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1. 发明申请

US20080306027A1 Fluoroalkoxycombretastatin Derivatives, Method For Producing the Same and Use Thereof 有权
标题翻译：氟烷氧基复兴素衍生物，其生产方法和用途
公开(公告)号：US20080306027A1
公开(公告)日：2008-12-11
申请号：US12088984
申请日：2006-11-22
申请人： Weiping Shen , Jianping Wang , Jianguo Wang , Feng Qian , Fei Wang , Hongmei Jin
发明人： Weiping Shen , Jianping Wang , Jianguo Wang , Feng Qian , Fei Wang , Hongmei Jin
IPC分类号： A61K31/661 , C07C43/205 , A61K31/085 , C07C211/43 , A61K31/164 , A61P35/00 , C07C237/00 , A61K31/136 , C07F9/06
CPC分类号： C07C217/84 , C07C43/23 , C07C237/04 , C07F9/12
摘要： Combretastatin derivatives of formula (I), preparation and use thereof are disclosed, wherein: Rf is alkyl with 1-8 carbon atoms and 1-17 fluorine atoms, R is amino, substituted amino, hydroxyl, nitro, halo, alkyloxy, phosphate or amino acid side chain. Said derivatives have a capability to inhibit the polymerization of microtubules and are useful in treatment against tumor and neovascularization.
摘要翻译：公开了式（I）的组合抑制素衍生物，其制备和用途，其中：Rf是具有1-8个碳原子和1-17个氟原子的烷基，R是氨基，取代的氨基，羟基，硝基，卤素，烷氧基，磷酸酯或氨基酸侧链。所述衍生物具有抑制微管聚合的能力，可用于治疗肿瘤和新血管形成。

2. 发明授权

US07786098B2 Fluoroalkoxycombretastatin derivatives, method for producing the same and use thereof 有权
标题翻译：氟烷氧基复兴胸苷衍生物，其制备方法及其应用
公开(公告)号：US07786098B2
公开(公告)日：2010-08-31
申请号：US12088984
申请日：2006-11-22
申请人： Weiping Shen , Jianping Wang , Jianguo Wang , Hongmei Jin , Feng Qian , Fei Wang
发明人： Weiping Shen , Jianping Wang , Jianguo Wang , Hongmei Jin , Feng Qian , Fei Wang
IPC分类号： A61K31/661 , A61K31/085 , A61K31/164 , A61K31/136 , A61P35/00 , C07C43/205 , C07C211/43 , C07C237/00 , C07F9/06
CPC分类号： C07C217/84 , C07C43/23 , C07C237/04 , C07F9/12
摘要： Combretastatin derivatives of formula (I), preparation and use thereof are disclosed, wherein: Rf is alkyl with 1-8 carbon atoms and 1-17 fluorine atoms, R is amino, substituted amino, hydroxyl, nitro, halo, alkyloxy, phosphate or amino acid side chain. Said derivatives have a capability to inhibit the polymerization of microtubules and are useful in treatment against tumor and neovascularization.
摘要翻译：公开了式（I）的组合抑制素衍生物，其制备和用途，其中：Rf是具有1-8个碳原子和1-17个氟原子的烷基，R是氨基，取代的氨基，羟基，硝基，卤素，烷氧基，磷酸酯或氨基酸侧链。所述衍生物具有抑制微管聚合的能力，并且可用于治疗肿瘤和新生血管形成。

3. 发明申请

US20090170956A1 PREPARATION AND THE USE OF ETHOXY COMBRETASTATINS AND THEIR PRODRUGS 审中-公开
标题翻译：制备和使用乙氧基化合物及其制剂
公开(公告)号：US20090170956A1
公开(公告)日：2009-07-02
申请号：US12439783
申请日：2007-05-16
申请人： Weiping Shen , Jianping Wang , Jianguo Wang
发明人： Weiping Shen , Jianping Wang , Jianguo Wang
IPC分类号： A61K31/09 , C07C43/23
CPC分类号： C07C217/84 , C07C43/23 , C07C237/04 , C07F9/12
摘要： The invention disclosed a total synthesis process of novel ethoxy combretastatins and their prodrugs. Combretastatins are chemically modified by ethoxy substituted on the 4′-position of their B aryl ring and are converted to be their soluble prodrugs of phosphate or their inner salt of phosphorylcholine by modifying the hydroxyl on the 3′-position of their B aryl ring. Similarly, 3′-amino combretastatin is 4′-ethoxy chemically modified and further side chain of amino acid can be introduced to the amino to form soluble prodrug of amino acidamide. The structure of the said compound is showed as formula (I). Ethoxy combretastatins possess potent tubulin polymerization inhibitory activity and can be used for the treatment of inhibiting tumor or neovascular.
摘要翻译：本发明公开了新型乙氧基考布他汀及其前药的全合成方法。 Combretastatins通过在其B芳环的4'位上被乙氧基取代化学修饰，并通过修饰其B芳环的3'-位上的羟基而转化为磷酸或其内磷酸胆碱的可溶性前药。类似地，3'-氨基考布他汀是4'-乙氧基化学修饰的，氨基酸的另外侧链可以被引入氨基以形成氨基酰胺的可溶性前药。所述化合物的结构如式（I）所示。乙氧基考布他汀具有有效的微管蛋白聚合抑制活性，可用于治疗抑制肿瘤或新生血管。

4. 发明授权

US09221825B2 Pyrazolopyrimidinone compound and imidazo triazone compound for treating erectile dysfunction 有权
标题翻译：吡唑并嘧啶酮化合物和咪唑并三唑类化合物，用于治疗勃起功能障碍
公开(公告)号：US09221825B2
公开(公告)日：2015-12-29
申请号：US13980736
申请日：2012-01-20
申请人： Jianping Wang , Jianguo Wang
发明人： Jianping Wang , Jianguo Wang
IPC分类号： A61K31/551 , C07D487/04 , A61K9/20
CPC分类号： C07D487/04 , A61K9/2018
摘要： Disclosed are selective phosphodiesterase inhibitor compounds shown in formula (I) or (II) for treating Erectile Dysfunction, the pharmaceutically acceptable salts and configurational isomers thereof. In the formula, the substituents R1, R2, R3, R4 and R5 are defined as in the specification. Also disclosed are methods for preparing same, and a medical composition comprising compounds of formula (I) or (II), and the use of these compounds for preparing a drug treating or preventing male Erectile Dysfunction.
摘要翻译：公开了用于治疗勃起功能障碍的式（I）或（II）所示的选择性磷酸二酯酶抑制剂化合物，其药学上可接受的盐和构型异构体。在该式中，取代基R 1，R 2，R 3，R 4和R 5如在说明书中所定义。还公开了其制备方法和包含式（I）或（II）化合物的医药组合物，以及这些化合物用于制备治疗或预防男性勃起功能障碍的药物的用途。

5. 发明申请

US20140018351A1 Pyrazolopyrimidinone Compound and Imidazo Triazone Compound for Treating Erectile Dysfunction 有权
标题翻译：吡唑并嘧啶酮化合物和咪唑三唑类化合物治疗勃起功能障碍
公开(公告)号：US20140018351A1
公开(公告)日：2014-01-16
申请号：US13980736
申请日：2012-01-20
申请人： Jianping Wang , Jianguo Wang
发明人： Jianping Wang , Jianguo Wang
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K9/2018
摘要： Disclosed are selective phosphodiesterase inhibitor compounds shown in formula (I) or (II) for treating Erectile Dysfunction, the pharmaceutically acceptable salts and configurational isomers thereof. In the formula, the substituents R1, R2, R3, R4 and R5are defined as in the specification. Also disclosed are a medical composition comprising compounds of formula (I) or (II), and the use of these compounds for preparing a drug treating or preventing male Erectile Dysfunction.
摘要翻译：公开了用于治疗勃起功能障碍的式（I）或（II）所示的选择性磷酸二酯酶抑制剂化合物，其药学上可接受的盐和构型异构体。在该式中，取代基R 1，R 2，R 3，R 4和R 5如本说明书中所定义。还公开了包含式（I）或（II）化合物的医药组合物，以及这些化合物用于制备治疗或预防男性勃起功能障碍的药物的用途。

6. 发明授权

US07838706B2 Preparation and the use of ethoxy combretastatins and their prodrugs 有权
标题翻译：乙氧基考布他汀及其前药的制备和应用
公开(公告)号：US07838706B2
公开(公告)日：2010-11-23
申请号：US12439783
申请日：2007-05-16
申请人： Weiping Shen , Jianping Wang , Jianguo Wang
发明人： Weiping Shen , Jianping Wang , Jianguo Wang
IPC分类号： C07C237/00 , C07C235/00 , C07C233/00 , C07C231/00 , A61K31/165 , A61K31/16 , A61K31/66
CPC分类号： C07C43/23 , C07C217/84 , C07C237/04 , C07F9/12 , F16K27/003 , Y10T137/87249 , Y10T137/87885
摘要： The invention disclosed a total synthesis process of novel ethoxy combretastatins and their prodrugs. Combretastatins are chemically modified by ethoxy substituted on the 4′-position of their B aryl ring and are converted to be their soluble prodrugs of phosphate or their inner salt of phosphorylcholine by modifying the hydroxyl on the 3′-position of their B aryl ring. Similarly, 3′-amino combretastatin is 4′-ethoxy chemically modified and further side chain of amino acid can be introduced to the amino to form soluble prodrug of amino acidamide. The structure of the said compound is showed as formula (I). Ethoxy combretastatins possess potent tubulin polymerization inhibitory activity and can be used for the treatment of inhibiting tumor or neovascular.
摘要翻译：本发明公开了新型乙氧基考布他汀及其前药的全合成方法。 Combretastatins通过在其B芳环的4'位上被乙氧基取代化学修饰，并通过修饰其B芳环的3'-位上的羟基而转化为磷酸或其内磷酸胆碱的可溶性前药。类似地，3'-氨基考布他汀是4'-乙氧基化学修饰的，氨基酸的另外侧链可以被引入氨基以形成氨基酰胺的可溶性前药。所述化合物的结构如式（I）所示。乙氧基考布他汀具有有效的微管蛋白聚合抑制活性，可用于治疗抑制肿瘤或新生血管。

7. 发明授权

US09790560B2 Primers for detecting serotypes of Shigella flexneri and multiplex amplifications using the same 有权
公开(公告)号：US09790560B2
公开(公告)日：2017-10-17
申请号：US14241833
申请日：2012-08-29
申请人： Qiangzheng Sun , Jianping Wang , Jianguo Xu
发明人： Qiangzheng Sun , Jianping Wang , Jianguo Xu
IPC分类号： C12Q1/68 , G01N33/569 , C07H21/02
CPC分类号： C12Q1/689 , C12Q2600/112 , C12Q2600/16 , G01N33/56916
摘要： The present inventions relates to primers for identifying Shigella flexneri serotypes comprising the sequences of SEQ ID Nos. 1 and 2, SEQ ID Nos. 3 and 4, SEQ ID Nos. 5 and 6, SEQ ID Nos. 7 and 8, SEQ ID Nos. 9 and 10, SEQ ID Nos. 11 and 12, SEQ ID Nos. 13 and 14, SEQ ID Nos. 15 and 16. These primers are specific and have a common annealing temperature. The present invention further relates to a multiplex amplification-based identification method using the primers. The present invention further relates to the use of the primers for identifying Shigella flexneri serotypes for the preparation of identification agents. The present invention further relates to a kit for identifying Shigella flexneri comprising the above primers.

8. 发明授权

US09328927B2 All around radiation heating apparatus 有权
标题翻译：辐射加热装置
公开(公告)号：US09328927B2
公开(公告)日：2016-05-03
申请号：US12314273
申请日：2008-12-08
申请人： Jianping Wang
发明人： Jianping Wang
IPC分类号： F24C15/22 , F24C1/12 , F24C3/04 , F24C5/00
CPC分类号： F23D14/145 , F23D14/14 , F23D14/28 , F23D2203/005 , F23D2203/1012 , F23D2203/102 , F24C1/12 , F24C3/04 , F24C5/00
摘要： The present invention provides a safer all-around radiation heating assembly than similar traditional heaters. As typical with traditional heaters, a shroud is used to surroundably cover a portable liquid propane tank. To replace the portable liquid propane tank, the shroud must be continuously raised to a predetermined height while a service person accesses the propane tank. There is a danger that if and when the shroud drops, a spark could be created resulting in igniting highly flammable escaped propane gas. The present invention overcomes dangers associated with the traditional heaters by eliminating the spark creation danger and by introducing a ventilation system to allow any leaked propane gas to escape away from the heater.
摘要翻译：与类似的传统加热器相比，本发明提供了一种更安全的全能辐射加热装置。与传统的加热器一样，护罩用于围绕便携式液体丙烷罐。为了更换便携式液体丙烷罐，当服务人员访问丙烷罐时，护罩必须连续地升高到预定高度。有一种危险，如果护罩掉落，可能产生火花，导致点燃高度易燃的逸出的丙烷气体。本发明克服了与传统加热器相关的危险，消除了火花产生危险，并引入了通风系统以允许任何泄漏的丙烷气体从加热器中逸出。

9. 发明授权

US09042071B2 Breaker failure protection of HVDC circuit breakers 有权
标题翻译： HVDC断路器的断路器故障保护
公开(公告)号：US09042071B2
公开(公告)日：2015-05-26
申请号：US13702333
申请日：2010-09-13
申请人： Bertil Berggren , Jianping Wang , Juiping Pan , Kerstin Linden , Reynaldo Nuqui
发明人： Bertil Berggren , Jianping Wang , Juiping Pan , Kerstin Linden , Reynaldo Nuqui
IPC分类号： H02H3/44 , H02H7/26 , H02H7/22 , H02H7/30
CPC分类号： H02H7/268 , H02H3/044 , H02H3/05 , H02H3/445 , H02H7/222 , H02H7/30
摘要： A breaker failure protection system for a high voltage direct current, HVDC, circuit breaker is provided. The circuit breaker is arranged for interrupting a DC circuit upon reception of a trip signal. The protection system includes a current sensor, at least one inductor, and a breaker failure detection unit. The current sensor is arranged for measuring a current I(t) through the DC circuit. The at least one inductor is connected in series with the DC circuit. The breaker failure detection unit is arranged for assessing, whether the circuit breaker has failed, and sending, if the circuit breaker has failed, a trip signal to an adjacent circuit breaker. The assessment is based on the measured current. The stability of HVDC grids may be improved by sending, in case of a breaker failure, a trip signal to adjacent circuit breakers. Further, a method of breaker failure protection for an HVDC circuit breaker is provided.
摘要翻译：提供高压直流，HVDC，断路器的断路器故障保护系统。断路器被布置成在接收到跳闸信号时中断DC电路。保护系统包括电流传感器，至少一个电感器和断路器故障检测单元。电流传感器用于测量通过直流电路的电流I（t）。至少一个电感器与DC电路串联连接。断路器故障检测单元用于评估断路器是否发生故障，并且如果断路器发生故障，则发送到相邻断路器的跳闸信号。评估是基于测量的电流。在断路器故障的情况下，通过向相邻的断路器发送跳闸信号，可以提高HVDC电网的稳定性。此外，提供了一种用于HVDC断路器的断路器故障保护的方法。

10. 发明授权

US08935561B2 Progressive network recovery 有权
标题翻译：逐步恢复网络
公开(公告)号：US08935561B2
公开(公告)日：2015-01-13
申请号：US13403922
申请日：2012-02-23
申请人： Jianping Wang
发明人： Jianping Wang
IPC分类号： G06F11/00
CPC分类号： G06Q10/08 , H04L41/0654 , H04L41/145
摘要： Technologies are generally described for systems and methods effective to schedule repair (e.g., allocate repair resources, determine a repair sequence, etc.) of a system effected by a large-scale failure caused by a natural disaster, malicious attack, faulty components, or the like. In an example, the system can generate a schedule that indicates amounts of repair resources allocated for repair of specific components of a disrupted system as well as a time or sequence in which the components are to be repaired. The schedule, in some instance, can operate to maximize an amount of restoration, at each stage of a recovery process, relative to the characteristic of the disrupted system. For example, with a communications network as the disrupted system, the schedule can maximize the amount of total traffic flow capacity recovered after respective steps of the recovery process.
摘要翻译：技术通常被描述用于有效地安排由自然灾害，恶意攻击，故障组件引起的大规模故障影响的系统的修复（例如，分配维修资源，确定修复顺序等）的系统和方法，或类似。在一个示例中，系统可以生成指示分配用于修复被破坏的系统的特定组件的修复资源的数量以及要修复组件的时间或顺序的调度。在某些情况下，该计划可以在恢复过程的每个阶段相对于被破坏的系统的特征来最大化恢复的量。例如，以通信网络为中断的系统，该调度可以最大化在恢复过程的相应步骤之后恢复的总业务流量的量。

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