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1. 发明申请

US20050276842A1 Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same 有权
标题翻译：用于皮肤递送药物的粘合剂剥离形成剂及其使用方法
公开(公告)号：US20050276842A1
公开(公告)日：2005-12-15
申请号：US11146917
申请日：2005-06-06
申请人： Jie Zhang , Kevin Warner , Michael Ashburn , Larry Rigby , Suyi Niu
发明人： Jie Zhang , Kevin Warner , Michael Ashburn , Larry Rigby , Suyi Niu
IPC分类号： A61K9/70
CPC分类号： A61K9/7015 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/445 , A61K31/573 , A61K47/10 , A61K47/32
摘要： The present invention is drawn to adhesive peel-forming formulations for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a peel-forming agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein the non-volatile solvent system has a solubility for the drug that is within a window of operable solubility for the drug such that the drug can be delivered at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified peelable layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及用于药物真皮递送的粘合剂剥离形成制剂。制剂可以包括药物，溶剂载体和剥离形成剂。溶剂载体可以包括具有一种或多种挥发性溶剂的挥发性溶剂体系和具有一种或多种非挥发性溶剂的非挥发性溶剂体系，其中所述非挥发性溶剂体系对于在窗口内的药物具有溶解性对药物具有可操作的溶解性，使得药物可以在持续的时间段内以治疗有效率递送。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发之后，制剂可以形成固化的可剥离层。

2. 发明申请

US20050112068A1 Systems and methods for reducing unintended use of active ingredients in dermal delivery devices 审中-公开
标题翻译：用于减少皮肤递送装置中活性成分意外使用的系统和方法
公开(公告)号：US20050112068A1
公开(公告)日：2005-05-26
申请号：US10975766
申请日：2004-10-27
申请人： Kevin Warner , Michael Ashburn , Suyi Niu
发明人： Kevin Warner , Michael Ashburn , Suyi Niu
IPC分类号： A61F13/00 , A61K20060101 , A61K9/70 , A61K49/00
CPC分类号： A61K9/7023 , B09B3/0075 , B09B2220/14
摘要： The present invention is drawn to systems and methods for reducing unintended use of an active ingredient, such as residual active ingredients present in spent dermal patches and peels. The system can include a dermal patch including an active ingredient and a destructive agent configured to chemically react with the active ingredient. The destructive agent can be present in a container or an absorber. In one embodiment, the absorber can be used within the container. The container can be configured to receive the dermal patch such that the active ingredient contacts the destructive agent within the container. The absorber can be configured to contact the dermal patch such that the active ingredient contacts the destructive agent of the absorber. Additionally, systems and methods for impeding the unintended use of an active ingredient, such as those present in dermal patches or peels, are also provided. The system includes a dermal patch having a first side configured to deliver an active ingredient to a skin or mucosal surface, wherein the first side also includes a dermal adhesive. The system also includes an adhesive-coated device. The adhesive-coated surface of the device can be configured to adhere to the first side, wherein upon use of the dermal patch followed by contacting the adhesive-coated surface with the first side, residual active ingredient is rendered substantially inaccessible.
摘要翻译：本发明涉及用于减少活性成分的非预期用途的系统和方法，所述活性成分例如存在于有效皮肤贴剂和皮肤中的残留活性成分。该系统可以包括皮肤贴片，其包括配置成与活性成分发生化学反应的活性成分和破坏剂。破坏剂可存在于容器或吸收器中。在一个实施例中，吸收器可以在容器内使用。容器可以被配置为接收皮肤贴片，使得活性成分与容器内的破坏剂接触。吸收器可以被配置为接触皮肤贴片，使得活性成分与吸收体的破坏剂接触。此外，还提供了用于阻止意图使用活性成分（例如存在于真皮贴剂或皮肤中的那些）的系统和方法。该系统包括皮肤贴片，其具有构造成将活性成分递送至皮肤或粘膜表面的第一侧，其中第一面还包括真皮粘合剂。该系统还包括涂有粘合剂的装置。装置的粘合剂涂覆的表面可以被配置为粘附到第一侧，其中在使用皮肤贴片然后使粘合剂涂覆的表面与第一面接触时，残留的活性成分基本上不可接近。

3. 发明申请

US20080079708A1 Low voltage driver for high voltage LCD 有权
标题翻译：低电压驱动器用于高压LCD
公开(公告)号：US20080079708A1
公开(公告)日：2008-04-03
申请号：US11904931
申请日：2007-09-28
申请人： Abhishek Bandyopadhyay , Eric Nestler , Michael Ashburn
发明人： Abhishek Bandyopadhyay , Eric Nestler , Michael Ashburn
IPC分类号： G09G5/00
CPC分类号： G09G3/3696 , G09G3/3233 , G09G3/3681 , G09G3/3692 , G09G2310/0289 , G09G2330/02 , G09G2330/04
摘要： A low voltage driver for a higher voltage LCD includes a plurality of LCD drive bias voltage input-terminals; an LCD drive voltage output terminal; an input transistor switching circuit having at least one switch for each LCD drive bias voltage for selecting one of the bias voltages; an output transistor switching circuit, responsive to the input transistor switching circuit, for applying the selected one of the bias voltages to the LCD drive voltage output terminal, the transistors of the switching circuits having a predetermined breakdown voltage; a level shifter for providing switching voltages counterpart to the plurality of bias voltages; a logic circuit for enabling the first transistor switching circuit to select a one of the bias voltages and applying a set of counterpart switching voltages to the input and output transistor switching circuits for connecting the selected one of the bias voltages to the output terminal and applying a set of switching voltages to the input and output switching circuits which limit the voltage across the transistor junctions in the switching circuit to less than the predetermined breakdown voltage.
摘要翻译：用于较高电压LCD的低电压驱动器包括多个LCD驱动偏置电压输入端子; LCD驱动电压输出端子; 输入晶体管切换电路，具有用于每个LCD驱动偏置电压的至少一个开关，用于选择所述偏置电压之一; 输出晶体管切换电路，响应于输入晶体管切换电路，将所选择的一个偏置电压施加到LCD驱动电压输出端，开关电路的晶体管具有预定的击穿电压; 电平移位器，用于提供与多个偏置电压相对应的开关电压; 逻辑电路，用于使第一晶体管开关电路能够选择一个偏置电压，并将一组对应的开关电压施加到输入和输出晶体管开关电路，用于将所选择的一个偏置电压连接到输出端子，并施加一个一组开关电压到输入和输出开关电路，其将开关电路中的晶体管结两端的电压限制到小于预定的击穿电压。

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