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1. 发明授权

US09102762B2 Virus filtration of liquid factor VII compositions 有权
标题翻译：液体因子VII组合物的病毒过滤
公开(公告)号：US09102762B2
公开(公告)日：2015-08-11
申请号：US13349980
申请日：2012-01-13
申请人： Jesper Christensen , Erik Halkjær , Turid Preuss , Thomas Budde Hansen , Lene Vædele Madsen Tomoda , Nina Johansen
发明人： Jesper Christensen , Erik Halkjær , Turid Preuss , Thomas Budde Hansen , Lene Vædele Madsen Tomoda , Nina Johansen
IPC分类号： C07K14/745 , C12N7/00 , C12N9/64
CPC分类号： C12N7/00 , C07K14/745 , C12N9/6437 , C12N2740/13063 , C12Y304/21021
摘要： The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).
摘要翻译：本发明涉及一种用于改善液体因子VII组合物，特别是包含活性因子VII多肽（因子VIIa多肽）的病毒安全性的新方法。

2. 发明申请

US20120115204A1 VIRUS FILTRATION OF LIQUID FACTOR VII COMPOSITIONS 有权
标题翻译：液体因子VII组成的病毒过滤
公开(公告)号：US20120115204A1
公开(公告)日：2012-05-10
申请号：US13349980
申请日：2012-01-13
申请人： Jesper Christensen , Erik Halkjaer , Turid Preuss , Thomas Budde Hansen , Lene Vaedele Madsen Tomoda , Nina Johansen
发明人： Jesper Christensen , Erik Halkjaer , Turid Preuss , Thomas Budde Hansen , Lene Vaedele Madsen Tomoda , Nina Johansen
IPC分类号： C12N9/50
CPC分类号： C12N7/00 , C07K14/745 , C12N9/6437 , C12N2740/13063 , C12Y304/21021
摘要： The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).
摘要翻译：本发明涉及一种用于改善液体因子VII组合物，特别是包含活性因子VII多肽（因子VIIa多肽）的病毒安全性的新方法。

3. 发明申请

US20080274534A1 Virus Filtration of Liquid Factor VII Compositions 审中-公开
标题翻译：液体因子VII组合物的病毒过滤
公开(公告)号：US20080274534A1
公开(公告)日：2008-11-06
申请号：US12173475
申请日：2008-07-15
申请人： Jesper Christensen , Erik Halkjaer , Turid Preuss , Thomas Budde Hansen , Lene Vaedele Madsen Tomoda , Nina Johansen
发明人： Jesper Christensen , Erik Halkjaer , Turid Preuss , Thomas Budde Hansen , Lene Vaedele Madsen Tomoda , Nina Johansen
IPC分类号： C12N7/06 , C07K1/34
CPC分类号： C12N7/00 , C07K14/745 , C12N9/6437 , C12N2740/13063 , C12Y304/21021
摘要： The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).
摘要翻译：本发明涉及一种用于改善液体因子VII组合物，特别是包含活性因子VII多肽（因子VIIa多肽）的病毒安全性的新方法。

4. 发明申请

US20070142625A1 Virus filtration of liquid Factor VII compositions 审中-公开
标题翻译：液体因子VII组合物的病毒过滤
公开(公告)号：US20070142625A1
公开(公告)日：2007-06-21
申请号：US11439828
申请日：2006-05-23
申请人： Jesper Christensen , Erik Halkjaer , Turid Preuss , Thomas Hansen , Lene Tomoda , Nina Johansen
发明人： Jesper Christensen , Erik Halkjaer , Turid Preuss , Thomas Hansen , Lene Tomoda , Nina Johansen
IPC分类号： C07K14/745
CPC分类号： C12N7/00 , C07K14/745 , C12N9/6437 , C12N2740/13063 , C12Y304/21021
摘要： The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).
摘要翻译：本发明涉及一种用于改善液体因子VII组合物，特别是包含活性因子VII多肽（因子VIIa多肽）的病毒安全性的新方法。

5. 发明申请

US20060027963A1 Golf game assembly and a method of playing a golf game on a board 审中-公开
标题翻译：高尔夫游戏组合和一种在棋盘上玩高尔夫游戏的方式
公开(公告)号：US20060027963A1
公开(公告)日：2006-02-09
申请号：US11187635
申请日：2005-07-22
申请人： Jesper Christensen , Mette Lisby
发明人： Jesper Christensen , Mette Lisby
IPC分类号： A63F3/00
CPC分类号： A63F3/0005 , A63F9/0641
摘要： A golf game assembly includes a game board representing a single hole of a golf course showing a tee, a fairway, a green, and hazards. A set of drive or stroke cards are provided for positioning on the board, each card representing possible drives or strokes performed with a specific golf club, and each having a first indication of a starting point and a plurality of second indications representing a specific drive or stroke of a specific length and direction from the starting point. A mechanism randomly generates an indication from among the plurality of second indications, and displays the randomly generated indication representing a player's drive or stroke from the starting point, and one or more transfer indicators for transferring to the board a drive or stroke indicated on a specific drive or stroke card positioned on the board and determined by the randomly generated indication.
摘要翻译：高尔夫游戏组件包括代表高尔夫球场的单孔的游戏板，显示出三通，球道，绿色和危险。提供一组驱动器或冲程卡以用于在板上定位，每个卡表示用特定高尔夫球杆执行的可能的驱动或冲程，并且每个卡具有起始点的第一指示和表示特定驱动器的多个第二指示，来自起点的特定长度和方向的行程。一种机构从多个第二指示中随机地生成指示，并且从起始点显示表示玩家的驱动或冲程的随机生成的指示，以及一个或多个转移指示符，用于将指定的特定驱动器或行程卡位于板上并由随机生成的指示确定。

6. 发明授权

US06180939B2 Method and apparatus for temperature compensation of measurements from a non-contact sensor 有权
标题翻译：用于从非接触传感器测量的温度补偿的方法和装置
公开(公告)号：US06180939B2
公开(公告)日：2001-01-30
申请号：US09205742
申请日：1998-12-04
申请人： Myles Markey, Jr. , Dale R. Greer , Stephen James Tenniswood , Jesper Christensen
发明人： Myles Markey, Jr. , Dale R. Greer , Stephen James Tenniswood , Jesper Christensen
IPC分类号： H01J724
CPC分类号： G01B5/0014
摘要： A temperature compensation system (300) is provided for compensating measurements from a sensor (240). A temperature transducer (310) is placed in close proximity to a manufacturing workstation as a means of measuring the ambient temperature associated with the workstation (200). A reference workpiece (100) is placed within a sensing zone of the sensor (240). The system (300) includes a temperature compensating module (320) that is connected to the sensor (240) and to the temperature transducer (310) for determining a baseline measurement of the reference workpiece at a reference temperature. The temperature compensating module (320) is further adapted for collecting a plurality of measurements of the reference workpiece over a plurality of temperatures for establishing a relationship between these measurements and their corresponding temperature values. In addition, a workpiece measuring module (330) is also connected to the sensor (240) and to the temperature transducer (310) for measuring a first workpiece at a first temperature, whereby the sensor measurement is compensated for temperature using this relationship. In this way, the temperature compensation system (300) compensates the sensor measurement for physical changes in any of the components of the workstation that are caused by fluctuations in ambient temperature. Rather than compensate for ambient temperature changes, the temperature compensation system (300) may also be adapted to compensate sensor measurements based on process driven temperature changes (i.e., a “hot” workpiece).
摘要翻译：提供了用于补偿来自传感器（240）的测量值的温度补偿系统（300）。作为测量与工作站（200）相关联的环境温度的手段，将温度传感器（310）放置在靠近制造工作站的位置。参考工件（100）被放置在传感器（240）的感测区域内。系统（300）包括连接到传感器（240）和温度传感器（310）的温度补偿模块（320），用于确定参考温度下的参考工件的基线测量。温度补偿模块（320）还适于在多个温度上收集参考工件的多个测量值，以建立这些测量值与它们对应的温度值之间的关系。此外，工件测量模块（330）还连接到传感器（240）和温度传感器（310），用于在第一温度下测量第一工件，由此使用该关系来补偿传感器测量温度。以这种方式，温度补偿系统（300）补偿由环境温度波动引起的工作站的任何部件的物理变化的传感器测量。温度补偿系统（300）也可以适应于基于过程驱动的温度变化（即，“热”工件））补偿传感器测量值而不是补偿环境温度变化。

7. 发明授权

US08420335B2 Inhibition of GASC1 有权
标题翻译：抑制GASC1
公开(公告)号：US08420335B2
公开(公告)日：2013-04-16
申请号：US12282485
申请日：2007-03-14
申请人： Paul Cloos , Karl Agger , Jesper Christensen , Klaus H. Hansen , Kristian Helin
发明人： Paul Cloos , Karl Agger , Jesper Christensen , Klaus H. Hansen , Kristian Helin
IPC分类号： G01N33/53 , G01N31/00
CPC分类号： C12Q1/48 , G01N33/6875 , G01N2333/91011 , G01N2500/00 , Y10T436/10
摘要： The present invention provides a method of testing the ability of a test compound to bind to and optionally modulate the activity of a protein of the JMJD2 subfamily of Jumonji proteins. The method comprises incubating a test compound with a protein of the JMJD2 subfamily of Jumonji proteins, a co-factor of said protein and, optionally, a substrate for demethylation. The method of the invention can be used for screening large numbers of compounds to identify a group of compounds that are candidate compounds for clinical use for treatment of certain cancers especially prostate cancers. Other compounds that do not have activity in the screening assays can be eliminated from further consideration as candidate compounds. The method of the invention therefore has utility in the pharmaceutical industry.
摘要翻译：本发明提供了测试化合物与Jumonji蛋白的JMJD2亚家族蛋白质结合并任选调节其活性的能力的方法。该方法包括将测试化合物与Jumonji蛋白的JMJD2亚族蛋白质的蛋白质，所述蛋白质的辅因子和任选的脱甲基化底物一起孵育。本发明的方法可用于筛选大量化合物以鉴定作为临床用于治疗某些癌症，特别是前列腺癌的候选化合物的一组化合物。在筛选测定中不具有活性的其它化合物可以从作为候选化合物的进一步考虑中消除。因此，本发明的方法在制药工业中具有效用。

8. 外观设计

USD574645S1 Chair back 有权
标题翻译：椅子回来
公开(公告)号：USD574645S1
公开(公告)日：2008-08-12
申请号：US29274559
申请日：2007-05-02
申请人： Jesper Christensen
设计人： Jesper Christensen

9. 发明申请

US20090162945A1 INHIBITION OF GASC1 有权
标题翻译： GASC1的抑制
公开(公告)号：US20090162945A1
公开(公告)日：2009-06-25
申请号：US12282485
申请日：2007-03-14
申请人： Paul Cloos , Karl Agger , Jesper Christensen , Klaus H. Hansen , Kristian Helin
发明人： Paul Cloos , Karl Agger , Jesper Christensen , Klaus H. Hansen , Kristian Helin
IPC分类号： G01N33/68 , G01N33/53
CPC分类号： C12Q1/48 , G01N33/6875 , G01N2333/91011 , G01N2500/00 , Y10T436/10
摘要： The present invention provides a method of testing the ability of a test compound to bind to and optionally modulate the activity of a protein of the JMJD2 subfamily of Jumonji proteins. The method comprises incubating a test compound with a protein of the JMJD2 subfamily of Jumonji proteins, a co-factor of said protein and, optionally, a substrate for demethylation. The method of the invention can be used for screening large numbers of compounds to identify a group of compounds that are candidate compounds for clinical use for treatment of certain cancers especially prostate cancers. Other compounds that do not have activity in the screening assays can be eliminated from further consideration as candidate compounds. The method of the invention therefore has utility in the pharmaceutical industry.
摘要翻译：本发明提供了测试化合物与Jumonji蛋白的JMJD2亚家族蛋白质结合并任选调节其活性的能力的方法。该方法包括将测试化合物与Jumonji蛋白的JMJD2亚族蛋白质的蛋白质，所述蛋白质的辅因子和任选的脱甲基化底物一起孵育。本发明的方法可用于筛选大量化合物以鉴定作为临床用于治疗某些癌症，特别是前列腺癌的候选化合物的一组化合物。在筛选测定中不具有活性的其它化合物可以从作为候选化合物的进一步考虑中消除。因此，本发明的方法在制药工业中具有效用。

10. 外观设计

USD594257S1 Chair back 有权
公开(公告)号：USD594257S1
公开(公告)日：2009-06-16
申请号：US29309996
申请日：2008-12-02
申请人： Jesper Christensen
设计人： Jesper Christensen

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