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1. 发明授权

US07881781B2 Thoracic impedance detection with blood resistivity compensation 有权
标题翻译：胸部阻抗检测与血液电阻率补偿
公开(公告)号：US07881781B2
公开(公告)日：2011-02-01
申请号：US12628384
申请日：2009-12-01
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Boyce Moon
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Boyce Moon
IPC分类号： A61B5/00
CPC分类号： A61B5/053 , A61N1/3627 , A61N1/36521
摘要： This document discusses, among other things, a cardiac rhythm management device or other implantable medical device that uses thoracic impedance to determine how much fluid is present in the thorax, such as for detecting or predicting congestive heart failure, pulmonary edema, pleural effusion, hypotension, or the like. The thoracic fluid amount determined from the thoracic impedance is compensated for changes in blood resistivity, which may result from changes in hematocrit level or other factors. The blood-resistivity-compensated thoracic fluid amount can be stored in the device or transmitted to an external device for storage or display. The blood-resistivity-compensated thoracic fluid amount can also be used to adjust a cardiac pacing, cardiac resynchronization, or other cardiac rhythm management or other therapy to the patient. This document also discusses applications of the devices and methods for predicting or indicating anemia.
摘要翻译：本文件尤其涉及一种使用胸部阻抗来确定胸部存在多少液体的心律管理装置或其他可植入医疗装置，例如用于检测或预测充血性心力衰竭，肺水肿，胸腔积液，低血压，等等。根据胸部阻抗确定的胸腔液量补偿血液电阻率的变化，这可能是血细胞比容水平的变化或其他因素引起的。血液电阻补偿的胸腔液量可以存储在设备中或者传输到外部设备进行存储或显示。血液电阻补偿的胸液量也可用于调整心脏起搏，心脏再同步或其他心律控制或对患者的其他治疗。本文件还讨论了用于预测或指示贫血的装置和方法的应用。

2. 发明授权

US07672718B2 Thoracic impedance detection with blood resistivity compensation 有权
标题翻译：胸部阻抗检测与血液电阻率补偿
公开(公告)号：US07672718B2
公开(公告)日：2010-03-02
申请号：US12139948
申请日：2008-06-16
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Boyce Moon
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Boyce Moon
IPC分类号： A61B5/00
CPC分类号： A61B5/053 , A61N1/3627 , A61N1/36521
摘要： This document discusses, among other things, a cardiac rhythm management device or other implantable medical device that uses thoracic impedance to determine how much fluid is present in the thorax, such as for detecting or predicting congestive heart failure, pulmonary edema, pleural effusion, hypotension, or the like. The thoracic fluid amount determined from the thoracic impedance is compensated for changes in blood resistivity, which may result from changes in hematocrit level or other factors. The blood-resistivity-compensated thoracic fluid amount can be stored in the device or transmitted to an external device for storage or display. The blood-resistivity-compensated thoracic fluid amount can also be used to adjust a cardiac pacing, cardiac resynchronization, or other cardiac rhythm management or other therapy to the patient. This document also discusses applications of the devices and methods for predicting or indicating anemia.
摘要翻译：本文件尤其涉及一种使用胸部阻抗来确定胸部存在多少液体的心律管理装置或其他可植入医疗装置，例如用于检测或预测充血性心力衰竭，肺水肿，胸腔积液，低血压，等等。根据胸部阻抗确定的胸腔液量补偿血液电阻率的变化，这可能是血细胞比容水平的变化或其他因素引起的。血液电阻补偿的胸腔液量可以存储在设备中或者传输到外部设备进行存储或显示。血液电阻补偿的胸液量也可用于调整心脏起搏，心脏再同步或其他心律控制或对患者的其他治疗。本文件还讨论了用于预测或指示贫血的装置和方法的应用。

3. 发明授权

US08200326B2 Calibration of impedance monitoring of respiratory volumes using thoracic D.C. impedance 有权
标题翻译：使用胸部直流阻抗校正阻抗监测呼吸体积
公开(公告)号：US08200326B2
公开(公告)日：2012-06-12
申请号：US12557372
申请日：2009-09-10
申请人： John D. Hatlestad , Loell Boyce Moon , Jesse W. Hartley , Jeffrey E. Stahmann
发明人： John D. Hatlestad , Loell Boyce Moon , Jesse W. Hartley , Jeffrey E. Stahmann
IPC分类号： A61B5/05 , A61B5/08
CPC分类号： A61N1/36521 , A61B5/0809 , A61B2560/0223 , A61N1/3756
摘要： A system includes an implantable medical device that includes a trans-thoracic impedance measurement circuit providing a trans-thoracic impedance signal of a subject. A controller is coupled to the trans-thoracic impedance circuit. The controller extracts a respiration signal from the trans-thoracic impedance signal, measures a breathing volume of the subject using the amplitude of the respiration signal and a breathing volume calibration factor, computes an adjusted breathing volume calibration factor using a reference baseline value of the trans-thoracic impedance and a measured baseline value of the trans-thoracic impedance, and computes a calibrated breathing volume using the adjusted breathing volume calibration factor.
摘要翻译：一种系统包括可植入医疗装置，其包括提供受试者的胸部阻抗信号的跨胸阻抗测量电路。控制器耦合到跨胸阻抗电路。控制器从胸部阻抗信号中提取呼吸信号，使用呼吸信号的幅度和呼吸音量校准因子来测量受试者的呼吸体积，使用反式信号的参考基准值计算调整后的呼吸量校准因子胸廓阻抗和经胸阻抗的测量基线值，并使用调整后的呼吸量校准因子计算校准呼吸量。

4. 发明授权

US08483818B2 Enhancements to the detection of pulmonary edema when using transthoracic impedance 有权
标题翻译：使用经胸阻抗检测肺水肿的增强
公开(公告)号：US08483818B2
公开(公告)日：2013-07-09
申请号：US13033081
申请日：2011-02-23
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Jesse W. Hartley
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Jesse W. Hartley
IPC分类号： A61B5/05 , A61B5/04 , A61N1/00
CPC分类号： A61B5/0537 , A61B5/0002 , A61B5/0538 , A61B5/4869 , A61B5/4878
摘要： This patent document discusses, among other things, systems, devices, and methods for enhancing detection of pulmonary edema using, in addition to thoracic impedance, one or a combination of: physiologic information about a subject, at least one statistical parameter, a user-programmable detection level, at least one parameter associated with a previous pulmonary edema event, and patient symptom information about the subject. In one example, a (base) thoracic impedance threshold is modified to an adjusted thoracic impedance threshold. The adjusted thoracic impedance threshold provides an increased sensitivity of pulmonary edema detection as compared to the base thoracic impedance threshold. In another example, an alert is provided to a subject, a caregiver, or other user based on a pulmonary edema indication determined by the present systems, devices, and methods. In a further example, a therapy (provided to the subject) is adjusted or initiated in response to the pulmonary edema indication.
摘要翻译：该专利文献尤其涉及用于增强肺水肿检测的系统，装置和方法，除胸部阻抗之外，还包括以下之一或组合：关于受试者的生理信息，至少一个统计参数，可编程检测水平，与先前的肺水肿事件相关联的至少一个参数，以及关于受试者的患者症状信息。在一个示例中，（基底）胸部阻抗阈值被修改为经调整的胸部阻抗阈值。与基础胸廓阻抗阈值相比，经调整的胸廓阻抗阈值提供了肺水肿检测的灵敏度增加。在另一示例中，基于由本系统，设备和方法确定的肺水肿指示，向受检者，照顾者或其他用户提供警报。在另一个实例中，响应于肺水肿指示调整或启动治疗（提供给受试者）。

5. 发明授权

US08321022B2 Adaptive therapy for disordered breathing 有权
标题翻译：呼吸紊乱的自适应治疗
公开(公告)号：US08321022B2
公开(公告)日：2012-11-27
申请号：US12731103
申请日：2010-03-24
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Quan Ni , Jesse Hartley , Douglas R. Daum , Kent Lee
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Quan Ni , Jesse Hartley , Douglas R. Daum , Kent Lee
IPC分类号： A61N1/36
CPC分类号： A61N1/362 , A61N1/3601
摘要： An approach to providing disordered breathing therapy includes detecting disordered breathing and adapting a therapy to mitigate the disordered breathing. The therapy may be adapted to enhance therapy effectiveness, to provide therapy that reduces an impact of the therapy on the patient, or to achieve other therapeutic goals. Cardiac electrical therapy to mitigate the disordered breathing may include various cardiac pacing regimens and/or delivery of non-excitatory electrical stimulation to the heart.
摘要翻译：提供无序呼吸治疗的方法包括检测无序呼吸并适应治疗以减轻无序呼吸。治疗可以适应于增强治疗有效性，提供减少治疗对患者的影响或实现其它治疗目标的治疗。减轻无序呼吸的心脏电疗可能包括各种心脏起搏方案和/或向心脏递送非兴奋性电刺激。

6. 发明申请

US20110306850A1 Sleep quality data collection and evaluation 有权
标题翻译：睡眠质量数据收集和评估
公开(公告)号：US20110306850A1
公开(公告)日：2011-12-15
申请号：US13215592
申请日：2011-08-23
申请人： John D. Hatlestad , Quan Ni , Jeffrey E. Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce H. KenKnight , Douglas R. Daum , Kent Lee
发明人： John D. Hatlestad , Quan Ni , Jeffrey E. Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce H. KenKnight , Douglas R. Daum , Kent Lee
IPC分类号： A61B5/00
CPC分类号： A61B5/4815 , A61B5/0031 , A61B5/0205 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/0809 , A61B5/11 , A61B5/4528 , A61B5/4818 , A61N1/3621 , G06F19/00
摘要： A sleep quality assessment approach involves collecting data based on detected physiological or non-physiological patient conditions. At least one of detecting patient conditions and collecting data is performed using an implantable device. Sleep quality may be evaluated using the collected data by an implantable or patient-external sleep quality processor. One approach to sleep quality evaluation involves computing one or more summary metrics based on occurrences of movement disorders or breathing disorders during sleep.
摘要翻译：睡眠质量评估方法包括基于检测到的生理或非生理性患者状况收集数据。使用可植入装置执行检测患者状况和收集数据中的至少一个。可以使用可植入或患者外部的睡眠质量处理器收集的数据来评估睡眠质量。睡眠质量评估的一种方法包括基于睡眠期间的运动障碍或呼吸障碍的发生来计算一个或多个总结度量。

7. 发明申请

US20100174207A1 System and Method for Characterizing Patient Respiration 审中-公开
标题翻译：用于表征患者呼吸的系统和方法
公开(公告)号：US20100174207A1
公开(公告)日：2010-07-08
申请号：US12723998
申请日：2010-03-15
申请人： Kent Lee , Quan Ni , Jesse W. Hartley , John D. Hatlestad , Jeffrey E. Stahmann
发明人： Kent Lee , Quan Ni , Jesse W. Hartley , John D. Hatlestad , Jeffrey E. Stahmann
IPC分类号： A61B5/08
CPC分类号： A61B5/4806 , A61B5/0205 , A61B5/08 , A61B5/082 , A61N1/08
摘要： Patient respiration may be characterized using a marked respiration waveform involving a respiration waveform annotated with symbols, markers or other indicators representing one or more respiration characteristics. A respiration waveform may be acquired by sensing a physiological parameter modulated by respiration. A marked respiration waveform may be generated based on the acquired respiration waveform and one or more detected respiration waveform characteristics and/or respiration-related conditions. One or more components used to generate the marked respiratory waveform may be fully or partially implantable.
摘要翻译：患者呼吸可以使用标示的呼吸波形来表征，该呼吸波形涉及用符号，标记或代表一个或多个呼吸特征的其它指示符注释的呼吸波形。可以通过感测由呼吸调制的生理参数来获取呼吸波形。可以基于所获取的呼吸波形和一个或多个检测到的呼吸波形特征和/或呼吸相关条件来生成标记的呼吸波形。用于产生标记的呼吸波形的一个或多个组件可以是完全或部分可植入的。

8. 发明申请

US20100094102A1 MULTI-SENSOR STRATEGY FOR HEART FAILURE PATIENT MANAGEMENT 有权
标题翻译：心脏失败患者管理的多传感器策略
公开(公告)号：US20100094102A1
公开(公告)日：2010-04-15
申请号：US12576453
申请日：2009-10-09
申请人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
发明人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
IPC分类号： A61B5/02
CPC分类号： A61B5/02055 , A61B5/0008 , A61B5/0031 , A61B5/01 , A61B5/02028 , A61B5/0205 , A61B5/0215 , A61B5/026 , A61B5/029 , A61B5/042 , A61B5/0452 , A61B5/0531 , A61B5/0538 , A61B5/0816 , A61B5/085 , A61B5/1118 , A61B5/121 , A61B5/14542 , A61B5/686 , A61B5/6869 , A61B5/7275 , A61B7/04 , A61N1/36585 , G06F19/00
摘要： An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.
摘要翻译：一种装置包括多个传感器和一个处理器。每个传感器提供包括生理信息的传感器信号，并且至少一个传感器是可植入的。处理器包括生理变化事件检测模块，其从传感器信号检测生理变化事件，并产生一个或多个检测到的生理变化事件的发生的指示，以及心力衰竭（HF）检测模块。 HF检测模块使用第一规则确定检测到的生理变化事件是否指示受试者的HF状态的变化，使用第二规则确定是否覆盖第一规则HF确定，并且声明HF的变化状态根据第一和第二规则发生。

9. 发明授权

US07572225B2 Sleep logbook 有权
标题翻译：睡眠日志
公开(公告)号：US07572225B2
公开(公告)日：2009-08-11
申请号：US10920569
申请日：2004-08-17
申请人： Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni , Kent Lee , John D. Hatlestad
发明人： Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni , Kent Lee , John D. Hatlestad
IPC分类号： A61B5/08 , A61B5/02 , A61B5/00 , A61B5/103
CPC分类号： A61B5/4818 , A61B5/00 , A61B5/4528 , A61B5/4806 , A61B5/4812 , A61B5/4815 , A61N1/36514 , A61N1/36521 , A61N1/3925
摘要： An approach to collecting and organizing information associated with events affecting sleep is presented. The sleep logbook system may acquire information associated with the sleep during periods of sleep and/or during periods of wakefulness. The information is organized as a sleep logbook entry. The user can access the sleep information by operating a user interface. The information may be presented in textual or graphical form.
摘要翻译：介绍收集和组织与影响睡眠事件相关的信息的方法。休眠日志系统可以在睡眠期间和/或在觉醒期间获取与睡眠相关的信息。信息被组织为睡眠日志条目。用户可以通过操作用户界面访问睡眠信息。信息可以以文本或图形形式呈现。

10. 发明申请

US20080262360A1 USING RESPIRATION DISTRESS MANIFESTATIONS FOR HEART FAILURE DETECTION 有权
标题翻译：使用呼吸部分心理失调检测
公开(公告)号：US20080262360A1
公开(公告)日：2008-10-23
申请号：US11736058
申请日：2007-04-17
申请人： Yousufali Dalal , John D. Hatlestad , Yi Zhang , Aaron Lewicke , Jeffrey E. Stahmann
发明人： Yousufali Dalal , John D. Hatlestad , Yi Zhang , Aaron Lewicke , Jeffrey E. Stahmann
IPC分类号： A61B5/0205
CPC分类号： A61B5/0205 , A61B5/0816 , A61B5/1116 , A61B5/4818 , A61B5/686 , A61N1/3627
摘要： Systems and methods for diagnosing one or more respiration distress manifestations by implantably recognizing their occurrence and evaluating information about the same to provide an indication of present or impending worsening heart failure are discussed. Using information produced by an implantable respiration sensor circuit and an implantable physiological sensor circuit, such as at least one of a physical activity sensor circuit or a posture sensor circuit, an implantable or external processor circuit may detect a respiration disturbance and an associated subsequent arousal from stable state occurrence and thereafter evaluate over time arousal from stable state occurrences to provide the indication of present or impending worsening heart failure. In one example, information about a fluid level within a subject is used in determining the indication of worsening heart failure. In various examples, a regimen is initiated or adjusted in response to the indication of present or impending worsening heart failure.
摘要翻译：讨论了通过可植入地识别其发生并评估关于其的信息来诊断一种或多种呼吸困扰表现的系统和方法，以提供现在或即将恶化的心力衰竭的指征。使用由可植入呼吸传感器电路和植入式生理传感器电路产生的信息，例如物理活动传感器电路或姿势传感器电路中的至少一个，可植入或外部处理器电路可以检测呼吸障碍和相关联的随后的唤醒稳定状态发生，然后评估来自稳定状态发生的随着时间的兴奋，以提供目前或即将恶化的心力衰竭的指征。在一个示例中，关于受试者内的液位水平的信息用于确定恶化的心力衰竭的指示。在各种实例中，响应于目前或即将恶化的心力衰竭的指征开始或调整方案。

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