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1. 发明申请

US20050256039A1 Novel fibroblast growth factors and methods of use thereof 审中-公开
标题翻译：新型成纤维细胞生长因子及其使用方法
公开(公告)号：US20050256039A1
公开(公告)日：2005-11-17
申请号：US10842206
申请日：2004-05-10
申请人： Jeffery Peterson , Paul Sciore , Peter Mezes , Henri Lichenstein , Michael Jeffers , William LaRochelle , Marie Ruiz-Martinez , Galina Chernaya
发明人： Jeffery Peterson , Paul Sciore , Peter Mezes , Henri Lichenstein , Michael Jeffers , William LaRochelle , Marie Ruiz-Martinez , Galina Chernaya
IPC分类号： A61K38/17 , A61K38/18 , C07H21/04 , C07K14/47 , C07K14/50 , C12N15/09 , C12P21/06
CPC分类号： A61K38/1825 , C07K14/50
摘要： The present invention relates to compositions and methods of treatment of various conditions, including but are not limited to, stroke, wound healing, and joint diseases (e.g., osteoarthritis and rheumatoid arthritis). More particularly, the present invention relates to compositions comprising a member of the fibroblast growth factor family, FGF-CX (also known as CG53135-05 or FGF-20), its related polypeptides, nucleic acids encoding such polypeptides, and their uses for treating a condition, such as but is not limited to, stroke, would healing, and joint diseases (e.g., osteoarthritis and rheumatoid arthritis).
摘要翻译：本发明涉及治疗各种病症的组合物和方法，包括但不限于中风，伤口愈合和关节疾病（例如骨关节炎和类风湿性关节炎）。更具体地，本发明涉及包含成纤维细胞生长因子家族成员，FGF-CX（也称为CG53135-05或FGF-20）的成员，其相关多肽，编码这些多肽的核酸及其用于治疗一种情况，例如但不限于中风，会愈合，以及关节疾病（例如骨关节炎和类风湿性关节炎）。

2. 发明申请

US20050208514A1 Novel fibroblast growth factor and nucleic acids encoding dame 审中-公开
标题翻译：新型成纤维细胞生长因子和编码dame的核酸
公开(公告)号：US20050208514A1
公开(公告)日：2005-09-22
申请号：US10980659
申请日：2004-11-03
申请人： John Alsobrook , Ferenc Boldog , Michael Jeffers , William LaRochelle , Denise Lepley , Henri Lichenstein , Richard Shimkets , Meijia Yang , Marie Ruiz-Martinez , Galina Chernaya , Muralidhara Padigaru , Sudhirdas Prayaga , Mei Zhong
发明人： John Alsobrook , Ferenc Boldog , Michael Jeffers , William LaRochelle , Denise Lepley , Henri Lichenstein , Richard Shimkets , Meijia Yang , Marie Ruiz-Martinez , Galina Chernaya , Muralidhara Padigaru , Sudhirdas Prayaga , Mei Zhong
IPC分类号： A61K38/00 , A61K38/18 , C07K14/50 , C12Q1/68
CPC分类号： C07K14/50 , A61K38/00
摘要： The present invention generally relates to nucleic acids, proteins, and antibodies. The invention relates more particularly to nucleic acid molecules, proteins, and antibodies of Fibroblast Growth Factor-20 (FGF-20), or its fragments, derivatives, variants, homologs, analogs, or a combination thereof.
摘要翻译：本发明一般涉及核酸，蛋白质和抗体。本发明更具体涉及成纤维细胞生长因子-20（FGF-20）或其片段，衍生物，变体，同系物，类似物或其组合的核酸分子，蛋白质和抗体。

3. 发明授权

US08846873B2 Antibodies directed to GPNMB and uses thereof 有权
标题翻译：针对GPNMB的抗体及其用途
公开(公告)号：US08846873B2
公开(公告)日：2014-09-30
申请号：US13355366
申请日：2012-01-20
申请人： Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
发明人： Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
IPC分类号： C07K16/30 , C07K19/00 , C07K16/28 , A61K47/48 , A61K39/00
CPC分类号： C07K16/3053 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K2039/505 , A61K2039/545 , C07K16/2809 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/62 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/94
摘要： The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
摘要翻译：本发明提供了完全与GPNMB结合的人单克隆抗体及其应用。提供了编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列。本发明还提供了包含抗GPNMB抗体的免疫缀合物和使用这种免疫缀合物的方法。本发明还提供了包含抗GPNMB抗体组分和抗-CD3组分的双特异性抗体，以及使用这种双特异性抗体的方法。

4. 发明申请

US20130022597A1 Antibodies Directed To GPNMB And Uses Thereof 有权
标题翻译：针对GPNMB的抗体及其用途
公开(公告)号：US20130022597A1
公开(公告)日：2013-01-24
申请号：US13355366
申请日：2012-01-20
申请人： Meina Liang , Orit Foord , Scott Klakamp , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
发明人： Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
IPC分类号： A61K39/395 , C12N15/13 , C40B30/04 , C12N15/63 , C12N1/21 , C12N5/10 , C07K16/18 , A61P35/00
CPC分类号： C07K16/3053 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K2039/505 , A61K2039/545 , C07K16/2809 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/62 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/94
摘要： The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
摘要翻译：本发明提供了完全与GPNMB结合的人单克隆抗体及其应用。提供了编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列。本发明还提供了包含抗GPNMB抗体的免疫缀合物和使用这种免疫缀合物的方法。本发明还提供了包含抗GPNMB抗体组分和抗-CD3组分的双特异性抗体，以及使用这种双特异性抗体的方法。

5. 发明申请

US20050256042A1 Methods of preventing and treating alimentary mucositis 审中-公开
标题翻译：预防和治疗消化性粘膜炎的方法
公开(公告)号：US20050256042A1
公开(公告)日：2005-11-17
申请号：US10980459
申请日：2004-11-03
申请人： Michael Jeffers , Zachary Yim , Pascal Valax , Pradyumna Namdev , Rajeev Chillakuru , William LaRochelle , Henri Lichenstein , Enrique Alvarez , William Hahne
发明人： Michael Jeffers , Zachary Yim , Pascal Valax , Pradyumna Namdev , Rajeev Chillakuru , William LaRochelle , Henri Lichenstein , Enrique Alvarez , William Hahne
IPC分类号： A61K38/00 , A61K38/17 , C07K14/47 , C07K14/50 , C12N1/21 , C12N15/74 , C12P21/06
CPC分类号： C07K14/50 , A61K38/00
摘要： The present invention relates to compositions and methods for preventing and treating alimentary mucositis. More particularly, the present invention provides methods for preventing and/or treating alimetary mucositis by using compositions comprising FGF-20, a fragment, a derivative, a variant, a homolog, or an analog thereof.
摘要翻译：本发明涉及预防和治疗消化性粘膜炎的组合物和方法。更具体地，本发明提供了通过使用包含FGF-20，片段，衍生物，变体，同源物或类似物的组合物来预防和/或治疗哺乳动物粘膜炎的方法。

6. 发明申请

US20060094647A1 Treatment of inflammatory bowel disease using growth factors 审中-公开
标题翻译：用生长因子治疗炎症性肠病
公开(公告)号：US20060094647A1
公开(公告)日：2006-05-04
申请号：US09992840
申请日：2001-11-06
申请人： Michael Jeffers , Richard Shimkets , Sudhirdas Prayaga , Ferenc Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , Beth Rittman , Juliette Shimkets , William LaRochelle , Henri Lichenstein
发明人： Michael Jeffers , Richard Shimkets , Sudhirdas Prayaga , Ferenc Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , Beth Rittman , Juliette Shimkets , William LaRochelle , Henri Lichenstein
IPC分类号： A61K38/17
CPC分类号： A61K38/1825 , C07K14/49 , C07K14/50 , C07K14/51 , C07K14/52
摘要： The present invention is based upon methods of treating inflammatory conditions in the intestinal tract of mammals using growth factor related polypeptides. Methods of using fibroblast growth factor-CX (FGF-CX) polynucleotide sequences and the FGF-CX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, are claimed in the invention. Similarly, methods of using FCTRX polynucleotide sequences and the FCTRX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, alone or in combination, are also claimed in the invention. FCTRX collectively refers to any of six variant FCTRX sequences, variously designated FCTR1, FCTR2, FCTR3, FCTR4, FCTR5 and FCTR6.
摘要翻译：本发明是基于使用生长因子相关多肽治疗哺乳动物肠道炎症状况的方法。在本发明中要求使用成纤维细胞生长因子CX（FGF-CX）多核苷酸序列和由这种核酸序列编码的FGF-CX多肽或其变体，片段和同系物的方法。类似地，在本发明中还要求保护使用FCTRX多核苷酸序列和由此类核酸序列编码的FCTRX多肽，或其变体，片段和同源物单独或组合使用的方法。 FCTRX统称为六种变体FCTRX序列中的任何一种，分别为FCTR1，FCTR2，FCTR3，FCTR4，FCTR5和FCTR6。

7. 发明申请

US20050164929A1 Methods of preventing and treating inflammatory bowel disease 审中-公开
标题翻译：预防和治疗炎症性肠病的方法
公开(公告)号：US20050164929A1
公开(公告)日：2005-07-28
申请号：US10980764
申请日：2004-11-03
申请人： Enrique Alvarez , Jeffrey Peterson , William LaRochelle , Henri Lichenstein , Michael Jeffers
发明人： Enrique Alvarez , Jeffrey Peterson , William LaRochelle , Henri Lichenstein , Michael Jeffers
IPC分类号： A61K38/00 , A61K38/18 , A61K38/19 , C07K14/49 , C07K14/50 , C07K14/51 , C07K14/52 , A61K48/00 , A61K38/17
CPC分类号： C07K14/49 , A61K38/00 , C07K14/50 , C07K14/51 , C07K14/52 , Y02A50/473
摘要： The present invention relates to compositions and methods for preventing and treating an inflammatory disorder of a mucosa, including but is not limited to, inflammatory bowel disease and irritable bowel syndrome. More particularly, the present invention relates to compositions comprising FGF-20, a fragment, a derivative, a variant, a homolog, or an analog thereof, and their uses in preventing and treating an inflammatory disorder of a mucosa, such as inflammatory bowel disease or irritable bowel syndrome.
摘要翻译：本发明涉及用于预防和治疗粘膜炎症性疾病的组合物和方法，包括但不限于炎性肠病和肠易激综合征。更具体地，本发明涉及包含FGF-20，片段，衍生物，变体，同源物或类似物的组合物，以及它们在预防和治疗粘膜炎症性疾病如炎症性肠病中的用途或肠易激综合征。

8. 发明申请

US20050063971A1 Antibodies to fibroblast growth factor and their methods of use 审中-公开
标题翻译：成纤维细胞生长因子的抗体及其使用方法
公开(公告)号：US20050063971A1
公开(公告)日：2005-03-24
申请号：US10948588
申请日：2004-09-23
申请人： Michael Jeffers , Richard Shimkets , Sudhirdas Prayaga , Ferenc Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John Herrmann , William LaRochelle , Henri Lichenstein
发明人： Michael Jeffers , Richard Shimkets , Sudhirdas Prayaga , Ferenc Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John Herrmann , William LaRochelle , Henri Lichenstein
IPC分类号： A01K67/027 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/04 , A61P7/06 , A61P9/00 , A61P17/02 , A61P17/14 , A61P35/00 , A61P43/00 , C07K14/50 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C07K16/28
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , A61K2039/505
摘要： The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FGF-CX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as other uses.
摘要翻译：本发明提供了FGF-CX，一种新的分离的多肽，以及编码FGF-CX的多核苷酸和免疫特异性结合FGF-CX或FGF-CX多肽的任何衍生物，变体，突变体或片段的多核苷酸或抗体。本发明另外提供了FGF-CX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

9. 发明申请

US20130156784A1 Compositions Using Antibodies Directed To GPNMB And Uses Thereof 审中-公开
标题翻译：使用针对GPNMB的抗体的组合及其用途
公开(公告)号：US20130156784A1
公开(公告)日：2013-06-20
申请号：US13544526
申请日：2012-07-09
申请人： Michael Jeffers , William LaRochelle
发明人： Michael Jeffers , William LaRochelle
IPC分类号： A61K39/395 , A61K31/426 , A61K31/5025 , A61K31/4439 , A61K33/20 , A61K31/4706 , A61K31/35 , A61K45/06 , A61K31/506
CPC分类号： A61K39/39558 , A61K31/35 , A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/4706 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/54 , A61K33/20 , A61K45/06 , A61K47/6803 , A61K47/6851 , C07K16/30 , C07K2317/21 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to antibodies, including fully human monoclonal antibodies, with specificity to GPNMB, and uses of such antibodies. The present invention further provides compositions that increase expression of GPNMB on the surface of tumor cells, and methods of using such compositions to increase the anti-cancer activity or other therapeutic efficacy of the antibodies and immunoconjugates provided herein.
摘要翻译：本发明涉及对GPNMB具有特异性的抗体，包括完全人单克隆抗体，以及此类抗体的用途。本发明还提供增加GPNMB在肿瘤细胞表面的表达的组合物，以及使用这些组合物增加本文提供的抗体和免疫缀合物的抗癌活性或其它治疗功效的方法。

10. 发明授权

US06368828B1 Attenuated and dominant negative variant cDNAs of Stat6: Stat6b and Stat6c 有权
标题翻译： Stat6：Stat6b和Stat6c的减毒和显性负变异cDNA
公开(公告)号：US06368828B1
公开(公告)日：2002-04-09
申请号：US09511625
申请日：2000-02-23
申请人： William LaRochelle , Bharvin K. R. Patel , Jacalyn H. Pierce
发明人： William LaRochelle , Bharvin K. R. Patel , Jacalyn H. Pierce
IPC分类号： C12P2106
CPC分类号： C07K14/4705
摘要： The present invention provides an isolated nucleic acid encoding the polypeptide Stat6b, having an amino acid sequence of Stat6 wherein a deletion in the nucleic acid is present, encompassing the last base pair of codon 39 of Stat6 and continuing through to and including codon 86 of Stat6 and an isolated polypeptide, Stat6b, having an amino acid sequence of Stat6 wherein amino acids 39-86 are deleted at the amino terminus. Also provided is an isolated nucleic acid encoding the polypeptide Stat6c, having an amino acid sequence of Stat6 wherein amino acids 537-564 are deleted and an isolated polypeptide, Stat6c, having an amino acid sequence of Stat6 wherein amino acids 537-564 are deleted. Methods of producing the polypeptide Stat6b and polypeptide Stat6c are also provided, comprising culturing cells comprising nucleic acid encoding the polypeptide Stat6b or the polypeptide Stat6c under conditions whereby the polypeptide Stat6b or the polypeptide Stat6c is produced.
摘要翻译：本发明提供了编码多肽Stat6b的分离的核酸，其具有Stat6的氨基酸序列，其中存在核酸中的缺失，其包含Stat6的最后一对密码子39，并持续到并包括Stat6的密码子86 和具有Stat6的氨基酸序列的分离的多肽Stat6b，其中在氨基末端缺失氨基酸39-86。还提供了编码多肽Stat6c的分离的核酸，其具有Stat6的氨基酸序列，其中氨基酸537-564缺失，分离的多肽Stat6c具有Stat6的氨基酸序列，其中氨基酸537-564被缺失。还提供了产生多肽Stat6b和多肽Stat6c的方法，包括在产生多肽Stat6b或多肽Stat6c的条件下培养包含编码多肽Stat6b或多肽Stat6c的核酸的细胞。

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