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1. 发明申请

US20130136805A1 FOAMABLE COMPOSITIONS OF STABILIZED CHLORITE 审中-公开
标题翻译：稳定化氯化物的可燃组合物
公开(公告)号：US20130136805A1
公开(公告)日：2013-05-30
申请号：US13816056
申请日：2011-08-12
申请人： Servet Buyuktimkin , Nadir Buyuktimkin , Edward T. Kisak , John M. Newsam , Dominic King-Smith , Jagat Singh , Rainer Martin
发明人： Servet Buyuktimkin , Nadir Buyuktimkin , Edward T. Kisak , John M. Newsam , Dominic King-Smith , Jagat Singh , Rainer Martin
IPC分类号： A61K9/12
CPC分类号： A61K9/122 , A61K9/0014 , A61K33/00 , A61K47/02 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/38
摘要： The present application relates to foamable compositions and foams comprising stabilized chlorite, including stabilized chlorite solutions such as Oxovasin™, and to medical uses thereof, in particular for wound healing. The foamable compositions comprise at least one foaming agent, stabilized chlorite, water and optionally, a buffering agent.
摘要翻译：本发明涉及可发泡组合物和包含稳定的亚氯酸盐的泡沫，包括稳定的亚氯酸盐溶液，例如Oxovasin TM，以及其医疗用途，特别是用于伤口愈合。可发泡组合物包含至少一种发泡剂，稳定的亚氯酸盐，水和任选的缓冲剂。

2. 发明授权

US08208666B2 Method for determining unbiased signal amplitude estimates after cepstral variance modification 失效
标题翻译：倒谱方差修正后确定无偏信号幅度估计的方法
公开(公告)号：US08208666B2
公开(公告)日：2012-06-26
申请号：US12684147
申请日：2010-01-08
申请人： Timo Gerkmann , Rainer Martin
发明人： Timo Gerkmann , Rainer Martin
IPC分类号： H04R25/00
CPC分类号： G10L21/0208 , G10L25/24
摘要： A method for determining unbiased signal amplitude estimates () after cepstral variance modification of a discrete time domain signal (s(t)), wherein the cepstrally-modified spectral amplitudes () of the discrete time domain signal (s(t)) are χ-distributed with 2{tilde over (μ)} degrees of freedom. A bias reduction factor (r) is determined using the equation r 2 = μ μ ~ ⁢ ⅇ ψ ⁡ ( μ ~ ) - ψ ⁡ ( μ ) , where 2μ are the degrees of freedom of the χ-distributed spectral amplitudes of the discrete time domain signal (s(t)) and ψ ⁡ ( x ) = - 0.5772 - ∑ n = 0 ∞ ⁢ ( 1 x + n - 1 1 + n ) ; then the unbiased signal amplitude estimates () are determined by multiplying the cepstrally-modified spectral amplitudes () with the bias reduction factor (r) according to the equation =r. A method for speech enhancement and a hearing aid use the method for determining unbiased signal amplitude estimates () in order to offer the advantage of spectral modification, such as smoothing, of spectral quantities without affecting their signal power.
摘要翻译：一种用于确定离散时域信号（s（t））的倒谱方差修正后的无偏信号幅度估计（）的方法，其中离散时域信号（s（t））的经频谱修正的频谱幅度（χ）为χ 分布为2（波形）超过（μ）}自由度。使用等式r 2 =μμ〜ψψ（μ〜）-ψ⁡（μ）确定偏置约简因子（r），其中2μ是离散时间的χ分布频谱幅度的自由度域信号（s（t））和ψ⁡（x）= - 0.5772 - Σn = 0∞（1 x + n - 1 1 + n）那么无偏信号幅度估计（）通过将倒频修正的频谱幅度（）与偏置简化因子（r）相乘来确定，方程式= r。用于语音增强和助听器的方法使用用于确定无偏信号幅度估计（）的方法，以便提供频谱修改的优点，例如频谱量化的平滑，而不影响其信号功率。

3. 发明申请

US20100056490A1 Cyclic sulfones with aminobenzyl substitution useful as BACE inhibitors 失效
标题翻译：具有氨基苄基取代基的环砜用作BACE抑制剂
公开(公告)号：US20100056490A1
公开(公告)日：2010-03-04
申请号：US12500093
申请日：2009-07-09
申请人： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
发明人： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
IPC分类号： A61K31/397 , C07D401/12 , C07D205/02 , C07D335/02 , A61K31/4535 , A61K31/382 , A61P25/00 , A61P9/10
CPC分类号： C07D335/02 , C07D409/10 , C07D409/12 , C07D413/12 , C07F7/0812
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
摘要翻译：本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备方式，其用作药物和包含它们的药物。

4. 发明申请

US20070028696A1 Pressure sensor 有权
标题翻译：压力传感器
公开(公告)号：US20070028696A1
公开(公告)日：2007-02-08
申请号：US10566364
申请日：2004-07-16
申请人： Ulfert Drewes , Karl Floegel , Frank Hegner , Thomas Uehlin , Rainer Martin
发明人： Ulfert Drewes , Karl Floegel , Frank Hegner , Thomas Uehlin , Rainer Martin
IPC分类号： G01L7/00
CPC分类号： G01L19/003
摘要： A pressure sensor including: A pressure measuring cell having an end face loadable with the medium; a housing having a media opening and a ring-shaped, axial bearing surface, which surrounds the media opening; a clamping apparatus; and a ring-shaped sealing arrangement. The pressure measuring cell is positioned in the housing and the sealing arrangement is positioned between the bearing surface and the end face, and the sealing arrangement, as well as the pressure measuring cell, are axially clamped between the bearing surface and the clamping apparatus. The sealing arrangement includes, a decoupling ring, as well as a first and a second, ring-shaped sealing element. The first sealing element lies against the end face, the second sealing element lies against the bearing surface, and the decoupling ring is axially clamped between the first and the second sealing elements.
摘要翻译：一种压力传感器，包括：压力测量单元，其具有可与介质一起装载的端面; 壳体，其具有介质开口和围绕介质开口的环形的轴向支承表面; 夹紧装置; 和环形密封装置。压力测量单元位于壳体中，并且密封装置位于支承表面和端面之间，并且密封装置以及压力测量单元被轴向地夹紧在支承表面和夹紧装置之间。密封装置包括脱钩环以及第一和第二环形密封元件。第一密封元件靠在端面上，第二密封元件位于支承表面上，并且解耦环被轴向夹紧在第一和第二密封元件之间。

5. 发明授权

US5835607A Mobile radiotelephone with handsfree device 失效
标题翻译：手机无线电话免提设备
公开(公告)号：US5835607A
公开(公告)日：1998-11-10
申请号：US424257
申请日：1995-06-12
申请人： Rainer Martin , Kees Janse , Charles Knibbler , Walter Kellermann
发明人： Rainer Martin , Kees Janse , Charles Knibbler , Walter Kellermann
IPC分类号： H04M1/02 , H04M1/19 , H04M1/60 , H04R3/00 , H04R3/04 , H04B15/00
CPC分类号： H04M1/6075 , H04M1/19 , H04R3/005 , H04R3/04 , H04R2499/13
摘要： A mobile radio transceiver comprising a hands-free facility, which hands-free facility combines at least two acoustic input signals to produce an output signal, and an adaptive filter is provided for filtering the combined output signal. To achieve an improved speech quality, a high-pass filter is provided for filtering the acoustic input signals.
摘要翻译： PCT No.PCT / IB94 / 00265 Sec。 371日期：1995年6月12日 102（e）1995年6月12日PCT PCT 1994年9月7日PCT公布。公开号WO95 / 07597 日期1995年3月16日一种包括免提设施的移动无线电收发机，其免提设施组合至少两个声输入信号以产生输出信号，并且提供自适应滤波器以对组合的输出信号进行滤波。为了实现改进的语音质量，提供了用于对声输入信号进行滤波的高通滤波器。

6. 发明授权

US5699480A Apparatus for improving disturbed speech signals 失效
标题翻译：用于改善受干扰的语音信号的装置
公开(公告)号：US5699480A
公开(公告)日：1997-12-16
申请号：US673151
申请日：1996-07-01
申请人： Rainer Martin
发明人： Rainer Martin
IPC分类号： G10L21/0208 , G10L21/0216 , H03H17/00 , H03H21/00 , G10L3/02
CPC分类号： G10L21/0208 , G10L2021/02165
摘要： An apparatus for the transmission of speech signals reduces the effect of disturbances on the transmission quality. Two microphones are provided for picking up speech signals. Signal processing ensues in three partial frequency bands. The microphone signals are high-pass filtered in a lower frequency band, in the middle frequency band the signal is weighted with a scalar factor, so that this frequency band is damped during the speech pauses, and in the upper frequency band, an adaptive filter is used. At the beginning of the processing, a treble enhancement of the signals ensues, which is canceled by an inverse filter before the output of the improved signal.
摘要翻译：用于传输语音信号的装置减少了干扰对传输质量的影响。提供两个麦克风用于拾取语音信号。在三个部分频带中进行信号处理。麦克风信号在较低频带中被高通滤波，在中频段，信号用标量因子加权，使得该频带在语音暂停期间被衰减，而在较高频带中，自适应滤波器用来。在处理开始时，信号的高音增强，在改善的信号的输出之前由逆滤波器抵消。

7. 发明申请

US20150374807A1 Amyloid beta1-6 Antigen Arrays 审中-公开
标题翻译：淀粉样β1-6抗原阵列
公开(公告)号：US20150374807A1
公开(公告)日：2015-12-31
申请号：US14788896
申请日：2015-07-01
申请人： Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Martin Lueoend , Matthias Staufenbiel , Peter Frey
发明人： Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Martin Lueoend , Matthias Staufenbiel , Peter Frey
IPC分类号： A61K39/00
CPC分类号： A61K39/0007 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/64
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune, responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含有序和重复的抗原或抗原决定簇，特别是Aβ肽-VLP组合物的组合物。更具体地，本发明提供了包含病毒样颗粒和与其结合的至少一个Aβ1-6肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物，并有效诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别可用于在指定的上下文中有效诱导自身特异性免疫，应答。

8. 发明申请

US20150203481A1 Novel Heterocyclic Derivatives and Their Use in the Treatment of Neurological Disorders 审中-公开
标题翻译：新型杂环衍生物及其在神经障碍治疗中的应用
公开(公告)号：US20150203481A1
公开(公告)日：2015-07-23
申请号：US14482662
申请日：2014-09-10
申请人： Sangamesh BADIGER , Murali CHEBROLU , Konstanze HURTH , Sebastien JACQUIER , Rainer Martin LUEOEND , Rainer MACHAUER , Heinrich RUEEGER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
发明人： Sangamesh BADIGER , Murali CHEBROLU , Konstanze HURTH , Sebastien JACQUIER , Rainer Martin LUEOEND , Rainer MACHAUER , Heinrich RUEEGER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
IPC分类号： C07D413/14 , C07D487/04 , C07D471/04 , A61K31/5377
CPC分类号： C07D413/14 , A61K31/5377 , C07B59/002 , C07B2200/05 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
摘要翻译：本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，其药物组合物，其组合及其作为药物的用途，特别是用于通过BACE-抑制剂的抑制治疗阿尔茨海默病或糖尿病， 1或BACE-2。

9. 发明申请

US20150150877A1 NOVEL OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE 审中-公开
标题翻译：新型氧化氮衍生物及其在治疗疾病中的应用
公开(公告)号：US20150150877A1
公开(公告)日：2015-06-04
申请号：US14615418
申请日：2015-02-05
申请人： Rainer Martin LUEOEND , Rainer MACHAUER , Heinrich RUEEGER , Siem Jacob VEENSTRA
发明人： Rainer Martin LUEOEND , Rainer MACHAUER , Heinrich RUEEGER , Siem Jacob VEENSTRA
IPC分类号： A61K31/5355
CPC分类号： C07D413/14 , A61K31/5355 , A61K45/06
摘要： The invention relates to novel oxazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
摘要翻译：本发明涉及式（I）的新的恶嗪衍生物及其药学上可接受的盐，其中所有变量如说明书，其药物组合物，其组合，及其作为药物的用途，特别是用于治疗通过抑制BACE-1或BACE-2来治疗阿尔茨海默病或糖尿病。

10. 发明授权

US08948424B2 Hearing device and method for operating a hearing device with two-stage transformation 有权
标题翻译：用于操作具有两级变换的听力装置的听力装置和方法
公开(公告)号：US08948424B2
公开(公告)日：2015-02-03
申请号：US13180642
申请日：2011-07-12
申请人： Timo Gerkmann , Rainer Martin , Henning Puder , Wolfgang Soergel
发明人： Timo Gerkmann , Rainer Martin , Henning Puder , Wolfgang Soergel
IPC分类号： H04R25/00
CPC分类号： H04R25/505 , H04R2430/03
摘要： A filter bank with a sufficiently high resolution for amplification and noise reduction and with the lowest possible computational complexity is provided for a hearing device and, in particular, for a hearing aid. Two-stage frequency transformation with little latency is therefore proposed for hearing aids. Some of the processing, for example the amplification, is carried out after high stopband attenuation in the first stage. An increased frequency resolution is achieved in a second stage before the back-transformation in the first stage, which is favorable for noise reduction, for example.
摘要翻译：提供了一种具有足够高分辨率用于放大和降噪并且具有最低可能的计算复杂度的滤波器组，用于听力设备，特别是用于助听器。因此，为助听器提出了具有很小延迟的两级频率变换。一些处理，例如放大，是在第一阶段的高阻带衰减之后进行的。例如，在第一阶段的反向变换之前的第二阶段中实现增加的频率分辨率，这有利于噪声降低。

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