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1. 发明授权

US06924341B2 Polymer formation in room temperature ionic liquids 失效
标题翻译：聚合物在室温离子液体中的形成
公开(公告)号：US06924341B2
公开(公告)日：2005-08-02
申请号：US10473455
申请日：2002-04-01
申请人： Jimmy W. Mays , Lujia Bu , Robin D. Rogers , Kunlun Hong , Hongwei Zhang
发明人： Jimmy W. Mays , Lujia Bu , Robin D. Rogers , Kunlun Hong , Hongwei Zhang
IPC分类号： C08F2/00 , C08F2/06 , C08F4/00 , C08F6/00 , C08F293/00
CPC分类号： C08F293/005 , C08F2/00 , C08F2/06 , C08F6/00 , C08F293/00
摘要： Methods and compositions for polymerization in ionic medium liquid at room temperature provide the benefit of allowing polymerization reactions to be carried out cheaply, and relatively quickly. The replacement of VOCs by these environmentally benign solvents has the further advantage of increased safety for chemical workers.
摘要翻译：在室温下在离子介质液中聚合的方法和组合物提供了使聚合反应进行成本低廉且相对较快的优点。通过这些环境友好的溶剂代替挥发性有机化合物具有增加化学工人安全性的进一步优势。

2. 发明授权

US09193909B2 Liquid crystal composition and liquid crystal display device with the liquid crystal composition 有权
标题翻译：液晶组成和具有液晶组成的液晶显示装置
公开(公告)号：US09193909B2
公开(公告)日：2015-11-24
申请号：US14235628
申请日：2012-07-31
申请人： Feng Wu , Wenming Han , Hongwei Zhang , Yudong Tan , Canhui Jin , Xia Zhu
发明人： Feng Wu , Wenming Han , Hongwei Zhang , Yudong Tan , Canhui Jin , Xia Zhu
IPC分类号： G02F1/1333 , C09K19/32 , C09K19/44 , C09K19/04 , C09K19/12 , C09K19/30
CPC分类号： C09K19/32 , C09K19/3066 , C09K19/44 , C09K2019/0444 , C09K2019/0466 , C09K2019/123 , C09K2019/124 , C09K2019/3004 , C09K2019/3021 , C09K2019/3025
摘要： A liquid crystal composition that is useful for an active matrix (AM) device has a nematic phase and positive dielectric anisotropy. An active matrix liquid crystal display device includes the liquid crystal composition. By the total weight of the liquid crystal composition, the liquid crystal composition comprises 8%-50% of a compound of the general formula (I), 10%-70% (by weight) of a compound of the general formula (II), and 5%-50% (by weight) of a compound of the general formula (III).
摘要翻译：用于有源矩阵（AM）器件的液晶组合物具有向列相和正介电各向异性。有源矩阵液晶显示装置包括液晶组合物。通过液晶组合物的总重量，液晶组合物包含8％-50％的通式（I）化合物，10％-70％（重量）的通式（II）化合物，，和5％-50％（重量）的通式（III）的化合物。

3. 发明申请

US20130195801A1 CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF 有权
标题翻译： CNS目标AAV矢量及其使用方法
公开(公告)号：US20130195801A1
公开(公告)日：2013-08-01
申请号：US13642719
申请日：2011-04-22
申请人： Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
发明人： Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC分类号： C12N15/864 , A61K31/713 , A61K38/50 , A61K48/00 , C12N15/113
CPC分类号： C12N15/86 , A61K31/713 , A61K38/50 , A61K48/00 , A61K48/0058 , A61K48/0075 , C12N7/00 , C12N9/80 , C12N15/1137 , C12N15/635 , C12N15/8645 , C12N2310/141 , C12N2750/14133 , C12N2750/14141 , C12N2750/14143 , C12N2750/14145 , C12N2750/14162 , C12N2810/10 , C12N2840/007 , C12Y305/01015
摘要： The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
摘要翻译：本发明在一些方面涉及可用于靶向转基因到CNS组织的重组腺相关病毒，以及包含其的组合物及其使用方法。在一些方面，本发明提供了用于治疗CNS相关疾病的方法和组合物。

4. 发明授权

US08483968B2 Method of diagnosing mild osteoarthritis 失效
标题翻译：诊断轻度骨关节炎的方法
公开(公告)号：US08483968B2
公开(公告)日：2013-07-09
申请号：US12777140
申请日：2010-05-10
申请人： Choong-Chin Liew , Hongwei Zhang , Adam Dempsey , Thomas Yager , Samuel Chao
发明人： Choong-Chin Liew , Hongwei Zhang , Adam Dempsey , Thomas Yager , Samuel Chao
IPC分类号： G01N33/48
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2800/102
摘要： The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis.
摘要翻译：本发明涉及新生物标志物的鉴定和选择以及与没有骨关节炎的个体相比，在具有轻度骨关节炎的个体中差异表达的新型生物标志物组合的鉴定和选择。与本发明的生物标志物的产物特异性和/或选择性杂交的多核苷酸和蛋白质也包括在本发明的范围内，如含有用于诊断轻度骨关节炎的所述多核苷酸和蛋白质的试剂盒。本发明进一步包括使用与本发明的生物标志物的产物特异性和/或选择性杂交的多核苷酸和蛋白质，以监测个体的疾病回归并监测治疗方案的功效。本发明还提供了使用本发明的生物标志物的产物鉴定骨关节炎的新型治疗靶标的方法。

5. 发明申请

US20130013214A1 METHOD AND APPARATUS FOR CORRELATING LEVELS OF BIOMARKER PRODUCTS WITH DISEASE 审中-公开
标题翻译：用于与疾病相关的生物标记产品水平的方法和装置
公开(公告)号：US20130013214A1
公开(公告)日：2013-01-10
申请号：US13566394
申请日：2012-08-03
申请人： Choong-Chin Liew , Mark Han , Thomas Yager , Samuel Chao , Run Zheng , Hongwei Zhang
发明人： Choong-Chin Liew , Mark Han , Thomas Yager , Samuel Chao , Run Zheng , Hongwei Zhang
IPC分类号： G06F19/24 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G16B5/00 , G16B20/00 , G16B25/00 , G16B40/00 , G16H50/30 , Y02A90/26
摘要： In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies.
摘要翻译：在一个方面，本发明是通过提供对应于所选生物标志物的产物水平的数据并应用所述生物标志物的一个或多个结直肠病理学或一种或多种结直肠病理学亚型（在一个实施方案中为结肠直肠癌）的测试个体中的方法，数据提供给公式，以提供测试个体是否具有一种或多种结肠直肠病变或一种或多种结直肠病理学亚型的指示。在某些方面，该方法是基于计算机的，并且计算机将数据应用于公式。还包括用于测量与所选生物标志物的产物相对应的数据的试剂盒，其在一些实施方案中包括计算机可读介质。还包括监测一种或多种结肠直肠病变治疗效果的试剂盒和方法。

6. 发明申请

US20130000452A1 METHOD FOR PREVENTING WEAR OF MONOCRYSTALLINE DIAMOND TOOLS BY APPLYING MULTIPLE PHYSICAL FIELDS DURING ULTRA-PRECISION MACHINING 审中-公开
标题翻译：通过在超精密加工中应用多个物理场地来预防单晶金刚石工具的磨损方法
公开(公告)号：US20130000452A1
公开(公告)日：2013-01-03
申请号：US13515280
申请日：2010-07-09
申请人： Fengzhou Fang , Zhongjun Qiu , Xiaotang Hu , Hongwei Zhang
发明人： Fengzhou Fang , Zhongjun Qiu , Xiaotang Hu , Hongwei Zhang
IPC分类号： B26D7/08
CPC分类号： B24B53/001 , B23B27/20 , B23B2222/44 , B23B2222/84 , B23B2226/31 , B23B2260/092 , B23B2270/022 , B23B2270/38 , Y10T83/0405
摘要： A method for preventing the wear of monocrystalline diamond tools by applying multiple physical fields during ultra-precision machining is disclosed, wherein dislocation form of lower energy state will appear by applying different physical fields such as electric field, magnetic field and laser irradiation around the diamond tool so as to change the construction of crystal interface and interfacial energy. Consequently, solid transformation will appear in the materials during the cutting process of nano-scale precision so as to change the cutting characteristic of the materials and prevent the wear of monocrystalline diamond tools during ultra-precision machining The method can be mainly used for ultra-precision machining
摘要翻译：公开了一种通过在超精密加工期间应用多个物理场来防止单晶金刚石工具的磨损的方法，其中通过在钻石周围施加不同的物理场，例如电场，磁场和激光照射，将出现较低能态的位错形式工具，以改变晶界面和界面能的结构。因此，在纳米尺度精密切割过程中材料将出现固体转变，从而改变材料的切割特性，防止单晶金刚石工具在超精密加工过程中的磨损。该方法主要用于超精密加工，精密加工

7. 发明授权

US07432049B2 Compositions and methods relating to osteoarthritis 失效
标题翻译：与骨关节炎相关的组成和方法
公开(公告)号：US07432049B2
公开(公告)日：2008-10-07
申请号：US10085783
申请日：2002-02-28
申请人： Choong-Chin Liew , Wayne Marshall , Hongwei Zhang
发明人： Choong-Chin Liew , Wayne Marshall , Hongwei Zhang
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158
摘要： The invention provides for nucleic acid sequences that are expressed in chondrocytes from any of the following developmental and disease stages: fetal, normal, mild osteoarthritic, moderate osteoarthritic, marked and osteoarthritic. The invention also relates to arrays and compositions comprising any combination of these nucleic acid sequences. The invention also provides for methods of using the arrays of the invention to diagnose osteoarthritis. The invention also provides for methods of identifying therapeutic agents that alter the level of expression of the nucleic acids of the invention or alter the anabolic level of a chondrocyte.
摘要翻译：本发明提供在以下任何发育和疾病阶段的软骨细胞中表达的核酸序列：胎儿，正常，轻度骨关节炎，中度骨关节炎，标记和骨关节炎。本发明还涉及包含这些核酸序列的任何组合的阵列和组合物。本发明还提供了使用本发明的阵列来诊断骨关节炎的方法。本发明还提供了鉴定改变本发明的核酸的表达水平或改变软骨细胞的合成代谢水平的治疗剂的方法。

8. 发明授权

US09102949B2 CNS targeting AAV vectors and methods of use thereof 有权
标题翻译：针对AAV载体的CNS及其使用方法
公开(公告)号：US09102949B2
公开(公告)日：2015-08-11
申请号：US13642719
申请日：2011-04-22
申请人： Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
发明人： Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC分类号： C12N15/86 , C12N15/864 , C12N15/113 , A61K38/50 , A61K31/713 , C12N9/80 , C12N7/00 , A61K48/00 , C12N15/63
CPC分类号： C12N15/86 , A61K31/713 , A61K38/50 , A61K48/00 , A61K48/0058 , A61K48/0075 , C12N7/00 , C12N9/80 , C12N15/1137 , C12N15/635 , C12N15/8645 , C12N2310/141 , C12N2750/14133 , C12N2750/14141 , C12N2750/14143 , C12N2750/14145 , C12N2750/14162 , C12N2810/10 , C12N2840/007 , C12Y305/01015
摘要： The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
摘要翻译：本发明在一些方面涉及可用于靶向转基因到CNS组织的重组腺相关病毒，以及包含其的组合物及其使用方法。在一些方面，本发明提供了用于治疗CNS相关疾病的方法和组合物。

9. 发明申请

US20110020809A1 MILD OSTEOARTHRITIS BIOMARKERS AND USES THEREOF 失效
标题翻译： MILD OSTEOARTHRITIS生物标记及其用途
公开(公告)号：US20110020809A1
公开(公告)日：2011-01-27
申请号：US12777140
申请日：2010-05-10
申请人： Choong-Chin Liew , Hongwei Zhang , Adam Dempsey , Thomas Yager , Samuel Chao
发明人： Choong-Chin Liew , Hongwei Zhang , Adam Dempsey , Thomas Yager , Samuel Chao
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2800/102
摘要： The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis.
摘要翻译：本发明涉及新生物标志物的鉴定和选择以及与没有骨关节炎的个体相比，在具有轻度骨关节炎的个体中差异表达的新型生物标志物组合的鉴定和选择。与本发明的生物标志物的产物特异性和/或选择性杂交的多核苷酸和蛋白质也包括在本发明的范围内，如含有用于诊断轻度骨关节炎的所述多核苷酸和蛋白质的试剂盒。本发明进一步包括使用与本发明的生物标志物的产物特异性和/或选择性杂交的多核苷酸和蛋白质，以监测个体的疾病回归并监测治疗方案的功效。本发明还提供了使用本发明的生物标志物的产物鉴定骨关节炎的新型治疗靶标的方法。

10. 发明申请

US20090208942A1 Method and Apparatus for Correlating Levels of Biomarker Products with Disease 失效
标题翻译：将生物标志物产品与疾病相关联的方法和装置
公开(公告)号：US20090208942A1
公开(公告)日：2009-08-20
申请号：US12091049
申请日：2006-10-23
申请人： Choong-Chin Liew , Mark Han , Thomas Yager , Samuel Chao , Run Zheng , Hongwei Zhang
发明人： Choong-Chin Liew , Mark Han , Thomas Yager , Samuel Chao , Run Zheng , Hongwei Zhang
IPC分类号： C12Q1/68 , G06G7/48
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G06F19/12 , G06F19/18 , G06F19/20 , G06F19/24 , G16H50/30 , Y02A90/26
摘要： In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. In other aspects a computer system is configured with instructions that cause the processor to provide a user with the indication of whether the test individual has colorectal pathology. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies.
摘要翻译：在一个方面，本发明是通过提供对应于所选生物标志物的产物水平的数据并应用所述生物标记物的一个或多个结直肠病理学或一种或多种结直肠病理学（在一个实施方案中为结肠直肠癌）亚型的方法，数据提供给公式，以提供测试个体是否具有一种或多种结肠直肠病变或一种或多种结直肠病理学亚型的指示。在某些方面，该方法是基于计算机的，并且计算机将数据应用于公式。在其他方面，计算机系统配置有指令，其使得处理器向用户提供测试个体是否具有结肠直肠病理学的指示。还包括用于测量与所选生物标志物的产物相对应的数据的试剂盒，其在一些实施方案中包括计算机可读介质。还包括监测一种或多种结肠直肠病变治疗效果的试剂盒和方法。

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