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    • 3. 发明授权
    • Method and apparatus for near well structural modeling based on borehole dips
    • 基于钻孔倾角近井结构建模的方法和装置
    • US08793113B2
    • 2014-07-29
    • US12966716
    • 2010-12-13
    • Philippe MarzaArnaud EtchecoparKang WangMi ZhouShiduo Yang
    • Philippe MarzaArnaud EtchecoparKang WangMi ZhouShiduo Yang
    • G06G7/48
    • G06T17/05G01V1/301G01V1/50G01V2210/643G01V2210/665
    • A method for structure modeling of a formation penetrated by multiple wells includes obtaining borehole dips from borehole measurements; filtering the borehole dips based on a dip sequence analysis; computing structural dips based on the filtered dips; computing structural delineation by using the structural dips; projecting the structural dips to horizon point sets based on the structural delineation; and generating stratigraphic surfaces by mapping the projected horizon point sets. A system for structure modeling of a formation penetrated by multiple wells includes a processor and a memory that store a program having instructions for: obtaining borehole dips from borehole measurements; filtering the borehole dips based on a dip sequence analysis; computing structural dips based on the filtered dips; computing structural delineation by using the structural dips; projecting the structural dips to horizon point sets based on the structural delineation; and generating stratigraphic surfaces by mapping the projected horizon point sets.
    • 由多个井渗透的地层的结构建模方法包括从钻孔测量获得钻孔倾角; 基于dip序列分析过滤井眼凹陷; 基于过滤的倾倒计算结构倾斜; 通过结构性倾斜计算结构划分; 根据结构性划分将结构倾斜预测为水平点集; 并通过映射投影的水平点集来产生地层表面。 用于由多个井渗透的地层的结构建模的系统包括处理器和存储器,其存储具有以下指令的程序的存储器:从井眼测量获得钻孔倾斜; 基于dip序列分析过滤井眼凹陷; 基于过滤的倾倒计算结构倾斜; 通过结构性倾斜计算结构划分; 根据结构性划分将结构倾斜预测为水平点集; 并通过映射投影的水平点集来产生地层表面。
    • 4. 发明申请
    • CAPACITIVE MORPHOLINO DIAGNOSTICS FOR ANALYSIS OF NUCLEIC ACIDS
    • 用于核酸分析的电容性多元醇诊断
    • US20120211375A1
    • 2012-08-23
    • US13423228
    • 2012-03-18
    • Rastislav LevickyNapoleon TerceroKang WangPing GongKenneth Shepard
    • Rastislav LevickyNapoleon TerceroKang WangPing GongKenneth Shepard
    • G01N33/50G01N27/26
    • C12Q1/6825Y10T436/143333C12Q2525/113
    • Use of Morpholinos, a class of uncharged DNA analogues, for surface-hybridization applications. Monolayers of Morpholino probes on gold supports are fabricated with methods similar to those employed with DNA, and are used to hybridize efficiently and sequence-specifically with target strands. Hybridization-induced changes in the interfacial charge organization are analyzed with electrochemical methods and compared for Morpholino and DNA probe monolayers. Molecular mechanisms connecting surface hybridization state to the interfacial capacitance are identified and interpreted through comparison to numerical Poisson-Boltzmann calculations. Positive as well as negative capacitive responses (contrast inversion) to hybridization are possible, depending on surface populations of mobile ions as controlled by the applied potential. Quantitative comparison of surface capacitance with target coverage (targets/area) reveals a near-linear relationship, and demonstrates sensitivities (limits of quantification) in the pg mm−2 range.
    • 使用Morpholinos,一类不带电荷的DNA类似物,用于表面杂交应用。 使用类似于DNA使用的方法制备金支持物上的Morpholino探针的单层,并且用于与靶链有效地和序列特异性地杂交。 用电化学方法分析杂交诱导的界面电荷组织变化,并比较Morpholino和DNA探针单层。 通过与数值泊松 - 玻尔兹曼计算进行比较,可以确定和解释连接表面杂交态与界面电容的分子机制。 取决于由施加电位控制的移动离子的表面种群,对于杂交,阳性以及负电容反应(对比反转)是可能的。 表面电容与目标覆盖(目标/面积)的定量比较显示近似线性关系,并显示pg mm-2范围内的灵敏度(定量限度)。
    • 6. 发明申请
    • TELEGRAPH SIGNAL MICROSCOPY DEVICE AND METHOD
    • 电视信号显微镜装置及方法
    • US20060231754A1
    • 2006-10-19
    • US11279540
    • 2006-04-12
    • Kang WangFei Liu
    • Kang WangFei Liu
    • G21K7/00
    • G01Q60/48G01Q70/12Y10S977/84Y10S977/849Y10S977/86Y10S977/875Y10S977/876
    • A microscope device includes a probe having a dielectric material with a first side and a second side. First and second electrodes are disposed on the first side of the dielectric material. A nanotube connects the first and second electrodes. A gate electrode is disposed on the second side (e.g., backside) of the dielectric material. The device includes a stage adapted for holding a sample. The stage and probe are moveable with respect to one another such that the sample can be brought in close proximity to the nanotube. The device further includes current measurement circuitry for measuring current (e.g., Random Telegraph Signals) passing through the nanotube. The microscope device is able to identify and characterize single defects on the molecular or atomic scale. The probe device may be combined with spin resonance and/or optical systems such that the detection/mapping/manipulate of single spin and single photon could be achieved.
    • 显微镜装置包括具有第一侧和第二侧的电介质材料的探针。 第一和第二电极设置在电介质材料的第一侧上。 纳米管连接第一和第二电极。 栅电极设置在电介质材料的第二侧(例如背面)上。 该装置包括适于容纳样品的台。 阶段和探针可以相对于彼此移动,使得样品可以靠近纳米管。 该装置还包括用于测量通过纳米管的电流(例如,随机电报信号)的电流测量电路。 显微镜装置能够识别和表征分子或原子尺度上的单一缺陷。 探针装置可以与自旋共振和/或光学系统组合,使得可以实现单个旋转和单个光子的检测/映射/操纵。
    • 8. 发明申请
    • SYSTEM AND METHOD FOR PROVIDING CLINICAL DECISION SUPPORT
    • 提供临床决策支持的系统和方法
    • US20140025393A1
    • 2014-01-23
    • US13942925
    • 2013-07-16
    • Kang WangWilson S. WongDmitry Berdichevsky
    • Kang WangWilson S. WongDmitry Berdichevsky
    • G06F19/00
    • G16H50/70G16H50/20
    • A clinical decision support system comprises a memory device having a plurality of routines stored therein, a processor configured to execute the plurality of routines stored in the memory device, the plurality of routines comprising a routine configured to receive primary clinical information from a user associated with a patient, a routine configured to derive expanded clinical information from the user-provided primary clinical information, a routine configured to identify relevant rules from a data store based on the user-provided clinical information and the expanded clinical information, a routine configured to compute a diagnostic relevancy score for each of the identified relevant rules; a routine configured to assign by the processing device the computed diagnostic relevancy score to each identified relevant rule, and a routine configured to display each identified rule in ranked order based on the rule's assigned diagnostic relevancy score.
    • 临床决策支持系统包括具有存储在其中的多个例程的存储器设备,配置为执行存储在存储器设备中的多个例程的处理器,所述多个例程包括被配置为从与用户相关联的用户接收主要临床信息的例程 患者,被配置为从所述用户提供的主要临床信息中导出扩展的临床信息的例程,被配置为基于所述用户提供的临床信息和所述扩展的临床信息从数据存储区识别相关规则的例程,所述例程被配置为计算 每个确定的相关规则的诊断相关性得分; 配置为由处理装置将计算出的诊断相关性分数分配给每个识别的相关规则的例程,以及被配置为基于规则的分配的诊断相关性得分以排序的顺序显示每个识别的规则的例程。
    • 10. 发明申请
    • CAPACITIVE MORPHOLINO DIAGNOSTICS FOR ANALYSIS OF NUCLEIC ACIDS
    • 用于核酸分析的电容性多元醇诊断
    • US20100187133A1
    • 2010-07-29
    • US12362071
    • 2009-01-29
    • Rastislav LevickyNapoleon TerceroKang WangPing GongKenneth Shepard
    • Rastislav LevickyNapoleon TerceroKang WangPing GongKenneth Shepard
    • G01N27/26
    • C12Q1/6825Y10T436/143333C12Q2525/113
    • Surface hybridization, a reaction in which nucleic acid molecules in solution react with nucleic acid partners immobilized on a surface, is widely practiced in life science research. In these applications the immobilized partner, or “probe”, is typically single-stranded DNA. Because DNA is strongly charged, high salt conditions are required to enable binding between analyte nucleic acids (“targets”) in solution and the DNA probes. High salt, however, compromises prospects for label-free monitoring or control of the hybridization reaction through surface electric fields, as well as stabilizes secondary structure in target species that can interfere with probe-target recognition. In this work, initial steps toward addressing these challenges are taken by introducing Morpholinos, a class of uncharged DNA analogues, for surface-hybridization applications. Monolayers of Morpholino probes on gold supports can be fabricated with methods similar to those employed with DNA, and are shown to hybridize efficiently and sequence-specifically with target strands. Hybridization-induced changes in the interfacial charge organization are analyzed with electrochemical methods and compared for Morpholino and DNA probe monolayers. Molecular mechanisms connecting surface hybridization state to the interfacial capacitance are identified and interpreted through comparison to numerical Poisson-Boltzmann calculations. Interestingly, positive as well as negative capacitive responses (contrast inversion) to hybridization are possible, depending on surface populations of mobile ions as controlled by the applied potential. Quantitative comparison of surface capacitance with target coverage (targets/area) reveals a near-linear relationship, and demonstrates sensitivities (limits of quantification) in the pg mm−2 range.
    • 表面杂交,其中溶液中的核酸分子与固定在表面上的核酸配偶体反应的反应在生命科学研究中广泛应用。 在这些应用中,固定化的配偶体或“探针”通常是单链DNA。 由于DNA是强电荷的,因此需要高盐条件才能使溶液中的分析物核酸(“靶”)与DNA探针结合。 然而,高盐不利于通过表面电场进行无标记监测或控制杂交反应的前景,以及稳定可能干扰探针 - 目标识别的靶物种中的二级结构。 在这项工作中,通过引入Morpholinos(一类不带电荷的DNA类似物)进行表面杂交应用来采取解决这些挑战的最初步骤。 可以用与DNA一起使用的方法类似的方法制备金载体上的Morpholino探针的单层,并且显示与靶链有效地并且序列特异性地杂交。 用电化学方法分析杂交诱导的界面电荷组织变化,并比较Morpholino和DNA探针单层。 通过与数值泊松 - 玻尔兹曼计算进行比较,可以确定和解释连接表面杂交态与界面电容的分子机制。 有趣的是,取决于由施加电位控制的移动离子的表面种群,杂交的阳性和负电容反应(对比反转)是可能的。 表面电容与目标覆盖(目标/面积)的定量比较显示近似线性关系,并显示pg mm-2范围内的灵敏度(定量限度)。