面）处形成的第一图案和第二图案。可以将图案定位成使得由设备产生的光在发射时通过图案的界面。这些图案可以由具有特定特征（例如，特征尺寸，深度，周期性，最近相邻距离等）的一系列特征（例如，通孔，柱）来定义，这些特征可被控制以影响从装置，包括提高发射光的提取和/或准直。

9. 发明申请

US20070085084A1 Isotropic collimation devices and related methods 有权
标题翻译：各向同性准直装置及相关方法
公开(公告)号：US20070085084A1
公开(公告)日：2007-04-19
申请号：US11370395
申请日：2006-03-07
申请人： Alexei Erchak , Elefterios Lidorikis , Michael Lim , Nikolay Nemchuk , Jo Venezia
发明人： Alexei Erchak , Elefterios Lidorikis , Michael Lim , Nikolay Nemchuk , Jo Venezia
IPC分类号： H01L33/00
CPC分类号： H01L33/20 , B82Y20/00 , H01L2933/0083 , Y10S977/95
摘要： Devices, such as light-emitting devices (e.g., LEDs), and methods associated with such devices are provided. A light-emitting device may include an interface through which emitted light passes therethrough. The interface having a dielectric function that varies spatially according to a pattern, wherein the pattern is arranged to provide light emission that has a substantially isotropic emission pattern and is more collimated than a Lambertian distribution of light.
摘要翻译：提供诸如发光装置（例如，LED）的装置以及与这种装置相关联的方法。发光装置可以包括发射的光从其中穿过的界面。所述界面具有根据图案在空间上变化的介电功能，其中所述图案被布置成提供具有基本上各向同性的发射图案并且比朗伯分布更准确的发光。

10. 发明申请

US20070085083A1 Anisotropic collimation devices and related methods 有权
标题翻译：各向异性准直装置及相关方法
公开(公告)号：US20070085083A1
公开(公告)日：2007-04-19
申请号：US11369895
申请日：2006-03-07
申请人： Alexei Erchak , Elefterios Lidorikis , Michael Lim , Nikolay Nemchuk , Jo Venezia
发明人： Alexei Erchak , Elefterios Lidorikis , Michael Lim , Nikolay Nemchuk , Jo Venezia
IPC分类号： H01L33/00
CPC分类号： H01L33/20 , B82Y20/00 , G02B6/1225 , H01L2933/0083
摘要： Devices, such as light-emitting devices (e.g., LEDs), and methods associated with such devices are provided. A light-emitting device designed to emit light may include an interface through which emitted light passes therethrough, wherein the interface has a dielectric function that varies spatially according to a pattern. The pattern may be arranged to provide anisotropic light emission characterized by an emission pattern on a far-field projection plane substantially parallel to the interface, wherein a first total light intensity along a first axis on the projection plane is at least 20% greater than a second total light intensity along a second axis on the projection plane. Alternatively, or additionally, the pattern may be arranged to provide anisotropic light emission characterized by a first total light emission on a first plane that is at least 20% greater than a second total light emission on a second plane, wherein the first and second planes are perpendicular to the interface, and wherein the first and second planes are also perpendicular to each other.
摘要翻译：提供诸如发光装置（例如，LED）的装置以及与这种装置相关联的方法。设计成发射光的发光装置可以包括发射的光通过其中的界面，其中界面具有根据图案在空间上变化的介电功能。该图案可以被布置成提供特征在于基本上平行于界面的远场投影平面上的发射图案的各向异性光发射，其中沿着投影平面上的第一轴的第一总光强度大于在投影平面上沿着第二轴的第二总光强度。或者或附加地，图案可以被布置成提供各向异性光发射，其特征在于第一平面上的第一总光发射比第二平面上的第二总光发射大至少20％，其中第一和第二平面垂直于界面，并且其中第一和第二平面也彼此垂直。

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