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1. 发明申请

US20100092796A1 Microforming method and apparatus 有权
标题翻译：微成型方法和装置
公开(公告)号：US20100092796A1
公开(公告)日：2010-04-15
申请号：US12587408
申请日：2009-10-06
申请人： Jian Cao , Anthony Swanson , Tiffany Davis
发明人： Jian Cao , Anthony Swanson , Tiffany Davis
IPC分类号： B32B3/30 , B21D31/00 , B21D5/02 , B29C59/02 , B32B15/01
CPC分类号： B29C59/022 , B29C2059/023 , Y10T428/12389 , Y10T428/24479
摘要： Method of forming depressions (e.g. dimples) in a sheet material to form a textured surface thereon involves pressing one or more tool tips into a metallic or non-metallic sheet material while the sheet material is supported by a support layer that is relatively softer (e.g. having a lower Young's modulus) than the sheet material so as to allow plastic deformation and reduce pile-up of raised displaced material of the sheet material at the edges of the depressions.
摘要翻译：在片材中形成凹凸（例如凹坑）以形成其上的纹理化表面的方法包括将一个或多个工具尖端压入金属或非金属片材中，同时片材由相对较软的支撑层（例如，具有较低的杨氏模量），从而允许塑性变形并减少在凹陷的边缘处的片材的凸起的位移材料的堆积。

2. 发明授权

US08408039B2 Microforming method and apparatus 有权
标题翻译：微成型方法和装置
公开(公告)号：US08408039B2
公开(公告)日：2013-04-02
申请号：US12587408
申请日：2009-10-06
申请人： Jian Cao , Anthony Swanson , Tiffany Davis
发明人： Jian Cao , Anthony Swanson , Tiffany Davis
IPC分类号： B21J11/00 , B21D5/06 , B21B27/06
CPC分类号： B29C59/022 , B29C2059/023 , Y10T428/12389 , Y10T428/24479
摘要： Method of forming depressions (e.g. dimples) in a sheet material to form a textured surface thereon involves pressing one or more tool tips into a metallic or non-metallic sheet material while the sheet material is supported by a support layer that is relatively softer (e.g. having a lower Young's modulus) than the sheet material so as to allow plastic deformation and reduce pile-up of raised displaced material of the sheet material at the edges of the depressions.
摘要翻译：在片材中形成凹凸（例如凹坑）以形成其上的纹理化表面的方法包括将一个或多个工具尖端压入金属或非金属片材中，同时片材由相对较软的支撑层（例如，具有较低的杨氏模量），从而允许塑性变形并减少在凹陷的边缘处的片材的凸起的位移材料的堆积。

3. 发明授权

US09321090B2 Forming tools having textured surfaces 有权
标题翻译：成型工具具有纹理表面
公开(公告)号：US09321090B2
公开(公告)日：2016-04-26
申请号：US13465587
申请日：2012-05-07
申请人： Zhiyong Cedric Xia , Jian Cao , Qian Wang , Rajesh Talwar , Donald J. Grzina , Tiffany Davis Ling , Pinzhi Liu
发明人： Zhiyong Cedric Xia , Jian Cao , Qian Wang , Rajesh Talwar , Donald J. Grzina , Tiffany Davis Ling , Pinzhi Liu
IPC分类号： B21D22/00 , B21D22/20 , G06F17/50
CPC分类号： B21D22/02 , B21D22/00 , B21D22/20 , B21D24/04 , G06F17/50 , G06F17/5009 , G06F17/5018 , G06F17/5086 , G06F2217/42
摘要： A manufacturing method forms components having a desired shape. A contoured surface is defined for a forming tool for forming a metal blank into the desired shape, wherein respective portions of the metal blank flow over the contoured surface during forming. An intrinsic material flow pattern resulting from the contoured surface is compared to a desired flow in order to identify regions of the contoured surface having an insufficient flow that creates areas in the formed metal blank receiving less than a desired amount of metal. A surface microtexture is applied onto the contoured surface in a pattern selected to increase metal flow along the identified regions by providing a friction in the identified regions that is reduced relative to adjacent regions of the contoured surface.
摘要翻译：制造方法形成具有所需形状的部件。形成轮廓的表面被定义为用于将金属坯料形成为所需形状的成形工具，其中金属坯料的各个部分在成形期间流过轮廓表面。将由轮廓表面产生的本征材料流动图案与期望的流动进行比较，以便识别具有不足的流动的轮廓表面的区域，该区域在所形成的金属坯料中接收小于期望量的金属的区域。以选定的图案将表面微纹理施加到轮廓表面上，以通过在相对于轮廓表面的相邻区域减小的所识别的区域中提供摩擦来增加沿着所识别的区域的金属流动。

4. 发明授权

US09144845B1 Cutting tools with textured surfaces 有权
标题翻译：具有纹理表面的切割工具
公开(公告)号：US09144845B1
公开(公告)日：2015-09-29
申请号：US13409211
申请日：2012-03-01
申请人： Donald J. Grzina , Rajesh Talwar , Jian Cao , Qian Wang , Zhiyong Cedric Xia , Tiffany Davis Ling , Pinzhi Liu
发明人： Donald J. Grzina , Rajesh Talwar , Jian Cao , Qian Wang , Zhiyong Cedric Xia , Tiffany Davis Ling , Pinzhi Liu
IPC分类号： B23B27/00 , B23C5/10
CPC分类号： B23B27/00 , B23B51/02 , B23B2251/14 , B23B2251/44 , B23B2260/072 , B23B2260/092 , B23C5/10 , B23C5/207 , B23C2200/086 , B23C2200/128 , B23D77/00 , B23D2277/62
摘要： A cutting tool comprising first and second surfaces that intersect at an edge, wherein the first surface (e.g., a rake face, a flank surface or a margin) has a textured region comprising a multiplicity of recesses each having a length greater than its width. The recesses are distributed in a pattern comprising rows of recesses arranged lengthwise along respective lines with spaces between neighboring recesses. The recesses of one row are offset from the recesses of the next row. Each recess of the one row having one end portion that overlaps with an end portion of one recess in the next row and another end portion that overlaps with an end portion of another recess in the next row. The recesses are generally parallel to the edge.
摘要翻译：一种切割工具，包括在边缘处相交的第一和第二表面，其中第一表面（例如，前刀面，侧面或边缘）具有纹理区域，该纹理区域包括多个凹槽，每个凹槽的长度大于其宽度。这些凹槽以包括相应凹槽之间的间隔沿着相应的线纵向排列的凹槽排列的图案分布。一排的凹槽与下一排的凹槽偏移。一排的每个凹部具有与下一行中的一个凹部的端部重叠的一个端部和与下一行中的另一个凹部的端部重叠的另一个端部。凹槽通常平行于边缘。

5. 发明申请

US20130291613A1 Forming Tools Having Textured Surfaces 有权
标题翻译：具有纹理表面的成型工具
公开(公告)号：US20130291613A1
公开(公告)日：2013-11-07
申请号：US13465587
申请日：2012-05-07
申请人： Zhiyong Cedric Xia , Jian Cao , Qian Wang , Rajesh Talwar , Donald J. Grzina , Tiffany Davis Ling , Pinzhi Liu
发明人： Zhiyong Cedric Xia , Jian Cao , Qian Wang , Rajesh Talwar , Donald J. Grzina , Tiffany Davis Ling , Pinzhi Liu
IPC分类号： B21D24/04 , G06F17/50 , B21D22/00
CPC分类号： B21D22/02 , B21D22/00 , B21D22/20 , B21D24/04 , G06F17/50 , G06F17/5009 , G06F17/5018 , G06F17/5086 , G06F2217/42
摘要： A manufacturing method forms components having a desired shape. A contoured surface is defined for a forming tool for forming a metal blank into the desired shape, wherein respective portions of the metal blank flow over the contoured surface during forming. An intrinsic material flow pattern resulting from the contoured surface is compared to a desired flow in order to identify regions of the contoured surface having an insufficient flow that creates areas in the formed metal blank receiving less than a desired amount of metal. A surface microtexture is applied onto the contoured surface in a pattern selected to increase metal flow along the identified regions by providing a friction in the identified regions that is reduced relative to adjacent regions of the contoured surface.
摘要翻译：制造方法形成具有所需形状的部件。形成轮廓的表面被定义为用于将金属坯料形成为所需形状的成形工具，其中金属坯料的各个部分在成形期间流过轮廓表面。将由轮廓表面产生的本征材料流动图案与期望的流动进行比较，以便识别具有不足的流动的轮廓表面的区域，该区域在所形成的金属坯料中接收小于期望量的金属的区域。以选定的图案将表面微纹理施加到轮廓表面上，以通过在相对于轮廓表面的相邻区域减小的所识别的区域中提供摩擦来增加沿着所识别的区域的金属流动。

6. 发明申请

US20170247443A1 Safety and Efficacy with a CHO Cell Glycosylated Chimeric Antibody to TNF 审中-公开
公开(公告)号：US20170247443A1
公开(公告)日：2017-08-31
申请号：US15403115
申请日：2017-01-10
申请人： Jian Cao , Jeffrey Su
发明人： Jian Cao , Jeffrey Su
IPC分类号： C07K16/24
CPC分类号： C07K16/241 , C07K2317/41 , C07K2317/51 , C07K2317/515
摘要： There is disclosed a chimeric infliximab-like monoclonal antibody having at least 80% NANA glycosylation terminal sialic acid and a glycosylation pattern of Gal-α(2,3/6)-Gal that binds to tumor necrosis factor alpha (TNF). The disclosed infliximab-like monoclonal antibody is a chimeric antibody having the same amino acid sequence (light chain/heavy chain of SEQ ID NO. 1/SEQ ID NO. 2) as infliximab (Remicade®) which has at least 80% NGNA terminal sialic acid and a glycosylation pattern of Gal-α(1,3)-Gal.

7. 发明授权

US09133239B2 Compositions and methods for inhibiting matrix metalloproteinase (MMP)-mediated cell migration 有权
标题翻译：用于抑制基质金属蛋白酶（MMP）介导的细胞迁移的组合物和方法
公开(公告)号：US09133239B2
公开(公告)日：2015-09-15
申请号：US13642078
申请日：2011-04-19
申请人： Jian Cao , Antoine Dufour
发明人： Jian Cao , Antoine Dufour
IPC分类号： A61K38/08 , A61K38/04 , C07K7/00 , C07K7/06 , C12N9/64 , A61K38/00
CPC分类号： C07K7/06 , A61K38/00 , C12N9/6491
摘要： The invention provides peptides, portions and derivatives thereof, that are useful for reducing cell migration, and for reducing symptoms of pathological diseases that are associated with undesirable cell migration, and in particular MMP-induced cell migration. This invention also provides peptides that are useful for detecting (e.g., imaging) cancers.
摘要翻译：本发明提供了可用于减少细胞迁移和减少与不期望的细胞迁移相关的病理学疾病的症状，特别是MMP诱导的细胞迁移的肽，其部分和衍生物。本发明还提供了可用于检测（例如成像）癌症的肽。

8. 发明授权

US08741079B2 Electrical-assisted double side incremental forming and processes thereof 有权
标题翻译：电辅双面递增成型及其工艺
公开(公告)号：US08741079B2
公开(公告)日：2014-06-03
申请号：US13221304
申请日：2011-08-30
申请人： John Roth , Jian Cao
发明人： John Roth , Jian Cao
IPC分类号： B21D26/00
CPC分类号： C21D1/09 , B21D31/005 , B21D37/16 , B21J1/06 , C21D1/40 , C21D7/02 , C21D7/13 , C21D9/0018 , C21D9/0068 , C21D9/46 , C21D9/48 , C21D2261/00
摘要： A process for forming a sheet metal component using an electric current passing through the component is provided. The process can include providing a double side incremental forming machine, the machine operable to perform a plurality of double side incremental deformations on the sheet metal component and also apply an electric direct current to the sheet metal component during at least part of the forming. The direct current can be applied before or after the forming has started and/or be terminated before or after the forming has stopped. The direct current can be applied to any portion of the sheet metal. The electrical assistance can reduce the magnitude of force required to produce a given amount of deformation, increase the amount of deformation exhibited before failure and/or reduce any springback typically exhibited by the sheet metal component.
摘要翻译：提供了使用通过该部件的电流来形成钣金元件的工艺。该方法可以包括提供双面增量成型机，该机器可操作以在金属片部件上执行多个双面增量变形，并且还在成形的至少一部分期间向金属片部件施加电直流电。可以在成形开始之前或之后施加直流电流和/或在成形停止之后终止直流电流。直流电可以应用于金属片的任何部分。电气辅助可以减少产生给定量的变形所需的力的大小，增加在故障之前显示的变形量和/或减少通常由金属片组件表现的任何回弹。

9. 发明申请

US20140039735A1 METHOD AND SYSTEM FOR BATTERY CHARGING AND THERMAL MANGEMENT CONTROL IN ELECTRIFIED VEHICLES 有权
标题翻译：电动车辆电池充电和热电偶控制方法与系统
公开(公告)号：US20140039735A1
公开(公告)日：2014-02-06
申请号：US13566064
申请日：2012-08-03
申请人： Gregory Major , Mark Utter , Jian Cao
发明人： Gregory Major , Mark Utter , Jian Cao
IPC分类号： H02J7/00 , G06F17/00
CPC分类号： H02J7/007 , B60L11/184 , B60L11/1848 , B60L11/185 , B60L11/1866 , B60L11/1874 , B60L11/1875 , B60L2240/34 , B60L2240/545 , B60L2240/80 , B60L2250/14 , B60W10/26 , G06F17/00 , Y02T10/7005 , Y02T10/7061 , Y02T10/7072 , Y02T90/121 , Y02T90/128 , Y02T90/14 , Y02T90/169 , Y04S30/14
摘要： A method and a control system for charging a battery in a plug-in hybrid or all-electric vehicle, thermally conditioning the battery, and/or thermally conditioning the passenger compartment of the plug-in hybrid or all-electric vehicle.
摘要翻译：一种用于对插电式混合动力车辆或全电动车辆中的电池充电，对电池进行热调节和/或热调节插电式混合动力车辆或全电动车辆的乘客车厢的方法和控制系统。

10. 发明申请

US20130287826A1 COMPOSITE PARTICLES AND COMPOSITIONS WITH COMPOSITE PARTICLES 有权
标题翻译：复合颗粒和组合物与复合颗粒
公开(公告)号：US20130287826A1
公开(公告)日：2013-10-31
申请号：US13885721
申请日：2011-11-02
申请人： Jian Cao , Zhaoting Liu , Xiaoyi Pang , Robert Paul Velthuizen , Xiuxia Wang
发明人： Jian Cao , Zhaoting Liu , Xiaoyi Pang , Robert Paul Velthuizen , Xiuxia Wang
IPC分类号： A61K8/02 , A61Q19/00 , A61K8/81
CPC分类号： A61K8/0245 , A61K8/0279 , A61K8/19 , A61K8/27 , A61K8/28 , A61K8/29 , A61K8/8152 , A61K2800/412 , A61Q19/00 , C08K3/013 , C08K3/22 , C08K9/10
摘要： Composite particles and compositions with the composite particles are described. The particles have a polymeric base with or without voids and subparticles whereby the subparticles have indexes of refraction above and below the index of refraction of the polymeric base. When typically applied, the compositions impart excellent soft focus results on the skin of consumers.
摘要翻译：描述了具有复合颗粒的复合颗粒和组合物。颗粒具有聚合物基体，具有或不具有空隙和子颗粒，由此子颗粒的折射率高于和低于聚合物基底的折射率。当通常应用时，组合物赋予消费者皮肤优异的柔焦效果。

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