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1. 发明申请

US20070088246A1 Medical assembly with transducer for local delivery of a therapeutic substance and method of using same 审中-公开
公开(公告)号：US20070088246A1
公开(公告)日：2007-04-19
申请号：US11636097
申请日：2006-12-08
申请人： Jeffrey Steward , Brandon Gosiengfiao
发明人： Jeffrey Steward , Brandon Gosiengfiao
IPC分类号： A61B17/20
CPC分类号： A61M25/104 , A61M2025/0057 , A61M2025/1086
摘要： A medical Assembly is used to delivery a therapeutic substance to a treatment area. The medical assembly comprises a catheter having a distal end and a proximal end, a transducer supported by at least a portion of the distal end of the catheter assembly, and a delivery lumen mounted on the catheter for delivery of a therapeutic substance. Support for the transducer is provided at a preselected number of anchoring points, wherein an inner surface of the transducer is positioned at a preselected distance from an outer surface of the catheter. The preselected distance defines a gap that is occupied by a low density material such as a gas which reflects acoustic pressure waves directed toward the gap by a transducer when a voltage is applied to the transducer. The reflected pressure wave increases the energy in the system, enhancing transport of therapeutic substances from the delivery lumen to the surrounding tissues and/or cells to be treated. The medical assembly may optionally be used in conjunction with both macroporous and microporous balloons. The medical assembly may optionally be modified so that a plurality of transducers are used, wherein the distal end of a transducer is positioned at a preselected distance from the proximal end of an adjacent transducer.

2. 发明申请

US20070093745A1 Medical assembly with transducer for local delivery of a therapeutic substance and method of using same 审中-公开
标题翻译：具有用于局部递送治疗物质的换能器的医疗组件及其使用方法
公开(公告)号：US20070093745A1
公开(公告)日：2007-04-26
申请号：US11635854
申请日：2006-12-08
申请人： Jeffrey Steward , Brandon Gosiengfiao
发明人： Jeffrey Steward , Brandon Gosiengfiao
IPC分类号： A61B17/20
CPC分类号： A61M25/104 , A61M2025/0057 , A61M2025/1086
摘要： A medical Assembly is used to delivery a therapeutic substance to a treatment area. The medical assembly comprises a catheter having a distal end and a proximal end, a transducer supported by at least a portion of the distal end of the catheter assembly, and a delivery lumen mounted on the catheter for delivery of a therapeutic substance. Support for the transducer is provided at a preselected number of anchoring points, wherein an inner surface of the transducer is positioned at a preselected distance from an outer surface of the catheter. The preselected distance defines a gap that is occupied by a low density material such as a gas which reflects acoustic pressure waves directed toward the gap by a transducer when a voltage is applied to the transducer. The reflected pressure wave increases the energy in the system, enhancing transport of therapeutic substances from the delivery lumen to the surrounding tissues and/or cells to be treated. The medical assembly may optionally be used in conjunction with both macroporous and microporous balloons. The medical assembly may optionally be modified so that a plurality of transducers are used, wherein the distal end of a transducer is positioned at a preselected distance from the proximal end of an adjacent transducer.
摘要翻译：医疗组件用于将治疗物质递送到治疗区域。医疗组件包括具有远端和近端的导管，由导管组件的远端的至少一部分支撑的换能器，以及安装在导管上用于输送治疗物质的输送腔。在预选数量的锚固点处提供对换能器的支撑，其中换能器的内表面定位在离导管外表面预定距离处。预选距离限定了由低密度材料例如气体占据的间隙，当将电压施加到换能器时，该气体反射由换能器指向间隙的声压波。反射的压力波增加系统中的能量，增强治疗物质从输送腔向周围组织和/或待治疗细胞的转运。医疗组件可以任选地与大孔和微孔气囊一起使用。可以可选地修改医疗组件，使得使用多个换能器，其中换能器的远端定位在距相邻换能器近端的预选距离处。

3. 发明申请

US20070083149A1 Medical assembly with transducer for local delivery of a therapeutic substance and method of using same 审中-公开
公开(公告)号：US20070083149A1
公开(公告)日：2007-04-12
申请号：US11635852
申请日：2006-12-08
申请人： Jeffrey Steward , Brandon Gosiengfiao
发明人： Jeffrey Steward , Brandon Gosiengfiao
IPC分类号： A61B17/20
CPC分类号： A61M25/104 , A61M2025/0057 , A61M2025/1086
摘要： A medical Assembly is used to delivery a therapeutic substance to a treatment area. The medical assembly comprises a catheter having a distal end and a proximal end, a transducer supported by at least a portion of the distal end of the catheter assembly, and a delivery lumen mounted on the catheter for delivery of a therapeutic substance. Support for the transducer is provided at a preselected number of anchoring points, wherein an inner surface of the transducer is positioned at a preselected distance from an outer surface of the catheter. The preselected distance defines a gap that is occupied by a low density material such as a gas which reflects acoustic pressure waves directed toward the gap by a transducer when a voltage is applied to the transducer. The reflected pressure wave increases the energy in the system, enhancing transport of therapeutic substances from the delivery lumen to the surrounding tissues and/or cells to be treated. The medical assembly may optionally be used in conjunction with both macroporous and microporous balloons. The medical assembly may optionally be modified so that a plurality of transducers are used, wherein the distal end of a transducer is positioned at a preselected distance from the proximal end of an adjacent transducer.

4. 发明授权

US07713259B2 Guiding catheter shaft with improved radiopacity on the wire braid 有权
标题翻译：引导导管轴，在导线编织物上具有改善的射线不透性
公开(公告)号：US07713259B2
公开(公告)日：2010-05-11
申请号：US12049544
申请日：2008-03-17
申请人： Brandon Gosiengfiao , Jonathan M. Howland
发明人： Brandon Gosiengfiao , Jonathan M. Howland
IPC分类号： A61M25/098
CPC分类号： A61M25/0662 , A61M25/0045 , A61M25/005
摘要： An intracorporeal catheter, such as a guiding catheter, employed for intraluminal procedures is disclosed. The catheter generally has an elongated catheter shaft including a polymeric inner layer and a non-radiopaque outer polymeric layer, along with a radiopaque reinforcing structure disposed between the inner and outer layers. In one embodiment, the reinforcing layer consists of multiple drawn filled tubes braided or wound together. The drawn filled tubes may have a stainless steel outer jacket clad over a radiopaque inner core, or the drawn filled tubes may have a radiopaque outer jacket clad over a stainless steel core. In another embodiment, the reinforcing layer may consist of multiple wires containing radiopaque alloys braided or wound together, wherein at least two of the wires consist of different radiopaque alloys. The strands of the reinforcing structure may have a circular or a rectangular transverse cross-sectional shape.
摘要翻译：公开了一种用于管腔内手术的体内导管，例如引导导管。导管通常具有细长的导管轴，其包括聚合物内层和非辐射不透外部聚合物层，以及设置在内层和外层之间的不透射线的加强结构。在一个实施例中，加强层由编织或缠绕在一起的多个拉制的填充管组成。拉伸的填充管可以具有包覆在不透射线内芯上的不锈钢外护套，或者拉伸的填充管可以具有覆盖在不锈钢芯上的不透射线的外护套。在另一个实施例中，增强层可以由多根线组成，其中包含编织或缠绕在一起的不透射线合金，其中至少两根电线由不同的不透射线的合金组成。加强结构的股线可以具有圆形或矩形的横截面形状。

5. 发明申请

US20080161776A1 GUIDING CATHETER SHAFT WITH IMPROVED RADIOPACITY ON THE WIRE BRAID 有权
标题翻译：导线导杆在电线上有改善的放射性
公开(公告)号：US20080161776A1
公开(公告)日：2008-07-03
申请号：US12049544
申请日：2008-03-17
申请人： Brandon Gosiengfiao , Jonathan M. Howland
发明人： Brandon Gosiengfiao , Jonathan M. Howland
IPC分类号： A61M25/16
CPC分类号： A61M25/0662 , A61M25/0045 , A61M25/005
摘要： An intracorporeal catheter, such as a guiding catheter, employed for intraluminal procedures is disclosed. The catheter generally has an elongated catheter shaft including a polymeric inner layer and a non-radiopaque outer polymeric layer, along with a radiopaque reinforcing structure disposed between the inner and outer layers. In one embodiment, the reinforcing layer consists of multiple drawn filled tubes braided or wound together. The drawn filled tubes may have a stainless steel outer jacket clad over a radiopaque inner core, or the drawn filled tubes may have a radiopaque outer jacket clad over a stainless steel core. In another embodiment, the reinforcing layer may consist of multiple wires containing radiopaque alloys braided or wound together, wherein at least two of the wires consist of different radiopaque alloys. The strands of the reinforcing structure may have a circular or a rectangular transverse cross-sectional shape.
摘要翻译：公开了一种用于管腔内手术的体内导管，例如引导导管。导管通常具有细长的导管轴，其包括聚合物内层和非辐射不透外部聚合物层，以及设置在内层和外层之间的不透射线的加强结构。在一个实施例中，加强层由编织或缠绕在一起的多个拉制的填充管组成。拉伸的填充管可以具有包覆在不透射线内芯上的不锈钢外护套，或者拉伸的填充管可以具有覆盖在不锈钢芯上的不透射线的外护套。在另一个实施例中，增强层可以由多根线组成，其中包含编织或缠绕在一起的不透射线合金，其中至少两根电线由不同的不透射线的合金组成。加强结构的股线可以具有圆形或矩形的横截面形状。

6. 发明授权

US07166098B1 Medical assembly with transducer for local delivery of a therapeutic substance and method of using same 有权
标题翻译：具有用于局部递送治疗物质的换能器的医疗组件及其使用方法
公开(公告)号：US07166098B1
公开(公告)日：2007-01-23
申请号：US09475548
申请日：1999-12-30
申请人： Jeffrey A. Steward , Brandon Gosiengfiao
发明人： Jeffrey A. Steward , Brandon Gosiengfiao
IPC分类号： A61M31/00 , A61B17/20
CPC分类号： A61M25/104 , A61M2025/0057 , A61M2025/1086
摘要： A medical assembly is used to deliver a therapeutic substance to a treatment area. The medical assembly comprises a catheter having a distal end and a proximal end, a transducer supported by at least a portion of the distal end of the catheter assembly, and a delivery lumen mounted on the catheter for delivery of a therapeutic substance. Support for the transducer is provided at a preselected number of anchoring points, wherein an inner surface of the transducer is positioned at a preselected distance from an outer surface of the catheter. The preselected distance defines a gap that is occupied by a low density material such as a gas which reflects acoustic pressure waves directed toward the gap by a transducer when a voltage is applied to the transducer. The reflected pressure wave increases the energy in the system, enhancing transport of therapeutic substances from the delivery lumen to the surrounding tissues and/or cells to be treated. The medical assembly may optionally be used in conjunction with both macroporous and microporous balloons. The medical assembly may optionally be modified so that a plurality of transducers are used, wherein the distal end of a transducer is positioned at a preselected distance from the proximal end of an adjacent transducer.
摘要翻译：医疗组件用于将治疗物质递送至治疗区域。医疗组件包括具有远端和近端的导管，由导管组件的远端的至少一部分支撑的换能器，以及安装在导管上用于输送治疗物质的输送腔。在预选数量的锚固点处提供对换能器的支撑，其中换能器的内表面定位在离导管外表面预定距离处。预选距离限定了由低密度材料例如气体占据的间隙，当将电压施加到换能器时，该气体反射由换能器指向间隙的声压波。反射的压力波增加系统中的能量，增强治疗物质从输送腔向周围组织和/或待治疗细胞的转运。医疗组件可以任选地与大孔和微孔气囊一起使用。可以可选地修改医疗组件，使得使用多个换能器，其中换能器的远端定位在距相邻换能器近端的预选距离处。

7. 发明授权

US07354428B1 Guiding catheter shaft with improved radiopacity on the wire braid 有权
标题翻译：引导导管轴，在导线编织物上具有改善的射线不透性
公开(公告)号：US07354428B1
公开(公告)日：2008-04-08
申请号：US10385987
申请日：2003-03-11
申请人： Brandon Gosiengfiao , Jonathan M. Howland
发明人： Brandon Gosiengfiao , Jonathan M. Howland
IPC分类号： A61M31/00 , A61M25/00 , A61M25/098
CPC分类号： A61M25/0662 , A61M25/0045 , A61M25/005
摘要： An intracorporeal catheter, such as a guiding catheter, employed for intraluminal procedures is disclosed. The catheter generally has an elongated catheter shaft including a polymeric inner layer and a non-radiopaque outer polymeric layer, along with a radiopaque reinforcing structure disposed between the inner and outer layers. In one embodiment, the reinforcing layer consists of multiple drawn filled tubes braided or wound together. The drawn filled tubes may have a stainless steel outer jacket clad over a radiopaque inner core, or the drawn filled tubes may have a radiopaque outer jacket clad over a stainless steel core. In another embodiment, the reinforcing layer may consist of multiple wires containing radiopaque alloys braided or wound together, wherein at least two of the wires consist of different radiopaque alloys. The strands of the reinforcing structure may have a circular or a rectangular transverse cross-sectional shape.
摘要翻译：公开了一种用于管腔内手术的体内导管，例如引导导管。导管通常具有细长的导管轴，其包括聚合物内层和非辐射不透外部聚合物层，以及设置在内层和外层之间的不透射线的加强结构。在一个实施例中，加强层由编织或缠绕在一起的多个拉制的填充管组成。拉伸的填充管可以具有包覆在不透射线内芯上的不锈钢外护套，或者拉伸的填充管可以具有覆盖在不锈钢芯上的不透射线的外护套。在另一个实施例中，增强层可以由多根线组成，其中包含编织或缠绕在一起的不透射线合金，其中至少两根电线由不同的不透射线的合金组成。加强结构的股线可以具有圆形或矩形的横截面形状。

8. 发明授权

US06638267B1 Guidewire with hypotube and internal insert 有权
标题翻译：导丝带海波波和内插
公开(公告)号：US06638267B1
公开(公告)日：2003-10-28
申请号：US09728298
申请日：2000-12-01
申请人： Robert C. Esselstein , Brandon Gosiengfiao
发明人： Robert C. Esselstein , Brandon Gosiengfiao
IPC分类号： A61M2500
CPC分类号： A61M25/0905 , A61M25/09 , A61M2025/09083
摘要： A guidewire having a proximal hypotube portion with an insert to increase pushability and torqueability. The insert may comprise metals such as stainless steel, shape memory/super elastic materials such as nickel titanium alloys, composite materials or polymeric materials. The proximal end of the insert may be configured to dock with an extension guidewire. Preferably, the proximal end of the solid core distal portion of the guidewire is configured to fit within the hypotube and the two are secured by adhesive, solder or the like.
摘要翻译：导丝具有带有插入物的近端海波管部分以增加推力和可逆性。插入件可以包括诸如不锈钢，形状记忆/超弹性材料如镍钛合金，复合材料或聚合物材料的金属。插入件的近端可以被配置成与延伸导丝对接。优选地，导丝的实芯远端部分的近端被配置成装配在海波管内，并且两者通过粘合剂，焊料等固定。

9. 发明授权

US06612998B2 Guide wire with marker sleeve 有权
公开(公告)号：US06612998B2
公开(公告)日：2003-09-02
申请号：US09997811
申请日：2001-11-28
申请人： Brandon Gosiengfiao , Douglas Gesswein , Wayne Cornish , Sharon Y. Wong , Pablito Buan , Mark T. Richardson
发明人： Brandon Gosiengfiao , Douglas Gesswein , Wayne Cornish , Sharon Y. Wong , Pablito Buan , Mark T. Richardson
IPC分类号： A61B500
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09166
摘要： An intracorporeal device such as a guide wire with an elongated core having a radiopaque and optionally MRI-compatible markers embedded in a polymer sleeve disposed on a distal section of the elongated core is disclosed. The marker sleeve may be secured to a tapered portion of the distal core section or a constant diameter portion of the distal core section. Individual markers may be formed by radiopaque ribbons, bands, or strips, or may be in the form of a helical coil.

10. 发明授权

US06451026B1 Dock exchange system for composite guidewires 有权
标题翻译：复合导丝的码头交换系统
公开(公告)号：US06451026B1
公开(公告)日：2002-09-17
申请号：US09736854
申请日：2000-12-13
申请人： Emmanuel C. Biagtan , Shruti Bajaj , Wayne E. Cornish , Brandon Gosiengfiao , Mark Richardson , Peter J. D'Aquanni
发明人： Emmanuel C. Biagtan , Shruti Bajaj , Wayne E. Cornish , Brandon Gosiengfiao , Mark Richardson , Peter J. D'Aquanni
IPC分类号： A61B500
CPC分类号： A61M25/0905 , A61M25/0108 , A61M25/09 , A61M25/09033 , A61M2025/09083 , A61M2025/09133 , A61M2025/09166 , A61M2025/09175
摘要： An elongate intracorporeal guiding device for providing access to desired sites within a patients body. The device, which may be configured as a guidewire, is constructed so as to be compatible with sensitive imaging methods such as MRI and the like and not create imaging artifacts or interference with such imaging methods. The guiding device may be constructed so as to have a distal working section that has minimal metallic content or minimal content of materials that can cause imaging artifacts or interference with MRI imaging, other sensitive imaging methods or the like. The device may also have a dock exchange system to allow attachment and detachment of an extension guidewire.
摘要翻译：细长的体内引导装置，用于提供进入患者体内期望的部位。可以被配置为导丝的装置被构造成与诸如MRI等的敏感成像方法兼容，并且不产生成像伪像或对这种成像方法的干扰。引导装置可以构造成具有远程工作部分，该远端工作部分具有最小的金属含量或材料的最小含量，这可能导致成像伪影或与MRI成像，其他敏感成像方法等的干涉。该装置还可以具有坞站交换系统以允许延伸导丝的附接和分离。

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