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1. 发明授权

US06566362B2 Benzo[f]naphthyridine derivatives, their preparation and compositions containing them 失效
标题翻译：苯并[f]萘啶衍生物，其制备方法和含有它们的组合物
公开(公告)号：US06566362B2
公开(公告)日：2003-05-20
申请号：US10029950
申请日：2001-12-31
申请人： Jean-François Desconclois , Arielle Genevois-Borella , Philippe Girard , Michel Kryvenko , Marc Pierre Lavergne , Jean-Luc Malleron , Guy Picaut , Michel Tabart , Sylvie Wentzler
发明人： Jean-François Desconclois , Arielle Genevois-Borella , Philippe Girard , Michel Kryvenko , Marc Pierre Lavergne , Jean-Luc Malleron , Guy Picaut , Michel Tabart , Sylvie Wentzler
IPC分类号： A61K314375
CPC分类号： C07D215/38 , C07D471/04
摘要： Benzo[f]naphthyridine derivatives of formula (I): benzo[f]naphthyridine derivatives and benzo[f]naphthyridine esters of formula (IVa): aminoquinoline derivatives of formula (X): processes for preparing such compounds; and compositions comprising them.
摘要翻译：式（I）的苯并[f]萘啶衍生物：苯并[f]萘啶衍生物和式（IVa）的苯并[f]萘啶酯：式（X）的氨基喹啉衍生物：制备此类化合物的方法; 和包含它们的组合物。

2. 发明授权

US5556861A 1,8 benzonaphthyridine derivatives and antimicrobial compositions 失效
标题翻译： 1,8苯并萘啶衍生物和抗微生物组合物
公开(公告)号：US5556861A
公开(公告)日：1996-09-17
申请号：US472766
申请日：1995-06-07
申请人： Eric Bacque , Michel Barreau , Jean-Francois Desconclois , Philippe Girard , Michel Kryvenko , Marc P. Lavergne , Jean-Marc Paris , Guy Picaut
发明人： Eric Bacque , Michel Barreau , Jean-Francois Desconclois , Philippe Girard , Michel Kryvenko , Marc P. Lavergne , Jean-Marc Paris , Guy Picaut
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04
摘要： This invention relates to a novel 1,8 benzo[b]naphythyridine derivative of general formula (I), ##STR1## wherein R is H or a hydroxy, amino or alkylamino radical optionally substituted by amino or hydroxy, or R is dialkylamino of which the alkyl portions may form, with the nitrogen atom, a 5- or 6-membered heterocyclic ring which optionally contains a further heteroatom chosen from nitrogen, oxygen or sulphur, or R is C.sub.3-6 cycloalkylamino or an alkanylamino, N-alkyl N-alkanylamino or aminoalkylphenylamino radical; R.sub.1 and R.sub.2, which are the same or different, are in positions 2 and 3 and represent H, alkyl, C.sub.2-4 alkenyl, phenyl, or substituted phenyl, or R.sub.1 and R.sub.2 are in position 2 and represent alkyl; R.sub.3 is H or alkyl, fluoroalkyl, carboxyalkyl, C.sub.3-6 cycloalkyl, fluorophenyl, difluorophenyl, alkyloxy or alkylamino; and R.sub.4 is H or F, wherein the C.sub.1-4 alkanyl and alkyl radicals are linear or branched; stereoisomeric forms thereof or mixtures of these; and salts and hydrated forms thereof. These novel derivatives are useful as antimicrobials.
摘要翻译：本发明涉及通式（I）的新颖的1,8-苯并[b]萘啶衍生物，其中R是H或羟基，任选被氨基或羟基取代的氨基或烷基氨基，或R是烷基部分可以与氮原子形成的二烷基氨基，其任选地含有选自氮，氧或硫的另外的杂原子的5-或6-元杂环，或R是C 3-6环烷基氨基或烷基氨基，烷基N-烷基氨基或氨基烷基苯基氨基; R1和R2相同或不同，位于2和3位，代表H，烷基，C2-4烯基，苯基或取代苯基，或R1和R2位于2位，代表烷基; R3是H或烷基，氟代烷基，羧基烷基，C3-6环烷基，氟苯基，二氟苯基，烷氧基或烷基氨基; R4是H或F，其中C1-4烷基和烷基是直链或支链的; 其立体异构形式或它们的混合物; 及其盐和水合形式。这些新型衍生物可用作抗微生物剂。

3. 发明授权

US5403852A Oxazole derivatives, their preparation and pharmaceutical compositions containing them 失效
标题翻译：恶唑衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5403852A
公开(公告)日：1995-04-04
申请号：US960428
申请日：1992-12-11
申请人： Michel Barreau , Michel Kryvenko , Marc-Pierre Lavergne , Auguste Techer
发明人： Michel Barreau , Michel Kryvenko , Marc-Pierre Lavergne , Auguste Techer
IPC分类号： A61K31/41 , A61K31/42 , A61P29/00 , C07D20060101 , C07D413/06
CPC分类号： C07D413/06
摘要： Oxazole derivatives of the formula ##STR1## wherein R and R' are each hydrogen or alkyl containing 1 or 2 carbon atoms, R.sub.1 and R.sub.2 are the same or different and represent hydrogen, halogen or straight- or branched-chain (C.sub.1-4) alkyloxy radicals, and n is 3-6; their salts their isomers and mixtures and their preparation method, are method are described. These derivatives display anti-inflammatory activity.
摘要翻译： PCT No.PCT / FR91 / 00473 Sec。 371日期：1992年12月11日 102（e）日期1992年12月11日PCT提交1991年6月13日PCT公布。出版物WO91 / 19714 1991年12月26日。下式的化合物：其中R和R'各自为氢或含有1或2个碳原子的烷基，R 1和R 2相同或不同，代表氢，卤素或直链或支链链（C 1-4）烷氧基，n为3-6; 它们的盐的异构体和混合物及其制备方法，都是描述的方法。这些衍生物显示抗炎活性。

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