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1. 发明申请

US20120302645A1 USE OF HYDROXYTYROSOL FOR IMPROVING MUSCLE DIFFERENTIATION 审中-公开
标题翻译：用于改善肌肉分化的羟喹诺酮类药物
公开(公告)号：US20120302645A1
公开(公告)日：2012-11-29
申请号：US13500740
申请日：2010-10-08
申请人： Jiankang Liu , Ying Wang-Schmidt , Karin Wertz , Zhihui Feng
发明人： Jiankang Liu , Ying Wang-Schmidt , Karin Wertz , Zhihui Feng
IPC分类号： A61K31/05 , A61P29/00 , C07C39/11 , A61P21/00
CPC分类号： A61K31/05 , A23L2/52 , A23L33/105 , A61K36/63
摘要： The use of hydroxytyrosol or an olive juice extract containing hydroxytyrosol for improving muscle differentiation and thus improving or maintaining the body's adaptation to exercise is disclosed. The pharmaceutical and nutraceutical compositions comprising hydroxytyrosol useful for conditions characterized by altered muscle differentiation especially under inflammatory conditions, such as delayed onset muscle soreness subsequent to strenuous exercise or sarcopenia are provided.
摘要翻译：公开了使用羟基酪醇或含有羟基酪醇的橄榄汁提取物来改善肌肉分化，从而改善或维持身体对运动的适应性。提供了包含羟基酪醇的药物和营养组合物，其用于特征在于肌炎分化改变的病症，特别是在炎症状态下，例如剧烈运动或肌肉减少症后延迟发作的肌肉酸痛。

2. 发明申请

US20100130620A1 NOVEL USE OF HYDROXYTYROSOL AND OLIVE EXTRACTS/CONCENTRATES CONTAINING IT 审中-公开
标题翻译：使用羟肟酸和橄榄提取物/含有浓度的浓缩物
公开(公告)号：US20100130620A1
公开(公告)日：2010-05-27
申请号：US12596268
申请日：2007-04-18
申请人： Jiankang Liu , Wolfgang Schalch , Ying Wang-Schmidt , Karin Wertz
发明人： Jiankang Liu , Wolfgang Schalch , Ying Wang-Schmidt , Karin Wertz
IPC分类号： A61K31/047 , A61P27/02
CPC分类号： A61K31/05 , A23L33/105 , A23V2002/00 , A23V2200/30 , A23V2250/2132
摘要： The present invention is directed to the use of (a composition comprising) hydroxytyrosol for treating or preventing age-related macular degeneration in humans, for maintaining the eye health in animals (preferably in humans), especially in elderly animals (preferably elderly humans), for improving the vision of animals (preferably of humans), for maintaining the high resolution vision in animals (preferably in humans) and/or for maintaining the visual acuity in animals (preferably in humans), as well as for maintaining the visual performance in animals (preferably in humans) and/or the visual function in animals (preferably in humans).
摘要翻译：本发明涉及（羟基酪醇的组合物）用于治疗或预防人类年龄相关性黄斑变性，用于维持动物（优选人）中的眼睛健康，特别是在老年动物（优选老年人）中，为了维持动物（优选人类）中的高分辨率视觉和/或维持动物（优选人类）中的视力，以及维持动物（优选人类）的视力，以及维持动物动物（优选人）和/或动物（优选人类）中的视觉功能。

3. 发明申请

US20110112201A1 HYDROXYTYROSOL BENEFITS MITOCHONDRIA 审中-公开
标题翻译：羟喹诺酮益生菌
公开(公告)号：US20110112201A1
公开(公告)日：2011-05-12
申请号：US12988090
申请日：2009-04-17
申请人： Jiankang Liu , Daniel Raederstorff , Ying Wang-Schmidt , Karin Wertz
发明人： Jiankang Liu , Daniel Raederstorff , Ying Wang-Schmidt , Karin Wertz
IPC分类号： A61K31/05 , A61P3/00
CPC分类号： A61K31/05 , A61K36/63
摘要： Hydroxytyrosol or olive juice containing hydroxytyrosol can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.
摘要翻译：含有羟基酪醇的羟基酪醇或橄榄汁可用于维持或增加心肌，骨骼肌和肝组织中的线粒体生物发生。

4. 发明申请

US20100041746A1 NOVEL USE OF ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的新用途
公开(公告)号：US20100041746A1
公开(公告)日：2010-02-18
申请号：US12301505
申请日：2007-05-24
申请人： Daniel D'Orazio , Daniel Raederstorff , Goede Schueler , Ying Wang-Schmidt , Karin Wertz , Swen Wolfram
发明人： Daniel D'Orazio , Daniel Raederstorff , Goede Schueler , Ying Wang-Schmidt , Karin Wertz , Swen Wolfram
IPC分类号： A61K31/352 , A61K31/12 , A61K31/36 , C07C49/255 , C07D317/46 , C07D311/02 , A61P21/00
CPC分类号： A23K20/111 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K31/12 , A61K31/166 , A61K31/352 , A23V2200/316 , A23V2200/328 , A23V2200/326 , A23V2200/318 , A23V2200/32
摘要： The present invention refers to compounds of the general formulae Ia to Ie as defined above for use as/in a composition (especially foods and dietary supplements, cosmetic, as well as pharmaceutical compositions) for the prevention and improvement of muscular disorders and for the improvement of muscle function. Other fields of use are disorders connected to impaired lipid metabolism, impaired glucose metabolism and impaired insulin action, obesity, overweight conditions, eating disorders such as bulimia and anorexia nervosa, cardiovascular diseases, atherosclerosis, vascular diseases, heart failure, inflammatory disorders such as arthritis, rheumatoid arthritis, osteoarthritis, gout, gastrointestinal disorders such as inflammatory bowel syndrome, Crohn's disease, gastritis, irritable bowel syndrome and ulcerative colitis, skin related conditions such as psoriasis, eczema, burns, dermatitis, and allergy, respiratory disorders such as asthma, chronic obstructive pulmonary disease (COPD), allergic diseases, and/or bone disorders such as osteoporosis and osteopenia. The compounds may also be used for bodyshaping, for improving the muscle:fat ratio or for accelerating skin wound healing. The present invention is also directed to dietary compositions such as (fortified) food, beverages, (fortified) feed, food additives, beverage additives, feed additives, clinical nutrition, dietary supplements, functional food, functional feed and nutraceuticals and to pharmaceutical compositions containing such compounds, to methods of treating the above mentioned disorders/diseases in mammals including humans and to the compounds of the formula I themselves. Another object of the present invention is the use of such compounds for the manufacture of a composition for the treatment of such disorders/diseases as mentioned above.
摘要翻译：本发明涉及如上定义的用于预防和改善肌肉疾病和改善的组合物（特别是食品和膳食补充剂，化妆品以及药物组合物）中的上述通式Ia至Ie的化合物的肌肉功能。其他使用领域是与脂质代谢受损，葡萄糖代谢受损和胰岛素作用受损，肥胖症，超重症状，进食障碍如贪食症和神经性厌食症，心血管疾病，动脉粥样硬化，血管疾病，心力衰竭，炎症性疾病如关节炎相关的疾病类风湿性关节炎，骨关节炎，痛风，胃肠道疾病如炎性肠综合征，克罗恩病，胃炎，肠易激综合征和溃疡性结肠炎，皮肤相关病症如牛皮癣，湿疹，烧伤，皮炎和过敏，呼吸系统疾病如哮喘，慢性阻塞性肺疾病（COPD），过敏性疾病和/或骨骼疾病如骨质疏松症和骨质减少。这些化合物也可用于体脂整形，用于改善肌肉：脂肪比例或用于加速皮肤伤口愈合。本发明还涉及饮食组合物，例如（强化）食品，饮料，（强化）饲料，食品添加剂，饮料添加剂，饲料添加剂，临床营养，膳食补充剂，功能性食品，功能性饲料和营养食品，以及含有这些化合物，涉及治疗哺乳动物（包括人）和式I本身化合物的上述疾病/疾病的方法。本发明的另一个目的是使用这些化合物来制备用于治疗如上所述的这种疾病/疾病的组合物。

5. 发明申请

US20100130621A1 USE OF HYDROXYTYROSOL AS ANTI-AGING AGENT 审中-公开
标题翻译：羟喹诺酮作为抗老化剂的使用
公开(公告)号：US20100130621A1
公开(公告)日：2010-05-27
申请号：US12595984
申请日：2008-04-17
申请人： Daniel Raederstorff , Ying Wang-Schmidt , Karin Wertz
发明人： Daniel Raederstorff , Ying Wang-Schmidt , Karin Wertz
IPC分类号： A61K31/05 , A61P39/06 , A61P27/16 , A61P19/10 , A61P9/00 , C07C39/11
CPC分类号： A23L2/52 , A23L33/105 , A23V2002/00 , A23V2200/302 , A23V2250/2132
摘要： The present invention is directed to the use of (a composition comprising) hydroxytyrosol as anti-aging agent. The composition, to which the present invention is also directed, does essentially not comprise resveratrol and is administered orally to animals. The present invention is further directed to anti-aging methods. “Anti-aging” meaning in the context of the present invention: retarding the aging processes in said animals, improving age-related physiological deficits in said animals and/or promoting a healthy aging in said animals.
摘要翻译：本发明涉及（含有羟基酪醇的组合物）作为抗老化剂的用途。本发明也涉及的组合物基本上不包含白藜芦醇，并且经口给予动物。本发明进一步涉及抗衰老方法。在本发明的上下文中，“抗衰老”意义：延缓所述动物的老化过程，改善所述动物的年龄相关生理缺陷和/或促进所述动物的健康老化。

6. 发明申请

US20090203773A1 Compounds for the Treatment of Non-Autoimmune Type 2 Diabetes Mellitus and/or Syndrome X 审中-公开
标题翻译：用于治疗非自身免疫性2型糖尿病和/或综合征X的化合物
公开(公告)号：US20090203773A1
公开(公告)日：2009-08-13
申请号：US11922604
申请日：2006-06-23
申请人： Daniel D'Orazio , Antoine De Saizieu , Goede Schuler , Ying Wang-Schmidt , Christof Wehrli , Swen Wolfram , Karin Wertz , Daniel Raederstorff
发明人： Daniel D'Orazio , Antoine De Saizieu , Goede Schuler , Ying Wang-Schmidt , Christof Wehrli , Swen Wolfram , Karin Wertz , Daniel Raederstorff
IPC分类号： A61K31/357 , C07D317/44 , C07C69/76 , A61K31/235 , A61P3/10
CPC分类号： C07H15/04 , C07C49/796 , C07C49/835 , C07C49/84 , C07C69/618 , C07C69/78 , C07C233/33 , C07D317/64
摘要： The present invention relates to compounds of the formula (I); wherein R1 is H, CH3 or OCH3; R3=H, OH, CH3, OCH3, O-glucose or benzoyloxy; R4=H; R5=H or OH; R6=H or OCH3; R7=H, CH3, OCH3, cinnamoyloxy or (3,4,5-trimethoxy)-benzoyloxy; R8=H, OH, CH3 or OCH3; or R7 and R8 form together a group 0-CH2—O; R9=H or OCH3; R10=H or N-acetyl, N-methyl-2-aminoethyl; to their use as medicament for the treatment of non-autoimmune type 2 diabetes mellitus and/or syndrome X, to dietary and pharmaceutical compositions containing them and to a method for the treatment of non-autoimmune type 2 diabetes mellitus and/or syndrome X in animals including humans, said method comprising the step of administering an effective dose of a compound of the formula (I) to animals including humans which are in need thereof.
摘要翻译：本发明涉及式（I）的化合物; 其中R1是H，CH3或OCH3; R3 = H，OH，CH3，OCH3，O-葡萄糖或苯甲酰氧基; R4 = H; R5 = H或OH; R6 = H或OCH3; R7 = H，CH3，OCH3，肉桂酰氧基或（3,4,5-三甲氧基） - 苯甲酰氧基; R8 = H，OH，CH3或OCH3; 或者R 7和R 8一起形成O-CH 2 -O基团; R9 = H或OCH3; R 10 = H或N-乙酰基，N-甲基-2-氨基乙基; 用于治疗非自身免疫性2型糖尿病和/或综合征X的药物用于含有它们的膳食和药物组合物以及用于治疗非自身免疫性2型糖尿病和/或症状X的综合征的方法包括人的动物，所述方法包括向有需要的动物（包括人）施用有效剂量的式（I）化合物的步骤。

7. 发明授权

US08772230B2 Niacin and/or trigonelline as a muscle stimulant 有权
标题翻译：烟酸和/或葫芦巴碱作为肌肉兴奋剂
公开(公告)号：US08772230B2
公开(公告)日：2014-07-08
申请号：US13321971
申请日：2010-06-10
申请人： Angelika Friedel , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
发明人： Angelika Friedel , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
IPC分类号： A61K31/455 , A61K38/02 , A61P21/00 , A61K31/46
CPC分类号： A61K31/455 , A23L33/105 , A23L33/15 , A23L33/40 , A23V2002/00 , A61K31/46 , A61K36/00 , A61K36/74 , A61K45/06 , A23V2200/316 , A23V2250/7046 , A23V2250/21
摘要： This invention relates to the use of niacin and/or trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.
摘要翻译：本发明涉及烟酸和/或葫芦宁化合物在活动期间增加肌肉重量或在不活动期间抑制肌肉损失的用途。

8. 发明授权

US08323707B2 Trigonelline as a muscle stimulant 有权
标题翻译：鸢尾碱作为肌肉兴奋剂
公开(公告)号：US08323707B2
公开(公告)日：2012-12-04
申请号：US12959621
申请日：2010-12-03
申请人： Angelika Friedel , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
发明人： Angelika Friedel , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
IPC分类号： A01N65/00
CPC分类号： A61K31/455 , A23L33/105 , A23L33/15 , A23L33/40 , A23V2002/00 , A61K31/46 , A61K36/00 , A61K36/74 , A61K45/06 , A23V2200/316 , A23V2250/7046 , A23V2250/21
摘要： This invention relates to the use of trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.
摘要翻译：本发明涉及痤疮化合物在活动期间增加肌肉重量或在不活动期间抑制肌肉损失的用途。

9. 发明申请

US20120225840A1 HYDROXYTYROSOL COMBINATIONS FOR ENHANCING MITOCHONDRIAL FUNCTION AND ENERGY PRODUCTION 审中-公开
标题翻译：用于增强肌肉功能和能量生产的羟基吡咯烷酮组合
公开(公告)号：US20120225840A1
公开(公告)日：2012-09-06
申请号：US13264819
申请日：2009-10-15
申请人： Ann Fowler , Angelika Friedel , Darko Knutti , Karin Kuratli , Daniel Raederstorff , Ying Wang-Schmidt , Karin Wertz
发明人： Ann Fowler , Angelika Friedel , Darko Knutti , Karin Kuratli , Daniel Raederstorff , Ying Wang-Schmidt , Karin Wertz
IPC分类号： A61K31/714 , A61P3/02 , A61K31/522 , A61P21/00 , A61K31/045 , A61K31/352
CPC分类号： A61K31/05 , A23K20/111 , A23K20/121 , A23K20/147 , A23K20/174 , A23L2/52 , A23L33/10 , A23L33/105 , A23L33/11 , A23L33/15 , A23L33/175 , A23L33/40 , A23V2002/00 , A61K31/122 , A61K31/145 , A61K31/19 , A61K31/195 , A61K31/197 , A61K31/205 , A61K31/34 , A61K31/352 , A61K31/4188 , A61K31/4406 , A61K31/4415 , A61K31/455 , A61K31/51 , A61K31/522 , A61K31/525 , A61K31/714 , A61K36/63 , A61K45/06 , A61K2300/00 , A23V2200/33 , A23V2250/2108 , A23V2250/7042 , A23V2250/7044 , A23V2250/7046 , A23V2250/705 , A23V2250/706 , A23V2250/72
摘要： Hydroxytyrosol or olive juice containing hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1, B2, B3, B5, B6, and/or B12) and ginseng (preferably: root) extract can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.
摘要翻译：含有羟基酪醇的羟基酪醇或橄榄油与选自肌酸，辅酶Q10，白藜芦醇，咖啡因，肉碱，B族维生素（B1，B2，B3，B5，B6和/或B12）中的至少一种化合物组合）和人参（优选：根）提取物可用于维持或增加心肌，骨骼肌和肝组织中的线粒体生物发生。

10. 发明申请

US20110142974A1 TRIGONELLINE AS A MUSCLE STIMULANT 有权
标题翻译： TRIGONELLINE作为一种肌肉STIMULANT
公开(公告)号：US20110142974A1
公开(公告)日：2011-06-16
申请号：US12959621
申请日：2010-12-03
申请人： Angelika Friedel , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
发明人： Angelika Friedel , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
IPC分类号： A61K36/74 , A61K31/4406 , A61P43/00
CPC分类号： A61K31/455 , A23L33/105 , A23L33/15 , A23L33/40 , A23V2002/00 , A61K31/46 , A61K36/00 , A61K36/74 , A61K45/06 , A23V2200/316 , A23V2250/7046 , A23V2250/21
摘要： This invention relates to the use of trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.
摘要翻译：本发明涉及痤疮化合物在活动期间增加肌肉重量或在不活动期间抑制肌肉损失的用途。

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