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1. 发明申请

US20060004418A1 System and method for managing refractory periods in a cardiac rhythm management device with biventricular sensing 有权
$System and method for managing refractory periods in a cardiac rhythm management device with biventricular sensing$
公开(公告)号：US20060004418A1
公开(公告)日：2006-01-05
申请号：US11218865
申请日：2005-09-02
申请人： Jeffrey Stahmann , Andrew Kramer , James Gilkerson , Lorenzo DiCarlo , Rene Wentkowski
发明人： Jeffrey Stahmann , Andrew Kramer , James Gilkerson , Lorenzo DiCarlo , Rene Wentkowski
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A method and system for managing refractory periods in a cardiac rhythm management device configured for biventricular or biatrial sensing. Refractory periods for each channel of the pacemaker are provided by interval timers that are triggered by sensed or paced events in order to prevent misinterpretation of sensing signals.

2. 发明申请

US20050149135A1 Apparatus and method for treating ventricular tachyarrhythmias 有权
标题翻译：用于治疗室性快速性心律失常的装置和方法
公开(公告)号：US20050149135A1
公开(公告)日：2005-07-07
申请号：US11073818
申请日：2005-03-07
申请人： David Krig , James Gilkerson , Robert Dreher , Jan Wald , William Linder , William Zimmer
发明人： David Krig , James Gilkerson , Robert Dreher , Jan Wald , William Linder , William Zimmer
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/395 , A61N1/3962
摘要： A system and method for selectively treating a ventricular tachycardia based on sensed atrial and ventricular intervals from the patient's heart. A detection window of the ten most recent atrial and ventricular intervals are analyzed for the occurrence of either tachycardia or fibrillation. When a majority of the sensed intervals are satisfied, the apparatus starts a duration time interval. Ventricular intervals and atrial intervals are compare, ventricular interval greater than the atrial interval by a bias factor the system delivers tachycardia therapy to the heart. Alternatively, the method withholds tachycardia therapy to the heart when the atrial rate is classified as atrial fibrillation and the ventricular response is unstable.
摘要翻译：一种系统和方法，用于根据来自患者心脏的感觉的心房和心室间隔选择性地治疗室性心动过速。分析十个最近的心房和心室间隔的检测窗口，用于心动过速或颤动的发生。当满足感测间隔的大部分时，设备开始持续时间间隔。比较心室间隔和心房间隔，心室间隔大于心房间隔，系统将心动过速治疗提供给心脏。或者，当心房率被分类为心房颤动和心室反应不稳定时，该方法禁止对心脏的心动过速治疗。

3. 发明申请

US20050033385A1 Implantable medical device programming apparatus having a graphical user interface 有权
标题翻译：具有图形用户界面的植入式医疗装置编程装置
公开(公告)号：US20050033385A1
公开(公告)日：2005-02-10
申请号：US10841967
申请日：2004-05-06
申请人： Les Peterson , Paula Dieterle , LanAnh Nguyen , James Kalgren , James Gilkerson , Dorothy Nauman , Aaron Peterson , Mark Schwartz
发明人： Les Peterson , Paula Dieterle , LanAnh Nguyen , James Kalgren , James Gilkerson , Dorothy Nauman , Aaron Peterson , Mark Schwartz
IPC分类号： A61N1/08 , A61N1/372
CPC分类号： A61N1/37247
摘要： Systems and methods for a configurable programmer for an implantable cardiovascular medical device are disclosed. A preferred embodiment comprises a graphical user interface to visualize programming processes to alert a clinician to potential problems with the patient's condition or the therapy provided by the device, or the device itself. The programmer is further adapted to minimize the risk of programming potentially dangerous changes to the implantable device's parameter settings by requiring the clinician to first review new value changes before initiating the programming step. The programmer also allows the clinician to view how a change to one or more parameter settings affect other settings before the implantable device is programmed or re-programmed.
摘要翻译：公开了用于可植入心血管医疗装置的可配置编程器的系统和方法。优选实施例包括图形用户界面，用于可视化编程过程以警告临床医生潜在的患者状况或由设备提供的治疗或设备本身的问题。程序员进一步适应于通过要求临床医生在开始编程步骤之前首先检查新的值改变来最小化对可植入装置的参数设置的潜在危险变化的风险。程序员还允许临床医生查看在一个或多个参数设置的更改如何影响其他设置，然后才能对可植入设备进行编程或重新编程。

4. 发明申请

US20080021523A1 METHOD AND APPARATUS FOR INDICATION-BASED PROGRAMMING OF CARDIAC RHYTHM MANAGEMENT DEVICES 有权
标题翻译： CARDIAC RHYTHM管理设备的基于适应性编程的方法和装置
公开(公告)号：US20080021523A1
公开(公告)日：2008-01-24
申请号：US11831683
申请日：2007-07-31
申请人： Adam Cates , James Gilkerson , Kenneth Hoyme
发明人： Adam Cates , James Gilkerson , Kenneth Hoyme
IPC分类号： A61N1/00
CPC分类号： A61N1/37235 , A61N1/362 , A61N1/365 , A61N1/37211 , A61N1/37247 , A61N1/37252 , A61N1/37264 , A61N1/3956 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/40 , G16H40/63 , G16H50/20
摘要： A cardiac rhythm management (CRM) system includes a programming device that determines parameters for programming an implantable medical device based on patient-specific information including indications for use of the implantable medical device. By executing an indication-based programming algorithm, the programming device substantially automates the process between the diagnosis of a patient and the programming of an implantable medical device using parameters individually determined for that patient.
摘要翻译：心律管理（CRM）系统包括编程设备，其基于患者特定信息确定用于编程可植入医疗设备的参数，包括可植入医疗设备的使用的指示。通过执行基于指示的编程算法，编程设备使用为该患者单独确定的参数，使患者的诊断和可植入医疗设备的编程之间的过程基本上自动化。

5. 发明申请

US20070129765A1 Implantable medical device for generating cardiac pressure-volume loop and optimizing therapy 有权
标题翻译：用于产生心脏压力 - 体积循环和优化治疗的植入式医疗装置
公开(公告)号：US20070129765A1
公开(公告)日：2007-06-07
申请号：US11296732
申请日：2005-12-07
申请人： James Gilkerson , Yongxing Zhang , Yunlong Zhang , Sophia Wang
发明人： James Gilkerson , Yongxing Zhang , Yunlong Zhang , Sophia Wang
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/3962
摘要： An implantable medical device for generating a cardiac pressure-volume loop, the implantable medical device comprising a pulse generator including control circuitry, a first cardiac lead including a proximal end and a distal end and coupled to the pulse generator at the proximal end, a first electrode located at the distal end of the cardiac lead and operatively coupled to the control circuitry, a sound sensor operatively coupled to the control circuitry, and a pressure sensor operatively coupled to the control circuitry, wherein the implantable medical device is adapted for measuring intracardiac impedance. A method of using the implantable medical device to optimize therapy delivered to the heart.
摘要翻译：一种用于产生心脏压力 - 体积回路的可植入医疗装置，所述可植入医疗装置包括脉冲发生器，所述脉冲发生器包括控制电路，包括近端和远端的第一心脏引线，并且在近端处耦合到所述脉冲发生器，电极，位于心脏引线的远端并且可操作地耦合到控制电路，操作地耦合到控制电路的声音传感器和可操作地耦合到控制电路的压力传感器，其中可植入医疗装置适于测量心内阻抗。一种使用可植入医疗装置来优化递送至心脏的治疗的方法。

6. 发明申请

US20070043394A1 Intracardiac impedance and its applications 有权
标题翻译：心内阻抗及其应用
公开(公告)号：US20070043394A1
公开(公告)日：2007-02-22
申请号：US11208922
申请日：2005-08-22
申请人： Yunlong Zhang , James Gilkerson , Yongxing Zhang , Boyce Moon
发明人： Yunlong Zhang , James Gilkerson , Yongxing Zhang , Boyce Moon
IPC分类号： A61N1/39
CPC分类号： A61N1/3962 , A61N1/3621 , A61N1/36521 , A61N1/3925
摘要： A system to measure intracardiac impedance includes implantable electrodes and a medical device. The electrodes sense electrical signals of a heart of a subject. The medical device includes a cardiac signal sensing circuit coupled to the implantable electrodes, an impedance measurement circuit coupled to the same or different implantable electrodes, and a controller circuit coupled to the cardiac signal sensing circuit and the impedance measurement circuit. The cardiac signal sensing circuit provides a sensed cardiac signal. The impedance measurement circuit senses intracardiac impedance between the electrodes to obtain an intracardiac impedance signal. The controller circuit determines cardiac cycles of the subject using the sensed cardiac signal, and detects tachyarrhythmia using cardiac-cycle to cardiac-cycle changes in a plurality of intracardiac impedance parameters obtained from the intracardiac impedance signal.
摘要翻译：测量心内阻抗的系统包括可植入电极和医疗装置。电极感测受试者心脏的电信号。医疗装置包括耦合到可植入电极的心脏信号感测电路，耦合到相同或不同可植入电极的阻抗测量电路，以及耦合到心脏信号感测电路和阻抗测量电路的控制器电路。心脏信号感测电路提供感测的心脏信号。阻抗测量电路感测电极之间的心内阻抗，以获得心内阻抗信号。控制器电路使用感测到的心脏信号来确定受试者的心脏周期，并且使用从心脏内阻抗信号获得的多个心内阻抗参数中的心脏周期与心脏周期变化来检测快速性心律失常。

7. 发明申请

US20060241712A1 Method and apparatus for indication-based programming of cardiac rhythm management devices 有权
标题翻译：用于心律管理装置的基于指示的编程的方法和装置
公开(公告)号：US20060241712A1
公开(公告)日：2006-10-26
申请号：US11110500
申请日：2005-04-20
申请人： Adam Cates , James Gilkerson , Kenneth Hoyme
发明人： Adam Cates , James Gilkerson , Kenneth Hoyme
IPC分类号： A61N1/362
CPC分类号： A61N1/37235 , A61N1/362 , A61N1/365 , A61N1/37211 , A61N1/37247 , A61N1/37252 , A61N1/37264 , A61N1/3956 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/40 , G16H40/63 , G16H50/20
摘要： A cardiac rhythm management (CRM) system includes a programming device that determines parameters for programming an implantable medical device based on patient-specific information including indications for use of the implantable medical device. By executing an indication-based programming algorithm, the programming device substantially automates the process between the diagnosis of a patient and the programming of an implantable medical device using parameters individually determined for that patient.
摘要翻译：心律管理（CRM）系统包括编程设备，该编程设备基于包括用于可植入医疗设备的使用的指示的患者特定信息来确定用于编程可植入医疗设备的参数。通过执行基于指示的编程算法，编程设备使用为该患者单独确定的参数，使患者的诊断和可植入医疗设备的编程之间的过程基本上自动化。

8. 发明申请

US20050102004A1 Pacemaker passive measurement testing system and method 有权
标题翻译：起搏器被动测量系统及方法
公开(公告)号：US20050102004A1
公开(公告)日：2005-05-12
申请号：US11010974
申请日：2004-12-13
申请人： Vickie Conley , James Gilkerson , David Perschbacher
发明人： Vickie Conley , James Gilkerson , David Perschbacher
IPC分类号： A61N1/37
CPC分类号： A61N1/3706 , A61N1/3702
摘要： A system and method for passively testing a cardiac pacemaker in which sensing signal amplitudes and lead impedance values are measured and stored while the pacemaker is functioning in its programmed mode. The amplitude and impedance data may be gotten and stored periodically at regular intervals to generate a historical record for diagnostic purposes. Sensing signal amplitudes may also be measured and stored from a sensing channel which is currently not programmed to be active as long as the pacemaker is physically configured to support the sensing channel. Such data can be useful in evaluating whether a switch in the pacemaker's operating mode is desirable.
摘要翻译：一种用于被动测试心脏起搏器的系统和方法，其中在起搏器在其编程模式下起作用时测量和存储感测信号幅度和引线阻抗值。可以以规律的间隔周期性获得和存储振幅和阻抗数据，以产生用于诊断目的的历史记录。只要心脏起搏器物理配置为支持感测通道，感测信号幅度也可以从目前未编程为有效的感测通道测量和存储。这样的数据可用于评估起搏器的操作模式中的开关是否可取。

9. 发明申请

US20050096708A1 Atrial antitachycardia pacing management 审中-公开
标题翻译：心房抗心动过速起搏管理
公开(公告)号：US20050096708A1
公开(公告)日：2005-05-05
申请号：US10698858
申请日：2003-10-31
申请人： Gary Seim , James Gilkerson
发明人： Gary Seim , James Gilkerson
IPC分类号： A61N1/08 , A61N1/362 , A61N1/37
CPC分类号： A61N1/37 , A61N1/3621 , A61N1/371 , A61N2001/083
摘要： A system and method provides for managing atrial ATP therapy in response to possible atrial lead dislodgment. An impedance of an atrial lead is measured for a particular patient. The measured impedance is compared with an impedance threshold developed for the particular patient. Atrial ATP therapy delivery is disabled in response to the measured impedance deviating from the impedance threshold by a predetermined factor. The impedance threshold may be developed from one or more atrial lead impedance measurements, and may also be characterized by a mean or a median of several atrial lead impedance measurements. The predetermined factor may be characterized by a percentage change, a fixed delta change, or both a percentage change and a fixed delta change in the measured impedance relative to the impedance threshold.
摘要翻译：一种系统和方法提供用于管理心房ATP治疗以响应可能的心房前叉移位。针对特定患者测量心房线的阻抗。将测量的阻抗与为特定患者开发的阻抗阈值进行比较。响应于从阻抗阈值偏离预定因子的测量阻抗来禁用心房ATP治疗递送。阻抗阈值可以从一个或多个心房导联阻抗测量开发，并且还可以通过几个心房导联阻抗测量的平均值或中值来表征。预定因子可以通过百分比变化，固定的δ变化或者测量的阻抗相对于阻抗阈值的百分比变化和固定的增量变化来表征。

10. 发明申请

US20070299492A1 Implantable lead for septal placement of electrode with fixation mechanism in the pulmonary artery 审中-公开
标题翻译：在肺动脉中具有固定机制的电极间隔放置的植入性铅
公开(公告)号：US20070299492A1
公开(公告)日：2007-12-27
申请号：US11895808
申请日：2007-08-28
申请人： Yongxing Zhang , James Gilkerson , Paul Zarembo
发明人： Yongxing Zhang , James Gilkerson , Paul Zarembo
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/0585
摘要： A lead body includes an electrode coupled to an intermediate portion of the lead body. A distal end of the lead includes a pre-formed, biased shape adapted to passively fixate the distal end of the lead within a pulmonary artery with the electrode positioned in the right ventricle or ventricular outflow tract. The lead body can include a pre-formed J-shape, with the electrode coupled to the intermediate portion of the lead body and located distally from a bottom of the pre-formed J-shape. The lead body can include a section of the intermediate portion of the lead body being less stiff than adjacent sections of the lead body with the electrode coupled to the intermediate portion of the lead body and located distally from the less stiff section.
摘要翻译：引线体包括连接到引线主体的中间部分的电极。引线的远端包括预先形成的偏压形状，其适于被动地固定在肺动脉内的引线的远端，其中电极定位在右心室或心室流出道中。引线体可以包括预形成的J形，电极耦合到引线本体的中间部分并且位于远离预成形的J形的底部。引线主体可以包括引线主体的中间部分的一部分比引线主体的相邻部分刚性差，其中电极耦合到引线主体的中间部分并且位于较硬的部分的远侧。

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