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1. 发明申请

US20120070895A1 METHOD AND APPARATUS FOR SUSTAINING VIABILITY OF BIOLOGICAL CELLS ON A SUBSTRATE 有权
标题翻译：用于维持生物细胞在基底上的可行性的方法和装置
公开(公告)号：US20120070895A1
公开(公告)日：2012-03-22
申请号：US13305134
申请日：2011-11-28
申请人： Timothy E. McKnight , Anatoli V. Melechko , Michael L. Simpson
发明人： Timothy E. McKnight , Anatoli V. Melechko , Michael L. Simpson
IPC分类号： C12N5/071 , B82Y5/00
CPC分类号： B01L3/02 , Y10S977/876
摘要： A method for the transient transformation of a living biological cell having an intact cell membrane defining an intracellular domain, and an apparatus for the transient transformation of biological cells. The method and apparatus include introducing a compartmentalized extracellular component fixedly attached to a cellular penetrant structure to the intracellular domain of the cell, wherein the cell is fixed in a predetermined location and wherein the component is expressed within in the cell while being retained within the compartment and wherein the compartment restricts the mobility and interactions of the component within the cell and prevents transference of the component to the cell.
摘要翻译：用于瞬时转化具有限定细胞内结构域的完整细胞膜的活的生物细胞的方法和用于瞬时转化生物细胞的装置。所述方法和装置包括将固定连接到细胞渗透结构的分隔的细胞外组分引入细胞的细胞内结构域，其中细胞被固定在预定位置，并且其中所述成分在细胞内表达，同时被保留在隔室内并且其中所述隔室限制所述部件在所述电池内的移动性和相互作用并且防止所述部件移动到所述电池。

2. 发明授权

US07543482B2 Carbon thin line probe 有权
标题翻译：碳细线探头
公开(公告)号：US07543482B2
公开(公告)日：2009-06-09
申请号：US11710974
申请日：2007-02-27
申请人： Masashi Kitazawa , Masaki Tanemura , Junya Tanaka , Tatsuhiko Okita
发明人： Masashi Kitazawa , Masaki Tanemura , Junya Tanaka , Tatsuhiko Okita
IPC分类号： G12B21/08 , B82B1/00
CPC分类号： G01Q70/12 , C12N15/89 , G01Q60/54 , Y10S977/86 , Y10S977/863 , Y10S977/875 , Y10S977/876 , Y10S977/879
摘要： A carbon thin line probe having a carbon thin line selectively formed at a projection-like terminal end portion thereof by means of an irradiation of high-energy beam, the carbon thin line internally containing a metal. Thereby achieved is a carbon thin line probe suitable for example for the probe of SPM cantilever, which has a high aspect ratio and high durability and reliability, capability of batch processing based on a simple manufacturing method, and to which magnetic characteristic can be imparted.
摘要翻译：一种碳细线探针，其具有通过高能束的照射在其突起状端部选择性地形成的碳细线，所述碳细线在内部含有金属。由此实现了适用于例如SPM悬臂的探针的碳细线探针，其具有高纵横比和高耐久性和可靠性，基于简单制造方法的批处理能力，并且可赋予其磁特性。

3. 发明授权

US07538015B2 Method of manufacturing micro structure, and method of manufacturing mold material 失效
标题翻译：微结构的制造方法和模具材料的制造方法
公开(公告)号：US07538015B2
公开(公告)日：2009-05-26
申请号：US10540637
申请日：2003-11-25
申请人： Koji Kadono , Yosuke Murakami
发明人： Koji Kadono , Yosuke Murakami
IPC分类号： H01L21/00 , B82B1/00 , B82B3/00 , H01J9/02 , C01B31/02
CPC分类号： C30B25/18 , B01J37/34 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C01B32/162 , C01B32/18 , C30B29/02 , C30B29/602 , G11C2213/81 , H01J9/025 , Y10S977/842 , Y10S977/876 , Y10S977/893
摘要： Disclosed herein are a method of producing microstructure and a method of producing mold, the methods permitting production of much smaller pores than before in an atmosphere where impurities are negligible and also permitting production of microstructures having a smaller size and a higher crystallinity than before with the help of the pores. The method of producing microstructure comprises a step of making pores (4) in a substrate (1) to become a mold (5) by irradiation with a focused energy beam (3) and a step of growing a microstructure (8) in the thus made pores (4). The method of producing a mold includes a step of making pores (4) by irradiating a substrate (1) to become a mold (5) with a focused energy beam (3).
摘要翻译：本文公开了一种生产微结构的方法和一种生产模具的方法，该方法允许在杂质可忽略的气氛中生产比以前更小的孔，并且还允许生产具有比以前更小的尺寸和更高的结晶度的微结构帮助毛孔。生产微结构的方法包括通过用聚焦能量束（3）照射和在其中生长微结构（8）的步骤，使基底（1）中的孔（4）变成模具（5）的步骤制成毛孔（4）。制造模具的方法包括通过用聚焦能量束（3）照射基板（1）成为模具（5）来制造孔（4）的步骤。

4. 发明申请

US20080171386A1 METHOD AND APPARATUS FOR SUSTAINING VIABILITY OF BIOLOGICAL CELLS ON A SUBSTRATE 有权
标题翻译：用于维持生物细胞在基底上的可行性的方法和装置
公开(公告)号：US20080171386A1
公开(公告)日：2008-07-17
申请号：US11624040
申请日：2007-01-17
申请人： Timothy E. McKnight , Anatoli V. Melechko , Michael L. Simpson
发明人： Timothy E. McKnight , Anatoli V. Melechko , Michael L. Simpson
IPC分类号： C12M1/26 , C12N5/02
CPC分类号： B01L3/02 , Y10S977/876
摘要： A method for the transient transformation of a living biological cell having an intact cell membrane defining an intracellular domain, and an apparatus for the transient transformation of biological cells. The method and apparatus include introducing a compartmentalized extracellular component fixedly attached to a cellular penetrant structure to the intracellular domain of the cell, wherein the cell is fixed in a predetermined location and wherein the component is expressed within in the cell while being retained within the compartment and wherein the compartment restricts the mobility and interactions of the component within the cell and prevents transference of the component to the cell.
摘要翻译：用于瞬时转化具有限定细胞内结构域的完整细胞膜的活的生物细胞的方法和用于瞬时转化生物细胞的装置。所述方法和装置包括将固定连接到细胞渗透结构的分隔的细胞外组分引入细胞的细胞内结构域，其中细胞被固定在预定位置，并且其中所述成分在细胞内表达，同时被保留在隔室内并且其中所述隔室限制所述部件在所述电池内的移动性和相互作用并且防止所述部件移动到所述电池。

5. 发明申请

US20070240516A1 Self-sensing tweezer devices and associated methods for micro and nano-scale manipulation and assembly 失效
标题翻译：自我感应镊子装置及其相关方法用于微型和纳米尺度的操纵和装配
公开(公告)号：US20070240516A1
公开(公告)日：2007-10-18
申请号：US11818669
申请日：2007-06-15
申请人： Marcin Bauza , Shane Woody , Stuart Smith
发明人： Marcin Bauza , Shane Woody , Stuart Smith
IPC分类号： G12B21/20
CPC分类号： B25J7/00 , B25J15/022 , B25J15/10 , G01Q80/00 , Y10S977/849 , Y10S977/85 , Y10S977/851 , Y10S977/86 , Y10S977/863 , Y10S977/872 , Y10S977/873 , Y10S977/876 , Y10S977/88
摘要： The present invention provides a self-sensing tweezer device for micro and nano-scale manipulation, assembly, and surface modification, including: one or more elongated beams disposed in a first configuration; one or more oscillators coupled to the one or more elongated beams, wherein the one or more oscillators are operable for selectively oscillating the one or more elongated beams to form one or more “virtual” probe tips; and an actuator coupled to the one or more elongated beams, wherein the actuator is operable for selectively actuating the one or more elongated beams from the first configuration to a second configuration.
摘要翻译：本发明提供一种用于微尺度和纳米尺度操纵，组装和表面改性的自感镊子装置，包括：一个或多个沿第一构型设置的细长梁; 耦合到所述一个或多个细长波束的一个或多个振荡器，其中所述一个或多个振荡器可操作用于选择性地振荡所述一个或多个细长波束以形成一个或多个“虚拟”探针尖端; 以及联接到所述一个或多个细长梁的致动器，其中所述致动器可操作以选择性地将所述一个或多个细长梁从所述第一构型激活到第二构型。

6. 发明申请

US20060231754A1 TELEGRAPH SIGNAL MICROSCOPY DEVICE AND METHOD 有权
标题翻译：电视信号显微镜装置及方法
公开(公告)号：US20060231754A1
公开(公告)日：2006-10-19
申请号：US11279540
申请日：2006-04-12
申请人： Kang Wang , Fei Liu
发明人： Kang Wang , Fei Liu
IPC分类号： G21K7/00
CPC分类号： G01Q60/48 , G01Q70/12 , Y10S977/84 , Y10S977/849 , Y10S977/86 , Y10S977/875 , Y10S977/876
摘要： A microscope device includes a probe having a dielectric material with a first side and a second side. First and second electrodes are disposed on the first side of the dielectric material. A nanotube connects the first and second electrodes. A gate electrode is disposed on the second side (e.g., backside) of the dielectric material. The device includes a stage adapted for holding a sample. The stage and probe are moveable with respect to one another such that the sample can be brought in close proximity to the nanotube. The device further includes current measurement circuitry for measuring current (e.g., Random Telegraph Signals) passing through the nanotube. The microscope device is able to identify and characterize single defects on the molecular or atomic scale. The probe device may be combined with spin resonance and/or optical systems such that the detection/mapping/manipulate of single spin and single photon could be achieved.
摘要翻译：显微镜装置包括具有第一侧和第二侧的电介质材料的探针。第一和第二电极设置在电介质材料的第一侧上。纳米管连接第一和第二电极。栅电极设置在电介质材料的第二侧（例如背面）上。该装置包括适于容纳样品的台。阶段和探针可以相对于彼此移动，使得样品可以靠近纳米管。该装置还包括用于测量通过纳米管的电流（例如，随机电报信号）的电流测量电路。显微镜装置能够识别和表征分子或原子尺度上的单一缺陷。探针装置可以与自旋共振和/或光学系统组合，使得可以实现单个旋转和单个光子的检测/映射/操纵。

7. 发明授权

US07064341B2 Coated nanotube surface signal probe 失效
标题翻译：涂层纳米管表面信号探针
公开(公告)号：US07064341B2
公开(公告)日：2006-06-20
申请号：US10793531
申请日：2004-03-04
申请人： Yoshikazu Nakayama , Akio Harada , Seiji Akita
发明人： Yoshikazu Nakayama , Akio Harada , Seiji Akita
IPC分类号： G21G5/00
CPC分类号： G01Q60/16 , G01Q60/38 , G01Q60/54 , G01Q70/12 , Y10S977/869 , Y10S977/873 , Y10S977/876
摘要： The coated nanotube surface signal probe constructed from a nanotube, a holder which holds the nanotube, a coating film fastening a base end portion of the nanotube to a surface of the holder by way of adhering the base end portion on the surface of holder in a range of a base end portion length with an electric contact state and covering a specified region including the base end portion with the coating film maintaining the electric contact state between the nanotube and the holder, a tip end portion of the nanotube being caused to protrude from the holder; and the tip end portion is used as a probe needle so as to scan surface signals. The coated nanotube surface signal probe can be used as a probe in AFM (Atomic Force Microscope), STM (Scanning Tunneling Microscope) other SPM (Scanning Probe Microscope).
摘要翻译：由纳米管构成的涂覆的纳米管表面信号探针，保持纳米管的保持器，通过将基座端部粘附在保持器的表面上的涂膜将纳米管的基端部固定在保持器的表面上具有电接触状态的基端部长度的范围，并且覆盖包括基端部的规定区域，所述涂膜保持纳米管和保持器之间的电接触状态，使纳米管的前端部从持有人并且使用尖端部作为探针，以扫描表面信号。涂覆的纳米管表面信号探针可用作AFM（原子力显微镜），STM（扫描隧道显微镜）其他SPM（扫描探针显微镜）中的探针。

8. 发明申请

US20060102271A1 Apparatus for and method of bonding nano-tip using electrochemical etching 有权
标题翻译：使用电化学蚀刻将纳米尖端结合的装置和方法
公开(公告)号：US20060102271A1
公开(公告)日：2006-05-18
申请号：US11138772
申请日：2005-05-26
申请人： Soo Kim , Jun Lee , Jai Choi , Gyung Kang
发明人： Soo Kim , Jun Lee , Jai Choi , Gyung Kang
IPC分类号： B32B37/00 , B32B38/00 , B27G11/02
CPC分类号： G01Q70/12 , Y10S977/851 , Y10S977/856 , Y10S977/876 , Y10S977/882 , Y10S977/896
摘要： Disclosed herein are an apparatus for and a method of bonding a nano-tip using electrochemical etching, in which a good bonding stability can be provided. The nano-tip bonding apparatus comprises a glass plate having a top surface of a certain desired area. An electrolytic solution having conductivity is placed on the top surface of the glass plate by means of surface tension. Means for moving reciprocally a base material having conductivity in opposite direction is provided. A carbon nano-tube is adhered to a pointed tip of the base material by means of an adhesive. An end portion of the carbon nano-tube is to be immersed in the electrolytic solution. A power supply is provided for applying an electric power to the electrolytic solution and the base material.
摘要翻译：本文公开了一种使用电化学蚀刻来接合纳米尖端的装置和方法，其中可以提供良好的接合稳定性。纳米尖端接合装置包括具有一定期望面积的顶面的玻璃板。具有导电性的电解液通过表面张力放置在玻璃板的顶表面上。提供了用于相反方向移动具有相反方向的导电性的基材的装置。通过粘合剂将碳纳米管粘附到基材的尖端。将碳纳米管的端部浸入电解液中。提供电源以向电解液和基材施加电力。

9. 发明申请

US20050247929A1 Nanotube-based vacuum devices 有权
标题翻译：基于纳米管的真空装置
公开(公告)号：US20050247929A1
公开(公告)日：2005-11-10
申请号：US11134800
申请日：2005-05-23
申请人： Alexander Kastalsky , Sergey Shokhor
发明人： Alexander Kastalsky , Sergey Shokhor
IPC分类号： H01J19/24 , H01J21/04 , H01J21/10 , H01L29/10
CPC分类号： H01J19/24 , B82Y10/00 , H01J21/04 , H01J21/105 , H01J2201/30469 , Y10S977/876 , Y10S977/938
摘要： New, hybrid vacuum electronic devices are proposed, in which the electrons are extracted from the nanotube into vacuum. Each nanotube is either placed on the cathode electrode individually or grown normally to the cathode plane. Arrays of the nanotubes are also considered to multiply the output current. Two- and three-terminal device configurations are discussed. In all the cases considered, the device designs are such that both input and output capacitances are extremely low, while the efficiency of the electron extraction into vacuum is very high, so that the estimated operational frequencies are expected to be in a tera-hertz range. New vacuum triode structure with ballistic electron propagation along the nanotube is also considered.
摘要翻译：提出了新的混合真空电子器件，其中电子从纳米管提取到真空中。每个纳米管或者单独地放置在阴极电极上或正常地生长到阴极平面。纳米管阵列也被认为是乘以输出电流。讨论了两端和三端设备配置。在所有考虑的情况下，器件设计使得输入和输出电容都非常低，而电子提取到真空中的效率非常高，所以估计的工作频率预期为tera-Hz范围。也考虑了具有沿纳米管的弹道电子传播的新的真空三极管结构。

10. 发明授权

US06735046B2 Nano-magnetic head and nano-magnetic head device using the same 失效
标题翻译：纳米磁头和纳米磁头装置使用相同
公开(公告)号：US06735046B2
公开(公告)日：2004-05-11
申请号：US09990259
申请日：2001-11-21
申请人： Yoshikazu Nakayama , Akio Harada
发明人： Yoshikazu Nakayama , Akio Harada
IPC分类号： G11B5127
CPC分类号： B82Y10/00 , G11B5/127 , G11B5/48 , G11B5/54 , G11B5/58 , G11B5/581 , G11B2005/0002 , G11B2005/0005 , Y10S977/863 , Y10S977/865 , Y10S977/873 , Y10S977/876 , Y10S977/932
摘要： A nano-magnetic head for inputting and outputting magnetic signals with nano-region precision on a magnetic recording medium such as magnetic tapes, magnetic cards, magnetic disks, magnetic drums, etc. The nano-magnetic head uses a nanotube with its base end portion fastened to a holder that is at an end of an AFM cantilever. The tip end portion of the nanotube protrudes from the holder, and a nanocoil is wound around the outer circumference of the tip end portion of the nanotube so that signals are inputted and outputted at both ends of the nanocoil. By way of lining up ferromagnetic metal atoms in the hollow portion of the nanotube, it is possible to strengthen the magnetic signal. The nano-magnetic head is combinable with a signal controller, thus forming a nano-magnetic head device.
摘要翻译：一种用于在诸如磁带，磁卡，磁盘，磁鼓等的磁记录介质上输入和输出具有纳米区域精度的磁信号的纳米磁头。纳米磁头使用其基端部分的纳米管紧固在AFM悬臂末端的支架上。纳米管的前端部从保持器突出，纳米线卷绕在纳米管的前端部的外周，使得在纳米线的两端输入信号。通过在纳米管的中空部分排列铁磁金属原子，可以加强磁信号。纳米磁头可与信号控制器组合，从而形成纳米磁头装置。

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