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    • 4. 发明申请
    • PROCESS FOR PREPARING AMINO ACIDS OR ESTERS COMPRISING A METATHESIS STEP
    • 制备氨基酸或包含元素步骤的方法的方法
    • US20140163196A1
    • 2014-06-12
    • US14234818
    • 2012-07-27
    • Jean-Luc CouturierJean-Luc Dubois
    • Jean-Luc CouturierJean-Luc Dubois
    • C07C227/04C08G69/08
    • C07C227/04C07C253/32C08G69/08C07C229/08C07C255/23
    • A process for synthesizing a long-chain saturated α,ω-amino ester (acid) including from 6 to 17 carbon atoms, said process including a first step of cross metathesis between a first acrylic compound chosen from acrylonitrile, acrylic acid or an acrylic ester and a second monounsaturated compound including at least one nitrile, acid or ester trivalent function, one of these compounds including a nitrile function and the other an acid or ester function, in the presence of a ruthenium carbene metathesis catalyst, and a second step of hydrogenation of the monounsaturated nitrile-ester (acid) obtained, wherein said monounsaturated compound including at least one nitrile, acid or ester trivalent function has previously been subjected to a purification by thermal and/or chemical treatment.
    • 一种合成包含6至17个碳原子的长链饱和α,ω-氨基酯(酸)的方法,所述方法包括在选自丙烯腈,丙烯酸或丙烯酸酯的第一丙烯酸化合物之间进行交叉复分解的第一步 以及第二单不饱和化合物,其包含至少一种腈,酸或酯三价官能团,这些化合物中的一种,包括腈官能团,另一种是酸或酯官能团,在钌卡宾复分解催化剂存在下,第二步氢化 所得的单不饱和腈 - 酯(酸),其中包括至少一种腈,酸或酯三价官能团的所述单不饱和化合物已经经过热和/或化学处理的纯化。
    • 5. 发明授权
    • Process for preparing amino acids or esters comprising a metathesis step
    • 制备包含复分解步骤的氨基酸或酯的方法
    • US09221745B2
    • 2015-12-29
    • US14234818
    • 2012-07-27
    • Jean-Luc CouturierJean-Luc Dubois
    • Jean-Luc CouturierJean-Luc Dubois
    • C07C227/04C07C253/32C08G69/08
    • C07C227/04C07C253/32C08G69/08C07C229/08C07C255/23
    • A process for synthesizing a long-chain saturated α,ω-amino ester (acid) including from 6 to 17 carbon atoms, said process including a first step of cross metathesis between a first acrylic compound chosen from acrylonitrile, acrylic acid or an acrylic ester and a second monounsaturated compound including at least one nitrile, acid or ester trivalent function, one of these compounds including a nitrile function and the other an acid or ester function, in the presence of a ruthenium carbene metathesis catalyst, and a second step of hydrogenation of the monounsaturated nitrile-ester (acid) obtained, wherein said monounsaturated compound including at least one nitrile, acid or ester trivalent function has previously been subjected to a purification by thermal and/or chemical treatment.
    • 一种合成包含6至17个碳原子的长链饱和α,ω-氨基酯(酸)的方法,所述方法包括在选自丙烯腈,丙烯酸或丙烯酸酯的第一丙烯酸化合物之间进行交叉复分解的第一步 以及第二单不饱和化合物,其包含至少一种腈,酸或酯三价官能团,这些化合物中的一种,包括腈官能团,另一种是酸或酯官能团,在钌卡宾复分解催化剂的存在下,和第二步氢化 所得的单不饱和腈 - 酯(酸),其中包括至少一种腈,酸或酯三价官能团的所述单不饱和化合物已经经过热和/或化学处理的纯化。
    • 7. 发明授权
    • Method for synthesizing an omega-amino acid or ester from a monounsaturated fatty acid or ester
    • 从单不饱和脂肪酸或酯合成ω-氨基酸或酯的方法
    • US08884041B2
    • 2014-11-11
    • US14234879
    • 2012-07-26
    • Jean-Luc CouturierJean-Luc Dubois
    • Jean-Luc CouturierJean-Luc Dubois
    • C07C227/00C07B43/00C07C229/08C07C227/04C07C227/08
    • C07C227/08C07C227/04C07C229/08
    • A method for synthesizing ω-amino-alkanoic acids or the esters thereof from natural unsaturated fatty acids passing through an intermediate ω-unsaturated nitrile compound. The method is simple to implement and, relative to known methods, avoids the environmental constraints and economic disadvantages resulting from the reaction by-products. The method includes synthesizing an ω-amino acid (ester) of formula R3OOC—(CH2)q-CH2NH2, in which R3 is H or an n-butyl radical and q is an integral index of between 2 and 13, from a monounsaturated fatty acid (ester) of formula (R1-CH═CH—(CH2)p-COO)xR2, in which x represents 1, 2 or 3, R1 is H or a hydrocarbon radical comprising from 4 to 11 carbon atoms and, where appropriate, a hydroxyl function, R2 is H or an alkyl radical comprising from 2 to 4 carbon atoms, and may contain one or more heteroatoms, and p is an integral index of between 2 and 11, including a reaction step of ammoniation.
    • 由通过中间体ω-不饱和腈化合物的天然不饱和脂肪酸合成ω-氨基 - 链烷酸或其酯的方法。 该方法易于实施,并且相对于已知方法,避免了由反应副产物引起的环境限制和经济缺点。 该方法包括从单不饱和脂肪酸合成式R3OOC-(CH2)q-CH2NH2的ω-氨基酸(酯),其中R3是H或正丁基,q是2和13之间的整数指数 式(R1-CH =(CH2)p-COO)xR2的酸(酯),其中x表示1,2或3,R1是H或包含4至11个碳原子的烃基,并且在适当的情况下 羟基官能团,R2是H或包含2至4个碳原子的烷基,并且可以含有一个或多个杂原子,p是2和11之间的整数指数,包括氨化的反应步骤。
    • 8. 发明申请
    • METHOD FOR SYNTHESIZING AN OMEGA-AMINO ACID OR ESTER FROM A MONOUNSATURATED FATTY ACID OR ESTER
    • 用于合成来自一种单一脂肪酸或酯的欧米加 - 氨基酸或酯的方法
    • US20140187808A1
    • 2014-07-03
    • US14234879
    • 2012-07-26
    • Jean-Luc CouturierJean-Luc Dubois
    • Jean-Luc CouturierJean-Luc Dubois
    • C07C227/08
    • C07C227/08C07C227/04C07C229/08
    • A method for synthesizing ω-amino-alkanoic acids or the esters thereof from natural unsaturated fatty acids passing through an intermediate ω-unsaturated nitrile compound. The method is simple to implement and, relative to known methods, avoids the environmental constraints and economic disadvantages resulting from the reaction by-products. The method includes synthesizing an ω-amino acid (ester) of formula R3OOC—(CH2)q—CH2NH2, in which R3 is H or an n-butyl radical and q is an integral index of between 2 and 13, from a monounsaturated fatty acid (ester) of formula (R1-CH═CH—(CH2)p-COO) xR2, in which x represents 1, 2 or 3, R1 is H or a hydrocarbon radical comprising from 4 to 11 carbon atoms and, where appropriate, a hydroxyl function, R2 is H or an alkyl radical comprising from 2 to 4 carbon atoms, and may contain one or more heteroatoms, and p is an integral index of between 2 and 11, including a reaction step of ammoniation.
    • 由通过中间体ω-不饱和腈化合物的天然不饱和脂肪酸合成ω-氨基 - 链烷酸或其酯的方法。 该方法易于实施,并且相对于已知方法,避免了由反应副产物引起的环境限制和经济缺点。 该方法包括从单不饱和脂肪酸合成式R3OOC-(CH2)q-CH2NH2的ω-氨基酸(酯),其中R3是H或正丁基,q是2和13之间的整数指数 式(R1-CH =(CH2)p-COO)xR2的酸(酯),其中x表示1,2或3,R1是H或包含4至11个碳原子的烃基,并且在适当的情况下 羟基官能团,R2是H或包含2至4个碳原子的烷基,并且可以含有一个或多个杂原子,p是2和11之间的整数指数,包括氨化的反应步骤。