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    • 6. 发明授权
    • Pharmaceutical compositions and method for prophylaxis and therapy of radical-mediated cell damage
    • 用于预防和治疗自由基介导的细胞损伤的药物组合物和方法
    • US06172056B2
    • 2001-01-09
    • US08646341
    • 1996-05-09
    • Peter DroescherBernd MenzenbachKurt PonsoldBernd UndeutschMichael OettelWolfgang RömerG{umlaut over (u)}nter KaufmannJens Schroeder
    • Peter DroescherBernd MenzenbachKurt PonsoldBernd UndeutschMichael OettelWolfgang RömerG{umlaut over (u)}nter KaufmannJens Schroeder
    • A61K3156
    • A61K31/565A61K31/575
    • The method of prophylaxis and therapy of radical-mediated cell damage includes administering an effective amount of at least one steroid and at least one pharmaceutical adjuvant to a human being. The at least one steroid is selected from the group consisting of ent-estradiol, 17&agr;-estradiol, 8-dehydro-estradiol, 8-dehydro-17&agr;-estradiol, 8(14)-dehydroestradiol, 6,8-didehydro-17&agr;-estradiol, 6-dehydroestriol, 9(11)-dehydroestriol, 20-hydroxymethyl-3-hydroxy-19-norpregna-1,3,5(10)-triene, 14&agr;, 15&agr;-methylene-8-dehydroestradiol, 14&agr;, 15&agr;-methylene-estradiol, 2-hydroxy-estradiol-3-methyl ether, 3-hydroxy-1,3,5(10)-estratriene-17S-spirooxirane, 3-hydroxy-1,3,5(10),9(11)-estratetraene-17S-spirooxirane, and 14&bgr;,15&bgr;-methylene-8-dehydroestradiol. This method strongly inhibits changes in cells and tissues, such as lipid peroxidation and oxidation of low-density lipoprotein (LDL) cholesterol, triggered by reaction oxygen species, free oxygen radicals and other forms of radicals and thus reduces attendant irreversible membrane and endothelial damage.
    • 预防和治疗自由基介导的细胞损伤的方法包括向人施用有效量的至少一种类固醇和至少一种药物佐剂。 所述至少一种类固醇选自雌二醇,17α-雌二醇,8-脱氢雌二醇,8-脱氢-17α-雌二醇,8(14) - 脱氢雌二醇,6,8-二脱氢-17α-雌二醇 ,6-脱氢三醇,9(11) - 脱氢三醇,20-羟甲基-3-羟基-19-去甲基-13,5(10) - 三烯,14α,15α-亚甲基-8-脱氢雌二醇,14α,15α-亚甲基 - 雌二醇,2-羟基 - 雌二醇-3-甲基醚,3-羟基-1,3,5(10) - 雌三烯-17S-螺环氧乙烷,3-羟基-1,3,5(10),9(11) -estratetraene-17S-螺环氧乙烷和14beta,15beta-亚甲基-8-脱氢雌二醇。 这种方法强烈地抑制细胞和组织的变化,例如由反应氧物质,游离氧自由基和其他形式的基团触发的低密度脂蛋白(LDL)胆固醇的脂质过氧化和氧化,从而减少伴随的不可逆膜和内皮损伤。
    • 7. 发明授权
    • Height-regulatable hydropneumatic suspension
    • 高度可调节液压气动悬浮液
    • US6017023A
    • 2000-01-25
    • US912192
    • 1997-08-18
    • Adolph GreuterBernhard DollRomano LoriniJens SchroederFranz Osterwalder
    • Adolph GreuterBernhard DollRomano LoriniJens SchroederFranz Osterwalder
    • B60G17/015B60G17/04B60G17/056B60G21/06F16F5/00
    • B60G21/06B60G17/0152B60G17/04B60G2202/154B60G2204/80B60G2206/422B60G2500/20B60G2500/30B60G2600/18B60G2600/20B60G2800/019
    • The invention concerns a method and apparatus for regulating the distance between the frame and a wheel unit or axle of a motor vehicle by means of a hydrodynamic suspension element by varying the volume of the damping liquid. The vehicle frame is sprung and damped at both sides of the vehicle relative to one or more wheel axles by means of hydropneumatic springs, wherein one of the volumes of the hydropneumatic springs is variable. In this arrangement, to increase the distance the static volume is supplemented by an additonal volume and to reduce the distance the static volume is reduced by a reduction volume. Associated with one or more parallel-connected hydropneumatic springs is a metering unit which can add or withdraw at least one defined additional volume and/or reduction volume with respect to the instantaneous sum of the damping volumes of the associated hydropneumatic springs. The vehicle frame/wheel axle distance can be adjusted in the region of the hydropneumatic springs connected to the metering unit by detecting the condition of the metering unit by means of sensors arranged on the metering unit and readjusting to the reference functional condition.
    • 本发明涉及一种用于通过改变阻尼液体的体积通过流体动力悬挂元件来调节机架与机动车辆的车轮单元或轴之间的距离的方法和装置。 车辆框架通过液压气动弹簧相对于一个或多个车轮轴在车辆的两侧被弹簧和阻尼,其中液压气动弹簧的一个容积是可变的。 在这种布置中,为了增加静态体积由附加体积补充的距离,并且减小静态体积减小减小体积的距离。 与一个或多个并联连接的液压气动弹簧相关联的是计量单元,其可以相对于相关联的液压气动弹簧的阻尼体积的瞬时总和来添加或撤回至少一个限定的附加体积和/或减小体积。 通过设置在计量单元上的传感器检测计量单元的状态并重新调整到参考功能状态,可以在连接到计量单元的液压气动弹簧的区域中调整车架/车轮轴的距离。