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1. 发明授权

US06245916B1 Aminotriazole compounds 失效
标题翻译：氨基三唑化合物
公开(公告)号：US06245916B1
公开(公告)日：2001-06-12
申请号：US09549745
申请日：2000-04-14
申请人： Jean-Luc Fauchere , Jean-Claude Ortuno , Jacques Duhault , Jean Albert Boutin , Nigel Levens
发明人： Jean-Luc Fauchere , Jean-Claude Ortuno , Jacques Duhault , Jean Albert Boutin , Nigel Levens
IPC分类号： C07D24912
CPC分类号： C07D401/12 , C07D249/14 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , Y02P20/55
摘要： Compound of formula (I): wherein: n is 0 or 1, W represents —CO— or S(O)q and q is 0, 1 or 2, G represents a G1, G2, G3 or G4 group as defined in the description, Z represents alkyl, aryl, heteroaryl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkenyl, heteroarylalkynyl or heteroarylalkyl each optionally substituted. A represents a grouping selected from —A2—, —A1—A2—, —A2—A1— and —A1—A2—A1— wherein A1 is alkylene and A2 represents phenylene, cycloalkylene, naphthylene or heteroarylene each optionally substituted, R represents hydrogen, alkyl, aryl, heteroaryl, arylalkyl arylalkenyl, arylalkynyl, heteroarylakenyl, heteroarylalkynyl or heteroarylalkenyl each optionally substituted, R1 represents alkyl, aryl, heteroary, arylalkyl arylalkenyl, arylalkynyl, heteroarylalkenyl, heteroarylalkynyl or heteroarylalkyl each optionally substituted, and medicinal products containing the same which are useful as Neuropeptide Y receptor ligands.
摘要翻译：式（I）化合物：其中：n为0或1，W表示-CO-或S（O）q，q为0,1或2，G表示如上述定义的G1，G2，G3或G4基团描述，Z代表烷基，芳基，杂芳基，芳基烷基，芳基烯基，芳基炔基，杂芳基烯基，杂芳基炔基或杂芳基烷基，各自任选取代.A代表选自-A2-，-A1-A2-，-A2-A1-和-A1- 其中A1是亚烷基，A2代表亚苯基，亚环烷基，亚萘基或亚杂芳基，各自任选取代，R代表氢，烷基，芳基，杂芳基，芳基烷基芳基烯基，芳基炔基，杂芳基酰基，杂芳基炔基或杂芳基烯基，芳基，芳基烷基芳基烯基，芳基炔基，杂芳基烯基，杂芳基炔基或各自任意取代的杂芳基烷基，以及含有该芳基的可药用神经肽Y受体配体的医药产品。

2. 发明授权

US06596749B2 Aminotriazole compounds 失效
标题翻译：氨基三唑化合物
公开(公告)号：US06596749B2
公开(公告)日：2003-07-22
申请号：US09799199
申请日：2001-03-05
申请人： Jean-Luc Fauchere , Jean-Claude Ortuno , Jacques Duhault , Jean Albert Boutin , Nigel Levens
发明人： Jean-Luc Fauchere , Jean-Claude Ortuno , Jacques Duhault , Jean Albert Boutin , Nigel Levens
IPC分类号： A61K314196
CPC分类号： C07D401/12 , C07D249/14 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , Y02P20/55
摘要： Method of treating with compounds of formula (I): wherein: n is 0 or 1, W represents —CO— or S(O)q and q is 0, 1 or 2, G represents a G1, G2, G3 or G4 group as defined in the description, Z represents alkyl, aryl, heteroaryl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylakenyl, heteroarylalkynyl or heteroarylalkyl each optionally substituted, A represents a grouping selected from —A2—, —A1—A2—, —A2—A1—, and —A1—A2—A1— wherein A1 is alkylene and A2 represents phenylene, cycloalkylene, naphthylene or heteroarylene each optionally substituted, R represents hydrogen, alkyl, aryl, heteroaryl, arylalkyl arylalkenyl, arylalkynyl, heteroarylakenyl, heteroarylalkynyl or heteroarylalkyl each optionally substituted, R1 represents alkyl, aryl, heteroaryl, arylalkyl arylalkenyl, arylalkynyl, heteroarylakenyl, heteroarylalkynyl or heteroarylalkyl each optionally substituted, and medicinal products containing the same are useful as Neuropeptide Y receptor ligands.
摘要翻译：用式（I）化合物处理的方法：其中：n为0或1，W为-CO-或S（O）q，q为0,1或2，G为G1，G2，G3或G4基团 Z表示烷基，芳基，杂芳基，芳基烷基，芳基烯基，芳基炔基，杂芳基酰基，杂芳基炔基或杂芳基烷基，各自任选取代，A表示选自-A2-，-A1-A2-，-A2-A1- 和-A1-A2-A1-，其中A1是亚烷基，A2代表亚苯基，亚环烷基，亚萘基或亚杂芳基，各自任选取代，R表示氢，烷基，芳基，杂芳基，芳基烷基芳基烯基，芳基炔基，杂芳基酰基，杂芳基炔基或杂芳基烷基， R 1表示烷基，芳基，杂芳基，芳基烷基芳基烯基，芳基炔基，杂芳基酰基，杂芳基炔基或杂芳基烷基，各自任选被取代，并且含有它们的医药产品可用作神经肽Y受体配体。

3. 发明授权

US5708016A Pseudopeptides derived from neurokinins 失效
标题翻译：衍生自神经激肽的伪肽
公开(公告)号：US5708016A
公开(公告)日：1998-01-13
申请号：US801037
申请日：1997-02-14
申请人： Jean-Luc Fauchere , Nathalie Kucharczyk-Gentric , Emmanuel Canet , Michel Lonchampt
发明人： Jean-Luc Fauchere , Nathalie Kucharczyk-Gentric , Emmanuel Canet , Michel Lonchampt
IPC分类号： C07D403/14 , A61K31/41 , A61K38/00 , A61P1/08 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D409/14 , C07K5/02 , C07K5/023 , A01N43/713
CPC分类号： C07K5/0202 , A61K38/00
摘要： A compound of formula (I): ##STR1## in which: R.sub.1 represents an indolyl, naphthyl, tetrahydronaphthyl, thienyl, phenyl, optionally substituted, or (C.sub.3 -C.sub.7)cycloalkyl group, n represents an integer such that 1.ltoreq.n.ltoreq.8, m represents an integer such that 1.ltoreq.m.ltoreq.4, R.sub.2 represents an unsubstituted or substituted benzyl group, an unsubstituted or substituted phenyl group or a linear or branched (C.sub.1 -C.sub.6)alkyl group, its enantiomers, diastereoisomers and epimers as well as its addition salts with a pharmaceutically acceptable acid or base, and medicinal products containing the same are useful as substance P antagonists.
摘要翻译：式（I）化合物：其中：R 1表示吲哚基，萘基，四氢萘基，噻吩基，苯基，任选取代的或（C 3 -C 7）环烷基，n表示1 < / =n≤8，m表示1≤n≤4的整数，R2表示未取代或取代的苄基，未取代或取代的苯基或直链或支链（C1-C6）烷基基团，其对映体，非对映异构体和差向异构体以及其与药学上可接受的酸或碱的加成盐，以及含有它们的药物可用作P物质拮抗剂。

4. 发明授权

US5409899A Pseudopeptide compounds having anti-inflammatory activity 失效
标题翻译：具有抗炎活性的假肽化合物
公开(公告)号：US5409899A
公开(公告)日：1995-04-25
申请号：US6151
申请日：1993-01-13
申请人： Jean-Luc Fauchere , Christophe Thurieau , Emmanuel Canet
发明人： Jean-Luc Fauchere , Christophe Thurieau , Emmanuel Canet
IPC分类号： A61K38/00 , A61P3/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07K7/18 , A61K37/02
CPC分类号： C07K7/18
摘要： Compound of formula:G-Arg-Pro-Hyp-Gly-Thia-Ser-Tic-Oic-Arg-OHwhere G, Arg, Pro, Hyp, Gly, Thia, Ser, Tic and Oic are defined in the description.Medicinal products.
摘要翻译： G-Arg-Pro-Hyp-Gly-Thia-Ser-Tic-Oic-Arg-OH的化合物，其中G，Arg，Pro，Hyp，Gly，Thia，Ser，Tic和Oic在说明书中定义。药用产品。

5. 发明授权

US5317014A Peptides and pseudopeptides derived from tachykinin 失效
标题翻译：衍生自速激肽的肽和假肽
公开(公告)号：US5317014A
公开(公告)日：1994-05-31
申请号：US893930
申请日：1992-06-03
申请人： Jean-Luc Fauchere , Nathalie Kucharczyk , Angela D. Morris , Joseph Paladino , Jacqueline Bonnet , Christophe Thurieau
发明人： Jean-Luc Fauchere , Nathalie Kucharczyk , Angela D. Morris , Joseph Paladino , Jacqueline Bonnet , Christophe Thurieau
IPC分类号： A61K38/00 , A61P1/00 , A61P25/04 , A61P29/00 , A61P37/08 , C07K1/06 , C07K5/02 , C07K5/078 , C07K5/08 , C07K5/087 , C07K5/097 , C07K5/10 , C07K5/117 , C07K5/12 , C07K7/22 , A61K37/02 , C07K5/06
CPC分类号： C07K5/06139 , C07K5/0202 , C07K5/0207 , C07K5/0215 , C07K5/0812 , C07K5/0821 , C07K5/1024 , C07K7/22 , A61K38/00
摘要： A compound of formula (I): ##STR1## in which: R.sub.1 and R.sub.2, which are identical or different, represent hydrogen, or alkyl, cycloalkyl or benzyl,B represents a residue of an aromatic amino acid,A represents a peptide residue comprising from one to three amino acids, in cyclic or linear form, and medicaments containing the same, are disclosed.
摘要翻译：式（I）化合物：其中：R 1和R 2相同或不同，表示氢或烷基，环烷基或苄基，B表示芳族氨基酸的残基，A表示公开了包含1至3个氨基酸的环状或直链形式的肽残基和含有它们的药物。

6. 发明授权

US5786330A Peptide compounds which are therapeutically active in the cascade of blood coagulation, process for preparing them and pharmaceutical compositions containing them 失效
标题翻译：在凝血级联中具有治疗活性的肽化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US5786330A
公开(公告)日：1998-07-28
申请号：US619683
申请日：1996-04-02
申请人： Jean-Luc Fauchere , Christophe Thurieau , Tony Verbeuren , Alain Rupin , Serge Simonet
发明人： Jean-Luc Fauchere , Christophe Thurieau , Tony Verbeuren , Alain Rupin , Serge Simonet
IPC分类号： A61K38/55 , A61K38/00 , A61P7/00 , A61P7/02 , A61P9/08 , A61P9/10 , A61P43/00 , C07K7/08 , C07K14/745 , C07K14/815
CPC分类号： C07K14/815 , A61K38/00 , Y10S514/822
摘要： The invention relates to the compounds of formula (I) (SEQ ID NO: I: H-phe-A.sub.1 -Arg-Pro-(Gly).sub.4 -Asn-Gly-Asp-Phe-Glu-Abo-Ile-Pro-Glu-Glu-A.sub.2 -Leu-glu-OH(I) in which A.sub.1 and A.sub.2 are as defined in the description. Medicinal products containing the same are useful as anticoagulants.
摘要翻译： PCT No.PCT / FR94 / 01166 Sec。 371日期：1996年4月2日 102（e）日期1996年4月2日PCT 1994年10月6日PCT PCT。公开号WO95 / 09869 日期：1995年04月13日本发明涉及式（I）化合物（SEQ ID NO：I：H-phe-A1-Arg-Pro-（Gly）4-Asn-Gly-Asp-Phe-Glu-Abo- Ile-Pro-Glu-Glu-A2-Leu-glu-OH（I）其中A1和A2如说明书中所定义，其药物含量可用作抗凝剂。

7. 发明申请

US20050106707A1 Automatic apparatus for synthesis of small organic molecules and synthesis method using same 审中-公开
标题翻译：用于合成小有机分子的自动装置及其合成方法
公开(公告)号：US20050106707A1
公开(公告)日：2005-05-19
申请号：US10488993
申请日：2002-09-09
申请人： Jean Neimark , Jean-Michel Henlin , Jean-Luc Fauchere , Gisele Fauchere
发明人： Jean Neimark , Jean-Michel Henlin , Jean-Luc Fauchere , Gisele Fauchere
IPC分类号： B01J19/00 , C40B40/10 , C40B60/14 , B32B5/02 , C12M1/34 , G01N21/00
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00351 , B01J2219/00423 , B01J2219/00459 , B01J2219/00481 , B01J2219/00493 , B01J2219/00495 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00686 , B01J2219/00689 , B01J2219/0072 , B01J2219/00725 , C40B40/10 , C40B60/14
摘要： An automatic apparatus for synthesis of organic molecules, in accordance with combinative or parallel synthesis protocols. The apparatus comprises: several synthesis modules including each five reactors temperature-controlled by heating and cooling elements, a container forming a secondary mixing chamber whose capacity corresponds to at least the sum of capacities of the reactors of a module, being associated with each module and an additional container, forming a main mixing chamber whose capacity corresponds to at least the sum of capacities of the various secondary mixing chambers, and at least a circuit for transferring the contents of the reactors to one or more containers or reactors, and at least a supply or discharge circuit connected to the different inlets/outlets of the reactors and of the containers and, finally, a ramified system for managing and controlling the flow and distribution of fluids in the circuits and the temperature and stirring in the chambers.
摘要翻译：根据组合或并行合成方案的用于合成有机分子的自动装置。该装置包括：几个合成模块，包括通过加热和冷却元件温度控制的每个五个反应器，形成二次混合室的容器，其容量对应于与每个模块相关联的至少模块的反应器的容量之和，一个附加的容器，形成一个主混合室，其容量至少等于各种二次混合室的容量之和，至少一个用于将反应器的内容物转移到一个或多个容器或反应器的回路，以及至少一个供应或放电回路连接到反应堆和容器的不同入口/出口，最后是用于管理和控制回路中流体的流动和分布以及室中的温度和搅拌的分支系统。

8. 发明授权

US5569647A Angiopeptin cyclopeptide compounds 失效
标题翻译：血管紧张素环肽化合物
公开(公告)号：US5569647A
公开(公告)日：1996-10-29
申请号：US469784
申请日：1995-06-06
申请人： Jean-Luc Fauchere , Christophe Thurieau , Jean-Paul Vilaine , Philip Janiak
发明人： Jean-Luc Fauchere , Christophe Thurieau , Jean-Paul Vilaine , Philip Janiak
IPC分类号： A61K38/00 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P35/00 , C07K1/113 , C07K7/56 , C07K7/60 , C07K14/655 , A61K38/12
CPC分类号： C07K14/6555 , A61K38/00
摘要： The invention relates to a compound selected from those of formula (I) (SEQ ID NO:1): ##STR1## in which R.sub.1, R.sub.2, X.sub.1 and X.sub.2 are as defined in the description, useful as inhibitor of the proliferation component of vascular smooth muscle cells.
摘要翻译：本发明涉及选自式（I）（SEQ ID NO：1）的化合物：其中R1，R2，X1和X2如说明书中所定义，可用作增殖抑制剂血管平滑肌细胞成分。

9. 发明授权

US5565426A Peptide compounds active in cell adhesion processes 失效
标题翻译：在细胞粘附过程中活化的肽化合物
公开(公告)号：US5565426A
公开(公告)日：1996-10-15
申请号：US288984
申请日：1994-08-11
申请人： Jean-Luc Fauchere , Angela D. Morris , Christophe Thurieau , Tony Verbeuren , Serge Simonet
发明人： Jean-Luc Fauchere , Angela D. Morris , Christophe Thurieau , Tony Verbeuren , Serge Simonet
IPC分类号： A61K38/00 , A61P7/02 , C07K5/10 , C07K14/75 , A61K38/07
CPC分类号： C07K5/1019 , C07K14/75
摘要： The invention relates to peptide compounds of formula (I):R.sub.1 --A--Gly--Asp--Trp--R.sub.2 (I)in which R.sub.1, R.sub.2 and A are as defined in the description, and anti-aggregation medicaments containing the same.
摘要翻译：本发明涉及式（I）的肽化合物：其中R1，R2和A如说明书中所定义的R1-A-Gly-Asp-Trp-R2（Ⅰ）和含有该化合物的抗聚集药物。

10. 发明授权

US5561113A New pseudopeptide compounds of neurokinins 失效
标题翻译：新的假肽化合物的神经激肽
公开(公告)号：US5561113A
公开(公告)日：1996-10-01
申请号：US427802
申请日：1995-04-26
申请人： Jean-Luc Fauchere , Nathalie Kucharczyk-Gentric , Joseph Paladino , Jacqueline Bonnet , Emmanuel Canet , Graham Birrell
发明人： Jean-Luc Fauchere , Nathalie Kucharczyk-Gentric , Joseph Paladino , Jacqueline Bonnet , Emmanuel Canet , Graham Birrell
IPC分类号： A61K38/17 , A61K38/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/04 , A61P29/00 , A61P37/08 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/023 , A61K38/05 , C07D257/04
CPC分类号： C07K5/0202 , A61K38/00
摘要： A compound of formula (I): ##STR1## in which: R represents naphthyl, 5,6,7,8-tetrahydronaphthyl, 1,2,3,4-tetrahydronaphthyl, thienyl, optionally substituted phenyl or (C.sub.3 -C.sub.7)cycloalkyl,n represents an integer such that 1.ltoreq.n.ltoreq.8, their enantiomers, diastereoisomers and epimers as well as their addition salts with a pharmaceutically acceptable acid or base and medicinal products containing the same are useful as antagonists of substance P.
摘要翻译：式（I）的化合物：其中：R表示萘基，5,6,7,8-四氢萘基，1,2,3,4-四氢萘基，噻吩基，任选取代的苯基或（C3-C7）环烷基，n表示一个整数，使得它们的对映体，非对映异构体和差向异构体以及它们与药学上可接受的酸或碱的加成盐和含有它们的药用产物是有用的作为物质P的拮抗剂。

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