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1. 发明授权

US06726673B1 Methods and apparatus for improved administration of testosterone pharmaceuticals 失效
标题翻译：用于改善睾丸激素药物施用的方法和装置
公开(公告)号：US06726673B1
公开(公告)日：2004-04-27
申请号：US09317313
申请日：1999-05-24
申请人： Jie Zhang , Hao Zhang , Wade A. Hull , Larry Rigby
发明人： Jie Zhang , Hao Zhang , Wade A. Hull , Larry Rigby
IPC分类号： A61M3100
CPC分类号： A61K9/0024 , A61F7/032 , A61K9/0009 , A61K9/7023 , A61M31/002 , A61M2037/0007 , A61N1/30
摘要： The present invention relates to a method and apparatus for increasing the delivery rate of an androgen transdermal therapeutic system through the skin. An androgen transdermal therapeutic system can be applied to a patient's skin for delivery of the androgen. A temperature modification apparatus which is capable of generating controlled heat is applied approximate to the androgen transdermal therapeutic system. The heating from the temperature modification apparatus raises the temperature of the androgen transdermal therapeutic system and raises the temperature of the patient's skin to achieve an increased rate of delivery of androgen through the skin. The controlled heat can also be used to adjust dosage rates of the androgen transdermal therapeutic system and to mimic natural circadian patterns. The controlled heating may also be used to improve or regulate the release of androgen from injected/implanted extended/controlled release systems.
摘要翻译：本发明涉及通过皮肤增加雄激素透皮治疗系统的递送率的方法和装置。雄激素透皮治疗系统可以应用于患者的皮肤以递送雄激素。接近于雄激素透皮治疗系统的是能产生受控热量的温度调节装置。来自温度改变装置的加热提高了雄激素透皮治疗系统的温度，并且提高了患者皮肤的温度，以达到通过皮肤递送雄激素的增加的速率。受控热也可用于调节雄激素透皮治疗系统的剂量率，并模拟自然昼夜节律模式。受控加热也可用于改善或调节注射/植入的扩增/控制释放系统中雄激素的释放。

2. 发明授权

US06546281B1 Integrated apparatus for controlled heat aided dermal drug delivery 有权
标题翻译：用于受控热辅助皮肤药物递送的综合装置
公开(公告)号：US06546281B1
公开(公告)日：2003-04-08
申请号：US09317372
申请日：1999-05-24
申请人： Jie Zhang , Hao Zhang , Wade A. Hull , Larry Rigby
发明人： Jie Zhang , Hao Zhang , Wade A. Hull , Larry Rigby
IPC分类号： A61N130
CPC分类号： A61K9/0009 , A61F7/032 , A61F7/034 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0024 , A61K9/7023 , A61K31/4468 , A61K31/4535 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30 , Y10S514/817 , Y10S514/937 , Y10S514/944
摘要： An integrated apparatus for controlled heat aided dermal drug delivery is disclosed. The apparatus has a temperature control component and a drug delivery component. The temperature control component may and dermal drug delivery component are an integrated unit. The apparatus also comprises means to prevent exchange of substance(s) among the heat generating component, the drug delivery component and the outside environment. The apparatus is designed to be easy to use.
摘要翻译：公开了一种用于受控加热皮肤药物递送的综合装置。该装置具有温度控制部件和药物输送部件。温度控制组分可以和皮肤药物递送组分是一体化单元。该装置还包括防止发热部件，药物输送部件和外部环境之间的物质交换的装置。该设备被设计为易于使用。

3. 发明授权

US06453648B1 Method for manufacturing a heat generating apparatus 有权
标题翻译：制造发热装置的方法
公开(公告)号：US06453648B1
公开(公告)日：2002-09-24
申请号：US09347963
申请日：1999-07-06
申请人： Jie Zhang , Hao Zhang , Larry Rigby , Wade A. Hull
发明人： Jie Zhang , Hao Zhang , Larry Rigby , Wade A. Hull
IPC分类号： A61F700
CPC分类号： A61F7/034 , A61F2007/0226 , A61F2007/0249
摘要： The present invention relates to a method for manufacturing a heating device which is capable of generating heat when exposed to oxygen. The heat generating element comprises activated carbon and iron is used to generate an exothermic oxidation reaction within the heating device. Introducing an oxidation inhibitor during the manufacturing process allows the manufacturing of the device to take place in ambient atmospheric conditions. The present invention also includes a loading facilitator which allows the heat generating medium to be more easily and efficiently loaded into the heat generating device. When appropriate, the oxidation inhibitor and loading facilitator can be removed.
摘要翻译：本发明涉及一种能够在暴露于氧气时产生热量的加热装置的制造方法。发热元件包括活性炭和铁，用于在加热装置内产生放热氧化反应。在制造过程中引入氧化抑制剂可使装置的制造在环境大气条件下进行。本发明还包括能够使发热介质更容易且有效地装载到发热装置中的负载辅助装置。适当时，可以除去氧化抑制剂和负载促进剂。

4. 发明申请

US20120022158A1 SOLID-FORMING LOCAL ANESTHETIC FORMULATIONS FOR PAIN CONTROL 有权
标题翻译：用于疼痛控制的固体局部麻醉制剂
公开(公告)号：US20120022158A1
公开(公告)日：2012-01-26
申请号：US13006780
申请日：2011-01-14
申请人： Suyi Niu , Wade A. Hull , Jie Zhang
发明人： Suyi Niu , Wade A. Hull , Jie Zhang
IPC分类号： A61K31/245 , A61P23/02
CPC分类号： A61K31/167 , A61K9/0014 , A61K31/136 , A61K47/32 , A61K2300/00
摘要： Solid-forming local anesthetic formulations for pain control can include a lidocaine base and tetracaine base, polyvinyl alcohol, water, and an emulsifier. The formulation can be prepared to be in a semi-solid state prior to application to a skin surface, can form a soft solidified layer after application, and can provide pain relief when applied to a skin surface proximate a pain site.
摘要翻译：用于疼痛控制的固体形成局部麻醉剂制剂可以包括利多卡因碱和丁卡因碱，聚乙烯醇，水和乳化剂。制剂可以在施用于皮肤表面之前制备成半固体状态，在施用后可以形成柔软的固化层，并且当施加到疼痛部位附近的皮肤表面时可以提供疼痛缓解。

5. 发明授权

US07094228B2 Methods and formulations for photodynamic therapy 失效
公开(公告)号：US07094228B2
公开(公告)日：2006-08-22
申请号：US10208662
申请日：2002-07-30
申请人： Jie Zhang , Larry Rigby , Wade Hull
发明人： Jie Zhang , Larry Rigby , Wade Hull
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61M2037/0007 , A61M2205/36 , A61N5/062
摘要： An apparatus to rapidly deliver a drug to a patient, the invention comprising the method of locating a drug beneath a patient's skin in a drug depot site, placing a heating component near the drug depot site and generating heat in and near the drug depot site. A control component connected to the heating component is used to control the magnitude and duration of heat generated by the heating component.

6. 发明授权

US06756053B2 Controlled heat induced rapid delivery of pharmaceuticals from skin depot 失效
标题翻译：控制热量导致皮肤仓库快速运送药物
公开(公告)号：US06756053B2
公开(公告)日：2004-06-29
申请号：US09878558
申请日：2001-06-11
申请人： Jie Zhang , Wade Hull , Larry Rigby
发明人： Jie Zhang , Wade Hull , Larry Rigby
IPC分类号： A61K970
CPC分类号： A61K9/0024 , A61B2017/00765 , A61F7/02 , A61F7/032 , A61F7/034 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0009 , A61K9/7023 , A61K31/4468 , A61K31/4535 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30
摘要： The present invention is directed to a method and system for delivering a drug into the systemic circulation. The method comprises establishing a drug depot in a patient's skin and/or sub-skin tissues by applying a transdermal drug delivery system on the patients skin, for a predetermined time so that a drug depot is formed in said user's skin and/or sub-skin tissues. A heating source is placed proximate to the skin area to rapidly release a bolus of the drug from the depot into the systemic circulation when there is a need to rapidly increase the drug's concentrations in the systemic circulation.
摘要翻译：本发明涉及一种将药物输送到体循环中的方法和系统。该方法包括通过在患者皮肤上施用透皮药物递送系统在患者皮肤和/或亚皮肤组织中建立药物库，预定时间，使得在所述使用者的皮肤和/或子部分中形成药物库，皮肤组织。当需要快速增加药物在体循环中的浓度时，将加热源放置在皮肤区域附近，以迅速将药物从药剂释放到体循环中。

7. 发明申请

US20110086913A1 METHODS FOR TREATING MYOFASCIAL, MUSCLE, AND/OR BACK PAIN 审中-公开
标题翻译：治疗肌肉，肌肉和/或背部疼痛的方法
公开(公告)号：US20110086913A1
公开(公告)日：2011-04-14
申请号：US12752384
申请日：2010-04-01
申请人： Jie Zhang , Andrew Crockett , Larry Rigby
发明人： Jie Zhang , Andrew Crockett , Larry Rigby
IPC分类号： A61K31/24 , A61K31/167 , A61P29/00
CPC分类号： A61K9/0004 , A61F7/034 , A61F2007/0226 , A61F2007/0257 , A61F2007/0261 , A61K9/7084
摘要： The present disclosure is drawn to methods for treating myofascial pain, muscle pain, back pain, or combinations of these pains. Specifically, a method for treating myofascial pain, muscle pain, back pain, or combinations thereof includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation which includes at least one local anesthetic. The heating component can be capable of heating the skin surface to a temperature of 36° C. to 42° C.
摘要翻译：本公开涉及用于治疗肌筋膜疼痛，肌肉疼痛，背部疼痛或这些疼痛的组合的方法。具体而言，治疗肌筋膜疼痛，肌肉疼痛，背部疼痛或其组合的方法包括将镇痛系统施用于经历疼痛的受试者的皮肤表面，并将止痛系统保持在皮肤表面上一段时间至少30分钟。应用于皮肤表面的镇痛系统可以包括加热组分和包括至少一种局部麻醉剂的局部麻醉剂制剂。加热部件能够将皮肤表面加热至36℃至42℃的温度。

8. 发明申请

US20050276842A1 Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same 有权
标题翻译：用于皮肤递送药物的粘合剂剥离形成剂及其使用方法
公开(公告)号：US20050276842A1
公开(公告)日：2005-12-15
申请号：US11146917
申请日：2005-06-06
申请人： Jie Zhang , Kevin Warner , Michael Ashburn , Larry Rigby , Suyi Niu
发明人： Jie Zhang , Kevin Warner , Michael Ashburn , Larry Rigby , Suyi Niu
IPC分类号： A61K9/70
CPC分类号： A61K9/7015 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/445 , A61K31/573 , A61K47/10 , A61K47/32
摘要： The present invention is drawn to adhesive peel-forming formulations for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a peel-forming agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein the non-volatile solvent system has a solubility for the drug that is within a window of operable solubility for the drug such that the drug can be delivered at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified peelable layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及用于药物真皮递送的粘合剂剥离形成制剂。制剂可以包括药物，溶剂载体和剥离形成剂。溶剂载体可以包括具有一种或多种挥发性溶剂的挥发性溶剂体系和具有一种或多种非挥发性溶剂的非挥发性溶剂体系，其中所述非挥发性溶剂体系对于在窗口内的药物具有溶解性对药物具有可操作的溶解性，使得药物可以在持续的时间段内以治疗有效率递送。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发之后，制剂可以形成固化的可剥离层。

9. 发明授权

US06955819B2 Methods and apparatus for using controlled heat to regulate transdermal and controlled release delivery of fentanyl, other analgesics, and other medical substances 失效
标题翻译：使用受控热调节芬太尼，其他镇痛药和其他药物的透皮和控释药物的方法和装置
公开(公告)号：US06955819B2
公开(公告)日：2005-10-18
申请号：US09796250
申请日：2001-02-28
申请人： Jie Zhang , Wade Hull , Larry Rigby , Theodore Stanley
发明人： Jie Zhang , Wade Hull , Larry Rigby , Theodore Stanley
IPC分类号： A61F7/03 , A61F13/00 , A61K9/00 , A61K9/70 , A61M31/00 , A61N1/30
CPC分类号： A61K9/0024 , A61F7/032 , A61F2013/00646 , A61K9/0004 , A61K9/0009 , A61K9/703 , A61M31/002 , A61M2037/0007 , A61N1/30
摘要： The present invention is directed toward an apparatus to rapidly deliver a drug to a patient The invention comprises a drug beneath a patient's skin in a drug depot site. A heating component is placed near the drug depot site and generates heat in and near the drug depot site. A control component connected to the heating component is used to control the magnitude and duration of heat generated by the heating component.
摘要翻译：本发明涉及一种将药物快速输送给患者的装置。本发明包括在药物库位点的患者皮肤下面的药物。加热部件放置在药物库位附近，并在药物库位置内和附近产生热量。连接到加热部件的控制部件用于控制由加热部件产生的热量的大小和持续时间。

10. 发明授权

US06488959B2 Transdermal drug patch with attached pocket for controlled heating device 失效
公开(公告)号：US06488959B2
公开(公告)日：2002-12-03
申请号：US09864472
申请日：2001-05-24
申请人： Theodore Stanley , Wade Hull , Larry Rigby , Jie Zhang
发明人： Theodore Stanley , Wade Hull , Larry Rigby , Jie Zhang
IPC分类号： A61F1300
CPC分类号： A61K9/7084 , A61N1/30
摘要： The present invention relates to a transdermal drug delivery system comprising a dermal drug delivery patch and a heating element compartment securable to the dermal drug delivery patch. A freely transferrable heating element is securable within the heating element compartment. A drug can be administered transdermally using the present invention by placing the dermal drug delivery patch upon a patient's skin at an administration site. A heating element compartment is secured to the dermal drug delivery patch and a freely transferrable heating element is placed within the heating element compartment. The heating element provides controlled heat to the dermal drug patch and the patient's skin and thereby improves dermal drug administration.

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