专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07822249B2 Systems and methods for high-throughput radiation biodosimetry 有权
标题翻译：用于高通量辐射生物测定法的系统和方法
公开(公告)号：US07822249B2
公开(公告)日：2010-10-26
申请号：US11895417
申请日：2007-08-24
申请人： Guy Garty , David J. Brenner , Gerhard Randers-Pehrson , Y. Lawrence Yao , Nabil Simaan , Alessio Salerno , Anubha Bhatla , Jian Zhang , Oleksandra V. Lyulko , Aparajita Dutta
发明人： Guy Garty , David J. Brenner , Gerhard Randers-Pehrson , Y. Lawrence Yao , Nabil Simaan , Alessio Salerno , Anubha Bhatla , Jian Zhang , Oleksandra V. Lyulko , Aparajita Dutta
IPC分类号： G06K9/00
CPC分类号： C40B30/10 , C40B60/12
摘要： Systems and methods for high-throughput radiation biodosimetry are disclosed herein. In some embodiments, a high-throughput methods of analyzing a population for radiation exposure can include, in various possible sequences: marking a first capillary designed to retain a first sample from the population with a first identifier; transporting a plurality of samples to a biodosimetry system; inputting the samples into the biodosimetry system; centrifuging the plurality of samples including the first sample wherein each sample can be retained in a capillary and the first sample can be retained in the first capillary; transferring the plurality of capillaries including the first capillary from the centrifuge to a cutting device using a robotic device; cutting the first capillary; reading the first identifier; transferring at least one portion of the first sample from the first capillary to a well in an array, wherein the array can include one or more filters in a multi-well plate; correlating the first identifier to a location of the array that includes the at least one portion of the first sample; one or more cycles of biological processing, which can include addition of a reagent and/or incubation of a selected temperature such as, for example, 37° C., 4° C., room temperature, and the like; sealing the array; positioning the array adjacent to an imaging element; focusing the imaging element; capturing an image of the first sample in the array; and analyzing the image to determine whether the first sample indicates a level of radiation exposure exceeding a predetermined threshold.
摘要翻译：本文公开了用于高通量辐射生物测定法的系统和方法。在一些实施例中，用于分析用于辐射暴露的群体的高通量方法可以以各种可能的顺序包括：标记设计成用第一标识符从群体保留第一样本的第一毛细管; 将多个样品运送到生物测定系统; 将样品输入生物测定系统; 将包括第一样品的多个样品离心，其中每个样品可以保留在毛细管中，并且第一样品可以保留在第一毛细管中; 使用机器人装置将包括第一毛细管的多个毛细管从离心机转移到切割装置; 切割第一根毛细管; 阅读第一个标识符; 将所述第一样品的至少一部分从所述第一毛细管转移到阵列中的阱，其中所述阵列可以包括多孔板中的一个或多个过滤器; 将所述第一标识符与包括所述第一样本的所述至少一部分的所述阵列的位置相关联; 一个或多个生物处理循环，其可以包括添加试剂和/或选择温度的温育，例如37℃，4℃，室温等; 密封阵列; 将阵列定位成与成像元件相邻; 聚焦成像元件; 捕获阵列中第一个样本的图像; 并分析图像以确定第一样本是否指示超过预定阈值的辐射暴露水平。

2. 发明申请

US20080181473A1 Systems and methods for high-throughput radiation biodosimetry 有权
标题翻译：用于高通量辐射生物测定法的系统和方法
公开(公告)号：US20080181473A1
公开(公告)日：2008-07-31
申请号：US11895417
申请日：2007-08-24
申请人： Guy Garty , David J. Brenner , Gerhard Randers-Pehrson , Y. Lawrence Yao , Nabil Simaan , Alessio Salerno , Anubha Bhatla , Jian Zhang , Oleksandra V. Lyulko , Aparajita Dutta
发明人： Guy Garty , David J. Brenner , Gerhard Randers-Pehrson , Y. Lawrence Yao , Nabil Simaan , Alessio Salerno , Anubha Bhatla , Jian Zhang , Oleksandra V. Lyulko , Aparajita Dutta
IPC分类号： G06K9/00
CPC分类号： C40B30/10 , C40B60/12
摘要： Systems and methods for high-throughput radiation biodosimetry are disclosed herein. In some embodiments, a high-throughput methods of analyzing a population for radiation exposure can include, in various possible sequences: marking a first capillary designed to retain a first sample from the population with a first identifier; transporting a plurality of samples to a biodosimetry system; inputting the samples into the biodosimetry system; centrifuging the plurality of samples including the first sample wherein each sample can be retained in a capillary and the first sample can be retained in the first capillary; transferring the plurality of capillaries including the first capillary from the centrifuge to a cutting device using a robotic device; cutting the first capillary; reading the first identifier; transferring at least one portion of the first sample from the first capillary to a well in an array, wherein the array can include one or more filters in a multi-well plate; correlating the first identifier to a location of the array that includes the at least one portion of the first sample; one or more cycles of biological processing, which can include addition of a reagent and/or incubation of a selected temperature such as, for example, 37° C., 4° C., room temperature, and the like; sealing the array; positioning the array adjacent to an imaging element; focusing the imaging element; capturing an image of the first sample in the array; and analyzing the image to determine whether the first sample indicates a level of radiation exposure exceeding a predetermined threshold.
摘要翻译：本文公开了用于高通量辐射生物测定法的系统和方法。在一些实施例中，用于分析用于辐射暴露的群体的高通量方法可以以各种可能的顺序包括：标记设计成用第一标识符从群体保留第一样本的第一毛细管; 将多个样品运送到生物测定系统; 将样品输入生物测定系统; 将包括第一样品的多个样品离心，其中每个样品可以保留在毛细管中，并且第一样品可以保留在第一毛细管中; 使用机器人装置将包括第一毛细管的多个毛细管从离心机转移到切割装置; 切割第一根毛细管; 阅读第一个标识符; 将所述第一样品的至少一部分从所述第一毛细管转移到阵列中的阱，其中所述阵列可以包括多孔板中的一个或多个过滤器; 将所述第一标识符与包括所述第一样本的所述至少一部分的所述阵列的位置相关联; 一个或多个生物处理循环，其可以包括添加试剂和/或选择温度的温育，例如37℃，4℃，室温等; 密封阵列; 将阵列定位成与成像元件相邻; 聚焦成像元件; 捕获阵列中第一个样本的图像; 并分析图像以确定第一样本是否指示超过预定阈值的辐射暴露水平。

3. 发明授权

US07787681B2 Systems and methods for robotic transport 有权
标题翻译：机器人运输的系统和方法
公开(公告)号：US07787681B2
公开(公告)日：2010-08-31
申请号：US11895485
申请日：2007-08-24
申请人： Jian Zhang , Alessio Salerno , Nabil Simaan , Y. Lawrence Yao , Gerhard Randers-Pehrson , Guy Garty , Aparajita Dutta , David J. Brenner
发明人： Jian Zhang , Alessio Salerno , Nabil Simaan , Y. Lawrence Yao , Gerhard Randers-Pehrson , Guy Garty , Aparajita Dutta , David J. Brenner
IPC分类号： G06K9/00
CPC分类号： C40B30/10 , C40B60/12
摘要： Systems and methods for robotic transport are disclosed herein. In some embodiments, robotic systems for transporting biological samples include: a plurality of capillary vessels, in which each capillary vessel can contain a biological sample from a population; a receptacle that can contain the plurality of capillary vessels; a centrifuge; a first robotic device that can transport the receptacle between an input module and the centrifuge; a second robotic device that can transport the receptacle between the centrifuge and a sample harvest location; a cutting device that can cut each of the plurality of capillary vessels; a multi-well plate having a plurality of wells arranged in an array; and a third robotic device that can transfer at least one portion of each of the plurality of biological samples from each of the plurality of capillary vessels to a corresponding well in the array.
摘要翻译：本文公开了用于机器人运输的系统和方法。在一些实施例中，用于输送生物样品的机器人系统包括：多个毛细血管，其中每个毛细血管可以包含来自群体的生物样品; 可容纳多个毛细血管的容器; 离心机能够在输入模块和离心机之间输送容器的第一机器人装置; 第二机器人装置，其可以在离心机和样品收集位置之间运输容器; 切割装置，其可以切割所述多个毛细血管中的每一个; 具有排列成阵列的多个孔的多孔板; 以及第三机器人装置，其可以将多个生物样品中的每一个的至少一部分从多个毛细血管中的每一个转移到阵列中的对应的孔中。

4. 发明申请

US20090054222A1 Systems and methods for robotic transport 有权
标题翻译：机器人运输的系统和方法
公开(公告)号：US20090054222A1
公开(公告)日：2009-02-26
申请号：US11895485
申请日：2007-08-24
申请人： Jian Zhang , Alessio Salerno , Nabil Simaan , Y. Lawrence Yao , Gerhard Randers-Pehrson , Guy Garty , Aparajita Dutta , David J. Brenner
发明人： Jian Zhang , Alessio Salerno , Nabil Simaan , Y. Lawrence Yao , Gerhard Randers-Pehrson , Guy Garty , Aparajita Dutta , David J. Brenner
IPC分类号： B04B5/10
CPC分类号： C40B30/10 , C40B60/12
摘要： Systems and methods for robotic transport are disclosed herein. In some embodiments, robotic systems for transporting biological samples include: a plurality of capillary vessels, in which each capillary vessel can contain a biological sample from a population; a receptacle that can contain the plurality of capillary vessels; a centrifuge; a first robotic device that can transport the receptacle between an input module and the centrifuge; a second robotic device that can transport the receptacle between the centrifuge and a sample harvest location; a cutting device that can cut each of the plurality of capillary vessels; a multi-well plate having a plurality of wells arranged in an array; and a third robotic device that can transfer at least one portion of each of the plurality of biological samples from each of the plurality of capillary vessels to a corresponding well in the array.
摘要翻译：本文公开了用于机器人运输的系统和方法。在一些实施例中，用于输送生物样品的机器人系统包括：多个毛细血管，其中每个毛细血管可以包含来自群体的生物样品; 可容纳多个毛细血管的容器; 离心机能够在输入模块和离心机之间输送容器的第一机器人装置; 第二机器人装置，其可以在离心机和样品收集位置之间运输容器; 切割装置，其可以切割所述多个毛细血管中的每一个; 具有排列成阵列的多个孔的多孔板; 以及第三机器人装置，其可以将多个生物样品中的每一个的至少一部分从多个毛细血管中的每一个转移到阵列中的对应的孔中。

5. 发明申请

US20120132313A1 Systems and methods for cutting materials 审中-公开
标题翻译：切割材料的系统和方法
公开(公告)号：US20120132313A1
公开(公告)日：2012-05-31
申请号：US11895557
申请日：2007-08-24
申请人： Anubha Bhatla , Alessio Salerno , Nabil Simaan , Y. Lawrence Yao , Gerhard Randers-Pehrson , Guy Y. Garty , Aparajita Dutta , David J. Brenner
发明人： Anubha Bhatla , Alessio Salerno , Nabil Simaan , Y. Lawrence Yao , Gerhard Randers-Pehrson , Guy Y. Garty , Aparajita Dutta , David J. Brenner
IPC分类号： B65B3/26
CPC分类号： C40B30/10 , C40B60/12
摘要： Systems and methods for cutting materials are disclosed herein In some embodiments, methods of at least partially severing a capillary vessel can include: focusing a laser on a predetermined point on the capillary vessel, said capillary vessel containing a biological sample; and cutting the capillary vessel using a laser at the predetermined point. In some embodiments, the methods further can include capturing an image of the capillary vessel and analyzing the image to determine the predetermined point. In some embodiments, a beam of the laser can be moved using one or more galvanometric mirrors. In some embodiments, the methods further can include cutting a plurality of capillary vessels using the laser. In some embodiments, the methods can include utilizing a plurality of lasers, and/or further can include rotating the capillary vessel while the laser can be cutting the capillary vessel. In some embodiments, cutting the capillary vessel can include cutting only a portion of the capillary vessel.
摘要翻译：用于切割材料的系统和方法在一些实施例中，至少部分地切断毛细管的方法可以包括：将激光聚焦在毛细血管上的预定点上，所述毛细血管容纳生物样品; 以及在预定点处使用激光切割毛细血管。在一些实施例中，所述方法还可包括捕获毛细管血管的图像并分析图像以确定预定点。在一些实施例中，可以使用一个或多个电流计反射镜移动激光束。在一些实施例中，所述方法还可包括使用所述激光切割多个毛细血管。在一些实施例中，该方法可以包括利用多个激光器，和/或还可以包括旋转毛细血管，同时激光器可以切割毛细血管。在一些实施例中，切割毛细血管可包括仅切割毛细血管的一部分。

6. 发明申请

US20080179301A1 Systems and methods for etching materials 审中-公开
标题翻译：蚀刻材料的系统和方法
公开(公告)号：US20080179301A1
公开(公告)日：2008-07-31
申请号：US11895517
申请日：2007-08-24
申请人： Guy Garty , Gerhard Randers-Pehrson , Anubha Bhatla , Alessio Salerno , Nabil Simaan , Y. Lawrence Yao , David J. Brenner
发明人： Guy Garty , Gerhard Randers-Pehrson , Anubha Bhatla , Alessio Salerno , Nabil Simaan , Y. Lawrence Yao , David J. Brenner
IPC分类号： B23K26/00 , G06K7/10
CPC分类号： C40B30/10 , C40B60/12
摘要： Systems and methods for etching materials are disclosed herein. Embodiments of the disclosed subject matter include methods for marking at least one capillary, including etching the at least one capillary with a laser, as well as methods for reading the resulting markings using a second laser. Further embodiments incorporate the second laser within a barcode reader. Various embodiments of the disclosed subject matter include capillaries having outer diameters of about 2 mm. In some embodiments, the capillary is moved while the first laser marks the capillary.
摘要翻译：本文公开了蚀刻材料的系统和方法。所公开的主题的实施例包括用于标记至少一个毛细管的方法，包括用激光蚀刻至少一个毛细管，以及使用第二激光读取所得到的标记的方法。另外的实施例将第二激光器并入条形码读取器内。所公开的主题的各种实施例包括外径约2mm的毛细管。在一些实施例中，当第一激光器标记毛细管时毛细管被移动。

7. 发明申请

US20110066160A1 SYSTEMS AND METHODS FOR INSERTING STEERABLE ARRAYS INTO ANATOMICAL STRUCTURES 审中-公开
标题翻译：将可控阵列插入解剖结构的系统和方法
公开(公告)号：US20110066160A1
公开(公告)日：2011-03-17
申请号：US12934569
申请日：2009-04-03
申请人： Nabil Simaan , Jian Zhang , Spiros Manolidis , J. Thomas Roland, JR.
发明人： Nabil Simaan , Jian Zhang , Spiros Manolidis , J. Thomas Roland, JR.
IPC分类号： A61B19/00
CPC分类号： A61N1/05 , A61N1/0541
摘要： Systems and Methods are provided for inserting a steerable array into an anatomical structure of the body. The system includes an insertion module for holding a proximal end of the steerable array and a force sensor configured to detect force on the steerable array and to produce force information. The system includes a position sensor configured to detect a position of the insertion module and to produce position information, the position information including a lateral position along an insertion axis and a first approach angle relative to a first reference axis. The system further includes a processor configured to receive the force information from the force sensor and the position information from the position sensor. The processor outputs performance information to a user. The performance information includes an indication of a first differential approach angle relative to an insertion path plan.
摘要翻译：提供了系统和方法用于将可转向阵列插入身体的解剖结构中。该系统包括用于保持可转向阵列的近端的插入模块和被配置为检测可转向阵列上的力并产生力信息的力传感器。该系统包括位置传感器，其被配置为检测插入模块的位置并产生位置信息，该位置信息包括沿着插入轴线的横向位置和相对于第一参考轴线的第一接近角度。该系统还包括处理器，其被配置为从力传感器接收力信息和来自位置传感器的位置信息。处理器向用户输出性能信息。性能信息包括相对于插入路径计划的第一差分接近角度的指示。

8. 发明申请

US20120109274A1 ELECTRODE ARRAYS AND SYSTEMS FOR INSERTING SAME 审中-公开
标题翻译：电极阵列及其插入系统
公开(公告)号：US20120109274A1
公开(公告)日：2012-05-03
申请号：US13347041
申请日：2012-01-10
申请人： Nabil Simaan , Spiros Manolidis
发明人： Nabil Simaan , Spiros Manolidis
IPC分类号： A61F11/04 , A61N1/05
CPC分类号： A61N1/0541 , B33Y80/00
摘要： Electrode arrays and systems for inserting same are disclosed. In some embodiments, electrode arrays are provided, the electrode arrays comprising: a passive-bending portion; an active-bending portion coupled to the passive bending portion; a plurality of electrodes located in at least one of the passive-bending portion and the active bending portion; and an actuator that causes the active-bending portion to deflect from the passive-bending portion. In some embodiments, systems for inserting an electrode array in the body are provided, the systems comprising: an insertion module for controllably inserting the electrode array in the body and sensing forces applied to the electrode array; a monitor for providing information to a user; and a controller coupled to the insertion module and the monitor, wherein the controller causes the insertion module to control an amount of force that is applied to the electrode array.
摘要翻译：公开了用于插入其的电极阵列和系统。在一些实施例中，提供电极阵列，电极阵列包括：被动弯曲部分; 耦合到被动弯曲部分的主动弯曲部分; 多个电极，位于被动弯曲部和主动弯曲部中的至少一个中; 以及使主动弯曲部从被动弯曲部偏转的致动器。在一些实施例中，提供了用于在电极体内插入电极阵列的系统，所述系统包括：插入模块，用于将电极阵列可控地插入到体内并感测施加到电极阵列的力; 用于向用户提供信息的监视器; 以及耦合到所述插入模块和所述监视器的控制器，其中所述控制器使所述插入模块控制施加到所述电极阵列的力的量。

9. 发明申请

US20130090763A1 SYSTEMS AND METHODS FOR FORCE SENSING IN A ROBOT 审中-公开
标题翻译：机器人感应系统和方法
公开(公告)号：US20130090763A1
公开(公告)日：2013-04-11
申请号：US12811504
申请日：2009-01-26
申请人： Nabil Simaan , Kai Xu
发明人： Nabil Simaan , Kai Xu
IPC分类号： B25J19/02
CPC分类号： B25J19/02 , A61B5/11 , A61B5/4561 , A61B17/0469 , A61B34/30 , A61B34/71 , A61B34/76 , A61B90/361 , A61B2017/00323 , A61B2034/305 , A61B2034/306 , A61B2090/061 , A61B2090/064 , A61B2090/067 , B25J9/06 , B25J9/104 , B25J13/085 , B25J18/06 , B25J19/025
摘要： A system for force sensing in a robot is provided. The robot includes an end disk and a plurality of backbones coupled to the end disk. A plurality of spacer disks are dispersed along the plurality of backbones, and keep the plurality of backbones separated from one another. A base disk provides an interconnection point to a lumen, and the lumen provides a channel to an actuation device. The actuation device provides actuation of the backbones. At least one sensor measures the force being applied on one of the plurality of backbones, and a processor receives force measurements from the at least one sensor and determines the displacement of at least one of the plurality of backbones.
摘要翻译：提供了一种用于机器人中的力感测的系统。机器人包括端盘和耦合到端盘的多个主骨架。多个间隔盘沿着多个骨架分散，并且保持多个骨架彼此分离。基盘提供与内腔的互连点，并且内腔向致动装置提供通道。致动装置提供主干的致动。至少一个传感器测量施加在所述多个骨架之一上的力，并且处理器从所述至少一个传感器接收力测量值，并且确定所述多个骨架中的至少一个骨架的位移。

10. 发明申请

US20100331858A1 SYSTEMS, DEVICES, AND METHODS FOR ROBOT-ASSISTED MICRO-SURGICAL STENTING 审中-公开
标题翻译：机器人辅助微创手术的系统，设备和方法
公开(公告)号：US20100331858A1
公开(公告)日：2010-12-30
申请号：US12811506
申请日：2009-01-30
申请人： Nabil Simaan , Howard Fine , Wei Wei , Stanley Chang
发明人： Nabil Simaan , Howard Fine , Wei Wei , Stanley Chang
IPC分类号： A61B19/00 , A61F2/84
CPC分类号： A61F2/82 , A61B34/30 , A61B34/37 , A61B34/71 , A61B34/77 , A61B2017/00331 , A61B2017/00345 , A61B2017/00991 , A61B2034/304 , A61B2090/064 , A61F2/966 , A61F9/007
摘要： Systems, devices, and methods for robot-assisted microsurgical stenting are described herein. In some embodiments a tele-robotic microsurgical system for eye surgery include: a tele-robotic master and a slave hybrid-robot; wherein the tele-robotic master has at least one master slave interface controlled by a medical professional; wherein the slave hybrid-robot has at least one robotic arm attached to a frame releasably attached to a patient's head; wherein the at least one robotic arm has a parallel robot and a serial robot; and wherein the serial robot includes a stenting unit which includes a support tube, a pre-bent tube mounted within the support tube and a guide wire extending from the support tube for carrying a stent and for piercing a blood vessel.
摘要翻译：本文描述了用于机器人辅助显微外科支架置入术的系统，装置和方法。在一些实施例中，用于眼科手术的远程机器人显微手术系统包括远程机器人主机和从属混合机器人; 其中远程机器人主机具有由医疗专业人员控制的至少一个主从接口; 其中所述从动混合机器人具有附接到可释放地附接到患者头部的框架的至少一个机器人手臂; 其中所述至少一个机器臂具有并联机器人和串行机器人; 并且其中所述串联机器人包括支架单元，所述支架单元包括支撑管，安装在所述支撑管内的预弯曲管和从所述支撑管延伸以用于承载支架和用于刺穿血管的导丝。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式