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1. 发明申请

US20050255100A1 Antibodies to tumor necrosis factor receptor 5 失效
标题翻译：肿瘤坏死因子受体5的抗体
公开(公告)号：US20050255100A1
公开(公告)日：2005-11-17
申请号：US11182946
申请日：2005-07-18
申请人： Ying-Fei Wei , Jian Ni , Reiner Gentz , Steven Ruben
发明人： Ying-Fei Wei , Jian Ni , Reiner Gentz , Steven Ruben
IPC分类号： A61K31/522 , A61K31/66 , A61K38/00 , A61K38/13 , A61K38/17 , A61K38/19 , A61K38/20 , A61K38/21 , A61K39/395 , A61K45/06 , A61K48/00 , C07K14/705 , C07K16/28
CPC分类号： A61K31/522 , A61K31/66 , A61K39/395 , A61K45/06 , A61K48/00 , A61K2039/505 , C07K14/70578 , C07K16/2878 , C07K2319/00 , C07K2319/30 , C12N2799/026 , A61K2300/00
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
摘要翻译：本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。还提供了TRID多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。还提供了利用这种组合物的诊断和治疗方法。

2. 发明申请

US20070280903A1 T1 Receptor-Like Ligand II and Uses Thereof 审中-公开
标题翻译： T1受体样配体II及其用途
公开(公告)号：US20070280903A1
公开(公告)日：2007-12-06
申请号：US11554432
申请日：2006-10-30
申请人： Jian Ni , Reiner Gentz , Steven Ruben
发明人： Jian Ni , Reiner Gentz , Steven Ruben
IPC分类号： A61K38/19 , A61K38/17 , C12Q1/68 , A61K38/18
CPC分类号： G01N33/564 , A61K38/1709 , A61K38/20 , A61K45/06 , A61K48/00 , C07K14/54 , C12N2799/026 , G01N33/57407 , G01N33/57426 , G01N33/6893 , G01N33/6896 , G01N2800/24 , G01N2800/2821 , G01N2800/368
摘要： The present invention relates to a novel T1 Receptor (T1R)-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like ligand II polypeptides are also provided, as are recombinant vectors and host cells for expressing the same. This invention further relates to pharmaceutical compositions and formulations comprising T1R-like ligand II. Also provided are methods of using T1R-like ligand II polynucleotides, polypeptides, antibodies or agonists/antagonists for therapeutic and diagnostic purposes. Diagnostic kits are further provided.
摘要翻译：本发明涉及一种新颖的T1受体（T1R）样配体II蛋白。特别地，提供编码T1R样配体II蛋白质的分离的核酸分子。还提供了T1R样配体II多肽，重组载体和用于表达它们的宿主细胞也是如此。本发明还涉及包含T1R样配体II的药物组合物和制剂。还提供了用于治疗和诊断目的的T1R样配体II多核苷酸，多肽，抗体或激动剂/拮抗剂的方法。还提供诊断试剂盒。

3. 发明申请

US20070238130A1 Novel Metalloproteinases 审中-公开
标题翻译：新型金属蛋白酶
公开(公告)号：US20070238130A1
公开(公告)日：2007-10-11
申请号：US11627246
申请日：2007-01-25
申请人： Jian Ni , Steven Ruben , Laurie Brewer , Reiner Gentz , Craig Rosen
发明人： Jian Ni , Steven Ruben , Laurie Brewer , Reiner Gentz , Craig Rosen
IPC分类号： C12P1/04 , C07H21/04 , C07K14/00 , C07K16/18 , G01N33/53 , C12N15/00 , C12N5/06
CPC分类号： C12N9/6489 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70535 , C12N9/00 , C12N9/6475 , C12N9/6491 , C12N2799/026
摘要： The present invention relates to novel metalloproteinase- like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
摘要翻译：本发明涉及新型金属蛋白酶样蛋白质。特别地，提供了分离的核酸分子，其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体，宿主细胞和用于制备它们的重组方法提供。本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。

4. 发明申请

US20060063924A1 Leukocyte regulatory factors 1 and 2 审中-公开
标题翻译：白细胞调节因子1和2
公开(公告)号：US20060063924A1
公开(公告)日：2006-03-23
申请号：US11272833
申请日：2005-11-15
申请人： Jian Ni , Jing-Shan Hu , Steven Ruben , Reiner Gentz
发明人： Jian Ni , Jing-Shan Hu , Steven Ruben , Reiner Gentz
IPC分类号： C07K14/475 , C07H21/02 , C12P21/06
CPC分类号： C07K14/4702
摘要： The present invention relates to novel LRF-1 and LRF-2 proteins which are related to the CRISP family and a protein called “Neutrophil Inhibitory Factor (NIF)” isolated from the canine hookworm (Ancylostoma caninum) that potently inhibits CD11/CD18-dependent neutrophil function. In particular, isolated nucleic acid molecules are provided encoding the human LRF-1 and LRF-2 proteins. LRF-1 and LRF-2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of LRF-1 or LRF-2 activity. Also provided are diagnostic methods for detecting immune system or other LRF-1- or LRF-2-related disorders and therapeutic methods for treating such disorders.
摘要翻译：本发明涉及与CRISP家族相关的新型LRF-1和LRF-2蛋白质，以及从犬钩虫（Ancylostoma caninum）中分离的称为“中性嗜中性粒细胞抑制因子（NIF）”的蛋白质，其有效抑制CD11 / CD18依赖性中性粒细胞功能。特别地，提供编码人LRF-1和LRF-2蛋白的分离的核酸分子。还提供了LRF-1和LRF-2多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。本发明还涉及用于鉴定LRF-1或LRF-2活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统或其他LRF-1或LRF-2相关疾病的诊断方法以及用于治疗这种疾病的治疗方法。

5. 发明申请

US20060193861A1 Tumor necrosis factor receptors 6 alpha & 6 beta 有权
标题翻译：肿瘤坏死因子受体6α和6β
公开(公告)号：US20060193861A1
公开(公告)日：2006-08-31
申请号：US11416310
申请日：2006-05-03
申请人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven Ruben , Jian Ni , Ping Feng
发明人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven Ruben , Jian Ni , Ping Feng
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/24 , C12N1/18 , C12N5/06
CPC分类号： A61K48/005 , A61K38/00 , A61K48/0058 , C07K14/4703 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C07K2319/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides and antibodies that bind TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及新型肿瘤坏死因子受体蛋白。特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。还提供TNFR-6α和-6β多肽和结合TNFR-6α和-6β多肽的抗体，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

6. 发明申请

US20060234285A1 Tumor Necrosis Factor Receptors 6 Alpha & 6 Beta 审中-公开
标题翻译：肿瘤坏死因子受体6 Alpha＆6 Beta
公开(公告)号：US20060234285A1
公开(公告)日：2006-10-19
申请号：US11419656
申请日：2006-05-22
申请人： Reiner Gentz , Guo-Liang Yu , Jian Ni , Reinhard Ebner , Ping Feng , Steven Ruben
发明人： Reiner Gentz , Guo-Liang Yu , Jian Ni , Reinhard Ebner , Ping Feng , Steven Ruben
IPC分类号： C12Q1/68 , G01N33/574 , A61K38/17 , C07H21/04 , C12P21/06 , C07K14/715
CPC分类号： G01N33/57488 , A61K38/00 , C07K14/70578 , C07K14/7151
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及新型肿瘤坏死因子受体蛋白。特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。还提供了TNFR-6α和-6β多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

7. 发明申请

US20060045878A1 Pancreas-derived plasminogen activator inhibitor 审中-公开
标题翻译：胰腺来源的纤溶酶原激活物抑制剂
公开(公告)号：US20060045878A1
公开(公告)日：2006-03-02
申请号：US11048774
申请日：2005-02-03
申请人： Jian Ni , Reiner Gentz , Steven Ruben , Y. Shi
发明人： Jian Ni , Reiner Gentz , Steven Ruben , Y. Shi
IPC分类号： C07H21/04 , A61K39/395 , C07K16/44 , C12N5/06
CPC分类号： C07K14/81 , A61K38/00 , A61K48/00 , C07K14/8132 , C07K2319/00 , Y02A50/463
摘要： The present invention relates to a novel member of the plasminogen activator inhibitor protein family. In particular, isolated nucleic acid molecules are provided encoding the pancreas-derived plasminogen activator inhibitor protein. Pancreas-derived plasminogen activator inhibitor polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to methods for treating physiologic and pathologic disease conditions and diagnostic methods for detecting pathologic disorders.
摘要翻译：本发明涉及纤溶酶原激活物抑制剂蛋白家族的新成员。特别地，提供编码胰腺衍生的纤溶酶原激活物抑制蛋白的分离的核酸分子。还提供了胰腺来源的纤溶酶原激活物抑制剂多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于治疗生理和病理疾病状况的方法以及用于检测病理学疾病的诊断方法。

8. 发明申请

US20050037966A1 Keratinocyte growth factor-2 审中-公开
标题翻译：角质形成细胞生长因子-2
公开(公告)号：US20050037966A1
公开(公告)日：2005-02-17
申请号：US10901210
申请日：2004-07-29
申请人： Steven Ruben , Pablo Jimenez , Roxanne Duan , Mark Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul Moore , Timothy Coleman , Joachim Gruber , Patrick Dillon , Reiner Gentz
发明人： Steven Ruben , Pablo Jimenez , Roxanne Duan , Mark Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul Moore , Timothy Coleman , Joachim Gruber , Patrick Dillon , Reiner Gentz
IPC分类号： A61K38/00 , A61K48/00 , C07K14/50 , C12N5/08 , A61K38/18 , C07K14/475
CPC分类号： C07K14/50 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
摘要翻译：本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

9. 发明申请

US20060228359A1 Antibodies to Myeloid Progenitor Inhibitory Factor-1 (MPIF-1) 失效
标题翻译：骨髓祖细胞抑制因子-1（MPIF-1）抗体
公开(公告)号：US20060228359A1
公开(公告)日：2006-10-12
申请号：US11381977
申请日：2006-05-05
申请人： Reiner Gentz , Brent Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrik , Pablo Jimenez , Vikram Patel , Craig Rosen , Mark Adams , Haodong Li , Steven Ruben
发明人： Reiner Gentz , Brent Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrik , Pablo Jimenez , Vikram Patel , Craig Rosen , Mark Adams , Haodong Li , Steven Ruben
IPC分类号： A61K39/395 , G01N33/53 , C12N5/06 , C07K16/24
CPC分类号： G01N33/6863 , A61K38/00 , A61K48/00 , C07K1/113 , C07K1/36 , C07K14/50 , C07K14/521 , C07K14/523 , C07K16/24 , C07K2319/00 , C12N15/72 , C12N2799/026 , G01N2333/52
摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1(CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译：公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子β8（CKbeta8或ckb-8））的分离的核酸分子的治疗组合物和方法。人单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ和趋化因子β1（CKbeta1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4）以及MPIF-1 ，M-CIF和/或MIP-4多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。

10. 发明申请

US20070203070A1 28 HUMAN SECRETED PROTEINS 失效
标题翻译： 28人类分泌蛋白
公开(公告)号：US20070203070A1
公开(公告)日：2007-08-30
申请号：US11744695
申请日：2007-05-04
申请人： Craig Rosen , Steven Ruben , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie Fischer , Haodong Li , Daniel Soppet , Reiner Gentz , Ying-Fei Wei , Paul Moore , Paul Young , John Greene , Ann Ferrie , Gregg Hastings
发明人： Craig Rosen , Steven Ruben , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie Fischer , Haodong Li , Daniel Soppet , Reiner Gentz , Ying-Fei Wei , Paul Moore , Paul Young , John Greene , Ann Ferrie , Gregg Hastings
IPC分类号： A61K38/17 , C07H21/04 , C07K16/00 , C07K4/00 , C12N15/00 , C12N15/09 , C12N5/00 , C12N5/08 , C12Q1/00 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

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