专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100152099A1 MACROCYCLIC COMPOUNDS FOR INHIBITION OF TUMOR NECROSIS FACTOR ALPHA 失效
标题翻译：用于抑制肿瘤坏死因子ALPHA的大环化合物
公开(公告)号：US20100152099A1
公开(公告)日：2010-06-17
申请号：US12544604
申请日：2009-08-20
申请人： Jinbo Lee , Julian F. Bond , Nicholas Terrett , Frank G. Favaloro, JR. , Daniel Wang , Timothy F. Briggs , Benjamin A. Seigal , Wei-Chuan Sun , Stephen P. Hale
发明人： Jinbo Lee , Julian F. Bond , Nicholas Terrett , Frank G. Favaloro, JR. , Daniel Wang , Timothy F. Briggs , Benjamin A. Seigal , Wei-Chuan Sun , Stephen P. Hale
IPC分类号： A61K38/12 , C07K5/12 , A61P19/02 , A61P1/00 , A61P35/00 , A61P3/10 , A61P25/28
CPC分类号： C07D273/00 , C07D257/02
摘要： The invention provides macrocyclic compounds and methods for their synthesis and use. In particular, the invention provides macrocyclic compounds that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.
摘要翻译：本发明提供了大环化合物及其合成和使用方法。特别地，本发明提供调节肿瘤坏死因子α活性的大环化合物和/或可用于治疗诸如类风湿性关节炎，牛皮癣和哮喘的医学病症。

2. 发明授权

US08338565B2 Macrocyclic compounds for inhibition of tumor necrosis factor alpha 失效
标题翻译：用于抑制肿瘤坏死因子α的大环化合物
公开(公告)号：US08338565B2
公开(公告)日：2012-12-25
申请号：US12544604
申请日：2009-08-20
申请人： Jinbo Lee , Julian F. Bond , Nicholas Terrett , Frank G. Favaloro, Jr. , Daniel Wang , Timothy F. Briggs , Benjamin Adam Seigal , Wei-Chuan Sun , Stephen P. Hale
发明人： Jinbo Lee , Julian F. Bond , Nicholas Terrett , Frank G. Favaloro, Jr. , Daniel Wang , Timothy F. Briggs , Benjamin Adam Seigal , Wei-Chuan Sun , Stephen P. Hale
IPC分类号： C07K11/02 , A61K38/12
CPC分类号： C07D273/00 , C07D257/02
摘要： Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.
摘要翻译：本文公开了大环化合物及其合成和使用的方法。特别地，公开了调节肿瘤坏死因子α的活性和/或可用于治疗诸如类风湿性关节炎，牛皮癣和哮喘等医学病症的大环化合物。

3. 发明授权

US11126146B2 Wearable electronic device 有权
公开(公告)号：US11126146B2
公开(公告)日：2021-09-21
申请号：US16914857
申请日：2020-06-29
申请人： Daniel Wang , Li-Yuan Wang
发明人： Daniel Wang , Li-Yuan Wang
IPC分类号： G06F1/16 , G04G17/08 , G04G17/04 , H02J50/10 , G06F3/01
摘要： A wearable electronic device includes a body having a first battery and a port electrically connected to the first battery, a band having a connector and a set of first conductors electrically connected to the connector, and a belt having at least one second battery, a set of second conductors and an input port electrically connected to the second battery. The band is connected to the port via the connector so as to be electrically connected to the body. The belt may removably attach to an outer surface of the band, and the second battery may transmit power to the first battery by combining the two sets of conductors. When the belt is removed, the power consumed by the second battery is replenished by an external power source connected to the input port, mastering the information at any time.

4. 发明授权

US09931829B2 Methods and apparatus for hygromorphic shape control 有权
公开(公告)号：US09931829B2
公开(公告)日：2018-04-03
申请号：US14927375
申请日：2015-10-29
申请人： Lining Yao , Wen Wang , Jifei Ou , Chin-Yi Cheng , Guanyun Wang , Hiroshi Ishii , Daniel Wang , Helene Steiner , Clark Della Silva
发明人： Lining Yao , Wen Wang , Jifei Ou , Chin-Yi Cheng , Guanyun Wang , Hiroshi Ishii , Daniel Wang , Helene Steiner , Clark Della Silva
IPC分类号： B33Y80/00 , B33Y10/00 , B33Y30/00 , B29C67/00
CPC分类号： B33Y80/00 , B29C64/106 , B29C64/112 , B29C64/20 , B29C64/386 , B33Y10/00 , B33Y30/00
摘要： A composite film includes a substrate that is not responsive to relative humidity, and also one or more layers of hygromorphic material. The hygromorphic material expands in response to an increase in relative humidity and contracts in response to a decrease in relative humidity. In some cases, the composite film is bi-layer or tri-layer. The composite films are fabricated such that they undergo a desired bending pattern in response to changes in relative humidity. In some cases, these bending patterns are combinations of two bending primitives: a smooth curve and a sharply angled curve. These two primitives are combined to create a variety of shape transformations including 1D linear transformation, 2D surface expansion and contraction, 2.5D texture change and 3D folding. Any type of hygromorphic material may be employed, including living gram positive and gram negative bacterial cells, yeast cells, plant cells, mammalian cells, cell debris, or hydrogel.

5. 发明授权

US07749772B1 Antibody and immunoassays for determining the presence of Δ9-Tetrahydrocannabinol 失效
标题翻译：用于测定'D-9-四氢大麻酚的存在的抗体和免疫测定
公开(公告)号：US07749772B1
公开(公告)日：2010-07-06
申请号：US11478972
申请日：2006-06-29
申请人： Daniel Wang
发明人： Daniel Wang
IPC分类号： A61K35/14
CPC分类号： C07K16/16 , C07K2317/56 , C07K2317/565 , Y10S436/81
摘要： Antibodies having specific binding for the parent THC (Δ9-THC) and its major metabolites are provided which present a significant increase in sensitivity of immunoassays such as lateral flow immunoassays and ELISA for THC. The present invention also provides a rabbit hybridoma producing the antibody as a monoclonal antibody, a recombinant antibody, further molecularly engineered recombinant antibodies against parent Δ9-THC and its metabolites and cell lines producing the recombinant antibodies. The invention also provides applications of the antibody in immunoassays, particularly lateral flow immunoassays, specifically applications in detecting THC in body fluids, particularly saliva, and kits for determining the presence of THC.
摘要翻译：提供了对母体THC（＆Dgr; 9-THC）及其主要代谢物具有特异性结合的抗体，其显着增加免疫测定的灵敏度，例如THC的侧流免疫测定和ELISA。本发明还提供了产生抗体作为单克隆抗体的兔杂交瘤，重组抗体，针对母体和Dgr 9-THC的其他分子工程重组抗体及其代谢产物和产生重组抗体的细胞系。本发明还提供抗体在免疫测定中的应用，特别是横向流动免疫测定，特别是用于检测体液，特别是唾液中的THC，以及用于确定THC存在的试剂盒。

6. 发明申请

US20100035205A1 Non-90-Degree Ergonomically-Shaped Dental Prophylaxis Angle with a Straight Driving Shaft 审中-公开
标题翻译：非90度人体工程学形状的牙齿预防角度与直线驱动轴
公开(公告)号：US20100035205A1
公开(公告)日：2010-02-11
申请号：US12189152
申请日：2008-08-09
申请人： Daniel Wang , Jianping Shen , Yong Zhu
发明人： Daniel Wang , Jianping Shen , Yong Zhu
IPC分类号： A61C1/12
CPC分类号： A61C17/005 , A61C1/12 , A61C1/185
摘要： A disposable dental angle with a one-piece hollow housing, having the axis of its head section angled obtusely with respect to the axis of its tail section, is provided. The obtusely angled front aperture of the head section of the housing allows insertion of a driven rotor such that the driven rotor is positioned with an obtuse angle to the driving shaft in the end aperture of the tail section of the housing. The obtuse angle structure facilitates teeth cleaning operations by allowing the dental angle to easily reach all areas of the mouth and making practitioners feel more comfortable by allowing to maintain an ergonomically correct neutral wrist position and therefore reducing hand fatigue. A horseshoe-like snap retainer fits within the head section of the housing over the driven rotor to retain the rotor from coming out. A similar horseshoe-like snap retainer fits within the tail section of the housing over the driving shaft to retain the shaft firmly such that the gear of the driven rotor is always properly coupled to the matching gear of the driving shaft. The driving shaft transfers the rotation from a dental tool to the driven rotor for the purpose of tooth prophy using a cleaning cup.
摘要翻译：提供具有一体式中空壳体的一次性角度，其具有其头部部分的轴线相对于其尾部部分的轴线成角度倾斜。壳体头部的钝角前孔允许从动转子的插入，使得从动转子定位成与壳体尾部端部的端部孔中的驱动轴成钝角。钝角结构通过允许牙齿角度容易地到达口腔的所有区域并且通过允许维持符合人体工程学的正确的中性手腕位置并因此减少手部疲劳而使练习者感到更舒适，从而促进牙齿清洁操作。马蹄形卡扣保持器安装在驱动转子上的壳体的头部内，以保持转子不会脱出。类似的马蹄形卡扣保持器装配在驱动轴上的壳体的尾部内，以牢固地保持轴，使得从动转子的齿轮总是适当地联接到驱动轴的匹配齿轮。驱动轴将旋转从牙科工具转移到从动转子，以便使用清洁杯进行牙齿蚀刻。

7. 发明申请

US20090067284A1 TWISTED STATIC PASTE MIXER WITH A DYNAMIC PREMIXING CHAMBER 有权
标题翻译：具有动态预热室的TWISTED静态搅拌机
公开(公告)号：US20090067284A1
公开(公告)日：2009-03-12
申请号：US11852296
申请日：2007-09-08
申请人： Daniel Wang
发明人： Daniel Wang
IPC分类号： B01F7/00
CPC分类号： B01F5/0615 , B01F7/00216 , B01F7/00291 , B01F13/002 , B01F13/103 , B01F15/0087 , B01F2215/0027
摘要： A device for mixing two paste components, such as a dental impression substance and a catalyst, comprising a tubular housing, two inlet openings for the two paste components to be mixed, and an outlet opening for delivering the mixed paste, is presented. The housing consists of a premixing chamber at the front end and a tubular mixing chamber at the rear end. The two paste components are mixed first in the premixing chamber by a dynamic rotor and then mixed in the tubular mixing chamber by a twisted static shaft, resulting in a well mixed, bubble-free paste at the outlet opening of the housing.
摘要翻译：提供了一种用于混合两种糊剂组分的装置，例如牙印模物质和催化剂，其包括管状壳体，用于待混合的两种糊剂组分的两个入口开口和用于输送混合糊剂的出口。外壳由前端的预混合室和后端的管状混合室组成。两个糊料组分首先在预混合室中通过动态转子混合，然后通过扭转的静态轴在管状混合室中混合，从而在壳体的出口开口处形成充分混合的无气泡浆料。

8. 发明授权

US07448833B1 Automatic tool changing assembly for a machine tool 失效
标题翻译：机床自动换刀组件
公开(公告)号：US07448833B1
公开(公告)日：2008-11-11
申请号：US11970632
申请日：2008-01-08
申请人： Daniel Wang
发明人： Daniel Wang
IPC分类号： B23C5/26
CPC分类号： B23B31/266 , Y10T137/8671 , Y10T409/309464
摘要： An automatic tool changing assembly for a machine tool has a bottom frame, a base, a cylinder block, an air motor and an air transporting device. The bottom frame is securely mounted on the machine tool and has a bottom panel, two sliding bars and a spring. The base is movably mounted on the bottom frame above the bottom panel and abutting the spring. The cylinder block is securely mounted on the base and has a piston rod, a piston disk and an air cylinder. The air motor is securely mounted on the base and has a cylinder, a jacket, a mounting groove and a cylinder tube. The air transporting device is mounted in the air motor and has a mounting tube, a first compression ring, a first sealing ring, a middle compression ring, a second sealing ring, a second compression ring, a mounting axle and an axle spring.
摘要翻译：一种用于机床的自动换刀组件具有底架，底座，气缸体，气动马达和空气输送装置。底架牢固地安装在机床上，并具有底板，两个滑杆和弹簧。基座可移动地安装在底板上方的底架上并与弹簧抵接。气缸体牢固地安装在基座上，并具有活塞杆，活塞盘和气缸。气动马达牢固地安装在基座上，具有圆筒，护套，安装槽和气缸筒。空气输送装置安装在气动马达中，具有安装管，第一压缩环，第一密封环，中间压缩环，第二密封环，第二压缩环，安装轴和轴向弹簧。

9. 发明授权

US07255559B2 Disposable dental prophy angle with secure retention mechanism 失效
标题翻译：一次性牙科矫正角度与安全保持机制
公开(公告)号：US07255559B2
公开(公告)日：2007-08-14
申请号：US10929225
申请日：2004-08-30
申请人： Jianping Shen , Daniel Wang
发明人： Jianping Shen , Daniel Wang
IPC分类号： A61C3/06
CPC分类号： A61C17/005 , A61C1/141
摘要： A disposable, securely retained dental angle is provided. The angle includes a one-piece hollow housing having a short leg at its front end, which is angled with respect to the long leg. Both the short and long legs have a through bore. The short leg has an aperture, which is connected to the bore of the long leg to allow insertion of a driving shaft through the short leg of the angle. A driven rotor is inserted in the short leg. A horse-shoe-like snap rotor retainer fits within the short leg over the driven rotor to retain the driven rotor in the angle. A paw-like or, alternately, a horse-shoe-like locking means fits within the long leg over the driving shaft to lock the driving shaft in the angle and to retain the angle together. In one embodiment, a pair of splinters on the driven rotor provides the function to retain the rubber prophy cup firmly while the driven rotor is in operation.
摘要翻译：提供一次性，牢固保留的牙角。该角度包括一体式中空壳体，其前端具有短腿，该短腿相对于长腿成角度。短腿和长腿都有通孔。短腿具有孔，其连接到长腿的孔，以允许驱动轴穿过角度的短腿。从动转子插入短腿。马蹄状卡扣转子保持器适配在从动转子上的短腿内，以将从动转子保持在角度。爪状或者马蹄形的锁定装置配合在驱动轴上的长腿内，以将角度锁定在驱动轴上并将角度保持在一起。在一个实施例中，从动转子上的一对碎片提供了在被驱动的转子运行时牢固地保持橡胶垫的功能。

10. 发明申请

US20050215687A1 Multi-polymer-coated magnetic nanoclusters 失效
标题翻译：多聚合物涂覆磁性纳米团簇
公开(公告)号：US20050215687A1
公开(公告)日：2005-09-29
申请号：US11053678
申请日：2005-02-09
申请人： T. Hatton , Daniel Wang , Paul Laibinis , Andre Ditsch
发明人： T. Hatton , Daniel Wang , Paul Laibinis , Andre Ditsch
IPC分类号： C07K1/30 , C08K3/18 , C08K9/08 , C08K9/12
CPC分类号： C07K1/30 , B03C1/01 , C08K9/08 , C08K2201/014
摘要： The present invention relates to multi-polymer-coated magnetic nanoclusters, aqueous magnetic fluids comprising same, and methods of their use in separation procedures. The multi-polymer-coated magnetic nanoclusters comprise a super paramagnetic core, with a first polymer attached thereto, which does not render the first polymer-super paramagnetic particle complex colloidally stable, and a second polymer attached thereto, which stabilizes the complex of multi-polymer-coated magnetic nanoparticles. Methods of use comprise methods of separation, including separation of expressed protein from cells and viruses expressing the same.
摘要翻译：本发明涉及多聚合物涂覆的磁性纳米簇，包含其的含水磁性流体及其在分离过程中的使用方法。多聚合物涂覆的磁性纳米簇包括超顺磁核，其上连接有第一聚合物，其不使第一聚合物 - 超顺磁性颗粒复合物胶体稳定，并且连接有第二聚合物 - 超顺磁性颗粒的复合物，聚合物涂覆磁性纳米颗粒。使用方法包括分离方法，包括从表达蛋白质的细胞和表达其的病毒分离。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式