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1. 发明授权

US08932629B2 Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations 有权
标题翻译：共加工微晶纤维素和糖醇作为片剂制剂的赋形剂
公开(公告)号：US08932629B2
公开(公告)日：2015-01-13
申请号：US11925235
申请日：2007-10-26
申请人： Jian-Xin Li , Brian Carlin , Thomas Ruszkay
发明人： Jian-Xin Li , Brian Carlin , Thomas Ruszkay
IPC分类号： A61K9/20 , B27N3/00 , A61K9/16
CPC分类号： A61K9/1623 , A61K9/1652 , A61K9/1682 , A61K9/2018 , A61K9/2054
摘要： A particulate co-processed composition comprising microcrystalline cellulose and at least one sugar alcohol is disclosed. A preferred sugar alcohol is mannitol. The composition has an improved compactability profile, lubricant sensitivity, and ejection profile compared to microcrystalline cellulose and the at least one sugar alcohol, either alone or in combination as a simple dry blend, in the preparation of solid dosage formulations, such as tablets. Tablets comprising the particulate co-processed composition, an active, and, optionally, one or more other excipients, and method for their preparation, are also disclosed.
摘要翻译：公开了一种包含微晶纤维素和至少一种糖醇的颗粒状共处理组合物。优选的糖醇是甘露糖醇。在制备固体剂量制剂如片剂时，与微晶纤维素和至少一种糖醇单独或组合地作为简单的干混合物相比，该组合物具有改进的紧实性，润滑剂敏感性和喷射曲线。还公开了包含颗粒状共处理组合物，活性物质和任选的一种或多种其它赋形剂的片剂及其制备方法。

2. 发明申请

US20080131505A1 CO-PROCESSED MICROCRYSTALLINE CELLULOSE AND SUGAR ALCOHOL AS AN EXCIPIENT FOR TABLET FORMULATIONS 有权
标题翻译： CO处理的微晶纤维素和糖醇作为片剂配方的特殊物质
公开(公告)号：US20080131505A1
公开(公告)日：2008-06-05
申请号：US11925235
申请日：2007-10-26
申请人： Jian-Xin Li , Brian Carlin , Thomas Ruszkay
发明人： Jian-Xin Li , Brian Carlin , Thomas Ruszkay
IPC分类号： A61K9/20 , B27N3/00
CPC分类号： A61K9/1623 , A61K9/1652 , A61K9/1682 , A61K9/2018 , A61K9/2054
摘要： A particulate co-processed composition comprising microcrystalline cellulose and at least one sugar alcohol is disclosed. A preferred sugar alcohol is mannitol. The composition has an improved compactability profile, lubricant sensitivity, and ejection profile compared to microcrystalline cellulose and the at least one sugar alcohol, either alone or in combination as a simple dry blend, in the preparation of solid dosage formulations, such as tablets. Tablets comprising the particulate co-processed composition, an active, and, optionally, one or more other excipients, and method for their preparation, are also disclosed.
摘要翻译：公开了一种包含微晶纤维素和至少一种糖醇的颗粒状共处理组合物。优选的糖醇是甘露糖醇。在制备固体剂量制剂如片剂时，与微晶纤维素和至少一种糖醇单独或组合地作为简单的干混合物相比，该组合物具有改进的紧实性，润滑剂敏感性和喷射曲线。还公开了包含颗粒状共处理组合物，活性物质和任选的一种或多种其它赋形剂的片剂及其制备方法。

3. 发明申请

US20060127451A1 Coating composition 审中-公开
标题翻译：涂料组成
公开(公告)号：US20060127451A1
公开(公告)日：2006-06-15
申请号：US11232690
申请日：2005-09-22
申请人： Michael Augello , Sharon Ray , Jian-Xin Li , Brian Carlin
发明人： Michael Augello , Sharon Ray , Jian-Xin Li , Brian Carlin
IPC分类号： A61K9/68 , A61K9/20 , A61K31/717
CPC分类号： A61K9/2886 , A61K9/2826 , A61K9/2853 , A61K9/286 , A61K9/2866 , A61K9/7007 , A61K31/717
摘要： The present invention is directed to compositions containing: (i) sugar and/or a sugar substitute and (ii) microcrystalline cellulose present in an amount equal to greater than 41% of the total weight of the composition. The present invention is also directed to compositions containing: (i) sugar and/or a sugar substitute and (ii) microcrystalline cellulose having an average particle size equal to or less than 20 microns and present in an amount equal to or greater than 20% of the total weight of the composition. The compositions of the present invention are useful in coating a wide variety of solid forms such as pharmaceutical dosage forms, veterinary dosage forms, nutraceutical dosage forms, food, industrial material, cosmetic material or oral care material. The compositions of the invention are also useful as films such as cast films. The present invention is also directed to methods of making such compositions, as well as methods of coating such compositions on solid forms.
摘要翻译：本发明涉及含有：（i）糖和/或糖替代物的组合物和（ii）等于大于组合物总重量的41％量的微晶纤维素。本发明还涉及含有：（i）糖和/或糖替代物的组合物和（ii）平均粒度等于或小于20微米并且以等于或大于20％的量存在的微晶纤维素，的组合物的总重量。本发明的组合物可用于涂覆各种固体形式，例如药物剂型，兽用剂型，营养制剂剂型，食品，工业材料，化妆品材料或口腔护理材料。本发明的组合物也可用作薄膜如流延膜。本发明还涉及制备这种组合物的方法，以及在固体形式上涂覆这些组合物的方法。

4. 发明授权

US08088414B2 Latex or pseudolatex compositions, coatings and coating processes 有权
标题翻译：乳胶或假胶体组合物，涂层和涂层工艺
公开(公告)号：US08088414B2
公开(公告)日：2012-01-03
申请号：US11669630
申请日：2007-01-31
申请人： Juergen Siepmann , Florence Siepmann , Brian A. C. Carlin , Jian-Xin Li
发明人： Juergen Siepmann , Florence Siepmann , Brian A. C. Carlin , Jian-Xin Li
IPC分类号： A61K9/50
CPC分类号： C09D101/02 , A61K9/5026 , A61K9/5031 , A61K9/5036 , A61K9/5042 , A61K9/5047 , A61K9/5078 , A61K9/7007
摘要： A composition comprising: (i) at least one latex or pseudolatex water insoluble film former, (ii) at least one permeation enhancing agent and, optionally, (iii) one or more plasticizers. The present invention is also directed to substrates coated with the composition of the invention, films made from the composition and methods for making and using such compositions, coated substrates and films.
摘要翻译：一种组合物，其包含：（i）至少一种乳胶或pseudolatex水不溶性成膜剂，（ii）至少一种渗透促进剂和任选地（iii）一种或多种增塑剂。本发明还涉及用本发明组合物涂覆的基材，由组合物制成的膜，以及制备和使用这种组合物，涂布的基材和膜的方法。

5. 发明申请

US20110226987A1 ANODE FOR ELECTROCHEMICAL SYSTEM 审中-公开
标题翻译：电化学系统阳极
公开(公告)号：US20110226987A1
公开(公告)日：2011-09-22
申请号：US13151371
申请日：2011-06-02
申请人： Marina Yakovleva , Yuan Gao , Kenneth Brian Fitch , B. Troy Dover , Prakash Thyaga Palepu , Jian-Xin Li , Brian Anthony Christopher Carlin , Yangxing Li
发明人： Marina Yakovleva , Yuan Gao , Kenneth Brian Fitch , B. Troy Dover , Prakash Thyaga Palepu , Jian-Xin Li , Brian Anthony Christopher Carlin , Yangxing Li
IPC分类号： H01M4/40
CPC分类号： H01M4/366 , B22F1/0062 , B22F1/0077 , B22F1/02 , B22F2998/10 , B22F2999/00 , H01M4/131 , H01M4/1315 , H01M4/133 , H01M4/134 , H01M4/386 , H01M4/387 , H01M4/40 , H01M4/485 , H01M4/587 , H01M4/628 , H01M10/052 , H01M2004/027
摘要： The present invention provides an anode including a host material capable of absorbing or desorbing lithium in an electrochemical system. A stabilized lithium metal powder coated with a wax is dispersed in the host material.
摘要翻译：本发明提供一种阳极，其包括能够在电化学系统中吸收或解吸锂的主体材料。涂覆有蜡的稳定化的锂金属粉末分散在主体材料中。

6. 发明授权

US07829148B2 Coating process to produce controlled release coatings 失效
标题翻译：涂层工艺生产控释层
公开(公告)号：US07829148B2
公开(公告)日：2010-11-09
申请号：US11669748
申请日：2007-01-31
申请人： Jian-Xin Li , Brian A. C. Carlin
发明人： Jian-Xin Li , Brian A. C. Carlin
IPC分类号： B05D3/02
CPC分类号： B05D3/0486 , A61K9/2813 , A61K9/282 , A61K9/284 , A61K9/2846 , A61K9/2866 , A61K9/2893 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5089 , B01J2/006 , B01J2/30 , B05D3/0254 , B05D2401/20
摘要： An aqueous polymer coating composition containing at least one latex or pseudolatex is coated on a substrate in a high humidity coating process followed by heat treatment of the coated substrate above the film forming temperature of the coating at low humidity. The coated substrate gives a stable reproducible dissolution profile substantially insensitive to temperature or humidity conditions upon storage. The high humidity coating process is achieved by addition of water to the coating chamber through dilution of the coating formulation or humidification of inlet air. Contrary to the conventional low humidity coating process, residual water is retained in the coating layer of the coated substrates in the coating step. When the coated substrates are heat treated at a temperature greater than the minimum film forming temperature, the residual water in the coating layer will ensure adequate capillary force for the completion of film coalescence. High humidity heat treatment is not needed.
摘要翻译：含有至少一种乳胶或假胶体的含水聚合物涂料组合物在高湿度涂覆过程中涂覆在基材上，随后将涂覆的基材在低湿度下在涂层的成膜温度之上进行热处理。涂覆的基材在储存时提供基本上对温度或湿度条件不敏感的稳定的可再现溶出曲线。高湿度涂覆方法是通过稀释涂料配方或加入入口空气将水添加到涂层室来实现的。与传统的低湿度涂覆方法相反，在涂布步骤中残留的水保留在涂覆的基材的涂层中。当涂覆的基材在大于最低成膜温度的温度下进行热处理时，涂层中的残留水将确保用于完成膜聚结的足够的毛细作用力。不需要高湿度热处理。

7. 发明申请

US20100030159A1 SYRINGE PLUNGER 审中-公开
公开(公告)号：US20100030159A1
公开(公告)日：2010-02-04
申请号：US12524978
申请日：2007-11-19
申请人： Jian-Xin Li
发明人： Jian-Xin Li
IPC分类号： A61M5/315 , B29C45/14
CPC分类号： B29C45/14 , A61M5/31511
摘要： A syringe plunger has a hole is arranged in its plunger central axis, with a diaphragm arranged in the hole. The thickness of the diaphragm in the hole is from 0.01 mm to 0.5 mm. A manufacturing method of a syringe plunger includes the steps of: adding pigment into medical rubber and stirring uniformly; each of a fixed die and a movable die of a medical rubber syringe die being embedded with an impacting and penetrating needle, when molding and die closing, space between the impacting and penetrating needles of the fixed die and the movable die being 0.01 mm to 0.5 mm; demolding said molded medical rubber plunger.
摘要翻译：注射器柱塞在其柱塞中心轴线上设置有孔，隔膜布置在孔中。孔中的隔膜的厚度为0.01mm〜0.5mm。注射器柱塞的制造方法包括以下步骤：将颜料加入到医用橡胶中并均匀搅拌; 每个固定模具和医用橡胶注射器模具的可移动模具都嵌有冲击穿刺针，当模制和模具闭合时，固定模具和可动模具的冲击和穿透针之间的空间为0.01mm至0.5 毫米所述模制医用橡胶柱塞脱模。

8. 发明申请

US20070184102A1 LATEX OR PSEUDOLATEX COMPOSITIONS, COATINGS AND COATING PROCESSES 有权
标题翻译： LATEX或PSEUDOLATEX组合物，涂料和涂料工艺
公开(公告)号：US20070184102A1
公开(公告)日：2007-08-09
申请号：US11669630
申请日：2007-01-31
申请人： Juergen Siepmann , Florence Siepmann , Brian A.C. Carlin , Jian-Xin Li
发明人： Juergen Siepmann , Florence Siepmann , Brian A.C. Carlin , Jian-Xin Li
IPC分类号： A61K9/48 , A61K9/20 , A61K9/24
CPC分类号： C09D101/02 , A61K9/5026 , A61K9/5031 , A61K9/5036 , A61K9/5042 , A61K9/5047 , A61K9/5078 , A61K9/7007
摘要： A composition comprising: (i) at least one latex or pseudolatex water insoluble film former, (ii) at least one permeation enhancing agent and, optionally, (iii) one or more plasticizers. The present invention is also directed to substrates coated with the composition of the invention, films made from the composition and methods for making and using such compositions, coated substrates and films.
摘要翻译：一种组合物，其包含：（i）至少一种乳胶或pseudolatex水不溶性成膜剂，（ii）至少一种渗透促进剂和任选地（iii）一种或多种增塑剂。本发明还涉及用本发明组合物涂覆的基材，由组合物制成的膜，以及制备和使用这种组合物，涂布的基材和膜的方法。

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