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1. 发明申请

US20110092824A1 MONITORING A VITAL PARAMETER OF A PATIENT WITH "IN-SITU" MODULATION SCHEME TO AVOID INTERFERENCE 有权
标题翻译：用“现场”调解方案监测患者的健康参数，避免干扰
公开(公告)号：US20110092824A1
公开(公告)日：2011-04-21
申请号：US12996991
申请日：2009-06-09
申请人： Jeroen Veen , Theodorus Petrus Henricus Gerardus Jansen , Henricus Renatus Martinus Verberne , Tim Corneel Wilhelmus Schenk , Lorenzo Feri
发明人： Jeroen Veen , Theodorus Petrus Henricus Gerardus Jansen , Henricus Renatus Martinus Verberne , Tim Corneel Wilhelmus Schenk , Lorenzo Feri
IPC分类号： A61B6/00
CPC分类号： A61B5/14551 , A61B5/0059
摘要： The invention relates to a method of monitoring a vital parameter of a patient by measuringattenuation of light emitted onto tissue of the patient, comprising the following steps: modulating the light with a modulation frequency or/and a modulation code; emitting the modulated light onto the tissue of the patient; collecting lightwhich is transmitted through the tissue or/and which is reflected from the tissue; demodulating the collected light; analyzing the demodulated collected light with regard to interference with ambient light; determining amodulation frequency or/and a modulation code for which interference with the ambient light is minimized or falls under a predefined threshold; and setting the modulation frequency or/and the modulation code for modulating the light according to the determined modulation frequency or/and a modulation code for which interference with the ambient light is minimized or falls under a predefined threshold. In this way a versatile and reliable possibility of monitoring a vital parameter of a patient with a high signal-to-interference ratio is provided.
摘要翻译：本发明涉及通过测量发射到患者组织上的光的测量来监测患者的重要参数的方法，包括以下步骤：用调制频率或/和调制码调制光; 将调制的光发射到患者的组织上; 收集透过组织的光和/或从组织反射的光; 解调收集的光; 分析与干扰环境光的解调收集的光; 确定调节频率或/和调节码，使对环境光的干扰最小化或落在预定阈值以下; 以及根据确定的调制频率设置用于调制光的调制频率或/和调制码，或/和用于使环境光的干扰最小化或落在预定阈值以下的调制码。以这种方式，提供了用于监视具有高信号与干扰比的患者的重要参数的通用且可靠的可能性。

2. 发明授权

US08447372B2 Monitoring a vital parameter of a patient with “in-situ” modulation scheme to avoid interference 有权
标题翻译：用“原地”调制方案监测患者的重要参数，以避免干扰
公开(公告)号：US08447372B2
公开(公告)日：2013-05-21
申请号：US12996991
申请日：2009-06-09
申请人： Jeroen Veen , Theodorus Petrus Henricus Gerardus Jansen , Henricus Renatus Martinus Verberne , Tim Corneel Wilhelmus Schenk , Lorenzo Feri
发明人： Jeroen Veen , Theodorus Petrus Henricus Gerardus Jansen , Henricus Renatus Martinus Verberne , Tim Corneel Wilhelmus Schenk , Lorenzo Feri
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/0059
摘要： The invention relates to a method of monitoring a vital parameter of a patient by measuring attenuation of light emitted onto tissue of the patient, comprising the following steps: modulating the light with a modulation frequency or/and a modulation code; emitting the modulated light onto the tissue of the patient; collecting light which is transmitted through the tissue or/and which is reflected from the tissue; demodulating the collected light; analyzing the demodulated collected light with regard to interference with ambient light; determining a modulation frequency or/and a modulation code for which interference with the ambient light is minimized or falls under a predefined threshold; and setting the modulation frequency or/and the modulation code for modulating the light according to the determined modulation frequency or/and a modulation code for which interference with the ambient light is minimized or falls under a predefined threshold. In this way a versatile and reliable possibility of monitoring a vital parameter of a patient with a high signal-to-interference ratio is provided.
摘要翻译：本发明涉及通过测量发射到患者组织上的光的衰减来监测患者的重要参数的方法，包括以下步骤：用调制频率或/和调制码调制光; 将调制的光发射到患者的组织上; 收集透过组织的光和/或从组织反射的光; 解调收集的光; 分析与干扰环境光的解调收集的光; 确定对环境光的干扰最小化或落在预定阈值以下的调制频率或/和调制码; 以及根据确定的调制频率设置用于调制光的调制频率或/和调制码，或/和用于使环境光的干扰最小化或落在预定阈值以下的调制码。以这种方式，提供了用于监视具有高信号与干扰比的患者的重要参数的通用且可靠的可能性。

3. 发明申请

US20080246471A1 Magnetic Sensor Device With Different Internal Operating Frequencies 审中-公开
标题翻译：具有不同内部工作频率的磁传感器装置
公开(公告)号：US20080246471A1
公开(公告)日：2008-10-09
申请号：US12089947
申请日：2006-09-29
申请人： Josephus Arnoldus Henricus Maria Kahlman , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
发明人： Josephus Arnoldus Henricus Maria Kahlman , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
IPC分类号： G01N15/06
CPC分类号： G01R33/09 , B82Y25/00 , G01N15/0656 , G01N27/745 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： The invention relates to a magnetic sensor device (10) comprising wires (11, 13) for the generation of a magnetic field with a first frequency f1 a GMR sensor (12) operated with an input current of a second frequency f2, and a demodulator (26) operated at a third frequency f3. In order to avoid signal corruption by phase noise and to improve the signal-to-noise ratio, the first, second and third frequencies are derived by a supply unit (121) from a common reference frequency fref. Said derivation may for example be achieved with the help of digital frequency dividers. Furthermore, phase detectors (PD1, PD2) may be used in a feedback control loop to assure predetermined relations between the phases of the three frequencies. In another embodiment of the invention, the phase and/or amplitude of a model signal, which is used to process a desired signal component in the output of the sensor, is tracked by an adaptation algorithm, for example a gradient descent.
摘要翻译：本发明涉及一种磁传感器装置（10），其包括用于产生具有第一频率f 1的磁场的导线（11,13），GMR传感器（12）用输入电流第二频率f 2 2和在第三频率f 3 3处操作的解调器（26）。为了避免相位噪声的信号损坏并提高信噪比，第一，第二和第三频率由供电单元（121）从公共参考频率f ref 。所述推导可以例如在数字分频器的帮助下实现。此外，相位检测器（PD1，PD2）可以用在反馈控制环路中，以确保三个频率的相位之间的预定关系。在本发明的另一个实施例中，用于处理传感器的输出中的期望信号分量的模型信号的相位和/或幅度由适应算法（例如梯度下降）来跟踪。

4. 发明申请

US20100060275A1 MAGNETIC SENSOR DEVICE WITH ROBUST SIGNAL PROCESSING 审中-公开
标题翻译：具有鲁棒信号处理的磁传感器装置
公开(公告)号：US20100060275A1
公开(公告)日：2010-03-11
申请号：US12518897
申请日：2007-12-14
申请人： Jeroen Veen , Theodorus Petrus Henricus Gerardus Jansen , Bart Michiel De Boer , Josephus Arnoldus Henricus Maria Kahlman
发明人： Jeroen Veen , Theodorus Petrus Henricus Gerardus Jansen , Bart Michiel De Boer , Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： G01R33/12
CPC分类号： G01R33/093 , B82Y25/00 , G01R33/1269
摘要： The invention relates to a magnetic sensor device (100) comprising a magnetic field generator (1) driven with an excitation current of a first frequency (f1) and a magnetic sensor element (e.g. a GIVER sensor (2)) driven with a sensor current (I2) of a second frequency (f2) for measuring reaction fields (HB) generated by magnetized particles (3). In an associated evaluation unit (10), a reference component (uQ) of the measurement signal (uGMR) is separated that depends on the excitation current (I1) and the sensor current (I2) but not on the presence of magnetized particles (3). The reference component (uQ) may particularly be produced by a combination of the self-magnetization (H2) of the magnetic sensor element (2) and cross-talk related currents. The reference component (uQ) may be isolated based on its phase with respect to a particle-dependent component of the measurement signal (uGMR) or based on its scaling with one of the current frequencies. Monitoring of the reference component (uQ) reveals variations in operating conditions, for example in the sensor gain, that can be used to calibrate the measurement results.
摘要翻译：本发明涉及一种磁传感器装置（100），其包括用第一频率（f1）的激励电流驱动的磁场发生器（1）和由传感器电流驱动的磁传感器元件（例如GIVER传感器（2））（I2），用于测量由磁化颗粒（3）产生的反应场（HB）的第二频率（f2）。在相关联的评估单元（10）中，测量信号（uGMR）的参考分量（uQ）被分离，其取决于激励电流（I1）和传感器电流（I2），但不依赖于磁化颗粒（3 ）。参考分量（uQ）可以特别地通过磁传感器元件（2）的自磁化（H2）和串扰相关电流的组合来产生。参考分量（uQ）可以基于其相对于测量信号（uGMR）的粒子相关分量的相位或者基于其与当前频率之一的比例来隔离。参考组件（uQ）的监视显示了可用于校准测量结果的操作条件的变化，例如传感器增益。

5. 发明申请

US20100001722A1 MAGNETIC SENSOR DEVICE WITH SUPPRESSION OF SPURIOUS SIGNAL COMPONENTS 审中-公开
标题翻译：具有抑制SPUIOUS信号组件的磁传感器装置
公开(公告)号：US20100001722A1
公开(公告)日：2010-01-07
申请号：US12518890
申请日：2007-12-12
申请人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen , Jeroen Veen
发明人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen , Jeroen Veen
IPC分类号： G01R33/02
CPC分类号： G01R33/093 , B82Y25/00 , G01R33/1269
摘要： The invention relates to a magnetic sensor device for the determination of magnetized particles (3) which comprises a magnetic field generator (1, 1′)(e.g. a conductor wire) that is driven with an excitation current (I1) of a first frequency (f1), and a magnetic sensor element (2) (e.g. a GMR resistance), that is driven with a sensor current (I2) of a second frequency (f2) for generating measurement signals (UGMR). A preprocessed signal (uf) is then generated from the measurement signal (UGMR) that comprises a predetermined frequency (Δf), and an evaluation unit (10) separates from this preprocessed signal a spurious component that does not depend on the presence of magnetized particles (3) in the sample chamber. The spurious component (UQ) may particularly be caused by self-magnetization (H2) of the magnetic sensor element (2) in combination with parasitic (capacitive or inductive) cross-talk. Furthermore, an unknown, variable phase-shift (φSP) in the preprocessed signal (uf) may be determined by varying the ratio between the spurious component and a particle-dependent target component. This variation may for example be achieved if, in an optimization stage (OS), the excitation current (I1) is conducted through a bypass resistor (R, R′) and/or if an additional capacitor is introduced between the magnetic field generator and the magnetic sensor element. The determined phase shift can then be used to adjust the phase of a demodulation signal (udem) such that the spurious component is suppressed.
摘要翻译：本发明涉及一种用于确定磁化颗粒（3）的磁传感器装置，该磁化颗粒包括由第一频率的激励电流（I1）驱动的磁场发生器（1,1'）（例如导线） f1）和由用于产生测量信号（UGMR）的第二频率（f2）的传感器电流（I2）驱动的磁传感器元件（2）（例如，GMR电阻）。然后从包括预定频率（Deltaf）的测量信号（UGMR）生成预处理信号（uf），并且评估单元（10）从该预处理信号中分离出不依赖于磁化颗粒的存在的杂散分量（3）。杂散分量（UQ）可以特别地由磁传感器元件（2）与寄生（电容或电感）串扰的自磁化（H2）引起。此外，预处理信号（uf）中的未知的可变相移（phiSP）可以通过改变杂散分量和粒子相关目标分量之间的比率来确定。例如，如果在优化级（OS）中通过旁路电阻（R，R'）传导励磁电流（I1）和/或如果在磁场发生器和磁传感元件。然后可以使用所确定的相移来调整解调信号（udem）的相位，使得抑制杂散分量。

6. 发明申请

US20090219012A1 MICROELECTRONIC SENSOR DEVICE FOR CONCENTRATION MEASUREMENTS 审中-公开
标题翻译：用于浓度测量的微电子传感器装置
公开(公告)号：US20090219012A1
公开(公告)日：2009-09-03
申请号：US12299698
申请日：2007-04-24
申请人： Jeroen Hans Nieuwenhuis , Hans Van Zon , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
发明人： Jeroen Hans Nieuwenhuis , Hans Van Zon , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
IPC分类号： G01N27/74
CPC分类号： G01R33/093 , B82Y25/00 , G01N27/745 , G01R33/1269
摘要： The invention relates to a method and a magnetic sensor device for the determination of the concentration of target particles (2) in a sample fluid, wherein the amount of the target particles (2) in a sensitive region (14) is observed by sampling measurement signals with associated sensor units (10a-10d). The target particles (2) may optionally be bound to binding sites (3) in the sensitive region, and a parametric binding curve, e.g. a Langmuir isotherm, may be fitted to the sampled measurement signals to determine the desired particle concentration in the sample. Moreover, parameters like the sampling rate and the size of the sensitive region (14) can be dynamically fitted during the ongoing sampling process to improve the signal-to-noise ratio. In another embodiment of the invention, single events corresponding to the movement of target particles into, out of, or within the sensitive region are detected and counted.
摘要翻译：本发明涉及一种用于确定样品流体中目标颗粒（2）的浓度的方法和磁传感器装置，其中通过采样测量观察敏感区域（14）中的目标颗粒（2）的量信号与相关联的传感器单元（10a-10d）。目标颗粒（2）可以任选地结合到敏感区域中的结合位点（3），参与结合曲线，例如， Langmuir等温线可以适应于采样的测量信号，以确定样品中所需的颗粒浓度。此外，在持续采样过程中，可以动态拟合诸如采样率和敏感区域（14）的尺寸的参数，以提高信噪比。在本发明的另一个实施例中，检测并计数与目标颗粒移动到敏感区域内部或之内的单个事件。

7. 发明授权

US08797028B2 Sensor device for target particles in a sample 有权
标题翻译：样品中目标颗粒的传感器装置
公开(公告)号：US08797028B2
公开(公告)日：2014-08-05
申请号：US12738317
申请日：2008-10-21
申请人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
发明人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
IPC分类号： G01R33/02 , G01N33/00 , G01N21/55
CPC分类号： G01N15/06 , G01N15/0656 , G01N2015/0693 , G01R33/1269
摘要： A sensor device and a method for the determination of the amount of target particles at a contact surface adjacent to a sample chamber include detecting, by a detector, the target particles in the sample chamber by a sensor element, and providing at least one corresponding sensor signal. An evaluation unit determines the amount of target particles in a first zone at the contracts surface and in a second zone a distance away from the contact surface based on this sensor signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions, such as wavelength and/or angle of incidence, may be used to extract information about the first and second zones. In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently in the first and second zone.
摘要翻译：用于确定与样品室相邻的接触表面处的目标颗粒的量的传感器装置和方法包括通过检测器通过传感器元件检测样品室中的目标颗粒，并且提供至少一个相应的传感器信号。评估单元基于该传感器信号确定在合同表面处的第一区域中的目标颗粒的量和距接触表面一定距离的第二区域中的目标颗粒的量。在光学测量方法中，可以使用在诸如波长和/或入射角的不同操作条件下发生的沮丧的全内反射来提取关于第一和第二区域的信息。在磁测量方法中，可以使用不同的磁激励场来在第一和第二区域中不同地激励磁性目标颗粒。

8. 发明申请

US20100259254A1 SENSOR DEVICE FOR TARGET PARTICLES IN A SAMPLE 有权
标题翻译：传感器装置在样品中的目标颗粒
公开(公告)号：US20100259254A1
公开(公告)日：2010-10-14
申请号：US12738317
申请日：2008-10-21
申请人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
发明人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
IPC分类号： G01R33/02 , G01N33/00 , G01N21/55
CPC分类号： G01N15/06 , G01N15/0656 , G01N2015/0693 , G01R33/1269
摘要： The invention relates to a sensor device (100) and a method for the determination of the amount of target particles (1) at a contact surface (112) adjacent to a sample chamber (2). Target particles (1) in the sample chamber are detected by a sensor element (SE) and at least one corresponding sensor-signal (s, s′) is provided. An evaluation unit (EU) then determines the amount of target particles (1) in a first zone (Z1) immediately at the contracts surface (112) and a second zone (Z2) a distance (z) away from the contact surface based on this sensor-signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions (e.g. wavelength, angle of incidence) may be used to extract information about the first and second zones (Z1, Z2). In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently in the first and second zone (Z2). Moreover, the temporal course of a sensor-signal (s, s′) can be evaluated, particularly with respect to stochastic movements of the target particles (1).
摘要翻译：本发明涉及一种传感器装置（100）和用于确定在与样品室（2）相邻的接触表面（112）处的目标颗粒（1）的量的方法。通过传感器元件（SE）检测样品室中的目标颗粒（1），并提供至少一个对应的传感器信号（s，s'）。然后，评估单元（EU）基于紧接表面（112）立即确定第一区域（Z1）中的目标颗粒（1）的数量和远离接触表面的距离（z）的第二区域（Z2），基于这个传感器信号。在光学测量方法中，可以使用在不同操作条件（例如波长，入射角）下发生的沮丧的全内反射来提取关于第一和第二区（Z1，Z2）的信息。在磁测量方法中，可以使用不同的磁激励场来在第一和第二区（Z2）中不同地激励磁目标颗粒。此外，可以评估传感器信号（s，s'）的时间过程，特别是关于目标颗粒（1）的随机运动。

9. 发明申请

US20100231213A1 MAGNETORESISTIVE SENSOR AS TEMPERATURE SENSOR 审中-公开
标题翻译：磁传感器作为温度传感器
公开(公告)号：US20100231213A1
公开(公告)日：2010-09-16
申请号：US12294479
申请日：2007-03-23
申请人： Jeroen Hans Nieuwenhuis , Theodorus Petrus Henricus Gerardus Jansen , Jeroen Veen , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink
发明人： Jeroen Hans Nieuwenhuis , Theodorus Petrus Henricus Gerardus Jansen , Jeroen Veen , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink
IPC分类号： G01R33/02
CPC分类号： G01R33/09 , B82Y25/00 , G01R33/007 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： A detection system (100, 150) for qualitative or quantitative detection of a magnetic field property of a modulated magnetic field is described. The modulated magnetic field may e.g. stem from an adjacent electrical current (Iadj) or magnetic particles. The detection system (100, 150) comprises at least one magneto resistive sensor element (102), a current controller (104) for providing a sensing current (Isense) flowing through the magnetic sensor element (102) and a controlling means (108). The controlling means (108) is adapted for deriving at a first frequency f1 a temperature-related parameter of the at least one magneto resistive sensor. The controlling means (108) furthermore is adapted for deriving a qualitative or quantitative characteristic of the adjacent electrical current (Iadj) or magnetic particles, taking into account the derived temperature-related parameter. This second frequency (f1) is different from the first frequency (f1}). The invention also relates to a corresponding method.
摘要翻译：描述了用于定性或定量检测调制磁场的磁场特性的检测系统（100,150）。调制磁场可以例如。来自相邻的电流（Iadj）或磁性颗粒。检测系统（100,150）包括至少一个磁阻传感器元件（102），用于提供流过磁传感器元件（102）的感测电流（Isense）的电流控制器（104）和控制装置（108）。控制装置（108）适于以第一频率f1导出至少一个磁阻传感器的温度相关参数。此外，控制装置（108）还适于导出相邻电流（Iadj）或磁性颗粒的定性或定量特性，同时考虑导出的温度相关参数。该第二频率（f1）与第一频率（f1）不同。本发明还涉及相应的方法。

10. 发明申请

US20130109030A1 EXAMINATION SYSTEM WITH SAMPLE INCUBATION 审中-公开
标题翻译：检验系统与样本孵化
公开(公告)号：US20130109030A1
公开(公告)日：2013-05-02
申请号：US13808125
申请日：2011-07-04
申请人： Wilhelmina Maria Hardeman , Toon Hendrik Evers , Theodorus Petrus Henricus Gerardus Jansen
发明人： Wilhelmina Maria Hardeman , Toon Hendrik Evers , Theodorus Petrus Henricus Gerardus Jansen
IPC分类号： G01N21/75
CPC分类号： G01N21/75 , B01L3/502715 , B01L2200/027 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2400/0406 , B01L2400/0487 , G01N33/54366
摘要： The invention relates to a cartridge(10) and its use in an examination apparatus(100). A sample(1) can be introduced into an inlet(11) of the cartridge(10) and conducted through a channel(12) to a reaction chamber(13). In the reaction chamber(13), an examination of the sample takes place, for example by frustrated total internal reflection. An agent(21) is applied to the sample close to the inlet(11), wherein said agent(21) is preferably stored in a reservoir(16) at the inlet(11). In this way the filling time of the reaction chamber(13) is simultaneously used for the incubation of the sample with the agent(21). Moreover, the filling-course of the cartridge and/or the reaction chamber may preferably be determined and taken into account during the execution of the examination and/or the evaluation of the results.
摘要翻译：本发明涉及一种盒（10）及其在检查装置（100）中的应用。样品（1）可以被引入到药筒（10）的入口（11）中并且通过通道（12）传导到反应室（13）。在反应室（13）中，例如通过沮丧的全内反射来检查样品。将试剂（21）施加到靠近入口（11）的样品上，其中所述试剂（21）优选储存在入口（11）处的储存器（16）中。以这种方式，反应室（13）的填充时间同时用于样品与试剂（21）的孵育。此外，可以在执行检查和/或评估结果期间优选地确定和考虑盒和/或反应室的填充过程。

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