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1. 发明授权

US08712475B2 Method to calibrate RF paths of an FHOP adaptive base station 有权
标题翻译：校准FHOP自适应基站的RF路径的方法
公开(公告)号：US08712475B2
公开(公告)日：2014-04-29
申请号：US13350489
申请日：2012-01-13
申请人： John R. Noll , Jeffrey W. Smith , Shannon Tomarchio , Brady Gaughan
发明人： John R. Noll , Jeffrey W. Smith , Shannon Tomarchio , Brady Gaughan
IPC分类号： H04B1/38
CPC分类号： H04B7/0848 , H04B17/21
摘要： A base transceiver station including a transceiver unit is provided. A method of calibration uses a transceiver unit to receive an RF signal, measure a calibration value, and transmit the measured value. The calibration value is used to determine weighting parameters to compensate for relative RF path phase delay and amplitude variation.
摘要翻译：提供了包括收发器单元的基站收发器。校准方法使用收发器单元来接收RF信号，测量校准值并传输测量值。校准值用于确定加权参数以补偿相对RF路径相位延迟和幅度变化。

2. 发明授权

US07935785B2 Selective substrates for matrix metalloproteinases 失效
标题翻译：基质金属蛋白酶的选择性底物
公开(公告)号：US07935785B2
公开(公告)日：2011-05-03
申请号：US12252160
申请日：2008-10-15
申请人： Jeffrey W. Smith , Emily I. Chen , Steven J. Kridel
发明人： Jeffrey W. Smith , Emily I. Chen , Steven J. Kridel
IPC分类号： C07K5/00 , C07K14/00
CPC分类号： A61K49/0021 , A61K47/64 , A61K49/0056 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0821 , C07K5/0823 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K5/1024 , C07K7/06 , C07K7/08 , C12Q1/37
摘要： The invention provides isolated MMP-2, MMP-9 and MT1-MMP selective substrate polypeptides or functional peptidomimetics. The selective substrate polypeptides contain the following sequences: MMP-2 selective substrate polypeptides contain SEQ ID NOS:1-27, MMP-9 selective substrate polypeptides contain SEQ ID NOS:28-35, and MT1-MMP selective substrate polypeptide contain SEQ ID NOS:36-40. In addition, the invention provides a method of preferentially directing a moiety to a site of MMP-2 activity by administering to a subject an effective amount of an isolated MMP-2 selective substrate polypeptide containing SEQ ID NOS:45-47 linked to a moiety. Also provided is a method of preferentially directing a moiety to a site of MMP-9 activity by administering to a subject an effective amount of an isolated MMP-9 selective substrate polypeptide containing SEQ ID NO:44 linked to a moiety, and preferentially directing a moiety to a site of MT1-MMP activity by administering to a subject an effective amount of an isolated MT1-MMP selective substrate polypeptide containing SEQ ID NOS:36-40 linked to a moiety.
摘要翻译：本发明提供分离的MMP-2，MMP-9和MT1-MMP选择性底物多肽或功能肽模拟物。选择性底物多肽包含以下序列：MMP-2选择性底物多肽含有SEQ ID NO：1-27，含有SEQ ID NO：28-35的MMP-9选择性底物多肽，并且含有SEQ ID NOS的MT1-MMP选择性底物多肽：36-40。此外，本发明提供了通过向受试者施用有效量的与部分连接的含有SEQ ID NO：45-47的分离的MMP-2选择性底物多肽来优先将部分定向到MMP-2活性位点的方法。还提供了通过向受试者施用有效量的与部分连接的含有SEQ ID NO：44的分离的MMP-9选择性底物多肽，优先将一部分连接至部分MMP-9活性部位的方法，通过向受试者施用有效量的与部分连接的含有SEQ ID NO：36-40的分离的MT1-MMP选择性底物多肽，从而部分到MT1-MMP活性的位点。

3. 发明授权

US07643852B2 Method to calibrate RF paths of an FHOP adaptive base station 有权
标题翻译：校准FHOP自适应基站的RF路径的方法
公开(公告)号：US07643852B2
公开(公告)日：2010-01-05
申请号：US11333193
申请日：2006-01-17
申请人： John Noll , Jeffrey W. Smith , Shannon Tomarchio , Brady Gaughan
发明人： John Noll , Jeffrey W. Smith , Shannon Tomarchio , Brady Gaughan
IPC分类号： H04B1/38
CPC分类号： H04B7/0848 , H04B17/21
摘要： A method for calibration of RF paths of a frequency hopping adaptive base transceiver station is provided. The method of calibration calibrates a wireless cellular telecommunication system with a frequency hopping adaptive base transceiver station including an adaptive antenna array with two or more RF traffic transceiver apparatus chains. The wireless cellular telecommunication system communicates with mobile units on a frequencies defined by a hop list. The method of calibration includes the step of periodically interrupting a frequency hopping process of the frequency hopping adaptive base transceiver station while calls are in progress. The method of calibration further includes the step of calibrating an antenna transmit path for a RF traffic transceiver apparatus chain at a frequency selected to include one or more frequencies in the hop list to determine a set of weighting parameters for the antenna transmit path at the one or more frequencies. A self-calibrating frequency hopping adaptive base transceiver station is also provided.
摘要翻译：提供了一种用于校准跳频自适应基站的射频路径的方法。校准方法使用包括具有两个或更多个RF业务收发器设备链的自适应天线阵列的跳频自适应基站收发器校准无线蜂窝电信系统。无线蜂窝电信系统在跳频列表定义的频率上与移动单元进行通信。校准方法包括在呼叫进行期间周期性地中断跳频自适应基站收发机的跳频过程的步骤。校准方法还包括校准用于RF业务收发器设备链的天线发射路径的步骤，该频率被选择为包括跳频列表中的一个或多个频率，以确定一个天线发射路径的一组加权参数或更多的频率。还提供了自校准跳频自适应基站收发台。

4. 发明申请

US20090042922A1 NOVEL BELACTOSIN DERIVATIVES AS THERAPEUTIC AGENTS/BIOLOGICAL PROBES AND THEIR SYNTHESIS 失效
标题翻译：新型BELACTOSIN衍生物作为治疗药物/生物探针及其合成
公开(公告)号：US20090042922A1
公开(公告)日：2009-02-12
申请号：US11775154
申请日：2007-07-09
申请人： Daniel Romo , Sung Wook Cho , Jeffrey W. Smith , Robyn D. Richardson
发明人： Daniel Romo , Sung Wook Cho , Jeffrey W. Smith , Robyn D. Richardson
IPC分类号： A61K31/365 , C07D305/08 , A61K31/4375 , A61P35/00 , C07D491/16
CPC分类号： C07D407/12 , C07D305/12
摘要： Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or auto-immune therapeutic abilities. In general, methods of synthesis disclosed herein allow for introduction of a variety of substituents at numerous positions as well as the facile introduction of a beta-lactone ring moiety. The synthetic steps comprise, in preferred embodiments, a tandem Mukaiyama aldol lactonization reaction. Data demonstrating the utility of some of the derivatives as proteasome inhibitors is also disclosed.
摘要翻译：披露了双乳糖蛋白衍生物及其合成。在某些实施方案中，本发明的化合物表现出抗癌，抗病毒，抗生素和/或自身免疫治疗能力。通常，本文公开的合成方法允许在多个位置引入各种取代基以及容易地引入β-内酯环部分。在优选实施方案中，合成步骤包括串联的Mukaiyama醛醇内酯反应。还公开了证明一些衍生物作为蛋白酶体抑制剂的效用的数据。

5. 发明申请

US20090005307A1 Compositions and Methods for Detection of Colorectal Cancer 审中-公开
标题翻译：用于检测结肠直肠癌的组合物和方法
公开(公告)号：US20090005307A1
公开(公告)日：2009-01-01
申请号：US11992279
申请日：2006-09-21
申请人： Jeffrey W. Smith , Changming Fang
发明人： Jeffrey W. Smith , Changming Fang
IPC分类号： A61K38/17 , C12N15/12 , C07H21/00 , C12N15/79 , C07K16/18 , A61P35/00 , C12Q1/68 , G01N33/574 , C12N15/11 , C12N5/10
CPC分类号： C12Q1/6886 , C12Q2600/106
摘要： We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N-terminal sequence that is not found in the IBABP protein. The present invention provides methods for diagnosing colorectal cancer and other compositions and methods based on this discovery.
摘要翻译：我们已经确定了回肠胆汁酸结合蛋白（IBABP）的新变体，称为IBABP-L，其是结肠直肠癌的生物标志物。 IBABP-L的成绩单来自替代起始位点，并且包括IBABP中缺少的三个外显子。 IBABP-L还与IBABP共享第四外显子的一部分。由IBABP-L编码的蛋白质含有在IBABP蛋白中未发现的49个残基的N-末端序列。本发明提供了用于诊断结肠直肠癌的方法以及基于该发现的其它组合物和方法。

6. 外观设计

USD395960S Reclining theatre seat 失效
公开(公告)号：USD395960S
公开(公告)日：1998-07-14
申请号：US68284
申请日：1997-03-26
申请人： Jeffrey W. Smith
设计人： Jeffrey W. Smith

7. 发明授权

US08563248B2 Compositions and methods for detection of colorectal cancer 失效
标题翻译：用于检测结肠直肠癌的组合物和方法
公开(公告)号：US08563248B2
公开(公告)日：2013-10-22
申请号：US12959349
申请日：2010-12-02
申请人： Jeffrey W. Smith , Changming Fang
发明人： Jeffrey W. Smith , Changming Fang
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106
摘要： We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N-terminal sequence that is not found in the IBABP protein. The present invention provides methods for diagnosing colorectal cancer and other compositions and methods based on this discovery.
摘要翻译：我们已经确定了回肠胆汁酸结合蛋白（IBABP）的新变体，称为IBABP-L，其是结肠直肠癌的生物标志物。 IBABP-L的成绩单来自替代起始位点，并且包括IBABP中缺少的三个外显子。 IBABP-L还与IBABP共享第四外显子的一部分。由IBABP-L编码的蛋白质含有在IBABP蛋白中未发现的49个残基的N-末端序列。本发明提供了用于诊断结肠直肠癌的方法以及基于该发现的其它组合物和方法。

8. 发明授权

US08119653B2 Belactosin derivatives as therapeutic agents/biological probes and their synthesis 失效
标题翻译：贝米松星衍生物作为治疗剂/生物探针及其合成
公开(公告)号：US08119653B2
公开(公告)日：2012-02-21
申请号：US11775154
申请日：2007-07-09
申请人： Daniel Romo , Sung Wook Cho , Jeffrey W. Smith , Robyn D. Richardson
发明人： Daniel Romo , Sung Wook Cho , Jeffrey W. Smith , Robyn D. Richardson
IPC分类号： A61K31/436 , C07D221/18
CPC分类号： C07D407/12 , C07D305/12
摘要： Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or auto-immune therapeutic abilities. In general, methods of synthesis disclosed herein allow for introduction of a variety of substituents at numerous positions as well as the facile introduction of a beta-lactone ring moiety. The synthetic steps comprise, in preferred embodiments, a tandem Mukaiyama aldol lactonization reaction. Data demonstrating the utility of some of the derivatives as proteasome inhibitors is also disclosed.
摘要翻译：披露了双乳糖蛋白衍生物及其合成。在某些实施方案中，本发明的化合物表现出抗癌，抗病毒，抗生素和/或自身免疫治疗能力。通常，本文公开的合成方法允许在多个位置引入各种取代基以及容易地引入β-内酯环部分。在优选实施方案中，合成步骤包括串联的Mukaiyama醛醇内酯反应。还公开了证明一些衍生物作为蛋白酶体抑制剂的效用的数据。

9. 发明授权

US07799826B2 Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation 失效
标题翻译：通过β-内酯和其他化合物抑制脂肪酸合酶抑制细胞增殖
公开(公告)号：US07799826B2
公开(公告)日：2010-09-21
申请号：US10418513
申请日：2003-04-16
申请人： Jeffrey W. Smith , Fumiko Axelrod , Steven J. Kridel
发明人： Jeffrey W. Smith , Fumiko Axelrod , Steven J. Kridel
IPC分类号： A61K31/335
CPC分类号： A61K31/337 , A61K31/335 , A61K31/336 , A61K31/365 , A61K31/40 , A61K31/42 , A61K31/425 , A61K31/445 , A61K31/585 , G01N33/5011 , G01N2333/91057
摘要： The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis.
摘要翻译：本发明的特征在于通过向受试者施用有效量的β-内酯来治疗受试者的癌症的方法。本发明还具有通过向受试者施用有效量的脂肪酸合酶抑制剂来抑制受试者血管生成的方法。这些方法可用于治疗各种癌症和其他疾病和病症。本发明还涉及鉴定可用于本发明治疗肿瘤，抑制血管发生以及涉及病理性血管生成的疾病和病症的治疗的β-内酯和其它化合物的方法。

10. 发明申请

US20100069120A1 METHOD TO CALIBRATE RF PATHS OF AN FHOP ADAPTIVE BASE STATION 有权
标题翻译：校准FHOP自适应基站的RF PATHS的方法
公开(公告)号：US20100069120A1
公开(公告)日：2010-03-18
申请号：US12622956
申请日：2009-11-20
申请人： John R. Noll , Jeffrey W. Smith , Shannon Tomarchio , Brady Gaughan
发明人： John R. Noll , Jeffrey W. Smith , Shannon Tomarchio , Brady Gaughan
IPC分类号： H04B1/38 , H04B1/713
CPC分类号： H04B7/0848 , H04B17/21
摘要： A method for calibration of RF paths of a frequency hopping adaptive base transceiver station is provided. The method of calibration calibrates a wireless cellular telecommunication system with a frequency hopping adaptive base transceiver station including an adaptive antenna array with two or more RF traffic transceiver apparatus chains. The wireless cellular telecommunication system communicates with mobile units on a frequencies defined by a hop list. The method of calibration includes the step of periodically interrupting a frequency hopping process of the frequency hopping adaptive base transceiver station while calls are in progress. The method of calibration further includes the step of calibrating an antenna transmit path for a RF traffic transceiver apparatus chain at a frequency selected to include one or more frequencies in the hop list to determine a set of weighting parameters for the antenna transmit path at the one or more frequencies. A self-calibrating frequency hopping adaptive base transceiver station is also provided.
摘要翻译：提供了一种用于校准跳频自适应基站的射频路径的方法。校准方法使用包括具有两个或更多个RF业务收发器设备链的自适应天线阵列的跳频自适应基站收发器校准无线蜂窝电信系统。无线蜂窝电信系统在跳频列表定义的频率上与移动单元进行通信。校准方法包括在呼叫进行期间周期性地中断跳频自适应基站收发机的跳频过程的步骤。校准方法还包括校准用于RF业务收发器设备链的天线发射路径的步骤，该频率被选择为包括跳频列表中的一个或多个频率，以确定一个天线发射路径的一组加权参数或更多的频率。还提供了自校准跳频自适应基站收发台。

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