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1. 发明申请

US20060079135A1 Integrated telecommunications cabinet system with DSX assemblies and multiplexers 审中-公开
公开(公告)号：US20060079135A1
公开(公告)日：2006-04-13
申请号：US10991004
申请日：2004-01-20
申请人： Jim Vercruyssen , Peter Mohr , Jon Thorpe
发明人： Jim Vercruyssen , Peter Mohr , Jon Thorpe
IPC分类号： H01R24/04
CPC分类号： H04J3/1623 , H04J3/02 , H04Q1/025 , H04Q1/06 , H04Q1/15 , H04Q2201/10 , H04Q2201/12
摘要： A telecommunications cabinet system in which a cabinet with a first end and a second end includes a plurality of DSX-1 and/or DSX-3 jack assemblies and at least one multiplexer, are mounted such that they may be accessed from an end of the cabinet framework. The preferred system includes fifty-six DSX-1 jack assemblies and two active M13's, with two standby or redundant M13's being available for use.

2. 发明授权

US09260408B2 Dihydroquinoline-2-one derivatives 有权
标题翻译：二氢喹啉-2-酮衍生物
公开(公告)号：US09260408B2
公开(公告)日：2016-02-16
申请号：US13612956
申请日：2012-09-13
申请人： Johannes Aebi , Kurt Amrein , Benoit Hornsperger , Henner Knust , Bernd Kuhn , Yongfu Liu , Hans P. Maerki , Alexander V. Mayweg , Peter Mohr , Xuefei Tan , Mingwei Zhou
发明人： Johannes Aebi , Kurt Amrein , Benoit Hornsperger , Henner Knust , Bernd Kuhn , Yongfu Liu , Hans P. Maerki , Alexander V. Mayweg , Peter Mohr , Xuefei Tan , Mingwei Zhou
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/06 , C07D487/10 , C07F7/18 , A61P13/12 , A61P9/04 , A61P9/12
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/06 , C07D487/10 , C07F7/1804
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A1, A2 and A3 are as described herein, compositions including the compounds and methods of using the compounds. These compounds are useful for therapy or prophylaxis in a mammal, and in particular as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.
摘要翻译：本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，A1，A2和A3如本文所述，包括该化合物的组合物和使用该化合物的方法。这些化合物可用于治疗或预防哺乳动物，特别是用于治疗或预防慢性肾脏疾病，充血性心力衰竭，高血压，原发性醛固酮增多症和库兴综合征的醛固酮合酶（CYP11B2或CYP11B1）抑制剂。

3. 发明授权

US09011919B2 Compositions for targeted delivery of siRNA 有权
标题翻译：用于靶向递送siRNA的组合物
公开(公告)号：US09011919B2
公开(公告)日：2015-04-21
申请号：US13615938
申请日：2012-09-14
申请人： David B. Rozema , David L. Lewis , Darren H. Wakefield , Torsten Hoffmann , Eric Kitas , Peter Mohr , Philipp Hadwiger , Wilma Thuer , Linda Valis
发明人： David B. Rozema , David L. Lewis , Darren H. Wakefield , Torsten Hoffmann , Eric Kitas , Peter Mohr , Philipp Hadwiger , Wilma Thuer , Linda Valis
IPC分类号： A61K9/14 , C07H21/02 , C07K1/00 , A61K47/32 , A61K9/08 , A61K48/00 , C12N15/11 , C12N15/87 , A61K47/48
CPC分类号： C12N15/113 , A61K9/08 , A61K31/713 , A61K47/32 , A61K47/549 , A61K47/60 , A61K47/65 , A61K48/0041 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2310/141 , C12N2310/3515 , C12N2320/32
摘要： The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
摘要翻译：本发明涉及用于将体内RNA干扰（RNAi）多核苷酸靶向递送至肝细胞的组合物。靶向RNAi多核苷酸与共靶向递送聚合物一起施用。递送聚合物提供膜穿透功能，用于将RNAi多核苷酸从细胞外部移动到细胞内。可逆修饰提供对递送聚合物的生理反应性。

4. 发明申请

US20080306116A1 ARYLOXAZOLE, ARYLOXADIAZOLE AND BENZIMIDAZOLE DERIVATIVES 审中-公开
标题翻译：阿唑氧唑，阿魏酸和苯并咪唑衍生物
公开(公告)号：US20080306116A1
公开(公告)日：2008-12-11
申请号：US12123508
申请日：2008-05-20
申请人： Andreas D. Christ , Rainer E. Martin , Peter Mohr
发明人： Andreas D. Christ , Rainer E. Martin , Peter Mohr
IPC分类号： A61K31/454 , C07D405/12
CPC分类号： C07D413/12 , C07D401/12
摘要： This invention relates to compounds of the formula wherein X is O or NR8, Y is CR7 or N, and R1 to R8 are as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.
摘要翻译：本发明涉及下式的化合物，其中X为O或NR8，Y为CR7或N，R1至R8如说明书中所定义，及其药学上可接受的盐。本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5相关的疾病的用途。

5. 发明申请

US20080249101A1 BENZOIMIDAZOLE, TETRAHYDRO-QUINOXALINE, BENZOTRIAZOLE, DIHYDRO-IMIDAZO[4,5-c] PYRIDINONE AND DIHYDRO-ISOINDOLONE DERIVATIVES 失效
标题翻译：苯并咪唑，四氢喹喔啉，苯并噻唑，二氢咪唑并[4,5-c]吡啶酮和二氢吲哚酮衍生物
公开(公告)号：US20080249101A1
公开(公告)日：2008-10-09
申请号：US12053781
申请日：2008-03-24
申请人： Konrad Bleicher , Andreas D. Christ , Rainer E. Martin , Peter Mohr
发明人： Konrad Bleicher , Andreas D. Christ , Rainer E. Martin , Peter Mohr
IPC分类号： A61K31/498 , C07D403/04 , A61K31/454 , A61K31/437 , C07D471/04 , C07D241/36
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D471/04
摘要： This invention relates to compounds of the formula wherein A, R1 to R3 are as defined in the specification and G is benzoimidazole, quinoxaline, benzotriazole, dihydro-imidazo[4,5-c]pyridine and dihydro-isoindolone group as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.
摘要翻译：本发明涉及下式化合物其中A，R 1至R 3如说明书中所定义，G为苯并咪唑，喹喔啉，苯并三唑，二氢咪唑并[4 ，5-c]吡啶和二氢异吲哚酮基及其药学上可接受的盐。本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5相关的疾病的用途。

6. 发明申请

US20080139561A1 Pyrazolylaminopyridine Derivatives Useful as Kinases Inhibitors 有权
标题翻译：吡唑基氨基吡啶衍生物可用作激酶抑制剂
公开(公告)号：US20080139561A1
公开(公告)日：2008-06-12
申请号：US11815140
申请日：2006-02-01
申请人： Audrey Davies , Michelle Lamb , Paul Lyne , Tao Wang , Dingwei Yu , Peter Mohr , Bin Wang
发明人： Audrey Davies , Michelle Lamb , Paul Lyne , Tao Wang , Dingwei Yu , Peter Mohr , Bin Wang
IPC分类号： A61K31/4439 , A61P35/00 , C07D401/14 , C07D413/14 , C07D409/14 , A61K31/5377 , C07D401/12
CPC分类号： C07D401/12 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： This invention relates to novel compounds having the Formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
摘要翻译：本发明涉及具有式（I）的新化合物及其药物组合物及其使用方法。这些新型化合物为癌症提供治疗。

7. 发明申请

US20080064697A1 PYRIDINE, QUINOLINE AND PYRIMIDINE DERIVATIVES 失效
标题翻译：吡啶，喹啉和吡嗪衍生物
公开(公告)号：US20080064697A1
公开(公告)日：2008-03-13
申请号：US11847467
申请日：2007-08-30
申请人： Andreas Christ , Rainer Martin , Peter Mohr
发明人： Andreas Christ , Rainer Martin , Peter Mohr
IPC分类号： A61K31/496 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61P3/10 , C07D401/12 , C07D413/14
CPC分类号： C07D401/12
摘要： This invention is concerned with compounds of the formula wherein A, R1 to R5 are as defined in the specification and G is a pyridine, quinoline or pyrimidine group as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.
摘要翻译：本发明涉及下式的化合物，其中A，R 1至R 5如说明书中所定义，G为吡啶，喹啉或嘧啶基团，如说明书及其药学上可接受的盐。本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5相关的疾病的用途。

8. 发明申请

US20070034265A1 ROTARY FEED-THROUGH WITH LEAKAGE SENSOR 有权
标题翻译：旋转进给 - 带泄漏传感器
公开(公告)号：US20070034265A1
公开(公告)日：2007-02-15
申请号：US11460269
申请日：2006-07-27
申请人： Peter Mohr , Wolfgang Bechteler , Stephan Gast , Hans Leidl
发明人： Peter Mohr , Wolfgang Bechteler , Stephan Gast , Hans Leidl
IPC分类号： F16L27/08
CPC分类号： F16L27/0828 , G01M3/183 , G01M3/2853 , Y10T137/8326 , Y10T137/86268
摘要： The invention pertains to a rotary feed-through for supplying a fluid to a rotating machine part with a hollow shaft (3) that is rotatably supported in a housing (1, 2) and has a first sliding surface (29), with a sealing bushing (31) that is arranged in a rotationally fixed fashion within the housing (1, 2) coaxial to the shaft (3) and has a second sliding surface (30) for contacting the first sliding surface (29), and with a collecting chamber (27) that is arranged within the housing (1, 2) and serves for collecting the leakage fluid escaping between the two sliding surfaces (29, 30). The leakage fluid collected within the rotary feed-through can be monitored with the aid of a detection channel (26, 33, 34, 37, 39, 47) in the housing (1, 2) that is connected to the collecting chamber (27) and contains a leakage sensor (41).
摘要翻译：本发明涉及一种用于向旋转机器部件供应流体的旋转馈通，所述旋转机器部分具有可旋转地支撑在壳体（1,2）中并具有第一滑动表面（29）的中空轴（3）衬套（31），其以与所述轴（3）同轴的所述壳体（1,2）内以旋转固定的方式布置，并且具有用于接触所述第一滑动表面（29）的第二滑动表面（30）室（27），其布置在壳体（1,2）内，并用于收集在两个滑动表面（29,30）之间逸出的泄漏流体。可以借助于连接到收集室（27）的壳体（1,2）中的检测通道（26,33,34,37,39,47）来监测在旋转通过内收集的泄漏流体，）并且包含泄漏传感器（41）。

9. 发明申请

US20060116410A1 4-Aminomethyl benzamidine derivatives 审中-公开
标题翻译： 4-氨基甲基苯甲脒衍生物
公开(公告)号：US20060116410A1
公开(公告)日：2006-06-01
申请号：US11217860
申请日：2005-09-01
申请人： David Banner , Peter Mohr , Ulrike Obst , Christoph Stahl
发明人： David Banner , Peter Mohr , Ulrike Obst , Christoph Stahl
IPC分类号： A61K31/42 , A61K31/4172 , A61K31/415 , A61K31/165
CPC分类号： C07D263/34 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/04 , C07C311/08 , C07C311/13 , C07C311/21 , C07C2601/02 , C07D207/27 , C07D209/48 , C07D211/58 , C07D213/30 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/56 , C07D213/65 , C07D213/75 , C07D213/81 , C07D213/82 , C07D231/14 , C07D233/64 , C07D235/06 , C07D261/14 , C07D275/02 , C07D295/13 , C07D295/185 , C07D295/192
摘要： The invention is concerned with novel 4-aminomethyl benzamidine derivatives of formula (I) wherein Ar and X are as defined in the description and in the claims, as well as prodrugs and pharmaceutically acceptable salts thereof These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.
摘要翻译：本发明涉及式（I）的新型4-氨基甲基苯甲脒衍生物，其中Ar和X如说明书和权利要求书中所定义，以及其前药和药学上可接受的盐。这些化合物抑制凝血因子Xa， IXa和由因子VIIa和组织因子诱导的凝血酶，可用作药物。

10. 发明授权

US06969725B2 Oxazole derivatives 失效
标题翻译：恶唑衍生物
公开(公告)号：US06969725B2
公开(公告)日：2005-11-29
申请号：US10679604
申请日：2003-10-06
申请人： Alfred Binggeli , Markus Boehringer , Uwe Grether , Hans Hilpert , Georges Hirth , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Fabienne Ricklin
发明人： Alfred Binggeli , Markus Boehringer , Uwe Grether , Hans Hilpert , Georges Hirth , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Fabienne Ricklin
IPC分类号： A61K31/421 , A61P3/10 , C07D263/32 , C07D263/30
CPC分类号： C07D263/32
摘要： The present invention relates to compounds of formula (I) wherein wherein R1, R2, R3, R4, R5, R6 and n are as described herein. The compounds of the present invention can be used as medicaments for the treatment and/or prevention of diseases which are modulated by PPARα and/or PPARγ agonists. Examples of such diseases are diabetes, particularly non-insulin dependent diabetes mellitus, elevated blood pressure, increased lipid and cholesterol levels, atherosclerotic diseases, metabolic syndrome, endothelial dysfunction, procoagulant state, dyslipidemia, polycystic ovary syndrome, inflammatory diseases (such as e.g. crown disease, inflammatory bowel disease, collitis, pancreatitis, cholestasis/fibrosis of the liver, and diseases that have an inflammatory component such as e.g. Alzheimer's disease or impaired/improvable cognitive function) and proliferative diseases.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 5，R 6和n如本文所述。本发明的化合物可用作治疗和/或预防由PPARα和/或PPARγ激动剂调节的疾病的药物。这些疾病的例子包括糖尿病，特别是非胰岛素依赖性糖尿病，升高的血压，升高的脂质和胆固醇水平，动脉粥样硬化疾病，代谢综合征，内皮功能障碍，促凝血状态，血脂异常，多囊卵巢综合征，炎性疾病（例如冠疾病，炎性肠病，结肠炎，胰腺炎，胆汁郁积/肝脏纤维化，以及具有诸如阿尔茨海默病和受损/可改善的认知功能等炎症成分的疾病）和增殖性疾病。

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