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1. 发明授权

US08452388B2 Apparatus and method for assessing vascular health 有权
标题翻译：用于评估血管健康的装置和方法
公开(公告)号：US08452388B2
公开(公告)日：2013-05-28
申请号：US12464640
申请日：2009-05-12
申请人： Joseph R. Feldkamp , Jeffrey Robert Heller
发明人： Joseph R. Feldkamp , Jeffrey Robert Heller
IPC分类号： A61M25/00
CPC分类号： A61B5/053 , A61B5/0522 , A61B5/6824 , A61B2560/0431 , A61B2560/0462
摘要： Apparatus and methods for utilizing conductivity measurements to assess vascular health or to diagnose vascular conditions are disclosed. An exemplary method includes performing a first conductivity measurement of an extremity at a first elevation; elevating the extremity to a second elevation; performing a second conductivity measurement at the second elevation; and comparing the first conductivity measurement and the second conductivity measurement to determine a conductivity displacement Δσ. Another exemplary method includes maintaining a conductivity sensor adjacent to an individual for a period of time; performing a series of conductivity measurements; using the series of conductivity measurements to determine the transient behavior of the conductivity over the period of time; and using the transient behavior of the conductivity to assess the vascular health of the individual. A conductivity sensor and platform unit for performing conductivity measurements are also disclosed.
摘要翻译：公开了用于利用电导率测量来评估血管健康或诊断血管病症的装置和方法。示例性方法包括在第一高度处执行末端的第一电导率测量; 将肢体升高到第二高度; 在第二高度处执行第二电导率测量; 并且比较第一电导率测量和第二电导率测量以确定电导率位移Deltasigma。另一示例性方法包括在一段时间内保持与个体相邻的电导率传感器; 进行一系列电导率测量; 使用一系列电导率测量来确定电导率在一段时间内的瞬态行为; 并使用电导率的瞬态行为来评估个体的血管健康。还公开了用于执行电导率测量的电导率传感器和平台单元。

2. 发明申请

US20080003273A1 Transdermal Delivery of Oleocanthal for Relief of Inflammation 有权
标题翻译： Oleocanthal透皮输送用于缓解炎症
公开(公告)号：US20080003273A1
公开(公告)日：2008-01-03
申请号：US11427663
申请日：2006-06-29
申请人： Joseph R. Feldkamp , David William Koenig , Scott W. Wenzel , Wael Joseph
发明人： Joseph R. Feldkamp , David William Koenig , Scott W. Wenzel , Wael Joseph
IPC分类号： A61K31/22 , A61F13/02
CPC分类号： A61K9/0014 , A61K9/12 , A61K9/7038 , A61K31/216 , A61K47/10
摘要： The present disclosure generally relates to compositions for reducing inflammation, and more particularly, to compositions comprising oleocanthal. The oleocanthal-containing compositions are particularly suitable for transdermal delivery. The compositions may also be used in combination with personal care products, such as wipes and absorbent articles, and may be incorporated into transdermal patches.
摘要翻译：本公开内容一般涉及用于减少炎症的组合物，更具体地涉及包含油松醇的组合物。含有香草醇的组合物特别适用于透皮递送。组合物还可以与个人护理产品如擦拭物和吸收制品组合使用，并且可以并入透皮贴剂中。

3. 发明申请

US20100219841A1 Conductivity Sensor 有权
标题翻译：电导率传感器
公开(公告)号：US20100219841A1
公开(公告)日：2010-09-02
申请号：US12464431
申请日：2009-05-12
申请人： Joseph R. Feldkamp , Jeffrey Robert Heller , Douglas Glenn Laudenslager
发明人： Joseph R. Feldkamp , Jeffrey Robert Heller , Douglas Glenn Laudenslager
IPC分类号： G01R27/00 , G01R27/28
CPC分类号： G01R27/2611 , A61B5/053 , A61B5/0537 , A61B5/681 , A61B5/6824 , A61B5/6887 , A61B5/7282 , A61B2560/0431 , A61B2560/0462 , A61B2562/0223 , H01F5/003
摘要： A conductivity sensor is disclosed. The conductivity sensor includes an oscillator for providing an input signal and a reactive circuit having an induction coil, a capacitive element, and a resistive element connected in parallel. The induction coil is adapted to be placed adjacent to a specimen. The conductivity sensor further includes a control circuit for driving the reactive circuit to resonance when the induction coil is placed adjacent to the specimen. The reactive coil is configured to provide an output signal having a parameter representative of the conductivity of the specimen when the reactive circuit is at resonance. The induction coil may include a first conductive element that spirals outward to an external perimeter and a second conductive element operably connected to the first conductive element. The second conductive element spirals inward from the external perimeter staggered relative to the first conductive element.
摘要翻译：公开了电导率传感器。电导率传感器包括用于提供输入信号的振荡器和具有并联连接的感应线圈，电容元件和电阻元件的无功电路。感应线圈适于放置在与样本相邻的位置。电导率传感器还包括控制电路，用于当感应线圈与样本相邻放置时，驱动无功电路进行谐振。反应线圈被配置为当无功电路处于共振时提供具有表示样品的导电性的参数的输出信号。感应线圈可以包括向外螺旋到外部周边的第一导电元件和可操作地连接到第一导电元件的第二导电元件。第二导电元件相对于第一导电元件从外部周边向内螺旋地交错设置。

4. 发明申请

US20080048786A1 Resonant coil for measuring specimen condition 有权
标题翻译：用于测量样品状态的谐振线圈
公开(公告)号：US20080048786A1
公开(公告)日：2008-02-28
申请号：US11464284
申请日：2006-08-14
申请人： Joseph R. Feldkamp , Jeffrey R. Heller , Shawn J. Sullivan
发明人： Joseph R. Feldkamp , Jeffrey R. Heller , Shawn J. Sullivan
IPC分类号： H03L7/00
CPC分类号： G01H13/00 , A61B5/053 , A61B5/0537 , A61B5/4872
摘要： An oscillator provides a reference signal having a phase. A tunable reactive circuit, including an induction coil, is driven by the fixed frequency reference signal of the oscillator with coil adapted to be positioned adjacent the specimen to generate an oscillating signal corresponding to the condition of the specimen. The tunable reactive circuit provides an output signal having a parameter indicative of the condition of the specimen. A resonant control circuit compares the reference signal to the oscillating signal and provides to the tunable reactive circuit a resonance control signal representative of the comparison. The resonance control signal tunes the tunable reactive circuit, which may be a series RLC circuit, so that the frequency of the oscillating signal is substantially constant.
摘要翻译：振荡器提供具有相位的参考信号。包括感应线圈的可调谐无功电路由具有线圈的振荡器的固定频率参考信号驱动，其适于与样本相邻定位，以产生对应于样本条件的振荡信号。可调谐无功电路提供具有指示样本条件的参数的输出信号。谐振控制电路将参考信号与振荡信号进行比较，并向可调谐无功电路提供表示比较的谐振控制信号。谐振控制信号调谐可调谐无功电路，其可以是串联RLC电路，使得振荡信号的频率基本上是恒定的。

5. 发明授权

US08725245B2 Resonant coil for measuring specimen condition 有权
标题翻译：用于测量样品状态的谐振线圈
公开(公告)号：US08725245B2
公开(公告)日：2014-05-13
申请号：US11464284
申请日：2006-08-14
申请人： Joseph R. Feldkamp , Jeffrey R. Heller , Shawn J. Sullivan
发明人： Joseph R. Feldkamp , Jeffrey R. Heller , Shawn J. Sullivan
IPC分类号： A61B5/05 , G01R27/08
CPC分类号： G01H13/00 , A61B5/053 , A61B5/0537 , A61B5/4872
摘要： An oscillator provides a reference signal having a phase. A tunable reactive circuit, including an induction coil, is driven by the fixed frequency reference signal of the oscillator with coil adapted to be positioned adjacent the specimen to generate an oscillating signal corresponding to the condition of the specimen. The tunable reactive circuit provides an output signal having a parameter indicative of the condition of the specimen. A resonant control circuit compares the reference signal to the oscillating signal and provides to the tunable reactive circuit a resonance control signal representative of the comparison. The resonance control signal tunes the tunable reactive circuit, which may be a series RLC circuit, so that the frequency of the oscillating signal is substantially constant.
摘要翻译：振荡器提供具有相位的参考信号。包括感应线圈的可调谐无功电路由具有线圈的振荡器的固定频率参考信号驱动，其适于与样本相邻定位，以产生对应于样本条件的振荡信号。可调谐无功电路提供具有指示样本条件的参数的输出信号。谐振控制电路将参考信号与振荡信号进行比较，并向可调谐无功电路提供表示比较的谐振控制信号。谐振控制信号调谐可调谐无功电路，其可以是串联RLC电路，使得振荡信号的频率基本上是恒定的。

6. 发明授权

US08384378B2 Conductivity sensor 有权
标题翻译：电导率传感器
公开(公告)号：US08384378B2
公开(公告)日：2013-02-26
申请号：US12464431
申请日：2009-05-12
申请人： Joseph R. Feldkamp , Jeffrey Robert Heller , Douglas Glenn Laudenslager
发明人： Joseph R. Feldkamp , Jeffrey Robert Heller , Douglas Glenn Laudenslager
IPC分类号： G01N27/72
CPC分类号： G01R27/2611 , A61B5/053 , A61B5/0537 , A61B5/681 , A61B5/6824 , A61B5/6887 , A61B5/7282 , A61B2560/0431 , A61B2560/0462 , A61B2562/0223 , H01F5/003
摘要： A conductivity sensor is disclosed. The conductivity sensor includes an oscillator for providing an input signal and a reactive circuit having an induction coil, a capacitive element, and a resistive element connected in parallel. The induction coil is adapted to be placed adjacent to a specimen. The conductivity sensor further includes a control circuit for driving the reactive circuit to resonance when the induction coil is placed adjacent to the specimen. The reactive coil is configured to provide an output signal having a parameter representative of the conductivity of the specimen when the reactive circuit is at resonance. The induction coil may include a first conductive element that spirals outward to an external perimeter and a second conductive element operably connected to the first conductive element. The second conductive element spirals inward from the external perimeter staggered relative to the first conductive element.
摘要翻译：公开了电导率传感器。电导率传感器包括用于提供输入信号的振荡器和具有并联连接的感应线圈，电容元件和电阻元件的无功电路。感应线圈适于放置在与样本相邻的位置。电导率传感器还包括控制电路，用于当感应线圈与样本相邻放置时，驱动无功电路进行谐振。反应线圈被配置为当无功电路处于共振时提供具有表示样品的导电性的参数的输出信号。感应线圈可以包括向外螺旋到外部周边的第一导电元件和可操作地连接到第一导电元件的第二导电元件。第二导电元件相对于第一导电元件从外部周边向内螺旋地交错设置。

7. 发明申请

US20100222696A1 Apparatus and Method For Assessing Vascular Health 有权
标题翻译：用于评估血管健康的装置和方法
公开(公告)号：US20100222696A1
公开(公告)日：2010-09-02
申请号：US12464640
申请日：2009-05-12
申请人： Joseph R. Feldkamp , Jeffrey Robert Heller
发明人： Joseph R. Feldkamp , Jeffrey Robert Heller
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0522 , A61B5/6824 , A61B2560/0431 , A61B2560/0462
摘要： Apparatus and methods for utilizing conductivity measurements to assess vascular health or to diagnose vascular conditions are disclosed. An exemplary method includes performing a first conductivity measurement of an extremity at a first elevation; elevating the extremity to a second elevation; performing a second conductivity measurement at the second elevation; and comparing the first conductivity measurement and the second conductivity measurement to determine a conductivity displacement Δσ. Another exemplary method includes maintaining a conductivity sensor adjacent to an individual for a period of time; performing a series of conductivity measurements; using the series of conductivity measurements to determine the transient behavior of the conductivity over the period of time; and using the transient behavior of the conductivity to assess the vascular health of the individual. A conductivity sensor and platform unit for performing conductivity measurements are also disclosed.
摘要翻译：公开了用于利用电导率测量来评估血管健康或诊断血管病症的装置和方法。示例性方法包括在第一高度处执行末端的第一电导率测量; 将肢体升高到第二高度; 在第二高度处执行第二电导率测量; 并且比较第一电导率测量和第二电导率测量以确定电导率位移＆Dgr。另一示例性方法包括在一段时间内保持与个体相邻的电导率传感器; 进行一系列电导率测量; 使用一系列电导率测量来确定电导率在一段时间内的瞬态行为; 并使用电导率的瞬态行为来评估个体的血管健康。还公开了用于执行电导率测量的电导率传感器和平台单元。

8. 发明申请

US20090123504A1 OLIVE OIL FORMULATION FOR PAIN RELIEF 审中-公开
标题翻译：用于减轻疼痛的橄榄油配方
公开(公告)号：US20090123504A1
公开(公告)日：2009-05-14
申请号：US11938596
申请日：2007-11-12
申请人： Joseph R. Feldkamp , Laura Serra , Pierre Joseph , Corey Cunningham
发明人： Joseph R. Feldkamp , Laura Serra , Pierre Joseph , Corey Cunningham
IPC分类号： A61K9/00 , A61K31/22 , A61P29/00
CPC分类号： A61K47/44 , A61K9/0014 , A61K9/7023 , A61K31/00 , A61K31/22 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/14 , A61K2300/00
摘要： The present disclosure generally relates to methods and compositions for reducing inflammation and/or pain, and more particularly, to compositions comprising an NSAID and oleocanthal and/or a related compound. The compositions are particularly suitable for topical delivery and may be used to relieve the effects of arthritis.
摘要翻译：本公开一般涉及用于减少炎症和/或疼痛的方法和组合物，更具体地涉及包含NSAID和油鞘醇和/或相关化合物的组合物。该组合物特别适用于局部输送，并可用于缓解关节炎的作用。

9. 发明授权

US07879344B2 Transdermal delivery of oleocanthal for relief of inflammation 有权
标题翻译：用于缓解炎症的油甘油的透皮输送
公开(公告)号：US07879344B2
公开(公告)日：2011-02-01
申请号：US11427663
申请日：2006-06-29
申请人： Joseph R. Feldkamp , David William Koenig , Scott W. Wenzel , Wael Joseph
发明人： Joseph R. Feldkamp , David William Koenig , Scott W. Wenzel , Wael Joseph
IPC分类号： A61K9/00
CPC分类号： A61K9/0014 , A61K9/12 , A61K9/7038 , A61K31/216 , A61K47/10
摘要： The present disclosure generally relates to compositions for reducing inflammation, and more particularly, to compositions comprising oleocanthal. The oleocanthal-containing compositions are particularly suitable for transdermal delivery. The compositions may also be used in combination with personal care products, such as wipes and absorbent articles, and may be incorporated into transdermal patches.
摘要翻译：本公开内容一般涉及用于减少炎症的组合物，更具体地涉及包含油松醇的组合物。含有香草醇的组合物特别适用于透皮递送。组合物还可以与个人护理产品如擦拭物和吸收制品组合使用，并且可以并入透皮贴剂中。

10. 发明授权

US06855434B2 Ionic superabsorbent polymers with enhanced swelling characteristics 失效
标题翻译：具有增强溶胀特性的离子超吸收聚合物
公开(公告)号：US06855434B2
公开(公告)日：2005-02-15
申请号：US10084571
申请日：2002-02-27
申请人： Alice Y. Romasn-Hess , Joseph R. Feldkamp
发明人： Alice Y. Romasn-Hess , Joseph R. Feldkamp
IPC分类号： A61L15/20 , A61L15/42 , A61L15/60 , C08K5/17 , C08L33/02 , C08L33/08 , B32B27/00 , A61F13/15 , C08K5/42
CPC分类号： C08L33/08 , A61L15/20 , A61L15/42 , A61L15/60 , C08K5/175 , C08L33/02 , Y10T428/31725 , Y10T428/31855 , C08L41/00
摘要： Ionic superabsorbent polymers having increased swelling capacity of salt-containing solutions are disclosed. The ionic superabsorbent polymers of the present invention contain an additive to increase the osmotic activity of the polymer in the presence of a salt-containing solution. The additive used in combination with the ionic superabsorbent polymer is capable of forming a zwitterion at a pH of from about 1 to about 9, has a dipole moment greater than that of water, and has a molecular weight less than about 10,000 grams/mole.
摘要翻译：公开了具有增加的含盐溶液溶胀能力的离子超吸收聚合物。本发明的离子超吸收聚合物含有添加剂以增加聚合物在含盐溶液存在下的渗透活性。与离子超吸收聚合物组合使用的添加剂能够在约1至约9的pH下形成两性离子，具有大于水的偶极矩，并且具有小于约10,000克/摩尔的分子量。

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