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1. 发明授权

US07268126B2 Polymorphic and amorphous forms of the phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-ce]indol-6-one 有权
标题翻译： 8-氟-2- {4 - [（甲基氨基）甲基]苯基} -1,3,4,5-四氢-6H-氮杂[5,43-ce]吲哚的磷酸盐的多晶型和无定形形式 -6-one
公开(公告)号：US07268126B2
公开(公告)日：2007-09-11
申请号：US11233835
申请日：2005-09-21
申请人： Jia Liu , Naresh Nayyar , Ming Guo , Zhen-Ping Wu , Bennett Chaplin Borer , Aparna Nadig Srirangam , Mark Bryan Mitchell , Yi Li , Jan-Jon Chu
发明人： Jia Liu , Naresh Nayyar , Ming Guo , Zhen-Ping Wu , Bennett Chaplin Borer , Aparna Nadig Srirangam , Mark Bryan Mitchell , Yi Li , Jan-Jon Chu
IPC分类号： C07D487/06 , A61K31/55 , A61P35/00 , A61P35/28
CPC分类号： C07D487/06 , C07D487/04
摘要： The present invention relates to novel polymorphic and amorphous forms of a phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, and to processes for their preparation. Such polymorphic forms may be a component of a pharmaceutical composition and may be used to treat a mammalian disease condition mediated by poly(ADP-ribose) polymerase activity including the disease condition such as cancer.
摘要翻译：本发明涉及8-氟-2- {4 - [（甲基氨基）甲基]苯基} -1,3,4,5-四氢-6H-氮杂基[5,4]的磷酸盐的新型多晶型和无定形形式，3-cd]吲哚-6-酮，以及其制备方法。这样的多晶型物可以是药物组合物的组分，并且可以用于治疗由聚（ADP-核糖）聚合酶活性介导的哺乳动物疾病状况，包括疾病状况如癌症。

2. 发明申请

US20060100198A1 Polymorphic and amorphous forms of the phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-ce]indol-6-one 有权
标题翻译： 8-氟-2- {4 - [（甲基氨基）甲基]苯基} -1,3,4,5-四氢-6H-吖庚因并[5,4,3-ce]吲哚的磷酸盐的多晶型和无定形形式 -6-one
公开(公告)号：US20060100198A1
公开(公告)日：2006-05-11
申请号：US11233835
申请日：2005-09-21
申请人： Jia Liu , Naresh Nayyar , Ming Guo , Zhen-Ping Wu , Bennett Borer , Aparna Srirangam , Mark Mitchell , Yi Li , Jan-Jon Chu
发明人： Jia Liu , Naresh Nayyar , Ming Guo , Zhen-Ping Wu , Bennett Borer , Aparna Srirangam , Mark Mitchell , Yi Li , Jan-Jon Chu
IPC分类号： A61K31/55 , C07D487/04
CPC分类号： C07D487/06 , C07D487/04
摘要： The present invention relates to novel polymorphic and amorphous forms of a phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, and to processes for their preparation. Such polymorphic forms may be a component of a pharmaceutical composition and may be used to treat a mammalian disease condition mediated by poly(ADP-ribose) polymerase activity including the disease condition such as cancer.
摘要翻译：本发明涉及8-氟-2- {4 - [（甲基氨基）甲基]苯基} -1,3,4,5-四氢-6H-氮杂基[5,4]的磷酸盐的新型多晶型和无定形形式，3-cd]吲哚-6-酮，以及其制备方法。这样的多晶型物可以是药物组合物的组分，并且可以用于治疗由聚（ADP-核糖）聚合酶活性介导的哺乳动物疾病状况，包括疾病状况如癌症。

3. 发明授权

US07928226B2 Salts and polymorphs of a VEGF-R inhibitor 失效
标题翻译： VEGF-R抑制剂的盐和多晶型物
公开(公告)号：US07928226B2
公开(公告)日：2011-04-19
申请号：US12063076
申请日：2006-07-27
申请人： Yi Li , Jia Liu , Anand Sistla , Bruce Joseph Elder , Yufeng Hong , Paul Kenneth Isbester , Grant Jackson Palmer , Jonathon Stuart Salsbury , Luckner Gerard Ulysse
发明人： Yi Li , Jia Liu , Anand Sistla , Bruce Joseph Elder , Yufeng Hong , Paul Kenneth Isbester , Grant Jackson Palmer , Jonathon Stuart Salsbury , Luckner Gerard Ulysse
IPC分类号： C07D413/14
CPC分类号： C07D413/14 , C07D405/12
摘要： The invention relates to salts and free base forms of N,2-dimethyl-6-[7-(2-morpholinoethoxy)quinolin-4-yloxy]benzofuran-3-carboxamide. The invention further relates to pharmaceutical compositions of these salts and free base forms and methods of treating disorders such as cancer using such compositions.
摘要翻译：本发明涉及N，2-二甲基-6- [7-（2-吗啉代乙氧基）喹啉-4-基氧基]苯并呋喃-3-甲酰胺的盐和游离碱形式。本发明进一步涉及这些盐和游离碱形式的药物组合物以及使用这种组合物治疗疾病如癌症的方法。

4. 发明申请

US20090048254A1 SALTS AND POLYMORPHS OF A VEGF-R INHIBITOR 失效
标题翻译： VEGF-R抑制剂的SALTS和POLYMORPHS
公开(公告)号：US20090048254A1
公开(公告)日：2009-02-19
申请号：US12063076
申请日：2006-07-27
申请人： Yi Li , Jia Liu , Anand Sistla , Bruce Joseph Elder , Yufeng Hong , Paul Kenneth Isbester , Grant Jackson Palmer , Jonathon Stuart Salsbury , Luckner Gerard Ulysse
发明人： Yi Li , Jia Liu , Anand Sistla , Bruce Joseph Elder , Yufeng Hong , Paul Kenneth Isbester , Grant Jackson Palmer , Jonathon Stuart Salsbury , Luckner Gerard Ulysse
IPC分类号： A61K31/5377 , C07D413/14 , A61P35/00
CPC分类号： C07D413/14 , C07D405/12
摘要： The invention relates to salts and free base forms of N,2-dimethyl-6-[7-(2-morpholinoethoxy)quinolin-4-yloxy]benzofuran-3-carboxamide. The invention further relates to pharmaceutical compositions of these salts and free base forms and methods of treating disorders such as cancer using such compositions.
摘要翻译：本发明涉及N，2-二甲基-6- [7-（2-吗啉代乙氧基）喹啉-4-基氧基]苯并呋喃-3-甲酰胺的盐和游离碱形式。本发明进一步涉及这些盐和游离碱形式的药物组合物以及使用这种组合物治疗疾病如癌症的方法。

5. 发明申请

US20090197867A1 ENANTIOMERICALLY ENRICHED IMIDAZOAZEPINONE COMPOUNDS 审中-公开
标题翻译：完全强化的咪唑啉酮化合物
公开(公告)号：US20090197867A1
公开(公告)日：2009-08-06
申请号：US12270892
申请日：2008-11-14
申请人： Mark Spyvee , Christina J. Shaffer , Boris M. Seletsky , Shawn Schiller , Jia Liu , Xiang-Yi Li , Qian Chen , Roch Boivin
发明人： Mark Spyvee , Christina J. Shaffer , Boris M. Seletsky , Shawn Schiller , Jia Liu , Xiang-Yi Li , Qian Chen , Roch Boivin
IPC分类号： A61K31/55 , C07D487/10 , A61P37/06
CPC分类号： C07D487/10
摘要： The present invention provides an enantiomerically pure compound of Formula I: along with pharmaceutical formulations containing the same and methods of use thereof.
摘要翻译：本发明提供对映异构体纯的式I化合物以及含有其的药物制剂及其使用方法。

6. 发明授权

US10508279B2 Recombinant Escherichia coli for high efficiency production of fructosylated chondroitin and method for making thereof 有权
公开(公告)号：US10508279B2
公开(公告)日：2019-12-17
申请号：US15891564
申请日：2018-02-08
申请人： Jing Wu , Quan Zhang , Liming Liu , Xiulai Chen , Jia Liu , Qiuling Luo
发明人： Jing Wu , Quan Zhang , Liming Liu , Xiulai Chen , Jia Liu , Qiuling Luo
IPC分类号： C12N1/20 , C12N15/70 , C12N9/10 , C12N9/90 , C12P19/24 , C12P19/26
摘要： The present invention relates to the field of biotechnology engineering. It provides a recombinant Escherichia coli that can produce fructosylated chondroitin with high yields and the method for constructing the recombinant strain. The present invention discloses a method for constructing an expression plasmid pETM6R1-RBS-glmM-GGGS-glmS that contains a glmM and a glmS gene under regulation of ribosome binding sites. The recombinant plasmid was transformed into E. coli K4 to obtain a recombinant E. coli strain ZQ33 that can produce fructosylated chondroitin up to 3.99 g·L−1 by fed-batch fermentation in a 5-L fermentor, which was increased by 108.90% compared to that of the wild type strain.

7. 发明授权

US09344204B2 Method, apparatus, and computer program product for adaptive relaying data distribution in wireless networks 有权
标题翻译：用于无线网络中自适应中继数据分发的方法，装置和计算机程序产品
公开(公告)号：US09344204B2
公开(公告)日：2016-05-17
申请号：US14381688
申请日：2012-04-05
申请人： Canfeng Chen , Jia Liu , Yongguang Guo , Mika Kasslin
发明人： Canfeng Chen , Jia Liu , Yongguang Guo , Mika Kasslin
IPC分类号： H04H20/08 , H04H20/71 , H04W40/22
CPC分类号： H04H20/08 , H04H20/71 , H04W40/22
摘要： Method, apparatus, and computer program product example embodiments enable data distribution in wireless communication networks. In example embodiments, a method comprises receiving a wireless broadcast message including a message ID and an associated distributor address; buffering the received wireless broadcast message and starting an observation window timer for the message if the message ID of the received wireless broadcast message is not stored in a database of message IDs and associated distributor addresses for previously received wireless broadcast messages; calculating a relaying probability for the received wireless broadcast message, based on a number of distributor address entries associated with the message ID in the database, the entries resulting from receiving other wireless broadcast messages having the same message ID during the observation window; transmitting the buffered message following termination of the observation window, based on the calculated relaying probability; and starting a cooling window timer upon termination of the observation window and removing all records containing the message ID from the database following termination of the cooling window.
摘要翻译：方法，装置和计算机程序产品示例实施例使能无线通信网络中的数据分发。在示例实施例中，一种方法包括接收包括消息ID和相关联的分配器地址的无线广播消息; 如果所接收的无线广播消息的消息ID未被存储在用于先前接收到的无线广播消息的消息ID和相关联的分配器地址的数据库中，则缓存所接收的无线广播消息并启动该消息的观察窗口定时器; 基于与数据库中的消息ID相关联的分配器地址条目的数量来计算所接收的无线广播消息的中继概率，在观察窗口期间从接收到具有相同消息ID的其他无线广播消息导致的条目; 基于所计算的中继概率，在观察窗口终止后发送缓冲消息; 并在观察窗口终止后启动冷却窗口计时器，并在冷却窗口终止后从数据库中删除包含消息ID的所有记录。

8. 发明授权

US09217423B2 Energy storage system using supercritical air 有权
标题翻译：储能系统采用超临界空气
公开(公告)号：US09217423B2
公开(公告)日：2015-12-22
申请号：US13508019
申请日：2010-08-31
申请人： Haisheng Chen , Chunqing Tan , Jia Liu , Yujie Xu
发明人： Haisheng Chen , Chunqing Tan , Jia Liu , Yujie Xu
IPC分类号： F15B1/027 , F03G7/06 , F01K3/00 , F25J3/04 , F25J1/00 , F25J1/02
CPC分类号： F03G7/06 , F01K3/004 , F01K5/02 , F01K7/22 , F25J1/0012 , F25J1/0037 , F25J1/0045 , F25J1/0228 , F25J1/0251 , F25J3/04018 , F25J3/04054 , F25J3/04084 , F25J3/04187 , F25J3/04193 , F25J3/04309 , F25J3/044 , F25J3/04581 , F25J3/04842 , F25J2205/24 , F25J2230/04 , F25J2230/08 , F25J2230/30 , F25J2240/10 , F25J2240/90 , F25J2245/90 , Y02E60/15
摘要： Disclosed is an energy storage system using supercritical air, comprising a compressor unit, a heat exchanger and storage device, a cold exchanger and storage device, a cryogenic tank, a throttling valve, at least one cryogenic pump, an expander unit, a generator, and a driver unit. There are several advantages of this invention, including high energy density, high efficiency, no storage cycle and geographical conditions restriction, easy implementation with all kinds of power stations, environment friendliness and capability of recycling low to medium temperature waste heat and so on.
摘要翻译：公开了一种使用超临界空气的能量存储系统，包括压缩机单元，热交换器和存储装置，冷交换器和存储装置，低温罐，节流阀，至少一个低温泵，膨胀器单元，发电机，和驱动单元。本发明有几个优点，包括高能量密度，高效率，无储存循环和地理条件限制，易于实施各种发电站，环境友好和回收中低温余热等能力。

9. 发明授权

US09187333B2 Carbon activation in a microwave fluidized bed process 有权
标题翻译：微波流化床工艺中的碳活化
公开(公告)号：US09187333B2
公开(公告)日：2015-11-17
申请号：US13590682
申请日：2012-08-21
申请人： Kishor Purushottam Gadkaree , Andrew Fleitz Husted , Naveen Kekre , Jia Liu
发明人： Kishor Purushottam Gadkaree , Andrew Fleitz Husted , Naveen Kekre , Jia Liu
IPC分类号： C01B31/08 , C01B31/10
CPC分类号： C01B31/10 , C01B32/336 , C01B32/366
摘要： A method for forming activated carbon from carbon feedstock involves forming particles of the carbon feedstock, introducing the carbon feedstock particles into a microwave reaction chamber and forming a fluidized bed of the particles within the chamber, introducing steam into the reaction chamber, and introducing microwaves into the reaction chamber to heat the particles using microwave energy and react the heated particles with the steam to form activated carbon.
摘要翻译：从碳原料形成活性炭的方法包括形成碳原料的颗粒，将碳原料颗粒引入微波反应室，并在室内形成颗粒的流化床，将蒸汽引入反应室，并将微波引入反应室用微波能加热颗粒，并使加热的颗粒与蒸汽反应形成活性炭。

10. 发明授权

US08942015B2 Control device and control method during bypassing of power units 有权
标题翻译：旁路动力装置时的控制装置及控制方法
公开(公告)号：US08942015B2
公开(公告)日：2015-01-27
申请号：US13619416
申请日：2012-09-14
申请人： Jia Liu , Yong-Qiang Lang , Yu-Yang Mao
发明人： Jia Liu , Yong-Qiang Lang , Yu-Yang Mao
IPC分类号： H02M7/49 , H02M1/32
CPC分类号： H02M7/49 , H02M1/32 , H02M2001/325
摘要： A control device and a control method during bypassing of power units are provided. The method includes: detecting a first three-phase output electrical signal; calculating a first positive sequence component and a first negative sequence component of the first three-phase output electrical signal; providing a given positive sequence component and a given negative sequence component so as to respectively perform the closed-loop compensation on the first positive sequence component and the first negative sequence component, thereby outputting a second positive sequence component and a second negative sequence component; superimposing the second positive sequence component and the second negative sequence component; and outputting a second three-phase output electrical signal in a preset way.
摘要翻译：提供了在旁路功率单元期间的控制装置和控制方法。该方法包括：检测第一三相输出电信号; 计算第一三相输出电信号的第一正序分量和第一负序分量; 提供给定的正序分量和给定的负序分量，以分别对第一正序分量和第一负序分量执行闭环补偿，从而输出第二正序分量和第二负序分量; 叠加第二正序分量和第二负序分量; 并以预设的方式输出第二三相输出电信号。

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