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1. 发明授权

US5243007A Polymers based on vinyl chloride prepared by mass polymerization 失效
标题翻译：基于通过聚合制备的氯乙烯的聚合物
公开(公告)号：US5243007A
公开(公告)日：1993-09-07
申请号：US941777
申请日：1992-09-08
申请人： Jean Chatelain , Yves Legrand
发明人： Jean Chatelain , Yves Legrand
IPC分类号： B01F7/00 , B01F7/02 , B01F7/16 , B01F15/00 , B01J19/18 , C08F14/06
CPC分类号： B01F7/00275 , B01F15/00805 , B01J19/0066 , B01J19/18 , C08F14/06 , B01F7/021 , B01F7/16 , B01J2219/00094 , B01J2219/187 , B01J2219/1942
摘要： A process for preparing polymers and copolymers based on vinyl chloride by mass polymerization of a monomer composition based on vinyl chloride, comprising carrying out at least part of the polymerization reaction in a polymerization zone defined by an essentially spherical wall by effecting in the said polymerization zone a controlled and regulated circulation of the polymerization reaction mixture by means of a rotated blade-type turbine assembly, where the said blades pass by in the vicinity of the said wall over 10% to 60% of its surface, the reaction mixture being caused by the centrifugal force of said rotated blade-type turbine assembly to perform an at least partially ascending movement over at least part of the spherical wall and falling back, essentially under the action of gravity in the central part of the spherical polymerization zone, thus ensuring intensive mixing without dead space.
摘要翻译：一种通过基于氯乙烯的单体组合物的大量聚合制备基于氯乙烯的聚合物和共聚物的方法，包括在由基本上球形的壁限定的聚合区中进行至少一部分聚合反应，通过在所述聚合区通过旋转的叶片式涡轮机组件控制和调节聚合反应混合物的循环，其中所述叶片在所述壁的附近超过其表面的10％至60％，所述反应混合物由所述旋转的叶片式涡轮组件的离心力基本上在球形聚合区的中心部分的重力作用下，在至少部分球形壁上进行至少部分上升移动，从而确保密集混合没有死空间。

2. 发明授权

US4474761A Oligopeptides with specific inhibiting properties of collagen induced aggregation, process for preparing the same and pharmaceutical compositions containing them 失效
标题翻译：具有胶原诱导聚集的特异抑制性质的寡肽，其制备方法和含有它们的药物组合物
公开(公告)号：US4474761A
公开(公告)日：1984-10-02
申请号：US339437
申请日：1981-12-26
申请人： Jacques Caen , Yves Legrand , Pierre Lefrancier
发明人： Jacques Caen , Yves Legrand , Pierre Lefrancier
IPC分类号： A61K38/00 , C07K14/00 , C07K14/78 , A61K37/00 , C07C103/52
CPC分类号： C07K14/78 , A61K38/00 , Y02P20/55 , Y10S514/822
摘要： Oligopeptides having no more than 10 amino acids containing the sequence--(N-ter) A--X, --Gly--Y--Gly--X.sub.2 --A (C-ter)having the capacity of interacting with blood platelets and an ability to inhibit the aggregation of platelets induced by a collogen containing substance.
摘要翻译： PCT No.PCT / EP81 / 00046 Sec。 371日期：1981年12月26日 102（e）日期1981年12月26日PCT提交1981年5月11日PCT公布。公开号WO81 / 03329 日期：1981年11月26日。具有不超过10个氨基酸的寡肽包含具有与血小板相互作用的能力的序列 - （N-ter）AX，-Gly-Y-Gly-X2-A（C-ter）抑制由含胶原物质诱导的血小板聚集的能力。

3. 发明授权

US06638502B1 Adenovirus-mediated intratumoral delivery of an angiogenesis antagonist for the treatment of tumors 失效
标题翻译：腺瘤病毒介导的肿瘤内递送血管生成拮抗剂用于治疗肿瘤
公开(公告)号：US06638502B1
公开(公告)日：2003-10-28
申请号：US09403736
申请日：2000-06-29
申请人： Hong Li , He Lu , Frank Griscelli , Paule Opolon , Claudine Soria , Thierry Ragot , Yves Legrand , Jeannette Soria , Christelle Mabilat , Michel Perricaudet , Patrice Yeh
发明人： Hong Li , He Lu , Frank Griscelli , Paule Opolon , Claudine Soria , Thierry Ragot , Yves Legrand , Jeannette Soria , Christelle Mabilat , Michel Perricaudet , Patrice Yeh
IPC分类号： A61K4800
CPC分类号： A61K38/49 , A61K38/484 , A61K48/00 , C12N2799/022
摘要： The present invention relates to gene therapy for the treatment of tumors. The invention more particularly relates to introduction of a gene encoding an anti-angiogenic factor into cells of a tumor, for example with a defective adenovirus vector, to inhibit growth or metastasis, or both, of the tumor. In a specific embodiment, delivery of a defective adenovirus that expresses the amino terminal fragment of urokinase (ATF) inhibited growth and metastasis of tumors. These effects were correlated with a remarkable inhibition of neovascularization within, and at the immediate vicinity of, the injection site. Delivery of a defective adenovirus vector that expresses kringles 1 to 3 of angiostatin inhibited tumor growth and tumorigenicity, and induced apoptosis of tumor cells. The invention further provides viral vectors for use in the methods of the invention.
摘要翻译：本发明涉及用于治疗肿瘤的基因治疗。本发明更具体地涉及将编码抗血管生成因子的基因导入肿瘤细胞，例如用有缺陷的腺病毒载体，抑制肿瘤的生长或转移或两者。在具体实施方案中，表达尿激酶（ATF）的氨基末端片段的缺陷型腺病毒的递送抑制肿瘤的生长和转移。这些作用与注射部位内和附近的新生血管形成的显着抑制相关。递送表达血管抑素的三环酮1〜3的有缺陷的腺病毒载体抑制肿瘤生长和致瘤性，并诱导肿瘤细胞凋亡。本发明还提供了用于本发明方法的病毒载体。

4. 发明授权

US4729878A Vertical autoclave 失效
标题翻译：立式高压釜
公开(公告)号：US4729878A
公开(公告)日：1988-03-08
申请号：US850286
申请日：1986-04-10
申请人： Yves Pommier , Yves Legrand
发明人： Yves Pommier , Yves Legrand
IPC分类号： B01F7/00 , B01F7/16 , B01F15/00 , B01J3/04 , B01J19/18 , B01J19/20 , C08F2/00 , C08F2/02 , C08F14/00 , C08F14/06 , B01F3/08 , B01F3/14 , B01J14/00
CPC分类号： B01F7/00275 , B01F7/1665 , B01J19/18 , B01J19/20 , B01J3/04 , B01F7/00208 , B01F7/00266 , B01F7/00416 , B01J2219/00094 , B01J2219/185
摘要： A vertical autoclave for carrying out operations involving a medium having a liquid phase and/or a solid phase includes:(a) a concave autoclave bottom;(b) a shaft along a vertical axis of said autoclave, said shaft passing through said bottom of said autoclave; and(c) stirrers for driving said medium with a centripetal motion about said concave autoclave bottom.
摘要翻译：用于进行涉及具有液相和/或固相的介质的操作的立式高压釜包括：（a）凹形高压釜底部; （b）沿着所述高压釜的垂直轴的轴，所述轴穿过所述高压釜的所述底部; 和（c）用于以围绕所述凹形高压釜底部的向心运动来驱动所述介质的搅拌器。

5. 发明授权

US4921918A Process for utilizing vertical autoclave in polymerization of vinyl chloride 失效
标题翻译：在氯乙烯聚合中利用立式高压釜的方法
公开(公告)号：US4921918A
公开(公告)日：1990-05-01
申请号：US104480
申请日：1987-10-05
申请人： Yves Pommier , Yves Legrand
发明人： Yves Pommier , Yves Legrand
IPC分类号： B01F7/00 , B01F7/16 , B01F15/00 , B01J3/04 , B01J19/18 , B01J19/20 , C08F2/00 , C08F2/02 , C08F14/00 , C08F14/06
CPC分类号： B01F7/00275 , B01F7/1665 , B01J19/18 , B01J19/20 , B01J3/04 , B01F7/00208 , B01F7/00266 , B01F7/00416 , B01J2219/00094 , B01J2219/185
摘要： A vertical autoclave for carrying out operations involving a medium having a liquid phase and/or a solid phase, comprising:(a) a concave autoclave bottom;(b) a shaft along a vertical axis of said autoclave, said shaft passing through said bottom of said autoclave; and(c) stirrer means for driving said medium with a centripetal motion about said concave autoclave bottom.

6. 发明授权

US3978391A Direct current stabilizing device 失效
标题翻译：直接电流稳定器件
公开(公告)号：US3978391A
公开(公告)日：1976-08-31
申请号：US543046
申请日：1975-01-22
申请人： Rene Migeon , Yves Legrand
发明人： Rene Migeon , Yves Legrand
IPC分类号： G05F1/56 , G05F3/18 , H04M19/00 , G05F1/58
CPC分类号： H04M19/00 , G05F3/18
摘要： Current stabilizing device constituted by a two-terminal network in series with a load to be fed. The two-terminal network comprises, in series between its two poles a regulating transistor and a resistor, the regulating transistor being controlled by the current collector of another transistor whose base current is controlled by the difference between a stabilized voltage taken at the terminals of a voltage stabilizing diode through which a current which is itself stabilized flows and the voltage drop across the resistor; several two-terminal networks may be connected together in series. The device is particularly applicable to the stabilization of the remote feeding current for repeaters in telephone cables which are not accessible, for example, submarine telephone cables.
摘要翻译： 1461235自动电流控制COMPAGNIE INDUSTRIELLE DES TELECOMMUNICATIONS CIT-ALCATEL 23 Jan 1975 [1974年1月24日] 2933/75标题G3R A串联晶体管电流调节器包括电流检测电阻和从电阻网络提供稳定电流的恒压二极管。二极管通过第二晶体管和第二恒压二极管的基极集电极路连接到串联晶体管的基极。第三晶体管的基极 - 发射极结连接在电流检测电阻和第一二极管的串联连接上。如图所示，双终端网络2连接在中继电信线路中的直流源1和电阻负载3之间。电流由电阻器5感测，电位器控制晶体管12的电导率，晶体管12进而控制串联晶体管4.参考电位由齐纳二极管10提供，齐纳二极管10从晶体管9接收恒流源，电阻器7,11,13,14和第二齐纳二极管8.并联电阻器6限制串联晶体管4中消耗的功率，并且一对齐纳二极管17,18限制网络2上的总电压。二极管15， 16提供温度补偿。如果使用高电源电压和/或低电阻负载，则所示类型的几个网络可以串联连接。

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