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1. 发明申请

US20090062176A1 Foamable Compositions 有权
标题翻译：可发泡组合物
公开(公告)号：US20090062176A1
公开(公告)日：2009-03-05
申请号：US11847772
申请日：2007-08-30
申请人： Jeffrey R. Seidling , Scott W. Wenzel , Corey Thomas Cunningham , Pierre Joseph
发明人： Jeffrey R. Seidling , Scott W. Wenzel , Corey Thomas Cunningham , Pierre Joseph
IPC分类号： C11D17/00 , C11D3/37
CPC分类号： C11D3/0094 , C11D3/2041 , C11D3/2065 , C11D3/3738 , C11D3/43 , C11D17/0043
摘要： Foamable compositions are disclosed. The compositions contain one or more active ingredients combined with a foaming agent and optionally one or more surface tension adjusting agents. The foaming agent may comprise, for instance, a derivatized dimethicone. The surface tension adjusting agent, on the other hand, comprises a chemical species that either increases or decreases the surface tension of the composition within a desired range so that the composition is readily foamable. In this manner, active ingredients can be incorporated into the compositions that are typically hard to foam. Such ingredients include cleaning solvents and various skin care agents. Of particular advantage, foamable compositions can be formulated in accordance with the present disclosure that contain relatively small amounts of water such as less than about 20 percent by weight, such as less than about 10 percent by weight. In other embodiments, the composition can be completely anhydrous.
摘要翻译：公开了可发泡组合物。组合物含有一种或多种与发泡剂和任选的一种或多种表面张力调节剂组合的活性成分。发泡剂可以包括例如衍生的聚二甲基硅氧烷。另一方面，表面张力调节剂包括在所需范围内增加或降低组合物表面张力的化学物质，使组合物容易发泡。以这种方式，活性成分可以并入通常难以发泡的组合物中。这些成分包括清洁溶剂和各种护肤剂。特别有利的是，可根据本公开内容配制可发泡组合物，其含有相对少量的水，例如小于约20重量％，例如小于约10重量％。在其它实施方案中，组合物可以是完全无水的。

2. 发明授权

US08053399B2 Foamable compositions 有权
标题翻译：可发泡组合物
公开(公告)号：US08053399B2
公开(公告)日：2011-11-08
申请号：US11847772
申请日：2007-08-30
申请人： Jeffrey R. Seidling , Scott W. Wenzel , Corey Thomas Cunningham , Pierre Joseph
发明人： Jeffrey R. Seidling , Scott W. Wenzel , Corey Thomas Cunningham , Pierre Joseph
IPC分类号： A61K7/06
CPC分类号： C11D3/0094 , C11D3/2041 , C11D3/2065 , C11D3/3738 , C11D3/43 , C11D17/0043
摘要： Foamable compositions are disclosed. The compositions contain one or more active ingredients combined with a foaming agent and optionally one or more surface tension adjusting agents. The foaming agent may comprise, for instance, a derivatized dimethicone. The surface tension adjusting agent, on the other hand, comprises a chemical species that either increases or decreases the surface tension of the composition within a desired range so that the composition is readily foamable. In this manner, active ingredients can be incorporated into the compositions that are typically hard to foam. Such ingredients include cleaning solvents and various skin care agents. Of particular advantage, foamable compositions can be formulated in accordance with the present disclosure that contain relatively small amounts of water such as less than about 20 percent by weight, such as less than about 10 percent by weight. In other embodiments, the composition can be completely anhydrous.
摘要翻译：公开了可发泡组合物。组合物含有一种或多种与发泡剂和任选的一种或多种表面张力调节剂组合的活性成分。发泡剂可以包括例如衍生的聚二甲基硅氧烷。另一方面，表面张力调节剂包括在所需范围内增加或降低组合物表面张力的化学物质，使组合物容易发泡。以这种方式，可以将活性成分并入通常难以发泡的组合物中。这些成分包括清洁溶剂和各种护肤剂。特别有利的是，可根据本公开内容配制可发泡组合物，其含有相对少量的水，例如小于约20重量％，例如小于约10重量％。在其它实施方案中，组合物可以是完全无水的。

3. 发明申请

US20050009881A1 High concentration topical insecticides containing pyrethroids 有权
标题翻译：含有拟除虫菊酯的高浓度局部杀虫剂
公开(公告)号：US20050009881A1
公开(公告)日：2005-01-13
申请号：US10910542
申请日：2004-08-03
申请人： Ian Cottrell , Albert Ahn , Richard Fisher , Christine Monro , Pierre Joseph
发明人： Ian Cottrell , Albert Ahn , Richard Fisher , Christine Monro , Pierre Joseph
IPC分类号： A01N43/08 , A01N47/40 , A01N51/00 , A01N25/00 , A01N37/34 , A01N43/40
CPC分类号： A01N43/08 , A01N47/40 , A01N51/00 , Y10S514/875 , Y10S514/97 , A01N2300/00
摘要： A topical insecticide preparation is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The topical insecticide contains a combination of a first pyrethroid insecticide effective for killing fleas, a second pyrethroid insecticide effective for killing ticks, and an insect growth regulator (IGR). The topical insecticide preparation can be packaged together or packaged so that the first and second pyrethroid insecticides are stored separately prior to administration of the insecticide preparation to the animal. The combination of the first and second pyrethroid insecticides with an insect growth regulator results in an insecticide preparation formulated to have enhanced insecticidal activity against fleas and ticks compared to the effectiveness of the first and second insecticides used alone. Further, the combination of the first and second pyrethroid insecticides with an insect growth regulator produces an insecticide preparation having enhanced insecticidal activity against fleas and ticks while advantageously minimizing the total amount of insecticide needed for its effectiveness.
摘要翻译：提供一种局部用的杀虫剂制剂，其可以安全使用并避免常规外用杀虫剂的许多常见的有害副作用。局部杀虫剂包含有效杀死蚤的第一拟除虫菊酯杀虫剂，有效杀死蜱的第二拟除虫菊酯杀虫剂和昆虫生长调节剂（IGR）的组合。局部用杀虫剂可以包装在一起或包装，使得第一和第二拟除虫菊酯杀虫剂在向杀虫剂施用之前分开储存。第一和第二拟除虫菊酯杀虫剂与昆虫生长调节剂的组合产生了与单独使用的第一种和第二种杀虫剂的有效性相比，配制的杀虫剂制剂对跳蚤和蜱具有增强的杀虫活性。此外，第一和第二拟除虫菊酯杀虫剂与昆虫生长调节剂的组合产生了对跳蚤和蜱具有增强的杀虫活性的杀虫剂制剂，同时有利地最小化其有效性所需的杀虫剂总量。

4. 发明申请

US20050096386A1 High concentration topical insecticide containing insect growth regulator 有权
标题翻译：含有昆虫生长调节剂的高浓度局部杀虫剂
公开(公告)号：US20050096386A1
公开(公告)日：2005-05-05
申请号：US10700013
申请日：2003-11-03
申请人： Ian Cottrell , Christine Monro , Pierre Joseph , Albert Ahn , Richard Fisher
发明人： Ian Cottrell , Christine Monro , Pierre Joseph , Albert Ahn , Richard Fisher
IPC分类号： A01N20060101 , A01N25/00 , A01N25/22 , A01N33/12 , A01N33/14 , A01N37/00 , A01N37/02 , A01N37/06 , A01N43/08 , A01N43/40 , A01N51/00
CPC分类号： A01N51/00 , Y10S514/875 , Y10S514/97 , Y10S514/971 , A01N61/00 , A01N49/00 , A01N43/40 , A01N33/12 , A01N25/02 , A01N2300/00
摘要： A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The insecticide contains an insecticide and an insect growth regulator effective for killing fleas, flea larvae and flea eggs. The insecticide is formulated by dissolving an insecticidal (tetrahydro-3-furanyl) methylamine derivative and an insect growth regulator (IGR) in a solvent containing a quaternary ammonium salt to increase the solvency of the IGR component, thereby providing an insecticide having high insecticidal activity.
摘要翻译：提供了一种局部用杀虫剂，其可以安全使用并避免常规外用杀虫剂的许多常见的有害副作用。杀虫剂含有杀虫剂和昆虫生长调节剂，可有效杀死跳蚤，跳蚤幼虫和跳蚤卵。通过将杀虫剂（四氢-3-呋喃基）甲胺衍生物和昆虫生长调节剂（IGR）溶解在含有季铵盐的溶剂中来提高IGR成分的溶解能力，从而提供具有高杀虫活性的杀虫剂。

5. 发明授权

US07354595B2 High concentration dinotefuran formulations 有权
标题翻译：高浓度dinotefuran配方
公开(公告)号：US07354595B2
公开(公告)日：2008-04-08
申请号：US11124678
申请日：2005-05-09
申请人： Ian W. Cottrell , Christine Monro , Pierre Joseph , Richard Fisher
发明人： Ian W. Cottrell , Christine Monro , Pierre Joseph , Richard Fisher
IPC分类号： A01N25/32 , A01N43/08
CPC分类号： A01N51/00 , A01N43/08 , A01N47/40 , A01N43/40 , A01N49/00 , A01N25/02 , A01N2300/00
摘要： A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas dissolved in ethyl lactate.
摘要翻译：提供了一种局部用杀虫剂，其可以安全使用并避免常规外用杀虫剂的许多常见的有害副作用。在本发明的一个优选实施方案中，杀虫剂制剂的活性成分是具有硝基亚甲基，硝基氨基或氰基氨基的胺衍生物，其可配制成具有低毒性和优异的杀虫活性。一种特别合适的杀虫剂是1-{（四氢-3-呋喃基）甲基} -2-硝基-3-甲基胍（dinotefuran），其将杀死溶解在乳酸乙酯中的成年蚤。

6. 发明申请

US20090123504A1 OLIVE OIL FORMULATION FOR PAIN RELIEF 审中-公开
标题翻译：用于减轻疼痛的橄榄油配方
公开(公告)号：US20090123504A1
公开(公告)日：2009-05-14
申请号：US11938596
申请日：2007-11-12
申请人： Joseph R. Feldkamp , Laura Serra , Pierre Joseph , Corey Cunningham
发明人： Joseph R. Feldkamp , Laura Serra , Pierre Joseph , Corey Cunningham
IPC分类号： A61K9/00 , A61K31/22 , A61P29/00
CPC分类号： A61K47/44 , A61K9/0014 , A61K9/7023 , A61K31/00 , A61K31/22 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/14 , A61K2300/00
摘要： The present disclosure generally relates to methods and compositions for reducing inflammation and/or pain, and more particularly, to compositions comprising an NSAID and oleocanthal and/or a related compound. The compositions are particularly suitable for topical delivery and may be used to relieve the effects of arthritis.
摘要翻译：本公开一般涉及用于减少炎症和/或疼痛的方法和组合物，更具体地涉及包含NSAID和油鞘醇和/或相关化合物的组合物。该组合物特别适用于局部输送，并可用于缓解关节炎的作用。

7. 发明申请

US20050245582A1 High concentration topical insecticides containing pyrethroids 审中-公开
公开(公告)号：US20050245582A1
公开(公告)日：2005-11-03
申请号：US11181344
申请日：2005-07-14
申请人： Ian Cottrell , Albert Ahn , Richard Fisher , Christine Monro , Pierre Joseph
发明人： Ian Cottrell , Albert Ahn , Richard Fisher , Christine Monro , Pierre Joseph
IPC分类号： A01N25/34 , A01N37/18 , A01N37/34 , A01N43/08 , A01N43/40 , A01N53/00
CPC分类号： A01N47/40 , A01N25/34 , A01N53/00 , Y10S514/875 , Y10S514/97 , A01N43/40 , A01N49/00 , A01N51/00 , A01N57/12 , A01N2300/00 , A01N25/02
摘要： A topical insecticide preparation is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The topical insecticide contains a combination of a first pyrethroid insecticide effective for killing fleas, a second pyrethroid insecticide effective for killing ticks, and an insect growth regulator (IGR). The topical insecticide preparation can be packaged together or packaged so that the first and second pyrethroid insecticides are stored separately prior to administration of the insecticide preparation to the animal. The combination of the first and second pyrethroid insecticides with an insect growth regulator results in an insecticide preparation formulated to have enhanced insecticidal activity against fleas and ticks compared to the effectiveness of the first and second insecticides used alone. Further, the combination of the first and second pyrethroid insecticides with an insect growth regulator produces an insecticide preparation having enhanced insecticidal activity against fleas and ticks while advantageously minimizing the total amount of insecticide needed for its effectiveness.

8. 发明申请

US20080038214A1 HIGH CONCENTRATION DINOTEFURAN FORMULATIONS 审中-公开
标题翻译：高浓度DINOTEFURA配方
公开(公告)号：US20080038214A1
公开(公告)日：2008-02-14
申请号：US11877272
申请日：2007-10-23
申请人： Ian Cottrell , Christine Monro , Pierre Joseph , Richard Fisher
发明人： Ian Cottrell , Christine Monro , Pierre Joseph , Richard Fisher
IPC分类号： A01N43/08 , A01P7/04 , A61Q17/04
CPC分类号： A01N51/00 , A01N43/08 , A01N47/40 , A01N43/40 , A01N49/00 , A01N25/02 , A01N2300/00
摘要： A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas dissolved in ethyl lactate.
摘要翻译：提供了一种局部用杀虫剂，其可以安全使用并避免常规外用杀虫剂的许多常见的有害副作用。在本发明的一个优选实施方案中，杀虫剂制剂的活性成分是具有硝基亚甲基，硝基氨基或氰基氨基的胺衍生物，其可配制成具有低毒性和优异的杀虫活性。一种特别合适的杀虫剂是1-{（四氢-3-呋喃基）甲基} -2-硝基-3-甲基胍（dinotefuran），其将杀死溶解在乳酸乙酯中的成年蚤。

9. 发明申请

US20050209318A1 High concentration dinotefuran formulations 有权
标题翻译：高浓度dinotefuran配方
公开(公告)号：US20050209318A1
公开(公告)日：2005-09-22
申请号：US11124678
申请日：2005-05-09
申请人： Ian Cottrell , Christine Monro , Pierre Joseph , Richard Fisher
发明人： Ian Cottrell , Christine Monro , Pierre Joseph , Richard Fisher
IPC分类号： A01N43/08 , A01N47/40 , A01N51/00 , A01N37/18
CPC分类号： A01N51/00 , A01N43/08 , A01N47/40 , A01N43/40 , A01N49/00 , A01N25/02 , A01N2300/00
摘要： A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas dissolved in ethyl lactate.
摘要翻译：提供了一种局部用杀虫剂，其可以安全使用并避免常规外用杀虫剂的许多常见的有害副作用。在本发明的一个优选实施方案中，杀虫剂制剂的活性成分是具有硝基亚甲基，硝基氨基或氰基氨基的胺衍生物，其可配制成具有低毒性和优异的杀虫活性。一种特别合适的杀虫剂是1-{（四氢-3-呋喃基）甲基} -2-硝基-3-甲基胍（dinotefuran），其将杀死溶解在乳酸乙酯中的成年蚤。

10. 发明申请

US20050009880A1 High concentration topical insecticide containing insect growth regulator 有权
标题翻译：含有昆虫生长调节剂的高浓度局部杀虫剂
公开(公告)号：US20050009880A1
公开(公告)日：2005-01-13
申请号：US10910493
申请日：2004-08-03
申请人： Ian Cottrell , Albert Ahn , Richard Fisher , Christine Monro , Pierre Joseph
发明人： Ian Cottrell , Albert Ahn , Richard Fisher , Christine Monro , Pierre Joseph
IPC分类号： A01N43/08 , A01N47/40 , A01N51/00 , A01N43/40
CPC分类号： A01N43/08 , A01N47/40 , A01N51/00 , Y10S514/875 , Y10S514/97 , Y10S514/971 , A01N2300/00
摘要： A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The insecticide contains an insecticide and an insect growth regulator effective for killing fleas, flea larvae and flea eggs. The insecticide is formulated by dissolving an insecticidal (tetrahydro-3-furanyl) methylamine derivative or a chloronicotinyl insecticide and an insect growth regulator (IGR) in a solvent containing a quaternary ammonium salt to increase the solvency of the IGR component, thereby providing an insecticide having high insecticidal activity.
摘要翻译：提供了一种局部用杀虫剂，其可以安全使用并避免常规外用杀虫剂的许多常见的有害副作用。杀虫剂含有杀虫剂和昆虫生长调节剂，可有效杀死跳蚤，跳蚤幼虫和跳蚤卵。通过将杀虫剂（四氢-3-呋喃基）甲胺衍生物或氯代烟碱类杀虫剂和昆虫生长调节剂（IGR）溶解在含有季铵盐的溶剂中来提高IGR成分的溶解能力，从而提供杀虫剂具有很高的杀虫活性。

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