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    • 8. 发明授权
    • Antibody and immunoassays for determining the presence of Δ9-Tetrahydrocannabinol
    • 用于测定'D-9-四氢大麻酚的存在的抗体和免疫测定
    • US07749772B1
    • 2010-07-06
    • US11478972
    • 2006-06-29
    • Daniel Wang
    • Daniel Wang
    • A61K35/14
    • C07K16/16C07K2317/56C07K2317/565Y10S436/81
    • Antibodies having specific binding for the parent THC (Δ9-THC) and its major metabolites are provided which present a significant increase in sensitivity of immunoassays such as lateral flow immunoassays and ELISA for THC. The present invention also provides a rabbit hybridoma producing the antibody as a monoclonal antibody, a recombinant antibody, further molecularly engineered recombinant antibodies against parent Δ9-THC and its metabolites and cell lines producing the recombinant antibodies. The invention also provides applications of the antibody in immunoassays, particularly lateral flow immunoassays, specifically applications in detecting THC in body fluids, particularly saliva, and kits for determining the presence of THC.
    • 提供了对母体THC(&Dgr; 9-THC)及其主要代谢物具有特异性结合的抗体,其显着增加免疫测定的灵敏度,例如THC的侧流免疫测定和ELISA。 本发明还提供了产生抗体作为单克隆抗体的兔杂交瘤,重组抗体,针对母体和Dgr 9-THC的其他分子工程重组抗体及其代谢产物和产生重组抗体的细胞系。 本发明还提供抗体在免疫测定中的应用,特别是横向流动免疫测定,特别是用于检测体液,特别是唾液中的THC,以及用于确定THC存在的试剂盒。
    • 9. 发明申请
    • Non-90-Degree Ergonomically-Shaped Dental Prophylaxis Angle with a Straight Driving Shaft
    • 非90度人体工程学形状的牙齿预防角度与直线驱动轴
    • US20100035205A1
    • 2010-02-11
    • US12189152
    • 2008-08-09
    • Daniel WangJianping ShenYong Zhu
    • Daniel WangJianping ShenYong Zhu
    • A61C1/12
    • A61C17/005A61C1/12A61C1/185
    • A disposable dental angle with a one-piece hollow housing, having the axis of its head section angled obtusely with respect to the axis of its tail section, is provided. The obtusely angled front aperture of the head section of the housing allows insertion of a driven rotor such that the driven rotor is positioned with an obtuse angle to the driving shaft in the end aperture of the tail section of the housing. The obtuse angle structure facilitates teeth cleaning operations by allowing the dental angle to easily reach all areas of the mouth and making practitioners feel more comfortable by allowing to maintain an ergonomically correct neutral wrist position and therefore reducing hand fatigue. A horseshoe-like snap retainer fits within the head section of the housing over the driven rotor to retain the rotor from coming out. A similar horseshoe-like snap retainer fits within the tail section of the housing over the driving shaft to retain the shaft firmly such that the gear of the driven rotor is always properly coupled to the matching gear of the driving shaft. The driving shaft transfers the rotation from a dental tool to the driven rotor for the purpose of tooth prophy using a cleaning cup.
    • 提供具有一体式中空壳体的一次性角度,其具有其头部部分的轴线相对于其尾部部分的轴线成角度倾斜。 壳体头部的钝角前孔允许从动转子的插入,使得从动转子定位成与壳体尾部端部的端部孔中的驱动轴成钝角。 钝角结构通过允许牙齿角度容易地到达口腔的所有区域并且通过允许维持符合人体工程学的正确的中性手腕位置并因此减少手部疲劳而使练习者感到更舒适,从而促进牙齿清洁操作。 马蹄形卡扣保持器安装在驱动转子上的壳体的头部内,以保持转子不会脱出。 类似的马蹄形卡扣保持器装配在驱动轴上的壳体的尾部内,以牢固地保持轴,使得从动转子的齿轮总是适当地联接到驱动轴的匹配齿轮。 驱动轴将旋转从牙科工具转移到从动转子,以便使用清洁杯进行牙齿蚀刻。