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1. 发明申请

US20130310559A1 ISOPRENYL COMPOUNDS AND METHODS THEREOF 有权
标题翻译：异丙苯化合物及其方法
公开(公告)号：US20130310559A1
公开(公告)日：2013-11-21
申请号：US13760627
申请日：2013-02-06
申请人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
发明人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
IPC分类号： C07D217/26 , C07D209/48 , C07D333/24 , C07D295/145 , C07C243/34 , C07C321/18 , C07D207/16
CPC分类号： A61K31/197 , A61K9/0014 , C07C243/34 , C07C321/18 , C07C323/59 , C07C335/08 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D209/18 , C07D209/48 , C07D217/26 , C07D243/34 , C07D295/145 , C07D307/54 , C07D333/24
摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.
摘要翻译：除此之外，本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物，化妆品，药妆和局部组合物。本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。本发明的促炎症化合物可用于治疗或预防与抑制炎性反应相关的疾病或病症。因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。

2. 发明授权

US08372884B2 Isoprenyl compounds and methods thereof 有权
标题翻译：异戊二烯基化合物及其方法
公开(公告)号：US08372884B2
公开(公告)日：2013-02-12
申请号：US12616781
申请日：2009-11-12
申请人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
发明人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
IPC分类号： A61K31/195 , C07C323/59
CPC分类号： A61K31/197 , A61K9/0014 , C07C243/34 , C07C321/18 , C07C323/59 , C07C335/08 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D209/18 , C07D209/48 , C07D217/26 , C07D243/34 , C07D295/145 , C07D307/54 , C07D333/24
摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.
摘要翻译：除此之外，本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物，化妆品，药妆和局部组合物。本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。本发明的促炎症化合物可用于治疗或预防与抑制炎症反应相关的疾病或病症。因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。

3. 发明申请

US20100184768A1 Isoprenyl Compounds and Methods Thereof 有权
标题翻译：异戊二烯基化合物及其方法
公开(公告)号：US20100184768A1
公开(公告)日：2010-07-22
申请号：US12616781
申请日：2009-11-12
申请人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
发明人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
IPC分类号： A61K31/5375 , C07C321/18 , A61K31/197 , C07D209/32 , A61K31/405 , A61K31/225 , C07D207/16 , A61K31/4015 , A61K31/265 , C07D333/24 , A61K31/381 , C07D217/26 , A61K31/472 , C07D265/30 , C07C233/46 , A61K31/16 , A61P29/00
CPC分类号： A61K31/197 , A61K9/0014 , C07C243/34 , C07C321/18 , C07C323/59 , C07C335/08 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D209/18 , C07D209/48 , C07D217/26 , C07D243/34 , C07D295/145 , C07D307/54 , C07D333/24
摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.
摘要翻译：除此之外，本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物，化妆品，药妆和局部组合物。本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。本发明的促炎症化合物可用于治疗或预防与抑制炎性反应相关的疾病或病症。因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。

4. 发明授权

US09376383B2 Isoprenyl compounds 有权
标题翻译：异戊二烯基化合物
公开(公告)号：US09376383B2
公开(公告)日：2016-06-28
申请号：US13760627
申请日：2013-02-06
申请人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen
发明人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
IPC分类号： C07C321/18 , C07C323/59 , C07C335/08 , C07D209/18 , C07D209/48 , C07D217/26 , C07D295/145 , C07D307/54 , C07D333/24 , C07D243/34 , C07D207/16
CPC分类号： A61K31/197 , A61K9/0014 , C07C243/34 , C07C321/18 , C07C323/59 , C07C335/08 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D209/18 , C07D209/48 , C07D217/26 , C07D243/34 , C07D295/145 , C07D307/54 , C07D333/24
摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.
摘要翻译：除此之外，本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物，化妆品，药妆和局部组合物。本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。本发明的促炎症化合物可用于治疗或预防与抑制炎性反应相关的疾病或病症。因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。

5. 发明授权

US08461204B2 Cysteinyl compounds, compositions and methods of use 有权
标题翻译：半胱氨酰化合物，组合物和使用方法
公开(公告)号：US08461204B2
公开(公告)日：2013-06-11
申请号：US13566839
申请日：2012-08-03
申请人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen
发明人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen
IPC分类号： A61K31/198 , C07C323/24 , A61K31/197 , C07C323/59
CPC分类号： A61K31/197 , C07C323/59
摘要： Among other things, the present invention provides novel compounds capable of effectively inhibiting inflammatory responses that are mediated by G-proteins or GPCRs in neutrophils, macrophages and platelets. In particular, the compounds of the present invention act as inhibitors of edema, inhibitors of erythema and inhibitors of MPO (myeloperoxidase), pharmaceutical compositions containing the same compounds and the use thereof for the treatment of diseases that may benefit from edema, erythema and MPO inhibition, such as inflammation (acute or chronic), asthma, autoimmune diseases, and chronic obstructive pulmonary disease (COPD) (e.g., emphysema, chronic bronchitis and small airways disease, etc.), inflammatory responses of the immune system, skin diseases (e.g., reducing acute skin irritation for patients suffering from rosacea, atopic dermatitis, seborrheic dermatitis, psoriasis), irritable bowel syndrome (e.g., Chron's disease and ulcerative colitis, etc.), and central nervous system disorders (e.g., Parkinson's disease).
摘要翻译：除此之外，本发明提供能够有效抑制嗜中性粒细胞，巨噬细胞和血小板中G蛋白或GPCR介导的炎症反应的新型化合物。特别地，本发明的化合物作为水肿抑制剂，红斑抑制剂和MPO抑制剂（髓过氧化物酶），含有相同化合物的药物组合物及其用于治疗可能受益于水肿，红斑和MPO的疾病的用途抑制，如炎症（急性或慢性），哮喘，自身免疫性疾病和慢性阻塞性肺疾病（COPD）（例如肺气肿，慢性支气管炎和小气道疾病等），免疫系统的炎症反应，皮肤疾病例如，对于患有酒渣鼻，特应性皮炎，脂溢性皮炎，牛皮癣的患者，肠易激综合征（例如，Chron氏病和溃疡性结肠炎等）以及中枢神经系统疾病（例如帕金森病）的患者减少急性皮肤刺激。

6. 发明申请

US20120328540A1 Cysteinyl compounds, compositions and methods of use 有权
标题翻译：半胱氨酰化合物，组合物和使用方法
公开(公告)号：US20120328540A1
公开(公告)日：2012-12-27
申请号：US13566839
申请日：2012-08-03
申请人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen
发明人： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen
IPC分类号： A61K31/197 , A61P17/00 , A61P17/14 , A61P17/12 , A61P29/00 , A61P17/08 , A61P17/06 , A61P37/08 , A61P19/04 , A61P19/02 , A61P31/00 , A61P17/10 , A61P31/04 , A61P17/02 , A61Q17/04 , C07C321/08
CPC分类号： A61K31/197 , C07C323/59
摘要： Among other things, the present invention provides novel compounds capable of effectively inhibiting inflammatory responses that are mediated by G-proteins or GPCRs in neutrophils, macrophages and platelets. In particular, the compounds of the present invention act as inhibitors of edema, inhibitors of erythema and inhibitors of MPO (myeloperoxidase), pharmaceutical compositions containing the same compounds and the use thereof for the treatment of diseases that may benefit from edema, erythema and MPO inhibition, such as inflammation (acute or chronic), asthma, autoimmune diseases, and chronic obstructive pulmonary disease (COPD) (e.g., emphysema, chronic bronchitis and small airways disease, etc.), inflammatory responses of the immune system, skin diseases (e.g., reducing acute skin irritation for patients suffering from rosacea, atopic dermatitis, seborrheic dermatitis, psoriasis), irritable bowel syndrome (e.g., Chron's disease and ulcerative colitis, etc.), and central nervous system disorders (e.g., Parkinson's disease).
摘要翻译：除此之外，本发明提供能够有效抑制嗜中性粒细胞，巨噬细胞和血小板中G蛋白或GPCR介导的炎症反应的新型化合物。特别地，本发明的化合物作为水肿抑制剂，红斑抑制剂和MPO抑制剂（髓过氧化物酶），含有相同化合物的药物组合物及其用于治疗可能受益于水肿，红斑和MPO的疾病的用途抑制，如炎症（急性或慢性），哮喘，自身免疫性疾病和慢性阻塞性肺疾病（COPD）（例如肺气肿，慢性支气管炎和小气道疾病等），免疫系统的炎症反应，皮肤疾病例如，对于患有酒渣鼻，特应性皮炎，脂溢性皮炎，牛皮癣的患者，肠易激综合征（例如，Chron氏病和溃疡性结肠炎等）以及中枢神经系统疾病（例如帕金森病）的患者减少急性皮肤刺激。

7. 发明授权

US08073655B2 Quantifying the impact of network latency on the end-to-end response time of distributed applications 有权
标题翻译：量化网络延迟对分布式应用程序端到端响应时间的影响
公开(公告)号：US08073655B2
公开(公告)日：2011-12-06
申请号：US12321623
申请日：2009-01-23
申请人： Shuyi Chen , William Sanders , Matti Hiltunen , Kaustubb Joshi , Richard Schlichting
发明人： Shuyi Chen , William Sanders , Matti Hiltunen , Kaustubb Joshi , Richard Schlichting
IPC分类号： G06F11/30
CPC分类号： H04L43/10 , H04L43/0852
摘要： A method for measuring system response sensitivity, using live traffic and an analysis that converts randomly arriving stimuli and reactions to the stimuli to mean measures over chosen intervals, thereby creating periodically occurring samples that are processed. The system is perturbed in a chosen location of the system in a manner that is periodic with frequency p, and the system's response to arriving stimuli is measured at frequency p. The perturbation, illustratively, is with a square wave pattern.
摘要翻译：一种用于测量系统响应灵敏度的方法，使用实时流量和将随机到达的刺激和反应转换为刺激的分析来表示所选间隔的测量，从而产生周期性地发生的被处理的样本。在系统的选定位置以与频率p周期性的方式扰动系统，并且系统对到达刺激的响应在频率p处被测量。例如，扰动是以方波模式。

8. 发明申请

US20100191505A1 Quantifying the impact of network latency on the end-to-end response time of distributed applications 有权
标题翻译：量化网络延迟对分布式应用程序端到端响应时间的影响
公开(公告)号：US20100191505A1
公开(公告)日：2010-07-29
申请号：US12321623
申请日：2009-01-23
申请人： Shuyi Chen , Matti Hiltunen , Kaustubb Joshi , William Sanders , Richard Schlichting
发明人： Shuyi Chen , Matti Hiltunen , Kaustubb Joshi , William Sanders , Richard Schlichting
IPC分类号： G06F15/00 , G06F15/18
CPC分类号： H04L43/10 , H04L43/0852
摘要： A method for measuring system response sensitivity, using live traffic and an analysis that converts randomly arriving stimuli and reactions to the stimuli to mean measures over chosen intervals, thereby creating periodically occurring samples that are processed. The system is perturbed in a chosen location of the system in a manner that is periodic with frequency p, and the system's response to arriving stimuli is measured at frequency p. The perturbation, illustratively, is with a square wave pattern.
摘要翻译：一种用于测量系统响应灵敏度的方法，使用实时流量和将随机到达的刺激和反应转换为刺激的分析来表示所选间隔的测量，从而产生周期性地发生的被处理的样本。在系统的选定位置以与频率p周期性的方式扰动系统，并且系统对到达刺激的响应在频率p处被测量。例如，扰动是以方波模式。

9. 发明公开

US20230163282A1 SILICON-BASED ANODES FOR HIGH ENERGY-DENSITY, HIGH CYCLE-LIFE LITHIUM-ION BATTERY 审中-公开
公开(公告)号：US20230163282A1
公开(公告)日：2023-05-25
申请号：US17455810
申请日：2021-11-19
申请人： Zhigang Lin , Shuyi Chen , Chunhu Tan
发明人： Zhigang Lin , Shuyi Chen , Chunhu Tan
IPC分类号： H01M4/38 , H01M4/62 , H01M4/505 , H01M4/525 , H01M4/04
CPC分类号： H01M4/386 , H01M4/625 , H01M4/505 , H01M4/525 , H01M4/0471 , H01M4/043 , H01M4/0416
摘要： A high-energy-density, high-cycling-life Si-based anode is used for rechargeable Lithium-ion batteries with either solid-state electrolyte or currently commercialized liquid electrolyte. The Si-based anodes include a silicon-based active material, conductive agent(s), and polymer(s) that act as binder(s). The silicon-based active material includes silicon, graphite, metallic or non-metallic oxide, and/or a polymer. The electrode has a specific capacity of at least 2328 mAh/g when cycled at a charge-discharge rate of about 0.5 C and 3245 mAh/g at 0.05 C. Sheets of the Si-based electrode are processable with a well-established industrial process that is cost-effective, scalable, and compatible with currently used Li-ion production lines. A lithium electrochemical pouch cell is manufactured with the Si-based anode sheet with either a liquid electrolyte or a solid-state electrolyte to offer high energy density, long cycle life, and high charge/discharge rates.

10. 发明授权

US08565081B1 Rate adaptation in a communication system 有权
公开(公告)号：US08565081B1
公开(公告)日：2013-10-22
申请号：US13033356
申请日：2011-02-23
申请人： Yuan Yuan , Shuyi Chen , C. Philip Gossett , Jeremy Thorpe
发明人： Yuan Yuan , Shuyi Chen , C. Philip Gossett , Jeremy Thorpe
IPC分类号： H04J1/16 , H04J3/14 , H04L1/00 , H04L12/26 , H04L12/28 , H04L12/56
CPC分类号： H04W72/082 , H04L1/0002 , H04L1/203 , H04L41/5022 , H04L43/0823 , H04L47/10 , H04L47/263 , H04W24/08 , H04W28/04 , Y02D50/10
摘要： In general, the subject matter described in this specification can be embodied in methods, systems, and program products for adapting data rate in a communication system. A receiving device receives a data transmission at an initial data rate. The device determines, based on an error rate of the data transmission at the initial data rate, that a first criterion is satisfied for requesting an increase in the data transmission. The device requests that a transmitting device increase the data transmission from the initial data rate to the first subsequent data rate. The device determines, based on an error rate of the data transmission at the first subsequent data rate, whether a second criterion is satisfied for maintaining the first subsequent data rate. The device maintains, if the second criterion is determined to be satisfied, a state of the device for receiving the data transmission at the first subsequent data rate.

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