专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5556861A 1,8 benzonaphthyridine derivatives and antimicrobial compositions 失效
标题翻译： 1,8苯并萘啶衍生物和抗微生物组合物
公开(公告)号：US5556861A
公开(公告)日：1996-09-17
申请号：US472766
申请日：1995-06-07
申请人： Eric Bacque , Michel Barreau , Jean-Francois Desconclois , Philippe Girard , Michel Kryvenko , Marc P. Lavergne , Jean-Marc Paris , Guy Picaut
发明人： Eric Bacque , Michel Barreau , Jean-Francois Desconclois , Philippe Girard , Michel Kryvenko , Marc P. Lavergne , Jean-Marc Paris , Guy Picaut
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04
摘要： This invention relates to a novel 1,8 benzo[b]naphythyridine derivative of general formula (I), ##STR1## wherein R is H or a hydroxy, amino or alkylamino radical optionally substituted by amino or hydroxy, or R is dialkylamino of which the alkyl portions may form, with the nitrogen atom, a 5- or 6-membered heterocyclic ring which optionally contains a further heteroatom chosen from nitrogen, oxygen or sulphur, or R is C.sub.3-6 cycloalkylamino or an alkanylamino, N-alkyl N-alkanylamino or aminoalkylphenylamino radical; R.sub.1 and R.sub.2, which are the same or different, are in positions 2 and 3 and represent H, alkyl, C.sub.2-4 alkenyl, phenyl, or substituted phenyl, or R.sub.1 and R.sub.2 are in position 2 and represent alkyl; R.sub.3 is H or alkyl, fluoroalkyl, carboxyalkyl, C.sub.3-6 cycloalkyl, fluorophenyl, difluorophenyl, alkyloxy or alkylamino; and R.sub.4 is H or F, wherein the C.sub.1-4 alkanyl and alkyl radicals are linear or branched; stereoisomeric forms thereof or mixtures of these; and salts and hydrated forms thereof. These novel derivatives are useful as antimicrobials.
摘要翻译：本发明涉及通式（I）的新颖的1,8-苯并[b]萘啶衍生物，其中R是H或羟基，任选被氨基或羟基取代的氨基或烷基氨基，或R是烷基部分可以与氮原子形成的二烷基氨基，其任选地含有选自氮，氧或硫的另外的杂原子的5-或6-元杂环，或R是C 3-6环烷基氨基或烷基氨基，烷基N-烷基氨基或氨基烷基苯基氨基; R1和R2相同或不同，位于2和3位，代表H，烷基，C2-4烯基，苯基或取代苯基，或R1和R2位于2位，代表烷基; R3是H或烷基，氟代烷基，羧基烷基，C3-6环烷基，氟苯基，二氟苯基，烷氧基或烷基氨基; R4是H或F，其中C1-4烷基和烷基是直链或支链的; 其立体异构形式或它们的混合物; 及其盐和水合形式。这些新型衍生物可用作抗微生物剂。

IPRDB

热门服务

关于我们

友情链接

联系方式