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1. 发明申请

US20120046287A1 Dihydroindolone compounds, a process for their preparation and pharmaceutical compositions containing them 有权
公开(公告)号：US20120046287A1
公开(公告)日：2012-02-23
申请号：US13373016
申请日：2011-11-02
申请人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Vincent Lacoste , Pauline Lacoste , Imre Fejes
发明人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Vincent Lacoste , Pauline Lacoste , Imre Fejes
IPC分类号： A61K31/5377 , A61K31/445 , A61P35/04 , A61K31/404
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14
摘要： Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO2 group, R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, R3 and R4, together with the atoms carrying them, form a heterocyclic group, R5 represents a hydrogen atom or an alkyl group, R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.

2. 发明申请

US20110034460A1 Dihydroindolone compounds, a process for their preparation and pharmaceutical compositions containing them 有权
标题翻译：二氢吲哚酮化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US20110034460A1
公开(公告)日：2011-02-10
申请号：US12806045
申请日：2010-08-04
申请人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Vincent Lacoste , Pauline Lacoste , Imre Fejes , Michael Burbridge , John Hickman , Alain Pierre
发明人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Vincent Lacoste , Pauline Lacoste , Imre Fejes , Michael Burbridge , John Hickman , Alain Pierre
IPC分类号： A61K31/5377 , C07D413/14 , A61K31/422 , A61K31/496 , A61K31/454 , A61P35/00
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14
摘要： Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO2 group, R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, R3 and R4, together with the atoms carrying them, form a heterocyclic group, R5 represents a hydrogen atom or an alkyl group, R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.
摘要翻译：式（I）化合物：其中：m和n表示1或2，A表示吡咯基，X表示C（O），S（O）或SO 2基团，R 1和R 2表示烷基，与它们携带的氮原子一起形成杂环基，R3和R4与携带它们的原子一起形成杂环基，R 5表示氢原子或烷基，R 6表示氢原子或卤素原子。含有该药物的药物可用于治疗癌症。

3. 发明授权

US08133889B2 Dihydroindolone compounds, a process for their preparation and pharmaceutical compositions containing them 有权
标题翻译：二氢吲哚酮化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US08133889B2
公开(公告)日：2012-03-13
申请号：US12806045
申请日：2010-08-04
申请人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Vincent Lacoste, legal representative , Pauline Lacoste, legal representative , Imre Fejes , Michael Burbridge , John Hickman , Alain Pierre
发明人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Imre Fejes , Michael Burbridge , John Hickman , Alain Pierre
IPC分类号： A61K31/5377 , A61K31/422 , A61K31/496 , A61K31/454 , C07D413/14 , A61P35/00
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14
摘要： Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO2 group, R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, R3 and R4, together with the atoms carrying them, form a heterocyclic group, R5 represents a hydrogen atom or an alkyl group, R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.
摘要翻译：式（I）化合物：其中：m和n表示1或2，A表示吡咯基，X表示C（O），S（O）或SO 2基团，R 1和R 2表示烷基，与它们携带的氮原子一起形成杂环基，R3和R4与携带它们的原子一起形成杂环基，R 5表示氢原子或烷基，R 6表示氢原子或卤素原子。含有该药物的药物可用于治疗癌症。

4. 发明授权

US08541412B2 Dihydroindolone compounds, a process for their preparation and pharmaceutical compositions containing them 有权
标题翻译：二氢吲哚酮化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US08541412B2
公开(公告)日：2013-09-24
申请号：US13373016
申请日：2011-11-02
申请人： Jean-Claude Ortuno , Alexis Cordi , Imre Fejes , Vincent Lacoste , Pauline Lacoste
发明人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Imre Fejes
IPC分类号： A61K31/5377 , A61K31/445 , A61K31/404
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14
摘要： Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO2 group, R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, R3 and R4, together with the atoms carrying them, form a heterocyclic group, R5 represents a hydrogen atom or an alkyl group, R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.
摘要翻译：式（I）化合物：其中：m和n表示1或2，A表示吡咯基，X表示C（O），S（O）或SO 2基团，R 1和R 2表示烷基，与它们携带的氮原子一起形成杂环基，R3和R4与携带它们的原子一起形成杂环基，R 5表示氢原子或烷基，R 6表示氢原子或卤素原子。含有该药物的药物可用于治疗癌症。

5. 发明授权

US08653073B2 Dihydroindolone compounds, a process for their preparation and pharmaceutical compositions containing them 有权
标题翻译：二氢吲哚酮化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US08653073B2
公开(公告)日：2014-02-18
申请号：US13772984
申请日：2013-02-21
申请人： Les Laboratoires Servier , Pauline Lacoste , Vincent Lacoste
发明人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Imre Fejes , Michael Burnbridge , John Hickman , Alain Pierre
IPC分类号： A61K31/5377 , A61K31/445 , A61K31/404
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14
摘要： Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO2 group, R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, R3 and R4, together with the atoms carrying them, form a heterocyclic group, R5 represents a hydrogen atom or an alkyl group, R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.
摘要翻译：式（I）化合物：其中：m和n表示1或2，A表示吡咯基，X表示C（O），S（O）或SO 2基团，R 1和R 2表示烷基，与它们携带的氮原子一起形成杂环基，R3和R4与携带它们的原子一起形成杂环基，R 5表示氢原子或烷基，R 6表示氢原子或卤素原子。含有该药物的药物可用于治疗癌症。

6. 发明申请

US20130331380A1 DIHYDROINDOLONE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权
标题翻译：二氢吲哚酮化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US20130331380A1
公开(公告)日：2013-12-12
申请号：US13772984
申请日：2013-02-21
申请人： Vincent Lacoste , Pauline Lacoste , LES LABORATOIRES SERVIER
发明人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Imre Fejes , Michael Burbridge , John Hickman , Alain Pierre
IPC分类号： C07D417/14 , C07D403/14 , C07D413/14
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14
摘要： Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO2 group, R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, R3 and R4, together with the atoms carrying them, form a heterocyclic group, R5 represents a hydrogen atom or an alkyl group, R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.
摘要翻译：式（I）化合物：其中：m和n表示1或2，A表示吡咯基，X表示C（O），S（O）或SO 2基团，R 1和R 2表示烷基，与它们携带的氮原子一起形成杂环基，R3和R4与携带它们的原子一起形成杂环基，R 5表示氢原子或烷基，R 6表示氢原子或卤素原子。含有该药物的药物可用于治疗癌症。

7. 发明授权

US06596749B2 Aminotriazole compounds 失效
标题翻译：氨基三唑化合物
公开(公告)号：US06596749B2
公开(公告)日：2003-07-22
申请号：US09799199
申请日：2001-03-05
申请人： Jean-Luc Fauchere , Jean-Claude Ortuno , Jacques Duhault , Jean Albert Boutin , Nigel Levens
发明人： Jean-Luc Fauchere , Jean-Claude Ortuno , Jacques Duhault , Jean Albert Boutin , Nigel Levens
IPC分类号： A61K314196
CPC分类号： C07D401/12 , C07D249/14 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , Y02P20/55
摘要： Method of treating with compounds of formula (I): wherein: n is 0 or 1, W represents —CO— or S(O)q and q is 0, 1 or 2, G represents a G1, G2, G3 or G4 group as defined in the description, Z represents alkyl, aryl, heteroaryl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylakenyl, heteroarylalkynyl or heteroarylalkyl each optionally substituted, A represents a grouping selected from —A2—, —A1—A2—, —A2—A1—, and —A1—A2—A1— wherein A1 is alkylene and A2 represents phenylene, cycloalkylene, naphthylene or heteroarylene each optionally substituted, R represents hydrogen, alkyl, aryl, heteroaryl, arylalkyl arylalkenyl, arylalkynyl, heteroarylakenyl, heteroarylalkynyl or heteroarylalkyl each optionally substituted, R1 represents alkyl, aryl, heteroaryl, arylalkyl arylalkenyl, arylalkynyl, heteroarylakenyl, heteroarylalkynyl or heteroarylalkyl each optionally substituted, and medicinal products containing the same are useful as Neuropeptide Y receptor ligands.
摘要翻译：用式（I）化合物处理的方法：其中：n为0或1，W为-CO-或S（O）q，q为0,1或2，G为G1，G2，G3或G4基团 Z表示烷基，芳基，杂芳基，芳基烷基，芳基烯基，芳基炔基，杂芳基酰基，杂芳基炔基或杂芳基烷基，各自任选取代，A表示选自-A2-，-A1-A2-，-A2-A1- 和-A1-A2-A1-，其中A1是亚烷基，A2代表亚苯基，亚环烷基，亚萘基或亚杂芳基，各自任选取代，R表示氢，烷基，芳基，杂芳基，芳基烷基芳基烯基，芳基炔基，杂芳基酰基，杂芳基炔基或杂芳基烷基， R 1表示烷基，芳基，杂芳基，芳基烷基芳基烯基，芳基炔基，杂芳基酰基，杂芳基炔基或杂芳基烷基，各自任选被取代，并且含有它们的医药产品可用作神经肽Y受体配体。

8. 发明授权

US06245916B1 Aminotriazole compounds 失效
标题翻译：氨基三唑化合物
公开(公告)号：US06245916B1
公开(公告)日：2001-06-12
申请号：US09549745
申请日：2000-04-14
申请人： Jean-Luc Fauchere , Jean-Claude Ortuno , Jacques Duhault , Jean Albert Boutin , Nigel Levens
发明人： Jean-Luc Fauchere , Jean-Claude Ortuno , Jacques Duhault , Jean Albert Boutin , Nigel Levens
IPC分类号： C07D24912
CPC分类号： C07D401/12 , C07D249/14 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , Y02P20/55
摘要： Compound of formula (I): wherein: n is 0 or 1, W represents —CO— or S(O)q and q is 0, 1 or 2, G represents a G1, G2, G3 or G4 group as defined in the description, Z represents alkyl, aryl, heteroaryl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkenyl, heteroarylalkynyl or heteroarylalkyl each optionally substituted. A represents a grouping selected from —A2—, —A1—A2—, —A2—A1— and —A1—A2—A1— wherein A1 is alkylene and A2 represents phenylene, cycloalkylene, naphthylene or heteroarylene each optionally substituted, R represents hydrogen, alkyl, aryl, heteroaryl, arylalkyl arylalkenyl, arylalkynyl, heteroarylakenyl, heteroarylalkynyl or heteroarylalkenyl each optionally substituted, R1 represents alkyl, aryl, heteroary, arylalkyl arylalkenyl, arylalkynyl, heteroarylalkenyl, heteroarylalkynyl or heteroarylalkyl each optionally substituted, and medicinal products containing the same which are useful as Neuropeptide Y receptor ligands.
摘要翻译：式（I）化合物：其中：n为0或1，W表示-CO-或S（O）q，q为0,1或2，G表示如上述定义的G1，G2，G3或G4基团描述，Z代表烷基，芳基，杂芳基，芳基烷基，芳基烯基，芳基炔基，杂芳基烯基，杂芳基炔基或杂芳基烷基，各自任选取代.A代表选自-A2-，-A1-A2-，-A2-A1-和-A1- 其中A1是亚烷基，A2代表亚苯基，亚环烷基，亚萘基或亚杂芳基，各自任选取代，R代表氢，烷基，芳基，杂芳基，芳基烷基芳基烯基，芳基炔基，杂芳基酰基，杂芳基炔基或杂芳基烯基，芳基，芳基烷基芳基烯基，芳基炔基，杂芳基烯基，杂芳基炔基或各自任意取代的杂芳基烷基，以及含有该芳基的可药用神经肽Y受体配体的医药产品。

9. 发明授权

US07442692B2 Indanyl-piperazine compounds 失效
标题翻译：茚基 - 哌嗪化合物
公开(公告)号：US07442692B2
公开(公告)日：2008-10-28
申请号：US11391916
申请日：2006-03-29
申请人： Guillaume De Nanteuil , Bernard Portevin , Philippe Gloanec , Mark Millan , Jean-Claude Ortuno , Clotilde Mannoury La Cour , Alain Gobert
发明人： Guillaume De Nanteuil , Bernard Portevin , Philippe Gloanec , Mark Millan , Jean-Claude Ortuno , Clotilde Mannoury La Cour , Alain Gobert
IPC分类号： A61K31/551 , A61K31/495 , A61K31/496 , C07D295/084 , C07D295/125 , C07D295/145
CPC分类号： C07D213/40 , C07D295/096 , C07D295/135 , C07D295/155 , C07D333/20
摘要： A compound selected from those of formula (I): wherein: R3 represents a hydrogen atom, and R1 and R2 together with the carbon atoms carrying them form a benzene, naphthalene or quinoline ring structure, each of the ring structures being optionally substituted, or R1 represents a hydrogen atom, and R2 and R3 together with the carbon atoms carrying them form a benzene, naphthalene or quinoline ring structure, each of the ring structures being optionally substituted, n represents 1 or 2, —X— represents a group selected from —(CH2)m—O-Ak-, —(CH2)m—NR4-Ak-, —(CO)—NR4-Ak- and —(CH2)m—NR4-(CO)—, m represents an integer between 1 and 6 inclusive, Ak represents an optionally substituted alkylene chain, and R4 represents a hydrogen atom or an alkyl group, Ar represents an aryl or heteroaryl group, its enantiomers, diasteroisomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK1 antagonist.
摘要翻译：选自式（I）的化合物的化合物：其中：R 3表示氢原子，R 1和R 2与带有它们的碳原子形成苯，萘或喹啉环结构，每个环结构任选被取代，或R 1表示氢原子，R 2和R 2 3个与携带它们的碳原子一起形成苯，萘或喹啉环结构，每个环结构可以被取代，n表示1或2，-X-表示选自 - （ CH 2 - （CH 2）n -O - ， - （CH 2 CH 2）m -NR 2 -Ak-， - （CO）-NR 4 - 和 - （CH 2）2 -N （CO） - ，m表示1和6之间的整数，包括1和6，Ak表示任选取代的亚烷基链，并且R 4表示氢原子或烷基，Ar 表示芳基或杂芳基，其对映异构体，diastero 异构体及其与药学上可接受的酸的加成盐。含有该药物的医药产品可用于治疗需要5-羟色胺再摄取抑制剂和/或NK1拮抗剂的病症。

10. 发明申请

US20060223830A1 Indanyl-piperazine compounds 失效
标题翻译：茚基 - 哌嗪化合物
公开(公告)号：US20060223830A1
公开(公告)日：2006-10-05
申请号：US11391916
申请日：2006-03-29
申请人： Guillaume De Nanteuil , Bernard Portevin , Philippe Gloanec , Mark Millan , Jean-Claude Ortuno , Clotilde Mannoury La Cour , Alain Gobert
发明人： Guillaume De Nanteuil , Bernard Portevin , Philippe Gloanec , Mark Millan , Jean-Claude Ortuno , Clotilde Mannoury La Cour , Alain Gobert
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D213/40 , C07D295/096 , C07D295/135 , C07D295/155 , C07D333/20
摘要： A compound selected from those of formula (I): wherein: R3 represents a hydrogen atom, and R1 and R2 together with the carbon atoms carrying them form a benzene, naphthalene or quinoline ring structure, each of the ring structures being optionally substituted, or R1 represents a hydrogen atom, and R2 and R3 together with the carbon atoms carrying them form a benzene, naphthalene or quinoline ring structure, each of the ring structures being optionally substituted, n represents 1 or 2, —X— represents a group selected from —(CH2)m—O-Ak-, —(CH2)m—NR4-Ak-, —(CO)—NR4-Ak- and —(CH2)m—NR4-(CO)—, m represents an integer between 1 and 6 inclusive, Ak represents an optionally substituted alkylene chain, and R4 represents a hydrogen atom or an alkyl group, Ar represents an aryl or heteroaryl group, its enantiomers, diasteroisomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK1 antagonist.
摘要翻译：选自式（I）的化合物的化合物：其中：R 3表示氢原子，R 1和R 2与带有它们的碳原子形成苯，萘或喹啉环结构，每个环结构任选被取代，或R 1表示氢原子，R 2和R 2 3个与携带它们的碳原子一起形成苯，萘或喹啉环结构，每个环结构可以被取代，n表示1或2，-X-表示选自 - （ CH 2 - （CH 2）n -O - ， - （CH 2 CH 2）m -NR 2 -Ak-， - （CO）-NR 4 - 和 - （CH 2）2 -N （CO） - ，m表示1和6之间的整数，包括1和6，Ak表示任选取代的亚烷基链，并且R 4表示氢原子或烷基，Ar 表示芳基或杂芳基，其对映异构体，diastero 异构体及其与药学上可接受的酸的加成盐。含有该药物的医药产品可用于治疗需要5-羟色胺再摄取抑制剂和/或NK1拮抗剂的病症。

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