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1. 发明申请

US20070049901A1 Method of treating acne with stratum corneum piercing device 审中-公开
标题翻译：用角质层穿刺装置治疗痤疮的方法
公开(公告)号：US20070049901A1
公开(公告)日：2007-03-01
申请号：US11409454
申请日：2006-04-21
申请人： Jeffrey Wu , Jue Liu , Ying Sun , Justin McDonough , Danilo Lambino , Mariam Maghribi
发明人： Jeffrey Wu , Jue Liu , Ying Sun , Justin McDonough , Danilo Lambino , Mariam Maghribi
IPC分类号： A61M31/00
CPC分类号： A61M37/0015 , A61B2017/00765 , A61M37/00 , A61M2037/0023 , A61M2037/0046 , A61N1/306 , A61N1/325
摘要： The invention features a method of treating acne by piercing the stratum corneum of skin in need of such treatment with a stratum corneum-piercing device that contains at east one stratum corneum-piercing microprotrusion and a compressible cover such that the compressible cover substantially encases the at least one stratum corneum-piercing microprotrusion, and wherein upon contacting the skin with the compressible cover, the at least one stratum corneum-piercing microprotrusion protrudes from the compressible cover and pierces the stratum corneum of the skin.
摘要翻译：本发明的特征在于一种通过用东方一角质层穿刺微灌注的角质层刺穿装置刺穿需要这种治疗的皮肤角质层来治疗痤疮的方法，使得可压缩盖基本上包围在至少一个角质层刺穿微灌注，并且其中当使皮肤与可压缩覆盖层接触时，至少一个角质层刺穿的微量突出从可压缩盖突出并刺穿皮肤的角质层。

2. 发明申请

US20070270738A1 Method of treating ACNE with stratum corneum piercing patch 审中-公开
标题翻译：用角质层刺穿补片处理ACNE的方法
公开(公告)号：US20070270738A1
公开(公告)日：2007-11-22
申请号：US11690960
申请日：2007-03-26
申请人： Jeffrey Wu , Jue Liu , Ying Sun , Justin McDonough , Danilo Lambino , Mariam Maghribi
发明人： Jeffrey Wu , Jue Liu , Ying Sun , Justin McDonough , Danilo Lambino , Mariam Maghribi
IPC分类号： A61B17/20 , A61B17/00
CPC分类号： A61B17/205 , A61B2017/00747
摘要： The invention features a method of treating acne by piercing the stratum corneum of skin in need of such treatment with a stratum corneum-piercing device that contains at least one stratum corneum-piercing microprotrusion and a compressible cover such that the compressible cover substantially encases the at least one stratum corneum-piercing microprotrusion, and wherein upon contacting the skin with the compressible cover, the at least one stratum corneum-piercing microprotrusion protrudes from the compressible cover and pierces the stratum corneum of the skin.
摘要翻译：本发明的特征在于一种通过用包含至少一种角质层穿孔微灌注的角质层刺穿装置刺穿需要这种治疗的皮肤角质层来治疗痤疮的方法，使得可压缩盖基本上包围在至少一个角质层刺穿微灌注，并且其中当使皮肤与可压缩覆盖层接触时，至少一个角质层刺穿的微量突出从可压缩盖突出并刺穿皮肤的角质层。

3. 发明申请

US20060253079A1 Stratum corneum piercing device 审中-公开
标题翻译：角质层刺穿装置
公开(公告)号：US20060253079A1
公开(公告)日：2006-11-09
申请号：US11113952
申请日：2005-04-25
申请人： Justin McDonough , Jue-Chen Liu , Ying Sun , Danilo Lambino , Jeffrey Wu , Mariam Maghribi
发明人： Justin McDonough , Jue-Chen Liu , Ying Sun , Danilo Lambino , Jeffrey Wu , Mariam Maghribi
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61B2017/00765 , A61M37/00 , A61M2037/0023 , A61M2037/0046 , A61N1/306 , A61N1/325
摘要： The present invention features a stratum corneum-piercing device including a microprotrusion member having a skin-contacting surface and plurality of stratum corneum piercing microprotrusions thereon, the device being adapted to move the microprotrusion member lateral to the surface of the skin surface upon contact with the skin.
摘要翻译：本发明的特征在于一种角质层穿刺装置，其包括具有皮肤接触表面和多个角质层穿孔微突起的微突出物构件，该装置适于在接触到皮肤表面时将微突出物横向移动到皮肤表面的表面皮肤。

4. 发明申请

US20080009802A1 Method of treating acne with stratum corneum piercing device 审中-公开
标题翻译：用角质层穿刺装置治疗痤疮的方法
公开(公告)号：US20080009802A1
公开(公告)日：2008-01-10
申请号：US11113937
申请日：2005-04-25
申请人： Danilo Lambino , Jue-Chen Liu , Ying Sun , Justin McDonough , Jeffrey Wu , Mariam Maghribi
发明人： Danilo Lambino , Jue-Chen Liu , Ying Sun , Justin McDonough , Jeffrey Wu , Mariam Maghribi
IPC分类号： A61M5/00
CPC分类号： A61N1/30 , A61B17/205 , A61B2017/00747 , A61B2017/00765 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61N1/205 , A61N1/328
摘要： The invention features a method of treating acne by piercing the stratum corneum of skin in need of such treatment with a stratum corneum-piercing device including a microprotrusion member having a skin-contacting surface and plurality of stratum corneum-piercing microprotrusions thereon.
摘要翻译：本发明的特征在于一种通过用角质层刺穿装置刺穿需要这种治疗的皮肤角质层来治疗痤疮的方法，所述角质层穿刺装置包括具有皮肤接触表面的微量输注构件和在其上的多个角质层穿孔微突起。

5. 发明申请

US20060253078A1 Method of treating skin disorders with stratum corneum piercing device 审中-公开
标题翻译：用角质层穿刺装置治疗皮肤病的方法
公开(公告)号：US20060253078A1
公开(公告)日：2006-11-09
申请号：US11113890
申请日：2005-04-25
申请人： Jeffrey Wu , Jue-Chen Liu , Ying Sun , Justin McDonough , Danilo Lambino , Mariam Maghribi
发明人： Jeffrey Wu , Jue-Chen Liu , Ying Sun , Justin McDonough , Danilo Lambino , Mariam Maghribi
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61B2017/00765 , A61M37/00 , A61M2037/0023 , A61M2037/0046 , A61N1/306 , A61N1/325
摘要： The present invention features a device having a barrier membrane contacting surface, the device containing: a power source; a first conductive electrode; a second conductive electrode; and a reservoir; wherein said power source is in electric communication with said first conductive electrode and said second conductive electrode, wherein said first conductive electrode and said second conductive electrode are arranged such that they are both capable of being in ionic communication with a carrier upon the inclusion of said carrier to said reservoir; and the use thereof.
摘要翻译：本发明的特征在于具有阻挡膜接触表面的装置，该装置包括：电源; 第一导电电极; 第二导电电极; 和一个水库; 其中所述电源与所述第一导电电极和所述第二导电电极电连通，其中所述第一导电电极和所述第二导电电极被布置成使得它们能够在包含所述第一导电电极和所述第二导电电极时能够与载体离子连通载体到所述储存器; 及其用途。

6. 发明授权

US08734421B2 Methods of treating pores on the skin with electricity 有权
标题翻译：用电处理皮肤毛孔的方法
公开(公告)号：US08734421B2
公开(公告)日：2014-05-27
申请号：US10875032
申请日：2004-06-23
申请人： Ying Sun , Jeffrey Wu , Jue-Chen Liu , Joseph B. Phipps
发明人： Ying Sun , Jeffrey Wu , Jue-Chen Liu , Joseph B. Phipps
IPC分类号： A61M31/00
CPC分类号： A61N1/0492 , A61K8/19 , A61K8/20 , A61K8/27 , A61K8/365 , A61K8/368 , A61K2800/28 , A61K2800/83 , A61N1/0428 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/205 , A61N1/30 , A61N1/303 , A61N1/325 , A61Q19/008 , A61Q19/02 , A61Q19/08 , A61Q19/10
摘要： The present invention features a method of treating pores on the skin by applying to skin in need of such treatment a device including a housing having a skin contacting surface, a first conductive electrode, a second conductive electrode, and a carrier; wherein the first conductive electrode is in electric communication with the second conductive electrode, wherein the first conductive electrode is in ionic communication with the carrier, wherein the carrier is in communication with the skin contacting surface, and wherein the skin contacting surface is placed in contact with the skin.
摘要翻译：本发明的特征在于一种通过向需要这种治疗的皮肤施加皮肤处理孔的方法，该装置包括具有皮肤接触表面的壳体，第一导电电极，第二导电电极和载体; 其中所述第一导电电极与所述第二导电电极电连通，其中所述第一导电电极与所述载体离子连通，其中所述载体与所述皮肤接触表面连通，并且其中所述皮肤接触表面接触与皮肤。

7. 发明授权

US07477940B2 Methods of administering an active agent to a human barrier membrane with galvanic generated electricity 有权
标题翻译：用电生电为人体屏障膜施用活性剂的方法
公开(公告)号：US07477940B2
公开(公告)日：2009-01-13
申请号：US10874916
申请日：2004-06-23
申请人： Ying Sun , Jeffrey Wu , Jue-Chen Liu
发明人： Ying Sun , Jeffrey Wu , Jue-Chen Liu
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61N1/0428 , A61N1/0492 , A61N1/205 , A61N1/325
摘要： The present invention features a method of administering an active agent to a human barrier membrane by applying to the membrane a device including a housing having the barrier membrane contacting surface, a first conductive electrode, a second conductive electrode, and a carrier containing the active agent; wherein the first conductive electrode is in electric communication with the second conductive electrode, wherein the first conductive electrode and the second conductive electrode are in ionic communication with the carrier, and wherein the carrier is in communication with the barrier membrane through the barrier membrane contacting surface, wherein the difference of the standard potentials of the first conductive electrode and the second conductive electrode is at least 0.2 V and wherein the electrons that pass between the first conductive electrode and the second conductive electrode are generated as a result of such difference of the standard potentials.
摘要翻译：本发明的特征在于通过向膜施加包括具有阻隔膜接触表面的壳体的装置，第一导电电极，第二导电电极和含有活性剂的载体，向人体屏障膜施用活性剂的方法 ; 其中所述第一导电电极与所述第二导电电极电连通，其中所述第一导电电极和所述第二导电电极与所述载体离子连通，并且其中所述载体通过所述阻挡膜接触表面与所述阻挡膜连通其中，所述第一导电电极和所述第二导电电极的标准电位差为至少0.2V，其中通过所述第一导电电极和所述第二导电电极之间的电子由于所述标准潜力

8. 发明申请

US20070060862A1 Method for administering electricity with particlulates 有权
标题翻译：用颗粒物给电的方法
公开(公告)号：US20070060862A1
公开(公告)日：2007-03-15
申请号：US11590380
申请日：2006-10-31
申请人： Ying Sun , Jue-Chen Liu , Jeffrey Wu , James Hauschild
发明人： Ying Sun , Jue-Chen Liu , Jeffrey Wu , James Hauschild
IPC分类号： A61N1/30
CPC分类号： A61N1/0492 , A61K8/19 , A61K8/20 , A61K8/27 , A61K8/365 , A61K8/368 , A61K2800/28 , A61K2800/83 , A61N1/0428 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/205 , A61N1/30 , A61N1/303 , A61N1/325 , A61Q19/008 , A61Q19/02 , A61Q19/08 , A61Q19/10
摘要： The present invention features a device having a barrier membrane contacting surface, the device containing: a power source; a first conductive electrode; a second conductive electrode; and a reservoir; wherein said power source is in electric communication with said first conductive electrode and said second conductive electrode, wherein said first conductive electrode and said second conductive electrode are arranged such that they are both capable of being in ionic communication with a carrier upon the inclusion of said carrier to said reservoir; and the use thereof.
摘要翻译：本发明的特征在于具有阻挡膜接触表面的装置，该装置包括：电源; 第一导电电极; 第二导电电极; 和一个水库; 其中所述电源与所述第一导电电极和所述第二导电电极电连通，其中所述第一导电电极和所述第二导电电极被布置成使得它们能够在包含所述第一导电电极和所述第二导电电极时能够与载体离子连通载体到所述储存器; 及其用途。

9. 发明申请

US20060009499A1 Compositions useful for the treatment of follicular diseases 审中-公开
标题翻译：可用于治疗滤泡性疾病的组合物
公开(公告)号：US20060009499A1
公开(公告)日：2006-01-12
申请号：US10886313
申请日：2004-07-07
申请人： Jeffrey Wu , Jue-Chen Liu , Jeannette Chantalat , Ying Sun
发明人： Jeffrey Wu , Jue-Chen Liu , Jeannette Chantalat , Ying Sun
IPC分类号： A61K31/44
CPC分类号： A61K31/44 , A61K45/06 , A61K2300/00
摘要： The invention features a composition including an anti-acne agent, an antimicrobial agent, and a lactate, and the use thereof in the treatment of follicular diseases such as acne.
摘要翻译：本发明的特征在于包含抗痤疮剂，抗微生物剂和乳酸盐的组合物及其在治疗滤泡疾病如痤疮中的用途。

10. 发明申请

US20050004550A1 Methods of treating a wound with galvanic generated electricity 有权
标题翻译：用电生电处理伤口的方法
公开(公告)号：US20050004550A1
公开(公告)日：2005-01-06
申请号：US10874860
申请日：2004-06-23
申请人： Ying Sun , Jeffrey Wu , Jue-Chen Liu , Aliya Omer
发明人： Ying Sun , Jeffrey Wu , Jue-Chen Liu , Aliya Omer
IPC分类号： A61N1/20 , A61N1/30 , A61N1/32 , A61M31/00
CPC分类号： A61N1/30 , A61N1/205 , A61N1/325
摘要： The present invention features a method of treating a wound by applying electricity to a barrier membrane in need of such treatment wherein said electricity is generated by a first conductive electrode in electric communication with a second conductive electrode, wherein both the first conductive electrode and the second conductive electrode are in ionic communication with the barrier membrane, wherein the difference of the standard potentials of the first conductive electrode and the second conductive electrode is at least 0.2 V and wherein the electrons that pass between the first conductive electrode and the second conductive electrode are generated as a result of such difference of the standard potentials.
摘要翻译：本发明的特征在于一种通过向需要这种处理的阻隔膜施加电力来治疗伤口的方法，其中所述电由与第二导电电极电连通的第一导电电极产生，其中第一导电电极和第二导电电极导电电极与阻挡膜离子连通，其中第一导电电极和第二导电电极的标准电位的差异为至少0.2V，并且其中在第一导电电极和第二导电电极之间通过的电子为由于标准电位差异而产生。

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