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1. 发明申请

US20080132575A1 Formulations Of Suberoylanilide Hydroxamic Acid And Methods For Producing Same 有权
标题翻译：苯乙酰苯胺羟肟酸的制剂及其制备方法
公开(公告)号：US20080132575A1
公开(公告)日：2008-06-05
申请号：US11663165
申请日：2006-05-16
申请人： Jeannie Chow Wong , Aaron S. Cote , Erik A. Dienemann , Kimberly Gallagher , Craig Ikeda , Justin Moser , Pavol Rajniak , Robert A. Reed , Cindy Starbuck , Hsien-Hsin Tung , Qingxi Wang , Benjamin Max Cohen , Vincent R. Capodanno , Brian Sell , Thomas A. Miller
发明人： Jeannie Chow Wong , Aaron S. Cote , Erik A. Dienemann , Kimberly Gallagher , Craig Ikeda , Justin Moser , Pavol Rajniak , Robert A. Reed , Cindy Starbuck , Hsien-Hsin Tung , Qingxi Wang , Benjamin Max Cohen , Vincent R. Capodanno , Brian Sell , Thomas A. Miller
IPC分类号： A61K31/185 , A61P35/00
CPC分类号： A61K31/19
摘要： The present invention provides a pharmaceutical composition or crystalline composition with a specific dissolution profile, which comprises suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof as an active ingredient. The present invention provides a process of producing said crystalline composition or pharmaceutical composition. The present invention also provides compositions with a specific particle size distribution.
摘要翻译：本发明提供具有特定溶出曲线的药物组合物或结晶组合物，其包含辛二酰苯胺异羟肟酸或其药学上可接受的盐或水合物作为活性成分。本发明提供了制备所述结晶组合物或药物组合物的方法。本发明还提供具有特定粒度分布的组合物。

2. 发明授权

US08450372B2 Formulations of suberoylanilide hydroxamic acid and methods for producing same 有权
标题翻译：辛二酰苯胺异羟肟酸的制剂及其制备方法
公开(公告)号：US08450372B2
公开(公告)日：2013-05-28
申请号：US12686843
申请日：2010-01-13
申请人： Jeannie Chow Wong , Aaron S. Cote , Erik A. Dienemann , Kimberly Gallagher , Craig Ikeda , Justin Moser , Pavol Rajniak , Robert A. Reed , Cindy Starbuck , Hsien-Hsin Tung , Qingxi Wang , Benjamin Max Cohen , Vincent R. Capodanno , Brian Sell , Thomas A. Miller
发明人： Jeannie Chow Wong , Aaron S. Cote , Erik A. Dienemann , Kimberly Gallagher , Craig Ikeda , Justin Moser , Pavol Rajniak , Robert A. Reed , Cindy Starbuck , Hsien-Hsin Tung , Qingxi Wang , Benjamin Max Cohen , Vincent R. Capodanno , Brian Sell , Thomas A. Miller
IPC分类号： A61K31/19
CPC分类号： A61K31/19
摘要： The present invention provides a pharmaceutical composition or crystalline composition with a specific dissolution profile, which comprises suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof as an active ingredient. The present invention provides a process of producing said crystalline composition or pharmaceutical composition. The present invention also provides compositions with a specific particle size distribution.
摘要翻译：本发明提供具有特定溶出曲线的药物组合物或结晶组合物，其包含辛二酰苯胺异羟肟酸或其药学上可接受的盐或水合物作为活性成分。本发明提供了制备所述结晶组合物或药物组合物的方法。本发明还提供具有特定粒度分布的组合物。

3. 发明申请

US20100119596A1 FORMULATIONS OF SUBEROYLANILIDE HYDROXAMIC ACID AND METHODS FOR PRODUCING SAME 有权
公开(公告)号：US20100119596A1
公开(公告)日：2010-05-13
申请号：US12686812
申请日：2010-01-13
申请人： Jeannie Chow Wong , Aaron S. Cote , Erik A. Dienemann , Kimberly Gallagher , Craig Ikeda , Justin Moser , Pavol Rajniak , Robert A. Reed , Cindy Starbuck , Hsien-Hsin Tung , Qingxi Wang , Benjamin Max Cohen , Vincent R. Capodanno , Brian Sell
发明人： Jeannie Chow Wong , Aaron S. Cote , Erik A. Dienemann , Kimberly Gallagher , Craig Ikeda , Justin Moser , Pavol Rajniak , Robert A. Reed , Cindy Starbuck , Hsien-Hsin Tung , Qingxi Wang , Benjamin Max Cohen , Vincent R. Capodanno , Brian Sell
IPC分类号： A61K9/48 , A61K31/16
CPC分类号： A61K31/19
摘要： The present invention provides a pharmaceutical composition or crystalline composition with a specific dissolution profile, which comprises suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof as an active ingredient. The present invention provides a process of producing said crystalline composition or pharmaceutical composition. The present invention also provides compositions with a specific particle size distribution.

4. 发明申请

US20100112046A1 FORMULATIONS OF SUBEROYLANILIDE HYDROXAMIC ACID AND METHODS FOR PRODUCING SAME 有权
标题翻译：磺苄青霉酸的制剂及其生产方法
公开(公告)号：US20100112046A1
公开(公告)日：2010-05-06
申请号：US12686843
申请日：2010-01-13
申请人： Jeannie Chow Wong , Aaron S. Cote , Erik A. Dienemann , Kimberly Gallagher , Craig Ikeda , Justin Moser , Pavol Rajniak , Robert A. Reed , Cindy Starbuck , Hsien-Hsin Tung , Qingxi Wang , Benjamin Max Cohen , Vincent R. Capodanno , Brian Sell
发明人： Jeannie Chow Wong , Aaron S. Cote , Erik A. Dienemann , Kimberly Gallagher , Craig Ikeda , Justin Moser , Pavol Rajniak , Robert A. Reed , Cindy Starbuck , Hsien-Hsin Tung , Qingxi Wang , Benjamin Max Cohen , Vincent R. Capodanno , Brian Sell
IPC分类号： A61K31/16 , A61K9/14 , A61K9/48 , A61P35/00
CPC分类号： A61K31/19
摘要： The present invention provides a pharmaceutical composition or crystalline composition with a specific dissolution profile, which comprises suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof as an active ingredient. The present invention provides a process of producing said crystalline composition or pharmaceutical composition. The present invention also provides compositions with a specific particle size distribution.
摘要翻译：本发明提供具有特定溶出曲线的药物组合物或结晶组合物，其包含辛二酰苯胺异羟肟酸或其药学上可接受的盐或水合物作为活性成分。本发明提供了制备所述结晶组合物或药物组合物的方法。本发明还提供具有特定粒度分布的组合物。

5. 发明授权

US08288440B2 Formulations of suberoylanilide hydroxamic acid and methods for producing same 有权
标题翻译：辛二酰苯胺异羟肟酸的制剂及其制备方法
公开(公告)号：US08288440B2
公开(公告)日：2012-10-16
申请号：US12686812
申请日：2010-01-13
申请人： Jeannie Chow Wong , Aaron S. Cote , Erik A. Dienemann , Kimberly Gallagher , Craig Ikeda , Justin Moser , Pavol Rajniak , Robert A. Reed , Cindy Starbuck , Hsien-Hsin Tung , Qingxi Wang , Benjamin Max Cohen , Vincent R. Capodanno , Brian Sell
发明人： Jeannie Chow Wong , Aaron S. Cote , Erik A. Dienemann , Kimberly Gallagher , Craig Ikeda , Justin Moser , Pavol Rajniak , Robert A. Reed , Cindy Starbuck , Hsien-Hsin Tung , Qingxi Wang , Benjamin Max Cohen , Vincent R. Capodanno , Brian Sell
IPC分类号： A61K31/19
CPC分类号： A61K31/19
摘要： The present invention provides a pharmaceutical composition or crystalline composition with a specific dissolution profile, which comprises suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof as an active ingredient. The present invention provides a process of producing said crystalline composition or pharmaceutical composition. The present invention also provides compositions with a specific particle size distribution.
摘要翻译：本发明提供具有特定溶出曲线的药物组合物或结晶组合物，其包含辛二酰苯胺异羟肟酸或其药学上可接受的盐或水合物作为活性成分。本发明提供了制备所述结晶组合物或药物组合物的方法。本发明还提供具有特定粒度分布的组合物。

6. 发明授权

US08093295B2 Formulations of suberoylanilide hydroxamic acid and methods for producing the same 有权
标题翻译：辛二酰苯胺异羟肟酸的制剂及其制备方法
公开(公告)号：US08093295B2
公开(公告)日：2012-01-10
申请号：US11663165
申请日：2006-05-16
申请人： Jeannie Chow Wong , Benjamin Max Cohen , Aaron S. Cote , Erik A. Dienemann , Kimberly Gallagher , Craig Ikeda , Justin Moser , Pavol Rajniak , Robert A. Reed , Brian Sell , Cindy Starbuck , Hsien-Hsin Tung , Qingxi Wang , Vincent R. Capodanno
发明人： Jeannie Chow Wong , Benjamin Max Cohen , Aaron S. Cote , Erik A. Dienemann , Kimberly Gallagher , Craig Ikeda , Justin Moser , Pavol Rajniak , Robert A. Reed , Brian Sell , Cindy Starbuck , Hsien-Hsin Tung , Qingxi Wang , Vincent R. Capodanno
IPC分类号： A61K31/19
CPC分类号： A61K31/19
摘要： The present invention provides a pharmaceutical composition or crystalline composition with a specific dissolution profile, which comprises suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof as an active ingredient. The present invention provides a process of producing said crystalline composition or pharmaceutical composition. The present invention also provides compositions with a specific particle size distribution.
摘要翻译：本发明提供具有特定溶出曲线的药物组合物或结晶组合物，其包含辛二酰苯胺异羟肟酸或其药学上可接受的盐或水合物作为活性成分。本发明提供了制备所述结晶组合物或药物组合物的方法。本发明还提供具有特定粒度分布的组合物。

7. 发明授权

US06015716A Detection of endotoxin levels in liposomes, lipid bilayers and lipid complexes 失效
标题翻译：检测脂质体，脂质双层和脂质复合物中的内毒素水平
公开(公告)号：US06015716A
公开(公告)日：2000-01-18
申请号：US679046
申请日：1996-07-12
申请人： Paul A. Harmon , Donna J. Cabral-Lilly , J. Craig Franklin , Robert A. Reed , Andrew S. Janoff
发明人： Paul A. Harmon , Donna J. Cabral-Lilly , J. Craig Franklin , Robert A. Reed , Andrew S. Janoff
IPC分类号： G01N33/579 , A61K9/50 , C07F9/02 , G01N31/00
CPC分类号： G01N33/579 , G01N2400/50 , G01N2405/04 , Y10S436/829 , Y10T436/104165
摘要： Endotoxin incorporated into liposomes, lipid bilayers or lipid complexes can be detected by combining an aqueous suspension of the liposomes, lipid complexes or lipid bilayers with a suitable detergent. Preferable detergents, e.g., Lubrol-PX.TM. or a polyoxyethylene ether, solubilize the lipid bilayers, liposomes or lipid complexes at acceptable lipid concentrations, forming micelles therefrom which contain lipid bilayer, liposome or lipid complex lipid, detergent and endotoxin, should it be present. The micelles are then assayed for the presence of endotoxin.
摘要翻译：可以通过将脂质体，脂质复合物或脂质双层的水性悬浮液与合适的洗涤剂组合来检测掺入脂质体，脂质双层或脂质复合物中的内毒素。优选的洗涤剂，例如Lubrol-PX TM或聚氧乙烯醚，以可接受的脂质浓度溶解脂质双层，脂质体或脂质复合物，形成其中含有脂质双层，脂质体或脂质复合物脂质，洗涤剂和内毒素的胶束，如果存在。然后测定胶束的内毒素的存在。

8. 发明授权

US5321267A Bench flotation sensor 失效
标题翻译：台式浮选传感器
公开(公告)号：US5321267A
公开(公告)日：1994-06-14
申请号：US951510
申请日：1992-09-25
申请人： Lynden A. Song , Karl B. Conroy , Robert A. Reed
发明人： Lynden A. Song , Karl B. Conroy , Robert A. Reed
IPC分类号： G01D5/30 , G01M11/04 , G01J5/10 , G01B11/16
CPC分类号： G01M11/04 , G01D5/30
摘要： A noncontact bench flotation sensor system for use with a flotation bench. The system comprises a plurality of reflectors that are disposed on the body of the bench, typically on the inside of the skirt or overhanging portion of the table surface of the bench. Each reflector is such that it reflects over a narrow region, or angle. Two sensor assemblies, preferably infrared, are disposed adjacent each reflector and are located on each leg of the bench. Each of the sensor assemblies is comprised of an transmitter and an detector. The two sensor assemblies are separated by a distance that corresponds to upper and lower limits of bench flotation. The sensor assemblies transmit infrared energy, for example, at the reflector. In the event that the isolator moves to a point where one of the transmitters is aligned with the reflector, energy is reflected back to the associated detector, and the reflected energy is detected. Output signals are generated by the sensor assemblies that are indicative of in flotation and out-of-flotation conditions of the bench. These signals are coupled to a display unit. The display unit incorporates a plurality of light emitting diodes (LEDs) that correspond to each of the possible flotation conditions, and an annunciator. In-flotation signals from the sensor assemblies are used to light selected LEDs, while out of flotation output signals from the sensor assemblies are used to light other LEDs and sound an alarm. This alerts an operator that the bench is out of flotation, permitting the operator to correct the problem.
摘要翻译：一种与浮选台一起使用的非接触台式浮选传感器系统。该系统包括多个反射器，其设置在工作台的主体上，通常位于工作台的工作台表面的裙部或伸出部分的内侧。每个反射器使得其在窄的区域或角度上反射。两个传感器组件，优选红外线，被布置在每个反射器附近并且位于台架的每个腿上。每个传感器组件由发射器和检测器组成。两个传感器组件分隔一段对应于台架浮选的上限和下限的距离。传感器组件例如在反射器处传送红外能量。在隔离器移动到其中一个发射器与反射器对准的位置的情况下，能量被反射回相关联的检测器，并且检测反射的能量。输出信号由传感器组件产生，其指示在台架的浮选和浮选条件下。这些信号耦合到显示单元。显示单元包括与可能的浮选条件中的每一个相对应的多个发光二极管（LED）和报警器。来自传感器组件的浮选信号用于点亮所选择的LED，而来自传感器组件的浮选输出信号用于点亮其他LED并发出报警。这样可以提醒操作员台架不能浮动，从而允许操作员纠正问题。

9. 发明授权

US07400400B2 Method for monitoring particle size 失效
标题翻译：监测粒径的方法
公开(公告)号：US07400400B2
公开(公告)日：2008-07-15
申请号：US10488604
申请日：2002-08-23
申请人： Steven M. Arrivo , William E. Bowen , Robert A. Reed , John P. Higgins
发明人： Steven M. Arrivo , William E. Bowen , Robert A. Reed , John P. Higgins
IPC分类号： G01N21/00
CPC分类号： G01N21/359 , G01N15/0205 , G01N15/0211 , G01N21/274 , G01N21/3563 , G01N21/3577 , G01N21/4738 , G01N21/474
摘要： The present invention provides methods for the use of visible and/or near-infrared spectroscopic methodology to monitor and control processes for the generation of particles, including processes that provide for a reduction in particle size and processes that result in an increase in particle size. One embodiment of the present invention employs visible and/or near-infrared diffuse reflectance spectroscopy to monitor particle size. The present invention is particularly useful for monitoring particle size of optically dense samples and is further useful for monitoring the endpoint of particle generation processes. In contrast to methods known in the art, the present invention is especially useful for on-line monitoring of particle size.
摘要翻译：本发明提供了使用可见光和/或近红外光谱方法来监测和控制颗粒产生过程的方法，包括提供粒径减小和导致粒度增加的方法。本发明的一个实施例采用可见光和/或近红外漫反射光谱来监测粒度。本发明对于监测光学密度样品的粒度特别有用，并且可用于监测颗粒生成过程的终点。与本领域已知的方法相反，本发明对于粒径的在线监测特别有用。

10. 发明授权

US4132480A Photographic mask structure 失效
标题翻译：摄影掩模结构
公开(公告)号：US4132480A
公开(公告)日：1979-01-02
申请号：US812553
申请日：1977-07-05
申请人： Robert A. Reed
发明人： Robert A. Reed
IPC分类号： G03B27/58 , G03B27/62
CPC分类号： G03B27/582
摘要： A photograhic cropping mask of a planar sheet, such as paper, plastic or cardboard, having defined therein a plurality of prescored, detachable rectilinear openings having a common center, indexing means and, optionally, an area of adhesive material and/or crop marks such that the sheet may be placed adjacent a transparent film to determine the cropping opening appropriate to the film image, the selected opening produced by detaching along an appropriate score line, the film attached by means of tape or the optional adhesive area to the sheet with the film properly aligned with the opening, and the film and sheet then accurately positioned in a photographic printing apparatus by the indexing means.
摘要翻译：平面片材（如纸张，塑料或纸板）的照相裁剪掩模，其中限定有多个预先分割的可拆卸的直线开口，其具有共同的中心，分度装置，以及任选的粘合剂材料和/或作物标记的区域可以将片材放置在透明膜附近以确定适合于胶片图像的裁切开口，通过沿着适当的刻痕线分离产生的所选择的开口，通过胶带或可选的粘合剂区域附着到具有胶片与开口正确对准，然后胶片和片材通过分度装置精确地定位在照相打印装置中。

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