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1. 发明授权

US07207980B2 Composite ophthalmic microcannula 有权
公开(公告)号：US07207980B2
公开(公告)日：2007-04-24
申请号：US11042825
申请日：2005-01-24
申请人： Jeffrey Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
发明人： Jeffrey Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
IPC分类号： A61M25/00
CPC分类号： A61F9/00781 , A61B3/0008 , A61B17/3421 , A61F9/007 , A61M25/005 , A61M2025/0042
摘要： Microcannulae are constructed with multiple components in a composite design, allowing the microcannulae to have varying mechanical and delivery properties that will enable ophthalmic treatments by minimally invasive means. The microcannula includes at least one flexible, tubular communicating element with an outer diameter of 350 microns or less, a proximal connector for introduction of materials, energy or tools. It may also include a reinforcing member attached to the communicating element, which may be designed to create variable stiffness along the length of the microcannula. The microcannula may also include other features such as a signal beacon near the distal tip.

2. 发明申请

US20100240987A1 COMPOSITE OPHTHALMIC MICROCANNULA 有权
标题翻译：复合光学微孔
公开(公告)号：US20100240987A1
公开(公告)日：2010-09-23
申请号：US12789231
申请日：2010-05-27
申请人： Jeffrey J. Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
发明人： Jeffrey J. Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
IPC分类号： A61F9/007 , A61B6/12
CPC分类号： A61F9/00781 , A61B3/0008 , A61B17/3421 , A61F9/007 , A61M25/005 , A61M2025/0042
摘要： Microcannulae are constructed with multiple components in a composite design, allowing the microcannulae to have varying mechanical and delivery properties that will enable ophthalmic treatments by minimally invasive means. The microcannula includes at least one flexible, tubular communicating element with an outer diameter of 350 microns or less, a proximal connector for introduction of materials, energy or tools. It may also include a reinforcing member attached to the communicating element, which may be designed to create variable stiffness along the length of the microcannula. The microcannula may also include other features such as a signal beacon near the distal tip.
摘要翻译：微复合材料以复合材料设计的多个组分构成，允许微囊具有不同的机械和传递性能，可通过微创手段进行眼科治疗。微型插管包括至少一个具有350微米或更小外径的柔性管状连通元件，用于引入材料，能量或工具的近端连接件。其还可以包括附接到连通元件的加强构件，该加强构件可被设计成沿着微型插管的长度产生可变的刚度。微型插管还可以包括其他特征，例如靠近远端的信号信标。

3. 发明授权

US08348924B2 Composite ophthalmic microcannula 有权
标题翻译：复合眼科微囊
公开(公告)号：US08348924B2
公开(公告)日：2013-01-08
申请号：US12789231
申请日：2010-05-27
申请人： Jeffrey J. Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
发明人： Jeffrey J. Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
IPC分类号： A61M25/00
CPC分类号： A61F9/00781 , A61B3/0008 , A61B17/3421 , A61F9/007 , A61M25/005 , A61M2025/0042
摘要： Microcannulae are constructed with multiple components in a composite design, allowing the microcannulae to have varying mechanical and delivery properties that will enable ophthalmic treatments by minimally invasive means. The microcannula includes at least one flexible, tubular communicating element with an outer diameter of 350 microns or less, a proximal connector for introduction of materials, energy or tools. It may also include a reinforcing member attached to the communicating element, which may be designed to create variable stiffness along the length of the microcannula. The microcannula may also include other features such as a signal beacon near the distal tip.
摘要翻译：微复合材料以复合材料设计的多个组分构成，允许微囊具有不同的机械和传递性能，可通过微创手段进行眼科治疗。微型插管包括至少一个具有350微米或更小外径的柔性管状连通元件，用于引入材料，能量或工具的近端连接件。其还可以包括附接到连通元件的加强构件，该加强构件可被设计成沿着微型插管的长度产生可变的刚度。微型插管还可以包括其他特征，例如靠近远端的信号信标。

4. 发明授权

US08172830B2 Composite ophthalmic microcannula 有权
标题翻译：复合眼科微囊
公开(公告)号：US08172830B2
公开(公告)日：2012-05-08
申请号：US11729603
申请日：2007-03-28
申请人： Jeffrey J. Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
发明人： Jeffrey J. Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
IPC分类号： A61M25/00
CPC分类号： A61F9/00781 , A61B3/0008 , A61B17/3421 , A61F9/007 , A61M25/005 , A61M2025/0042
摘要： Microcannulae are constructed with multiple components in a composite design, allowing the microcannulae to have varying mechanical and delivery properties that will enable ophthalmic treatments by minimally invasive means. The microcannula includes at least one flexible, tubular communicating element with an outer diameter of 350 microns or less, a proximal connector for introduction of materials, energy or tools. It may also include a reinforcing member attached to the communicating element, which may be designed to create variable stiffness along the length of the microcannula. The microcannula may also include other features such as a signal beacon near the distal tip.
摘要翻译：微复合材料以复合材料设计的多个组分构成，允许微囊具有不同的机械和传递性能，可通过微创手段进行眼科治疗。微型插管包括至少一个具有350微米或更小外径的柔性管状连通元件，用于引入材料，能量或工具的近端连接件。其还可以包括附接到连通元件的加强构件，该加强构件可被设计成沿着微型插管的长度产生可变的刚度。微型插管还可以包括其他特征，例如靠近远端的信号信标。

5. 发明授权

US08034105B2 Ophthalmic implant for treatment of glaucoma 失效
标题翻译：用于治疗青光眼的眼科植入物
公开(公告)号：US08034105B2
公开(公告)日：2011-10-11
申请号：US11305306
申请日：2005-12-16
申请人： Robert Stegmann , Stanley R. Conston , David J. Kupiecki , John McKenzie , Candice D. Pinson , Ronald K. Yamamoto
发明人： Robert Stegmann , Stanley R. Conston , David J. Kupiecki , John McKenzie , Candice D. Pinson , Ronald K. Yamamoto
IPC分类号： A61F2/14 , A61M5/00
CPC分类号： A61F9/00781
摘要： A method is provided for increasing the outflow of fluid through Schlemm's canal that is useful for treatment of glaucoma. The implant is placed in Schlemm's canal by use of a flexible delivery instrument attached to the implant. The instrument and implant are positioned within the canal, the implant is released and the distal and proximal ends of the implant are connected to apply sufficient axial tensioning force on the inner wall of the canal to increase fluid permeability. In another embodiment a delivery instrument attached to the implant is positioned in the canal securing one of the distal or proximal ends of the implant within the canal. The implant provides sufficient axial tensioning force on the inner wall of the canal to increase fluid permeability of the inner wall of the canal. The other of the distal or proximal ends may be secured to maintain the tensioning force on the inner wall of the canal.
摘要翻译：提供了一种增加流体穿过施莱姆氏管的流出方法，可用于治疗青光眼。通过使用附着在植入物上的柔性递送器械将植入物置于施莱姆氏管中。仪器和植入物定位在管内，植入物被释放，并且植入物的远端和近端被连接以在管的内壁上施加足够的轴向张力以增加流体渗透性。在另一个实施例中，附接到植入物的递送器械定位在将移植物的远端或近端中的一端固定在管内的运河中。植入物在管道的内壁上提供足够的轴向张力，以增加管道内壁的流体渗透性。远端或近端中的另一个可以被固定以保持在管的内壁上的张紧力。

6. 发明授权

US07967772B2 Injector for viscous materials 有权
标题翻译：注射器用于粘性材料
公开(公告)号：US07967772B2
公开(公告)日：2011-06-28
申请号：US10585909
申请日：2005-01-12
申请人： John R. McKenzie , Stanley R. Conston , David J. Kupiecki
发明人： John R. McKenzie , Stanley R. Conston , David J. Kupiecki
IPC分类号： A61N1/30
CPC分类号： A61M5/1456 , A61F9/0017 , A61M5/16854 , A61M5/31511 , A61M5/31586 , A61M5/486
摘要： An injector is provided to deliver microquantities of viscous materials into the body, such as the eye, for surgical purposes. The injector comprises a syringe body with a plunger disposed therein coupled to a positive displacement mechanism capable of progressively advancing the plunger to precisely deliver microquantities of materials at a constant or predetermined delivery rate.
摘要翻译：提供注射器用于将粘性物质的微量量输送到体内，例如眼睛，用于外科用途。注射器包括注射器本体，其中设置有柱塞，其联接到能够逐渐前进柱塞的正位移机构，以以恒定或预定的输送速率精确地输送材料的微量。

7. 发明申请

US20090043321A1 Apparatus And Method For Surgical Enhancement Of Aqueous Humor Drainage 审中-公开
标题翻译：水性幽默排水手术增强装置及方法
公开(公告)号：US20090043321A1
公开(公告)日：2009-02-12
申请号：US11587785
申请日：2005-04-29
申请人： Stanley R. Conston , Michael Hee , David J. Kupiecki , John R. McKenzie , Ronald Yamamoto
发明人： Stanley R. Conston , Michael Hee , David J. Kupiecki , John R. McKenzie , Ronald Yamamoto
IPC分类号： A61M1/00 , A61F9/04
CPC分类号： A61F9/008 , A61B18/14 , A61F9/00781
摘要： An apparatus is provided for forming a tissue tract (8, 11A, 17A) from within a first passageway of an eye (11, 17) connecting to a second passageway in the eye (12, 16) comprising an elongated tool with a proximal end and distal end. The tool has an outer diameter in the range of about 50 to about 1000 microns. Methods of using the tool are provided for creating a fluid path for aqueous humor of an eye from a first passageway of the eye, such as the Schlemm's Canal, to a second passageway, such as the suprachoroidal space
摘要翻译：提供一种用于从连接到眼睛（12,16）中的第二通道的眼睛（11,17）的第一通道内形成组织管道（8,11A，17A）的装置，包括具有近端的细长工具和远端。该工具的外径在约50至约1000微米的范围内。提供了使用该工具的方法，用于从眼睛的第一通道（例如施莱姆氏管）产生到眼睛的房水的流体路径到第二通道，例如脉管外空间

8. 发明申请

US20100173866A1 APPARATUS AND METHOD FOR OCULAR TREATMENT 审中-公开
标题翻译：用于眼科治疗的装置和方法
公开(公告)号：US20100173866A1
公开(公告)日：2010-07-08
申请号：US12609345
申请日：2009-10-30
申请人： MICHAEL HEE , Stanley R. Conston , David J. Kupiecki , John R. McKenzie , Ronald Yamamoto , Michael Nash
发明人： MICHAEL HEE , Stanley R. Conston , David J. Kupiecki , John R. McKenzie , Ronald Yamamoto , Michael Nash
IPC分类号： A61K31/728 , A61M37/00 , A61F9/00 , A61F9/011 , A61B3/14 , A61K31/56 , A61P27/02
CPC分类号： A61F9/0017 , A61B90/39 , A61B2090/3614 , A61B2090/3925 , A61B2090/3945 , A61F9/00736 , A61F9/00781 , A61F9/008 , A61F2009/00851
摘要： The invention provides tools, materials and related methods to surgically access the suprachoroidal space of an eye for the purpose of performing minimally invasive surgery or to deliver drugs to the eye. The invention provides a flexible microcannula or microcatheter device (11, 13) that may be placed into the suprachoroidal space (12, 14) through a small incision (12A) of the overlying tissues, maneuvered into the appropriate region of the space, and then activated to treat tissues adjacent to the distal tip of the device.
摘要翻译：本发明提供了用于手术进入眼睛的脉管外空间以进行微创手术或将药物递送至眼睛的工具，材料和相关方法。本发明提供了一种柔性微插管或微导管装置（11,13），其可以通过上层组织的小切口（12A）放置在脉管外空间（12,14）中，操纵到空间的适当区域，然后被激活以处理邻近该装置的远端的组织。

9. 发明申请

US20100274074A1 PELVIC FLOOR TREATMENTS AND RELATED TOOLS AND IMPLANTS 有权
标题翻译：皮肤地板处理及相关工具和植入物
公开(公告)号：US20100274074A1
公开(公告)日：2010-10-28
申请号：US12678923
申请日：2008-09-19
申请人： Chaouki A. Khamis , David J. Kupiecki , Jeffrey M. O'Hern , Shawn Michael Wignall
发明人： Chaouki A. Khamis , David J. Kupiecki , Jeffrey M. O'Hern , Shawn Michael Wignall
IPC分类号： A61B17/00 , A61F2/02
CPC分类号： A61F2/0063 , A61B17/00234 , A61B17/0401 , A61B17/3468 , A61B2017/00805 , A61B2017/0409 , A61B2017/0412 , A61B2017/0427 , A61B2017/0464 , A61B2090/0801 , A61B2090/08021 , A61F2/0045 , A61F2002/0072
摘要： Described are implants, tools, and methods useful for treating pelvic conditions such as prolapse, by placing an implant to support pelvic tissue, the implants, tools, and methods involving one or more of an insertion tool that works in coordination with a sheath, adjusting engagements, specific implants and pieces of implants, placement of implants at locations within the pelvic region, and insertion, adjusting, and grommet management tools.
摘要翻译：描述了可用于治疗盆腔状况的植入物，工具和方法，例如通过放置植入物来支撑骨盆组织，植入物，工具和涉及一种或多种与护套配合工作的插入工具的方法来调节接合，特定植入物和植入物，植入物在骨盆区域内的位置，以及插入，调整和护环管理工具。

10. 发明授权

US06371928B1 Guidewire for positioning a catheter against a lumen wall 失效
标题翻译：导管，用于将导管定位在管腔壁上
公开(公告)号：US06371928B1
公开(公告)日：2002-04-16
申请号：US09417228
申请日：1999-10-13
申请人： Timothy B. Mcfann , Kathy M. Mah , James D. Passafaro , Roger W. Perkins , Joan Huynh , Greg R. Patterson , Ronald G. Williams , David J. Kupiecki
发明人： Timothy B. Mcfann , Kathy M. Mah , James D. Passafaro , Roger W. Perkins , Joan Huynh , Greg R. Patterson , Ronald G. Williams , David J. Kupiecki
IPC分类号： A61B500
CPC分类号： A61B17/221 , A61B17/320758 , A61B2017/00867 , A61B2017/22042 , A61B2017/2217 , A61B2017/320766 , A61B2090/064 , A61M25/09 , A61M2025/09083 , A61M2025/09141 , A61M2025/09175 , A61M2205/0266
摘要： The present invention relates to a guidewire having a shaped three dimensional guide section. In the preferred embodiment the guide section is helical, and exerts an outward radial force on a lumen the guidewire is constrained in. The outward radial force can be measured or calculated according to methods of the present invention. Also described is a system comprising a guidewire and catheter where the force the catheter exerts on a body lumen can also be calculated. Apparatus and methods of making the guidewire are also disclosed, as well as alternative embodiments of the guidewire.
摘要翻译：本发明涉及具有成形三维引导部分的导丝。在优选实施例中，引导部分是螺旋形的，并且在导丝被限制在内腔上施加向外的径向力。可以根据本发明的方法来测量或计算向外的径向力。还描述了一种包括导丝和导管的系统，其中导管施加在体腔上的力也可以被计算。还公开了制造导丝的装置和方法，以及导丝的替代实施例。

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