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1. 发明申请

US20100126103A1 CONNECTOR FOR CONNECTING BUILDING COMPONENTS 有权
标题翻译：连接建筑构件的连接器
公开(公告)号：US20100126103A1
公开(公告)日：2010-05-27
申请号：US12468499
申请日：2009-05-19
申请人： Edward R. diGirolamo , John Herrmann , Nabil Abdel-Rahman
发明人： Edward R. diGirolamo , John Herrmann , Nabil Abdel-Rahman
IPC分类号： E04B1/38
CPC分类号： E04B2/58 , E04B2/767 , E04B2001/2415 , E04B2001/2448 , E04B2001/2463
摘要： A connector for a wall structure wherein the connector connects to and reinforces a stud within the wall structure, or in some cases, the connector actually functions as a stud. The connector includes an elongated web and a pair of flanges that project from the web. About the lower portion of the connector there is provided a series of tabs that extend from the web and the two flanges and are turned so as to overlap and form a transfer structure that extends between the flanges about the lower end of the connector. In use, the connector can be connected to respective studs in a wall structure and at the same time anchor to an underlying structure such as a floor. In other cases, the connector itself can be utilized in the wall structure as a stud.
摘要翻译：一种用于墙壁结构的连接器，其中连接器连接到壁结构内的螺柱，或者在一些情况下，连接器实际上用作螺柱。连接器包括细长腹板和从腹板突出的一对凸缘。关于连接器的下部，提供了从卷筒纸和两个凸缘延伸的一系列凸片，并且被转动以便重叠并且形成在连接器的下端周围的法兰之间延伸的传送结构。在使用中，连接器可以以壁结构连接到相应的螺栓，并且同时锚固到诸如地板的下面的结构。在其他情况下，连接器本身可以在壁结构中用作螺柱。

2. 发明申请

US20080171046A1 Novel proteins and nucleic acids encoding same 审中-公开
标题翻译：新型蛋白质和编码相同的核酸
公开(公告)号：US20080171046A1
公开(公告)日：2008-07-17
申请号：US10844295
申请日：2004-05-12
申请人： Corine Vermet , Elma Fernandes , Richard Shimkets , John Herrmann , Kumud Majumder , John MacDougall , Vishnu Mishra , Peter S. Mezes , Luca Rastelli
发明人： Corine Vermet , Elma Fernandes , Richard Shimkets , John Herrmann , Kumud Majumder , John MacDougall , Vishnu Mishra , Peter S. Mezes , Luca Rastelli
IPC分类号： A61K39/395 , C07K14/435 , C07H21/00 , C12N15/00 , C07K16/18 , C12N5/00 , A61K38/17 , A61P25/00 , A61P11/00 , A61P37/00 , A61P15/00 , A61P35/04 , A61K31/70 , G01N33/566 , C12Q1/68 , G01N33/00 , C12Q1/02
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , C07K14/54 , C07K14/70571 , Y02A50/423 , Y10T436/143333
摘要： Disclosed herein are novel human nucleic acid sequences which encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码多肽的新型人核酸序列。还公开了由这些核酸序列编码的多肽，以及与多肽免疫特异性结合的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

3. 发明授权

US07141549B2 Proteins and nucleic acids encoding same 失效
公开(公告)号：US07141549B2
公开(公告)日：2006-11-28
申请号：US11054281
申请日：2005-02-08
申请人： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Ferenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook, II , Denise Lepley , Daniel Rieger , Catherine Burgess , Shlomit Edinger , Edward Voss , Charles Miller
发明人： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Ferenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook, II , Denise Lepley , Daniel Rieger , Catherine Burgess , Shlomit Edinger , Edward Voss , Charles Miller
IPC分类号： A61K38/17 , C07K14/47
CPC分类号： C12N9/2462 , A61K38/00 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , G01N33/6893
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

4. 发明申请

US20050171020A1 Growth factor polypeptides and nucleic acids encoding same 审中-公开
标题翻译：生长因子多肽和编码相同的核酸
公开(公告)号：US20050171020A1
公开(公告)日：2005-08-04
申请号：US11096308
申请日：2005-04-01
申请人： Richard Shimkets , Henri Lichenstein , John Herrmann , Ferenc Boldog
发明人： Richard Shimkets , Henri Lichenstein , John Herrmann , Ferenc Boldog
IPC分类号： A61K38/00 , C07K14/47 , C07K14/49 , C07K14/51 , C07K14/52 , A61K38/18
CPC分类号： C07K14/49 , A61K38/00 , C07K14/47 , C07K14/51 , C07K14/52
摘要： Disclosed are novel nucleic acids encoding proteins and polypeptides related to bone morphogenetic protein-1 (BMF1) and to vascular endothelial growth factor E (VEGF-E).
摘要翻译：公开了编码与骨形态发生蛋白-1（BMF1）和血管内皮生长因子E（VEGF-E）相关的蛋白质和多肽的新型核酸。

5. 发明授权

US5134870A Electro-mechanical lock with rotary bolt 失效
标题翻译：带旋转螺栓的机电锁
公开(公告)号：US5134870A
公开(公告)日：1992-08-04
申请号：US533893
申请日：1990-06-06
申请人： Alan K. Uyeda , Klaus W. Gartner , Peter J. Phillips , John Herrmann
发明人： Alan K. Uyeda , Klaus W. Gartner , Peter J. Phillips , John Herrmann
IPC分类号： E05B47/06 , E05B65/00 , E05C9/00 , G07C9/00
CPC分类号： E05B47/0603 , E05B47/0002 , E05B65/0082 , E05B17/2092 , E05B2047/0093 , E05B47/0004 , E05C9/00 , G07C9/00674 , Y10T70/7062 , Y10T70/7254 , Y10T70/7424
摘要： An electronic lock for a safe door is provided with a digital keypad entry device, a mechanical bolt works and associated handle for retracting the door bolts, and a spring biased rotary bolt which engages and precludes operation of the bolt works, such that upon entry of the predetermined code into the entry device, an electric signal causes a solenoid to energize and retract its armature from a blocking position relative the rotary bolt, further enabling the rotary bolt to rotate against its bias in response to mechanical maniupulation of the handle by the user to retract the door bolts. Unauthorized operation of the safe handle causes the rotary bolt to be locked into a fixed position, preventing entry into the safe.
摘要翻译：用于安全门的电子锁具有数字小键盘进入装置，用于缩回门螺栓的机械螺栓工作和相关手柄以及与弹簧偏置的旋转螺栓接合并阻止螺栓工作的操作，使得在进入进入设备中的预定代码，电信号使得螺线管相对于旋转螺栓从阻挡位置使其电枢激励和缩回，进一步使得旋转螺栓能够响应于用户对手柄的机械操纵而反对其偏压旋转收回门螺栓。未经授权的安全手柄操作会使旋转螺栓锁定在固定位置，防止进入保险箱。

6. 发明授权

US08440315B2 Matte finish polyimide films and methods relating thereto 有权
标题翻译：哑光整理聚酰亚胺膜及其相关方法
公开(公告)号：US08440315B2
公开(公告)日：2013-05-14
申请号：US13486284
申请日：2012-06-01
申请人： Thomas Edward Carney , Jeffrey Michael Bartolin , Meredith L. Dunbar , Scott John Herrmann
发明人： Thomas Edward Carney , Jeffrey Michael Bartolin , Meredith L. Dunbar , Scott John Herrmann
IPC分类号： B32B27/28 , B32B27/38 , B32B5/16
CPC分类号： H01B3/306 , B32B5/16 , C08G73/105 , C08G73/1075 , C08J5/18 , C08J2379/08 , C09J7/25 , C09J163/00 , C09J2463/00 , C09J2479/086 , Y10T428/25 , Y10T428/256 , Y10T428/257 , Y10T428/258 , Y10T428/259 , Y10T428/26 , Y10T428/2982 , Y10T428/31515 , Y10T428/31721
摘要： The present disclosure is directed to a base film having a thickness from 8 to 152 microns, a 60 degree gloss value from 2 to 35, an optical density greater than or equal to 2 and a dielectric strength greater than 1400 V/mil. The base film comprises a chemically converted (partially or wholly aromatic) polyimide in an amount from 71 to 96 weight percent of the base film. The base film further comprises a pigment and a matting agent. The matting agent is present in an amount from 1.6 to 10 weight percent of the base film, has a median particle size from 1.3 to 10 microns, and has a density from 2 to 4.5 g/cc. The pigment is present in an amount from 2 to 9 weight percent of the base film. The present disclosure is also directed to coverlay films comprising the base film in combination with an adhesive layer.
摘要翻译：本公开涉及厚度为8至152微米，60度光泽值为2至35，光密度大于或等于2且介电强度大于1400V / mil的基膜。该基膜包含基础膜的71至96重量％的化学转化（部分或全部芳族）聚酰亚胺。基膜还包含颜料和消光剂。消光剂的存在量为基膜的1.6至10重量％，中值粒径为1.3至10微米，密度为2至4.5g / cc。颜料的存在量为基膜的2至9重量％。本公开还涉及包括基膜与粘合剂层组合的覆盖膜。

7. 发明申请

US20070178452A1 Method for analyzing a nucleic acid 审中-公开
标题翻译：分析核酸的方法
公开(公告)号：US20070178452A1
公开(公告)日：2007-08-02
申请号：US10277951
申请日：2002-10-21
申请人： Pascal Bouffard , John Herrmann , Chunli Huang , Michael Jeffers , Jingfang Ju , Luca Rastelli , Juliette Shimkets , Jan Simons , Bruce Taillon
发明人： Pascal Bouffard , John Herrmann , Chunli Huang , Michael Jeffers , Jingfang Ju , Luca Rastelli , Juliette Shimkets , Jan Simons , Bruce Taillon
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12N15/1096 , C12Q2600/158 , G16B30/00
摘要： Disclosed is a method in which DNA sequences derived from microsome-associated mRNA sequences in a mixed sample or in an arrayed single sequence clone can be determined and classified without sequencing. The methods make use of information on the presence of carefully chosen target subsequences, typically of length from 4 to 8 base pairs, and preferably the length between target subsequences in a sample DNA sequence together with DNA sequence databases containing lists of sequences likely to be present in the sample to determine a sample sequence. The preferred method uses restriction endonucleases to recognize target subsequences and cut the sample sequence. Then carefully chosen recognition moieties are ligated to the cut fragments, the fragments amplified, and the experimental observation made. Polymerase chain reaction (PCR) is the preferred method of amplification. Another embodiment of the invention uses information on the presence or absence of carefully chosen target subsequences in a single sequence clone together with DNA sequence databases to determine the clone sequence. Computer implemented methods are provided to analyze the experimental results and to determine the sample sequences in question and to carefully choose target subsequences in order that experiments yield a maximum amount of information
摘要翻译：公开了可以确定和分类来自混合样品或排列单序列克隆中的微粒体相关mRNA序列的DNA序列而不进行测序的方法。这些方法利用关于精确选择的目标子序列的存在的信息，通常长度为4至8个碱基对，优选样品DNA序列中目标子序列之间的长度以及含有可能存在的序列的DNA序列数据库在样品中确定样品序列。优选的方法是使用限制性核酸内切酶识别目标子序列并切割样品序列。然后仔细选择识别部分连接到切割片段，扩增片段，并进行实验观察。聚合酶链反应（PCR）是优选的扩增方法。本发明的另一个实施方案使用关于在单个序列克隆中与DNA序列数据库一起存在或不存在仔细选择的目标子序列的信息来确定克隆序列。提供计算机实现的方法来分析实验结果并确定所讨论的样本序列，并仔细选择目标子序列，以便实验产生最大量的信息

8. 发明授权

US08846873B2 Antibodies directed to GPNMB and uses thereof 有权
标题翻译：针对GPNMB的抗体及其用途
公开(公告)号：US08846873B2
公开(公告)日：2014-09-30
申请号：US13355366
申请日：2012-01-20
申请人： Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
发明人： Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
IPC分类号： C07K16/30 , C07K19/00 , C07K16/28 , A61K47/48 , A61K39/00
CPC分类号： C07K16/3053 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K2039/505 , A61K2039/545 , C07K16/2809 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/62 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/94
摘要： The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
摘要翻译：本发明提供了完全与GPNMB结合的人单克隆抗体及其应用。提供了编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列。本发明还提供了包含抗GPNMB抗体的免疫缀合物和使用这种免疫缀合物的方法。本发明还提供了包含抗GPNMB抗体组分和抗-CD3组分的双特异性抗体，以及使用这种双特异性抗体的方法。

9. 发明申请

US20130196134A1 MATTE FINISH POLYIMIDE FILMS AND METHODS RELATING THERETO 审中-公开
标题翻译： MATTE FINISH POLYIMIDE FILMS AND METHODS RELATTING THERETO
公开(公告)号：US20130196134A1
公开(公告)日：2013-08-01
申请号：US13811685
申请日：2011-02-14
申请人： Thomas Edward Carney , Jeffrey Michael Bartolin , Meredith L. Dunbar , Scott John Herrmann
发明人： Thomas Edward Carney , Jeffrey Michael Bartolin , Meredith L. Dunbar , Scott John Herrmann
IPC分类号： C08L79/08
CPC分类号： C08L79/08 , C08G73/105 , C08G73/1075 , C08J5/18 , C08J2379/08
摘要： The present disclosure is directed to a base film having a thickness from 8 to 152 microns, a 60 degree gloss value from 2 to 35, an optical density greater than or equal to 2 and a dielectric strength greater than 1400 V/mil. The base film comprises a chemically converted (partially or wholly aromatic) polyimide in an amount from 71 to 96 weight percent of the base film. The base film further comprises a pigment and a matting agent. The matting agent is present in an amount from 1.6 to 10 weight percent of the base film, has a median particle size from 1.3 to 10 microns, and has a density from 2 to 4.5 g/cc. The pigment is present in an amount from 2 to 9 weight percent of the base film. The present disclosure is also directed to coverlay films comprising the base film in combination with an adhesive layer.
摘要翻译：本公开涉及厚度为8至152微米，60度光泽值为2至35，光密度大于或等于2且介电强度大于1400V / mil的基膜。该基膜包含基础膜的71至96重量％的化学转化（部分或全部芳族）聚酰亚胺。基膜还包含颜料和消光剂。消光剂的存在量为基膜的1.6至10重量％，中值粒径为1.3至10微米，密度为2至4.5g / cc。颜料的存在量为基膜的2至9重量％。本公开还涉及包括基膜与粘合剂层组合的覆盖膜。

10. 发明申请

US20130022597A1 Antibodies Directed To GPNMB And Uses Thereof 有权
标题翻译：针对GPNMB的抗体及其用途
公开(公告)号：US20130022597A1
公开(公告)日：2013-01-24
申请号：US13355366
申请日：2012-01-20
申请人： Meina Liang , Orit Foord , Scott Klakamp , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
发明人： Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
IPC分类号： A61K39/395 , C12N15/13 , C40B30/04 , C12N15/63 , C12N1/21 , C12N5/10 , C07K16/18 , A61P35/00
CPC分类号： C07K16/3053 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K2039/505 , A61K2039/545 , C07K16/2809 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/62 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/94
摘要： The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
摘要翻译：本发明提供了完全与GPNMB结合的人单克隆抗体及其应用。提供了编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列。本发明还提供了包含抗GPNMB抗体的免疫缀合物和使用这种免疫缀合物的方法。本发明还提供了包含抗GPNMB抗体组分和抗-CD3组分的双特异性抗体，以及使用这种双特异性抗体的方法。

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