专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06638502B1 Adenovirus-mediated intratumoral delivery of an angiogenesis antagonist for the treatment of tumors 失效
标题翻译：腺瘤病毒介导的肿瘤内递送血管生成拮抗剂用于治疗肿瘤
公开(公告)号：US06638502B1
公开(公告)日：2003-10-28
申请号：US09403736
申请日：2000-06-29
申请人： Hong Li , He Lu , Frank Griscelli , Paule Opolon , Claudine Soria , Thierry Ragot , Yves Legrand , Jeannette Soria , Christelle Mabilat , Michel Perricaudet , Patrice Yeh
发明人： Hong Li , He Lu , Frank Griscelli , Paule Opolon , Claudine Soria , Thierry Ragot , Yves Legrand , Jeannette Soria , Christelle Mabilat , Michel Perricaudet , Patrice Yeh
IPC分类号： A61K4800
CPC分类号： A61K38/49 , A61K38/484 , A61K48/00 , C12N2799/022
摘要： The present invention relates to gene therapy for the treatment of tumors. The invention more particularly relates to introduction of a gene encoding an anti-angiogenic factor into cells of a tumor, for example with a defective adenovirus vector, to inhibit growth or metastasis, or both, of the tumor. In a specific embodiment, delivery of a defective adenovirus that expresses the amino terminal fragment of urokinase (ATF) inhibited growth and metastasis of tumors. These effects were correlated with a remarkable inhibition of neovascularization within, and at the immediate vicinity of, the injection site. Delivery of a defective adenovirus vector that expresses kringles 1 to 3 of angiostatin inhibited tumor growth and tumorigenicity, and induced apoptosis of tumor cells. The invention further provides viral vectors for use in the methods of the invention.
摘要翻译：本发明涉及用于治疗肿瘤的基因治疗。本发明更具体地涉及将编码抗血管生成因子的基因导入肿瘤细胞，例如用有缺陷的腺病毒载体，抑制肿瘤的生长或转移或两者。在具体实施方案中，表达尿激酶（ATF）的氨基末端片段的缺陷型腺病毒的递送抑制肿瘤的生长和转移。这些作用与注射部位内和附近的新生血管形成的显着抑制相关。递送表达血管抑素的三环酮1〜3的有缺陷的腺病毒载体抑制肿瘤生长和致瘤性，并诱导肿瘤细胞凋亡。本发明还提供了用于本发明方法的病毒载体。

2. 发明授权

US08207137B2 Method of inhibiting angiogenesis or invasion or formation of metastases 失效
标题翻译：抑制血管发生或侵袭或形成转移的方法
公开(公告)号：US08207137B2
公开(公告)日：2012-06-26
申请号：US10764628
申请日：2004-01-26
申请人： Véronique Trochon , He Lu , Claudine Soria
发明人： Véronique Trochon , He Lu , Claudine Soria
IPC分类号： A61K48/00 , C12N15/00 , C12N15/12
CPC分类号： A61N1/306 , A61K38/00 , A61K48/00 , C12N9/6489
摘要： A method of inhibiting angiogenesis or invasion or formation of metastases in a mammal including administering a therapeutically effective amount of an active agent selected from the group consisting of a protein substance including all or part of a disintegrin domain of an adamalysin or a derivative thereof, a nucleic acid molecule including a polynucleotide sequence coding all or part of the disintegrin domain of an adamalysin or a derivative thereof to the mammal.
摘要翻译：一种抑制哺乳动物血管生成或侵袭或转移形成的方法，包括施用治疗有效量的选自蛋白质物质的活性剂，所述蛋白质物质包括全部或部分阿达马林或其衍生物的去整合素结构域，核酸分子包括编码哺乳动物的阿达马林或其衍生物的全部或部分去整合素结构域的多核苷酸序列。

3. 发明申请

US20130158502A1 METHOD OF INHIBITING ANGIOGENESIS OR INVASION OR FORMATION OF METASTASES 审中-公开
标题翻译：抑制血管生成或侵入或形成METASTASES的方法
公开(公告)号：US20130158502A1
公开(公告)日：2013-06-20
申请号：US13477181
申请日：2012-05-22
申请人： Veronique Trochon , He Lu , Claudine Soria
发明人： Veronique Trochon , He Lu , Claudine Soria
IPC分类号： A61N1/30
CPC分类号： A61N1/306 , A61K38/00 , A61K48/00 , C12N9/6489
摘要： A method of treating a mammal with a tumor by decreasing intratumoral vessels associated with tumor or inhibiting formation of new intratumoral vessels includes injecting tumor with therapeutically effective amount of expression plasmid including polynucleotide coding for therapeutic peptide consisting of SEQ ID NO: 2 absent any operably linked coding sequence, wherein polynucleotide sequence is operably linked to promoter or expression control sequence, followed by application of electric pulses to site of injection in tumor or injecting muscle of mammal with therapeutically effective amount of expression plasmid including polynucleotide coding for therapeutic peptide consisting of SEQ ID NO: 2 absent any operably linked coding sequence, wherein polynucleotide sequence is operably linked to promoter or expression control sequence, followed by applying electric pulses to site of injection in muscle of mammal, whereby expression of SEQ ID NO: 2 decreases intratumoral vessels associated with tumor, or formation of new intratumoral vessels therein.
摘要翻译：通过减少与肿瘤相关的瘤内血管或抑制新的肿瘤内血管形成来治疗哺乳动物的方法包括用治疗有效量的表达质粒注射肿瘤，包括编码由SEQ ID NO：2组成的治疗性肽的多核苷酸，不存在任何可操作地连接编码序列，其中多核苷酸序列可操作地连接到启动子或表达控制序列，然后在治疗有效量的表达质粒包括用编码由SEQ ID NO：1所示的治疗肽组成的多核苷酸的肿瘤或注射哺乳动物的肌肉中施加电脉冲 NO：2不存在任何可操作连接的编码序列，其中多核苷酸序列可操作地连接到启动子或表达控制序列，随后在哺乳动物肌肉中施加电脉冲至注射位点，由此SEQ ID NO：2的表达降低肿瘤内血管相关肿瘤，或在其中形成新的肿瘤内血管。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式