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1. 发明授权

US09446006B2 Hydroxytyrosol combinations for enhancing mitochondrial function and energy production 有权
标题翻译：羟基酪醇组合用于增强线粒体功能和能量产生
公开(公告)号：US09446006B2
公开(公告)日：2016-09-20
申请号：US14450073
申请日：2014-08-01
申请人： Ann Fowler , Angelika Friedel , Darko Knutti , Karin Kuratli , Daniel Raederstorff , Ying Wang-Schmidt , Karin Wertz
发明人： Ann Fowler , Angelika Friedel , Darko Knutti , Karin Kuratli , Daniel Raederstorff , Ying Wang-Schmidt , Karin Wertz
IPC分类号： A61K31/05 , A61K31/122 , A61K31/522 , A61K31/195 , A61K31/51 , A61K31/19 , A61K31/145 , A61K31/34 , A61K31/352 , A61K31/4188 , A61K31/525 , A61K31/4406 , A23L1/29 , A23L1/30 , A23L1/302 , A23L1/305 , A23L2/52 , A61K31/197 , A61K31/205 , A61K31/4415 , A61K31/455 , A61K31/714 , A61K36/63 , A61K45/06
CPC分类号： A61K31/05 , A23K20/111 , A23K20/121 , A23K20/147 , A23K20/174 , A23L2/52 , A23L33/10 , A23L33/105 , A23L33/11 , A23L33/15 , A23L33/175 , A23L33/40 , A23V2002/00 , A61K31/122 , A61K31/145 , A61K31/19 , A61K31/195 , A61K31/197 , A61K31/205 , A61K31/34 , A61K31/352 , A61K31/4188 , A61K31/4406 , A61K31/4415 , A61K31/455 , A61K31/51 , A61K31/522 , A61K31/525 , A61K31/714 , A61K36/63 , A61K45/06 , A61K2300/00 , A23V2200/33 , A23V2250/2108 , A23V2250/7042 , A23V2250/7044 , A23V2250/7046 , A23V2250/705 , A23V2250/706 , A23V2250/72
摘要： Hydroxytyrosol or olive juice containing hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1, B2, B3, B5, B6, and/or B12) and ginseng (preferably: root) extract.can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.
摘要翻译：含有羟基酪醇的羟基酪醇或橄榄油与选自肌酸，辅酶Q10，白藜芦醇，咖啡因，肉碱，B族维生素（B1，B2，B3，B5，B6和/或B12）中的至少一种化合物组合）和人参（优选：根）提取物可用于维持或增加心肌，骨骼肌和肝组织中的线粒体生物发生。

2. 发明申请

US20120225840A1 HYDROXYTYROSOL COMBINATIONS FOR ENHANCING MITOCHONDRIAL FUNCTION AND ENERGY PRODUCTION 审中-公开
标题翻译：用于增强肌肉功能和能量生产的羟基吡咯烷酮组合
公开(公告)号：US20120225840A1
公开(公告)日：2012-09-06
申请号：US13264819
申请日：2009-10-15
申请人： Ann Fowler , Angelika Friedel , Darko Knutti , Karin Kuratli , Daniel Raederstorff , Ying Wang-Schmidt , Karin Wertz
发明人： Ann Fowler , Angelika Friedel , Darko Knutti , Karin Kuratli , Daniel Raederstorff , Ying Wang-Schmidt , Karin Wertz
IPC分类号： A61K31/714 , A61P3/02 , A61K31/522 , A61P21/00 , A61K31/045 , A61K31/352
CPC分类号： A61K31/05 , A23K20/111 , A23K20/121 , A23K20/147 , A23K20/174 , A23L2/52 , A23L33/10 , A23L33/105 , A23L33/11 , A23L33/15 , A23L33/175 , A23L33/40 , A23V2002/00 , A61K31/122 , A61K31/145 , A61K31/19 , A61K31/195 , A61K31/197 , A61K31/205 , A61K31/34 , A61K31/352 , A61K31/4188 , A61K31/4406 , A61K31/4415 , A61K31/455 , A61K31/51 , A61K31/522 , A61K31/525 , A61K31/714 , A61K36/63 , A61K45/06 , A61K2300/00 , A23V2200/33 , A23V2250/2108 , A23V2250/7042 , A23V2250/7044 , A23V2250/7046 , A23V2250/705 , A23V2250/706 , A23V2250/72
摘要： Hydroxytyrosol or olive juice containing hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1, B2, B3, B5, B6, and/or B12) and ginseng (preferably: root) extract can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.
摘要翻译：含有羟基酪醇的羟基酪醇或橄榄油与选自肌酸，辅酶Q10，白藜芦醇，咖啡因，肉碱，B族维生素（B1，B2，B3，B5，B6和/或B12）中的至少一种化合物组合）和人参（优选：根）提取物可用于维持或增加心肌，骨骼肌和肝组织中的线粒体生物发生。

3. 发明申请

US20130018076A1 TRIGONELLINE AS A MUSCLE STIMULANT 审中-公开
公开(公告)号：US20130018076A1
公开(公告)日：2013-01-17
申请号：US13606369
申请日：2012-09-07
申请人： Angelika FRIEDEL , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
发明人： Angelika FRIEDEL , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
IPC分类号： A61K31/455 , A61P21/00
CPC分类号： A61K31/455 , A23L33/105 , A23L33/15 , A23L33/40 , A23V2002/00 , A61K31/46 , A61K36/00 , A61K36/74 , A61K45/06 , A23V2200/316 , A23V2250/7046 , A23V2250/21
摘要： This invention relates to the use of trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.

4. 发明申请

US20120190617A1 NIACIN AND/OR TRIGONELLINE AS A MUSCLE STIMULANT 有权
标题翻译：硝酸和/或三铁作为肌肉刺激
公开(公告)号：US20120190617A1
公开(公告)日：2012-07-26
申请号：US13321971
申请日：2010-06-10
申请人： Angelika Friedel , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
发明人： Angelika Friedel , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
IPC分类号： A61K31/455 , A61K38/02 , A61P21/00 , C07D213/80
CPC分类号： A61K31/455 , A23L33/105 , A23L33/15 , A23L33/40 , A23V2002/00 , A61K31/46 , A61K36/00 , A61K36/74 , A61K45/06 , A23V2200/316 , A23V2250/7046 , A23V2250/21
摘要： This invention relates to the use of niacin and/or trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.
摘要翻译：本发明涉及烟酸和/或葫芦宁化合物在活动期间增加肌肉重量或在不活动期间抑制肌肉损失的用途。

5. 发明授权

US08772230B2 Niacin and/or trigonelline as a muscle stimulant 有权
标题翻译：烟酸和/或葫芦巴碱作为肌肉兴奋剂
公开(公告)号：US08772230B2
公开(公告)日：2014-07-08
申请号：US13321971
申请日：2010-06-10
申请人： Angelika Friedel , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
发明人： Angelika Friedel , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
IPC分类号： A61K31/455 , A61K38/02 , A61P21/00 , A61K31/46
CPC分类号： A61K31/455 , A23L33/105 , A23L33/15 , A23L33/40 , A23V2002/00 , A61K31/46 , A61K36/00 , A61K36/74 , A61K45/06 , A23V2200/316 , A23V2250/7046 , A23V2250/21
摘要： This invention relates to the use of niacin and/or trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.
摘要翻译：本发明涉及烟酸和/或葫芦宁化合物在活动期间增加肌肉重量或在不活动期间抑制肌肉损失的用途。

6. 发明授权

US08323707B2 Trigonelline as a muscle stimulant 有权
标题翻译：鸢尾碱作为肌肉兴奋剂
公开(公告)号：US08323707B2
公开(公告)日：2012-12-04
申请号：US12959621
申请日：2010-12-03
申请人： Angelika Friedel , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
发明人： Angelika Friedel , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
IPC分类号： A01N65/00
CPC分类号： A61K31/455 , A23L33/105 , A23L33/15 , A23L33/40 , A23V2002/00 , A61K31/46 , A61K36/00 , A61K36/74 , A61K45/06 , A23V2200/316 , A23V2250/7046 , A23V2250/21
摘要： This invention relates to the use of trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.
摘要翻译：本发明涉及痤疮化合物在活动期间增加肌肉重量或在不活动期间抑制肌肉损失的用途。

7. 发明申请

US20110142974A1 TRIGONELLINE AS A MUSCLE STIMULANT 有权
标题翻译： TRIGONELLINE作为一种肌肉STIMULANT
公开(公告)号：US20110142974A1
公开(公告)日：2011-06-16
申请号：US12959621
申请日：2010-12-03
申请人： Angelika Friedel , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
发明人： Angelika Friedel , Karin Kuratli , Christof Wehrli , Karin Wertz , Swen Wolfram , Ying Wang-Schmidt
IPC分类号： A61K36/74 , A61K31/4406 , A61P43/00
CPC分类号： A61K31/455 , A23L33/105 , A23L33/15 , A23L33/40 , A23V2002/00 , A61K31/46 , A61K36/00 , A61K36/74 , A61K45/06 , A23V2200/316 , A23V2250/7046 , A23V2250/21
摘要： This invention relates to the use of trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.
摘要翻译：本发明涉及痤疮化合物在活动期间增加肌肉重量或在不活动期间抑制肌肉损失的用途。

8. 发明申请

US20130059920A1 HYDROXYTYROSOL BENEFITS MUSCLE DIFFERENTIATION AND MUSCLE CONTRACTION AND RELAXATION 审中-公开
标题翻译：羟肟酸的好处肌肉分化和肌肉收缩和放松
公开(公告)号：US20130059920A1
公开(公告)日：2013-03-07
申请号：US13550972
申请日：2012-07-17
申请人： Angelika FRIEDEL , Daniel Raederstorff , Franz Roos , Christine Toepfer , Karin Wertz
发明人： Angelika FRIEDEL , Daniel Raederstorff , Franz Roos , Christine Toepfer , Karin Wertz
IPC分类号： A61K31/05 , A61P21/00 , C07C39/10
CPC分类号： A61K31/05
摘要： This invention is related to the use of hydroxytyrosol (“HT”), or an olive juice extract containing hydroxytyrosol as an agent to improve muscle differentiation and thus improve or maintain the body's adaptation to exercise. It is also related to the use of hydroxytyrosol (“HT”), or an olive juice extract containing hydroxytyrosol as an agent to improve calcium signaling and to improve skeletal muscle contraction and relaxation. It also relates to pharmaceutical and nutraceutical compositions useful for conditions characterized by altered muscle differentiation especially under inflammatory conditions, such as delayed onset muscle soreness subsequent to strenuous exercise or sarcopenia.
摘要翻译：本发明涉及使用羟基酪醇（HT）或含有羟基酪醇的橄榄汁提取物作为改善肌肉分化的因素，从而改善或维持身体对运动的适应性。它还涉及使用羟基酪醇（HT）或含有羟基酪醇的橄榄汁提取物作为改善钙信号传导和改善骨骼肌收缩和松弛的药剂。它还涉及用于特征在于改变肌肉分化的疾病的药物和营养组合物，特别是在炎症状态下，例如剧烈运动或肌肉减少症后延迟发作的肌肉酸痛。

9. 发明申请

US20100041746A1 NOVEL USE OF ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的新用途
公开(公告)号：US20100041746A1
公开(公告)日：2010-02-18
申请号：US12301505
申请日：2007-05-24
申请人： Daniel D'Orazio , Daniel Raederstorff , Goede Schueler , Ying Wang-Schmidt , Karin Wertz , Swen Wolfram
发明人： Daniel D'Orazio , Daniel Raederstorff , Goede Schueler , Ying Wang-Schmidt , Karin Wertz , Swen Wolfram
IPC分类号： A61K31/352 , A61K31/12 , A61K31/36 , C07C49/255 , C07D317/46 , C07D311/02 , A61P21/00
CPC分类号： A23K20/111 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K31/12 , A61K31/166 , A61K31/352 , A23V2200/316 , A23V2200/328 , A23V2200/326 , A23V2200/318 , A23V2200/32
摘要： The present invention refers to compounds of the general formulae Ia to Ie as defined above for use as/in a composition (especially foods and dietary supplements, cosmetic, as well as pharmaceutical compositions) for the prevention and improvement of muscular disorders and for the improvement of muscle function. Other fields of use are disorders connected to impaired lipid metabolism, impaired glucose metabolism and impaired insulin action, obesity, overweight conditions, eating disorders such as bulimia and anorexia nervosa, cardiovascular diseases, atherosclerosis, vascular diseases, heart failure, inflammatory disorders such as arthritis, rheumatoid arthritis, osteoarthritis, gout, gastrointestinal disorders such as inflammatory bowel syndrome, Crohn's disease, gastritis, irritable bowel syndrome and ulcerative colitis, skin related conditions such as psoriasis, eczema, burns, dermatitis, and allergy, respiratory disorders such as asthma, chronic obstructive pulmonary disease (COPD), allergic diseases, and/or bone disorders such as osteoporosis and osteopenia. The compounds may also be used for bodyshaping, for improving the muscle:fat ratio or for accelerating skin wound healing. The present invention is also directed to dietary compositions such as (fortified) food, beverages, (fortified) feed, food additives, beverage additives, feed additives, clinical nutrition, dietary supplements, functional food, functional feed and nutraceuticals and to pharmaceutical compositions containing such compounds, to methods of treating the above mentioned disorders/diseases in mammals including humans and to the compounds of the formula I themselves. Another object of the present invention is the use of such compounds for the manufacture of a composition for the treatment of such disorders/diseases as mentioned above.
摘要翻译：本发明涉及如上定义的用于预防和改善肌肉疾病和改善的组合物（特别是食品和膳食补充剂，化妆品以及药物组合物）中的上述通式Ia至Ie的化合物的肌肉功能。其他使用领域是与脂质代谢受损，葡萄糖代谢受损和胰岛素作用受损，肥胖症，超重症状，进食障碍如贪食症和神经性厌食症，心血管疾病，动脉粥样硬化，血管疾病，心力衰竭，炎症性疾病如关节炎相关的疾病类风湿性关节炎，骨关节炎，痛风，胃肠道疾病如炎性肠综合征，克罗恩病，胃炎，肠易激综合征和溃疡性结肠炎，皮肤相关病症如牛皮癣，湿疹，烧伤，皮炎和过敏，呼吸系统疾病如哮喘，慢性阻塞性肺疾病（COPD），过敏性疾病和/或骨骼疾病如骨质疏松症和骨质减少。这些化合物也可用于体脂整形，用于改善肌肉：脂肪比例或用于加速皮肤伤口愈合。本发明还涉及饮食组合物，例如（强化）食品，饮料，（强化）饲料，食品添加剂，饮料添加剂，饲料添加剂，临床营养，膳食补充剂，功能性食品，功能性饲料和营养食品，以及含有这些化合物，涉及治疗哺乳动物（包括人）和式I本身化合物的上述疾病/疾病的方法。本发明的另一个目的是使用这些化合物来制备用于治疗如上所述的这种疾病/疾病的组合物。

10. 发明申请

US20100113612A1 NOVEL USE OF HYDROXYTYROSOL AND OLIVE EXTRACTS/CONCENTRATE CONTAINING IT 审中-公开
标题翻译：使用羟肟酸和橄榄提取物/浓缩液
公开(公告)号：US20100113612A1
公开(公告)日：2010-05-06
申请号：US12596481
申请日：2008-04-17
申请人： Daniel Raederstorff , Ying Wang-Schmidt , Karin Wertz
发明人： Daniel Raederstorff , Ying Wang-Schmidt , Karin Wertz
IPC分类号： A61K31/05 , A61P39/06
CPC分类号： A61K36/63 , A23L2/52 , A23L33/105 , A23V2002/00 , A23V2250/2131 , A61K31/05 , A61K31/7048 , A23V2200/302 , A23V2250/2132 , A23V2250/708 , A23V2250/032 , A23V2250/5072 , A23V2250/211
摘要： The present invention is directed to the use of (a composition comprising) hydroxytyrosol as life prolonging agent. The composition, to which the present invention is also directed, does essentially not comprise resveratrol and is preferably administered orally to animals. The present invention is further directed to a life prolonging method. “Life prolonging” meaning in the context of the present invention: reducing the risk to die at a certain age compared to untreated; increasing the chance to live longer (longevity), i.e. increasing the average life expectancy compared to untreated; and/or extending the lifetime independent of medical care.
摘要翻译：本发明涉及（含有羟基酪醇的组合物）作为延长剂的用途。本发明也涉及的组合物基本上不包含白藜芦醇，并且优选口服给予动物。本发明还涉及寿命延长方法。本发明背景下的“延续寿命”意义：降低与未经治疗相比在一定年龄死亡的风险; 增加延长寿命（延长寿命）的机会，即增加与未治疗相比的平均预期寿命; 和/或延长终身独立于医疗保健的寿命。

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