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1. 发明申请

US20080090802A1 QUINAZOLINONE AND ISOQUINOLINONE ACETAMIDE DERIVATIVES 有权
标题翻译：喹唑啉酮和异喹啉酮酰胺衍生物
公开(公告)号：US20080090802A1
公开(公告)日：2008-04-17
申请号：US11852762
申请日：2007-09-10
申请人： Jeffrey Letourneau , Patrick Jokiel , Susan Napier , Koc-Kan Ho , Michael Ohlmeyer , Duncan McArthur , Fiona Jeremiah , Paul Ratcliffe , Jurgen Schulz
发明人： Jeffrey Letourneau , Patrick Jokiel , Susan Napier , Koc-Kan Ho , Michael Ohlmeyer , Duncan McArthur , Fiona Jeremiah , Paul Ratcliffe , Jurgen Schulz
IPC分类号： A61K31/517 , A61K31/5377 , A61K31/551 , A61P25/00 , C07D401/02 , C07D403/02 , C07D413/14
CPC分类号： C07D403/04 , C07D217/24 , C07D239/91 , C07D401/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/08 , C07D487/04
摘要： Disclosed herein are quinazolinone derivatives of formula I, or pharmaceutically acceptable salts or solvates thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions comprising quinazolinone or isoquinolinone according to the present invention and its use in therapy.
摘要翻译：本文公开的式I的喹唑啉酮衍生物或其药学上可接受的盐或溶剂化物，其中每个取代基都给出如说明书和权利要求书中所阐述的定义。还公开了包含根据本发明的喹唑啉酮或异喹啉酮及其在治疗中的用途的药物组合物。

2. 发明授权

US07820649B2 Quinazolinone and isoquinolinone acetamide derivatives 有权
标题翻译：喹唑啉酮和异喹啉酮乙酰胺衍生物
公开(公告)号：US07820649B2
公开(公告)日：2010-10-26
申请号：US11852762
申请日：2007-09-10
申请人： Jeffrey Letourneau , Patrick Jokiel , Susan Elizabeth Napier , Koc-Kan Ho , Michael Ohlmeyer , Duncan Robert McArthur , Fiona Jeremiah , Paul David Ratcliffe , Jurgen Schulz
发明人： Jeffrey Letourneau , Patrick Jokiel , Susan Elizabeth Napier , Koc-Kan Ho , Michael Ohlmeyer , Duncan Robert McArthur , Fiona Jeremiah , Paul David Ratcliffe , Jurgen Schulz
IPC分类号： C07D239/88
CPC分类号： C07D403/04 , C07D217/24 , C07D239/91 , C07D401/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/08 , C07D487/04
摘要： Disclosed herein are quinazolinone or isoquinolinone derivatives of formula I, or pharmaceutically acceptable salts or solvates thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions comprising quinazolinone or isoquinolinone according to the present invention and its use in therapy.
摘要翻译：本文公开的式I的喹唑啉酮或异喹啉酮衍生物或其药学上可接受的盐或溶剂化物，其中每个取代基都给出如说明书和权利要求书中所阐述的定义。还公开了包含根据本发明的喹唑啉酮或异喹啉酮及其在治疗中的用途的药物组合物。

3. 发明授权

US10905184B2 Winged visor stiffener for hat's brim 有权
公开(公告)号：US10905184B2
公开(公告)日：2021-02-02
申请号：US15341802
申请日：2016-11-02
申请人： Jurgen Schulz , Richard Knight
发明人： Jurgen Schulz , Richard Knight
IPC分类号： A42B1/18 , A42B1/06 , A42C5/04 , A42B1/04 , A42B3/22
摘要： A winged visor stiffener for a hat's bill. A flat horizontal front section is connected to two angled offset sections. Two flat horizontal wings are connected to the two angled offset sections. The winged visor stiffener is sewn into the hat's bill via a plurality of rows of tight stitching. The winged visor stiffener provides protection to the wearer's face from the sun while optimizing peripheral vision and prevents the bill from flopping up or down in wet and windy conditions.

4. 发明申请

US20180352889A1 REMOVABLE CHIN STRAP FOR A HAT'S BRIM 审中-公开
公开(公告)号：US20180352889A1
公开(公告)日：2018-12-13
申请号：US16105972
申请日：2018-08-21
申请人： Jurgen Schulz , Richard Knight
发明人： Jurgen Schulz , Richard Knight
IPC分类号： A42B1/04 , A42B1/06 , A42B7/00
CPC分类号： A42B1/063 , A42B1/045 , A42B1/062 , A42B7/00 , A42C5/04
摘要： A hat having a removable chin strap for the hat's brim. The flexible strap has end pieces connected to its ends. The strap also has a strap position lock device. Additionally, the strap includes an attachment clip that can be utilized for connecting the strap to the wearer's clothing. In one preferred embodiment the attachment clip is an alligator clip. In another preferred embodiment the attachment clip is a hook clip. Also, in a preferred embodiment the hat's brim includes a plurality of slots and the flexible strap is inserted through the slots and retained to the brim by the end pieces.

5. 发明申请

US20070050695A1 Error correction code transformation technique 有权
标题翻译：纠错码转换技术
公开(公告)号：US20070050695A1
公开(公告)日：2007-03-01
申请号：US11214194
申请日：2005-08-29
申请人： Jurgen Schulz
发明人： Jurgen Schulz
IPC分类号： H03M13/00
CPC分类号： H03M13/03
摘要： In one embodiment, a system comprises a source configured to provide data and a source error correction code (ECC) generated according to a source ECC scheme; a circuit comprising an ECC transform unit configured to generate a target ECC from the data, detect an error in the data responsive to the source ECC, and correct the error in the data, wherein the target ECC is generated according to a target ECC scheme different from the source ECC scheme, and wherein the ECC transform unit is configured to continuously protect the data with at least one of the source ECC and the target ECC; and a target coupled to receive the data and the target ECC from the circuit.
摘要翻译：在一个实施例中，系统包括被配置为提供数据的源和根据源ECC方案生成的源纠错码（ECC）; 包括被配置为从数据生成目标ECC的ECC变换单元的电路，响应于源ECC检测数据中的错误，并校正数据中的错误，其中根据目标ECC方案生成不同的目标ECC 来自所述源ECC方案，并且其中所述ECC变换单元被配置为使用所述源ECC和所述目标ECC中的至少一个连续保护所述数据; 以及被耦合以从所述电路接收所述数据和所述目标ECC的目标。

6. 发明授权

US07139308B2 Source synchronous bus repeater 有权
公开(公告)号：US07139308B2
公开(公告)日：2006-11-21
申请号：US10117427
申请日：2002-04-05
申请人： Drew G. Doblar , Jyh-Ming Jong , Brian L. Smith , Jurgen Schulz
发明人： Drew G. Doblar , Jyh-Ming Jong , Brian L. Smith , Jurgen Schulz
IPC分类号： H04L25/60
CPC分类号： H04L7/0008 , H04L7/0045
摘要： A device configured to recover and repeat source synchronous data. In one embodiment, the device is configured to receive source synchronous data via a first interface, recover the received data utilizing a corresponding received source synchronous clock signal, and transmit the recovered data and a corresponding clock signal in a source synchronous manner. In one embodiment, the device is configured to operate as a repeater without benefit of an internal clock signal. In addition, the device may be configured to remove data jitter and renew or restore amplitude to attenuated signals prior to retransmission.

7. 发明申请

US20170073354A1 PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS 审中-公开
标题翻译：作为HIV蛋白酶抑制剂的哌嗪衍生物
公开(公告)号：US20170073354A1
公开(公告)日：2017-03-16
申请号：US15124635
申请日：2015-03-06
申请人： Jurgen SCHULZ , Peter D. WILLIAMS , John A. MCCAULEY , Christopher J. BUNGARD , David Jonathan BENNETT , Sherman T. WADDELL , Gregori J. MORRIELLO , Lehua CHANG , Michael P. DWYER , Katharine M. HOLLOWAY , Alejandro CRESPO , Xin-Jie CHU , Catherine WISCOUNT , Marie H. LOUGHRAN , Jesse J. MANIKOWSKI , Kartik M. KEERTIKAR , Bin HU , Bin ZHONG , Tao JI , Merck Sharp & Dohme Corp. , MSD R&D (China) Co., Ltd.
发明人： Peter D. Williams , John A. McCauley , Christopher J. Bungard , David Jonathan Bennett , Sherman T. Waddell , Gregori J. Morriello , Lehua Chang , Michael P. Dwyer , M. Katharine Holloway , Alejandro Crespo , Xin-Jie Chu , Catherine Wiscount , H. Marie Loughran , Jesse J. Manikowski , Jurgen Schulz , Kartik M. Keertikar , Bin Hu , Bin Zhong , Tao Ji
IPC分类号： C07D513/08 , A61K31/554 , A61K45/06
CPC分类号： C07D513/08 , A61K31/554 , A61K45/06
摘要： The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
摘要翻译：本发明涉及含有该化合物的式I药物组合物的化合物及其在抑制HIV蛋白酶，抑制HIV复制，预防HIV感染，HIV感染治疗和预防，治疗和延迟艾滋病的发病或进展。

8. 发明申请

US20170071278A1 WINGED VISOR STIFFENER FOR HAT'S BRIM 审中-公开
公开(公告)号：US20170071278A1
公开(公告)日：2017-03-16
申请号：US15341802
申请日：2016-11-02
申请人： Jurgen Schulz , Richard Knight
发明人： Jurgen Schulz , Richard Knight
IPC分类号： A42B1/06 , A42C5/04 , A42B1/18 , A42B1/02
CPC分类号： A42B1/063 , A42B1/045 , A42B1/062 , A42C5/04
摘要： A winged visor stiffener for a hat's bill. A flat horizontal front section is connected to two angled offset sections. Two flat horizontal wings are connected to the two angled offset sections. The winged visor stiffener is sewn into the hat's bill via a plurality of rows of tight stitching. The winged visor stiffener provides protection to the wearer's face from the sun while optimizing peripheral vision and prevents the bill from flopping up or down in wet and windy conditions.
摘要翻译：帽子帐单的翼形遮阳板加强筋。平坦的水平前部连接到两个倾斜的偏移部分。两个扁平的水平翼连接到两个倾斜的偏移部分。翼形遮阳板加强件通过多排紧密缝合缝合到帽子的帐单中。翼形遮阳板扶强材为佩戴者的脸部提供保护，同时优化周边视力，防止帐单在潮湿和多风的条件下上下颠倒。

9. 发明授权

US08328157B2 Electromagnetic hydraulic valve 有权
标题翻译：电磁液压阀
公开(公告)号：US08328157B2
公开(公告)日：2012-12-11
申请号：US12763421
申请日：2010-04-20
申请人： Jurgen Schulz , Marco Meisborn
发明人： Jurgen Schulz , Marco Meisborn
IPC分类号： F16K31/02
CPC分类号： F16K31/0655 , B60T8/363 , F16K31/0693
摘要： An electromagnetic hydraulic valve (1) is provided having a valve housing (2) with a pressurized hydraulic medium inlet channel (24), a pressurized hydraulic medium outlet channel (25), a magnet coil (3), and a valve seat (23), with a magnet armature (9) that can be excited by the magnet coil and a valve tappet (10, 10′) fixed on this armature. A valve-closing element (13) is activated by the valve tappet and that blocks the connection between the pressurized hydraulic medium channels for contact on the valve seat. The magnet armature with the valve tappet and the valve-closing element are guided so that they can move longitudinally in the valve housing and the valve tappet and the valve-closing element contact each other with facing longitudinal end sides (26, 27) in a way that is free from tensile forces. Here, one annular, continuous lobe or several lobes (28, 28′) separated from each other are formed on the longitudinal end side of the valve tappet, which span a contact plane running perpendicular to a longitudinal direction of movement for the longitudinal end side of the valve-closing element.
摘要翻译：提供一种电磁液压阀（1），其具有带有加压液压介质入口通道（24）的阀壳体（2），加压液压介质出口通道（25），磁体线圈（3）和阀座（23）），具有可被磁体线圈激励的磁体电枢（9）和固定在该电枢上的阀挺杆（10,10'）。阀关闭元件（13）由阀挺杆启动，并且阻塞用于接触阀座的加压液压介质通道之间的连接。具有阀挺杆和闭阀元件的磁体衔铁被引导，使得它们可以在阀壳体中纵向运动，并且阀挺杆和阀关闭元件以相对的纵向端侧（26,27）彼此接触，没有拉力的方式。这里，在阀挺杆的纵向端侧上形成有一个环形连续的叶片或多个彼此分离的叶片（28,28'），其横跨垂直于纵向端侧的纵向移动方向的接触平面的阀关闭元件。

10. 发明授权

US08258293B2 Tetrahydroquinoline derivatives 有权
公开(公告)号：US08258293B2
公开(公告)日：2012-09-04
申请号：US13268214
申请日：2011-10-07
申请人： Nicole Corine Renee Van Straten , Rudolf Gijsbertus Van Someren , Jurgen Schulz
发明人： Nicole Corine Renee Van Straten , Rudolf Gijsbertus Van Someren , Jurgen Schulz
IPC分类号： C07D215/08 , C07D215/12 , C07D215/20 , C07D215/38 , C07D215/48 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D215/38 , A61K31/47 , A61K31/4709 , C07D215/08 , C07D215/20 , C07D215/48
摘要： The present invention relates to tetrahydroquinoline derivatives having general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is formyl, (1-6C)alkylcarbonyl or (1-6C)alkylsulfonyl; R2 and R3 are H or (1-4C)alkyl; R4 is phenyl; R5 is (1-4C)alkyl; Y—X is C(O)—O, S(O)2-O, NHC(O)—O, NHC(S)—O, OC(O)—O, bond-O, C(O)—NH, S(O)2-NH, NHC(O)—NH, NHC(S)—NH, OC(O)—NH, bond-NH, NH—C(O), O—C(O), NH—S(O)2, or O—S(O)2 or Y—X is a bond; R6 is H, trifluoromethyl, (1-6C)alkyl, 1- or 2-adamantyl(1-4C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (3-9C)heteroaryl, (3-6C)cycloalkyl, (2-6C)heterocycloalkyl, (1-4C)alkylthio(1-4C)alkyl, (6-10C)aryl(1-4C)alkyl, (3-9C)heteroaryl(1-4C)alkyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl(1-4C)alkyl, R8,R9-aminocarbonyl(1-4C)alkyl, R8,R9-amino(1-4C)alkyl, R8-oxycarbonyl(1-4C)alkyl, R8-oxy(1-4C)alkyl, R8-carbonyl(1-4C)alkyl or (6-10C)aryl; R7 is H, (1-4C)alkyl, (1-4C)alkoxy, halogen, trifluoromethyl, cyano, nitro, hydroxyl; and R8 and/or R9 is H, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (6-10C)aryl, (3-9C)heteroaryl, (6-10C)aryl(1-4C)alkyl, (3-9C)heteroaryl(1-4C)alkyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl(1-4C)alkyl, (1-4C)(di)alkylamino(1-4C)alkyl, (1-4C)alkoxy(1-4C)alkyl, (1-4C)alkylthio(1-4C)alkyl, (1-4C)alkylcarbonylamino(1-4C)alkyl, (1-4C)alkoxycarbonyl(1-4C)alkyl, (1-4C)alkoxycarbonylamino(1-4C)alkyl, (3-6C)cycloalkyl, (2-6C)heterocycloalkyl, or R8 and R9 may be joined in a (2-6C)heterocycloalkyl ring. The present invention also relates to pharmaceutical compositions comprising said derivatives and the use of these derivatives to control fertility.

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