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    • 2. 发明授权
    • Coating process to produce controlled release coatings
    • 涂层工艺生产控释层
    • US07829148B2
    • 2010-11-09
    • US11669748
    • 2007-01-31
    • Jian-Xin LiBrian A. C. Carlin
    • Jian-Xin LiBrian A. C. Carlin
    • B05D3/02
    • B05D3/0486A61K9/2813A61K9/282A61K9/284A61K9/2846A61K9/2866A61K9/2893A61K9/5026A61K9/5042A61K9/5047A61K9/5089B01J2/006B01J2/30B05D3/0254B05D2401/20
    • An aqueous polymer coating composition containing at least one latex or pseudolatex is coated on a substrate in a high humidity coating process followed by heat treatment of the coated substrate above the film forming temperature of the coating at low humidity. The coated substrate gives a stable reproducible dissolution profile substantially insensitive to temperature or humidity conditions upon storage. The high humidity coating process is achieved by addition of water to the coating chamber through dilution of the coating formulation or humidification of inlet air. Contrary to the conventional low humidity coating process, residual water is retained in the coating layer of the coated substrates in the coating step. When the coated substrates are heat treated at a temperature greater than the minimum film forming temperature, the residual water in the coating layer will ensure adequate capillary force for the completion of film coalescence. High humidity heat treatment is not needed.
    • 含有至少一种乳胶或假胶体的含水聚合物涂料组合物在高湿度涂覆过程中涂覆在基材上,随后将涂覆的基材在低湿度下在涂层的成膜温度之上进行热处理。 涂覆的基材在储存时提供基本上对温度或湿度条件不敏感的稳定的可再现溶出曲线。 高湿度涂覆方法是通过稀释涂料配方或加入入口空气将水添加到涂层室来实现的。 与传统的低湿度涂覆方法相反,在涂布步骤中残留的水保留在涂覆的基材的涂层中。 当涂覆的基材在大于最低成膜温度的温度下进行热处理时,涂层中的残留水将确保用于完成膜聚结的足够的毛细作用力。 不需要高湿度热处理。