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1. 发明授权

US5711947A Method to induce cytotoxic T Lymphocytes specific for a broad array of HIV-1 isolates using hybrid synthetic peptides 失效
标题翻译：使用杂合合成肽诱导特异于广泛的HIV-1分离株的细胞毒性T淋巴细胞的方法
公开(公告)号：US5711947A
公开(公告)日：1998-01-27
申请号：US95332
申请日：1993-07-23
申请人： Jay A. Berzofsky , Hidemi Takahashi , Ronald N. Germain
发明人： Jay A. Berzofsky , Hidemi Takahashi , Ronald N. Germain
IPC分类号： G01N33/569 , A61K39/00 , A61K39/21 , C07K7/08 , C07K14/00 , C07K14/16 , C12Q1/16 , G01N33/60 , A61K39/12 , C07K1/00 , C12P21/06
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122
摘要： The instant invention describes the synthesis of short peptides, corresponding to the amino acid residues of the V3 loop of the gp160 envelope glycoprotein of HIV-1 numbered 315 to 329 by Ratner (Ratner, L. et al., Nature 313, 277 (1985)) in the strain IIIB, wherein the residue corresponding to number 325 in HIV-1 IIIB is substituted by the homologous residue from another clinical isolate or strain. The invention further describes the use of said peptides in pharmaceutical compositions and an immunization protocol which elicits cytotoxic T cells reactive to a broad range of isolates of HIV-1.
摘要翻译：本发明描述了相应于Ratner的编号为315至329的HIV-1的gp160包膜糖蛋白的V3环的氨基酸残基的短肽（Ratner，L。等人，Nature 313,277（1985））），其中对应于HIV-1 IIIB中325号的残基被来自另一临床分离株或菌株的同源残基取代。本发明进一步描述了所述肽在药物组合物中的用途以及引发对广泛范围的HIV-1分离株具有反应性的细胞毒性T细胞的免疫方案。

2. 发明授权

US5820865A Method to induce cytotoxic T Lymphocytes specific for a broad array of HIV-1 isolates using hybrid synthetic peptides 失效
标题翻译：使用杂合合成肽诱导特异于广泛的HIV-1分离株的细胞毒性T淋巴细胞的方法
公开(公告)号：US5820865A
公开(公告)日：1998-10-13
申请号：US760530
申请日：1991-09-18
申请人： Jay A. Berzofsky , Hidemi Takahashi , Ronald N. Germain
发明人： Jay A. Berzofsky , Hidemi Takahashi , Ronald N. Germain
IPC分类号： G01N33/569 , A61K39/00 , A61K39/21 , C07K7/08 , C07K14/00 , C07K14/16 , C12Q1/16 , G01N33/60
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122
摘要： The instant invention describes the synthesis of short peptides, corresponding to the amino acid residues of the V3 loop of the gpl6O envelope glycoprotein of HIV-1 numbered 315 to 329 by Ratner (Ratner, L. et al., Nature 313, 277 (1985)) in the strain IIIB, wherein the residue corresponding to number 325 in HIV-1 IIIB is substituted by the homologous residue from another clinical isolate or strain. The invention further describes the use of said peptides in pharmaceutical compositions and an immunization protocol which elicits cytotoxic T cells reactive to a broad range of isolates of HIV-1.
摘要翻译：本发明描述了相应于Ratner的编号为315至329的HIV-1的gp16O包膜糖蛋白的V3环的氨基酸残基的短肽（Ratner，L。等人，Nature 313,277（1985））），其中对应于HIV-1 IIIB中325号的残基被来自另一临床分离株或菌株的同源残基取代。本发明进一步描述了所述肽在药物组合物中的用途以及引发对广泛范围的HIV-1分离株具有反应性的细胞毒性T细胞的免疫方案。

3. 发明授权

US07508741B2 Optical disc recording and reproduction apparatus having automatic gate signal generation modes 失效
标题翻译：具有自动门信号生成模式的光盘记录和再现装置
公开(公告)号：US07508741B2
公开(公告)日：2009-03-24
申请号：US11641886
申请日：2006-12-20
申请人： Yukio Iijima , Nobuaki Minakuchi , Hidemi Takahashi , Yasushi Ueda , Makoto Okazaki
发明人： Yukio Iijima , Nobuaki Minakuchi , Hidemi Takahashi , Yasushi Ueda , Makoto Okazaki
IPC分类号： G11B15/02
CPC分类号： G11B19/04 , G11B7/0037 , G11B7/0053 , G11B7/00745 , G11B19/122 , G11B20/10 , G11B20/10009 , G11B20/10222 , G11B20/1403 , G11B20/1426 , G11B27/19 , G11B27/24 , G11B27/3027 , G11B2020/10888 , G11B2020/1269 , G11B2020/1274 , G11B2220/20 , G11B2220/2537
摘要： An optical disc recording and reproducing apparatus for recording and reproducing data in and from an optical disc by the use of the optical disc as a recording medium, comprises analog processing means including a binarization unit for subjecting a signal read from the optical disc to binarization and a servo unit for controlling recording and reproducing a signal in and from the optical disc; synchronous clock generating means for generating a synchronous clock signal which is synchronized with the signal read from the optical disc; address detecting means for detecting address information indicating a physical position on the optical disc based on the signal read from the optical disc, and outputting a signal indicating the address information and a signal indicating that the address has been detected when the address information has been detected; a sector counter for holding a sector count value of a sector as a recording unit on the optical disc, and updating the sector count value according to the synchronous clock signal and the signal output from the address detecting means; and gate signal generation switching means for generating gate a signal which controls the analog processing means, based on one of the sector count value held in the sector counter and information obtained from the analog processing means, according to the signal indicating that the address has been detected, which is output from the address detecting means.
摘要翻译：一种用于通过使用光盘作为记录介质来记录和从光盘再现数据的光盘记录和再现装置，包括模拟处理装置，包括用于对从光盘读取的信号进行二值化的二值化单元，以及用于控制在光盘中记录和再现信号的伺服单元; 同步时钟发生装置，用于产生与从光盘读取的信号同步的同步时钟信号; 地址检测装置，用于基于从光盘读取的信号检测表示光盘上的物理位置的地址信息，并且当检测到地址信息时，输出指示地址信息的信号和指示已经检测到地址的信号 ; 用于将光盘的扇区计数值保持为记录单位的扇区计数器，并根据同步时钟信号和从地址检测装置输出的信号来更新扇区计数值; 以及门信号产生切换装置，用于根据表示地址已经被信号的信号，基于扇区计数器中保存的扇区计数值和从模拟处理装置获得的信息，产生控制模拟处理装置的信号从地址检测装置输出。

4. 发明申请

US20080037388A1 Optical disc recording and reproduction apparatus having automatic gate signal generation modes 有权
标题翻译：具有自动门信号生成模式的光盘记录和再现装置
公开(公告)号：US20080037388A1
公开(公告)日：2008-02-14
申请号：US11798713
申请日：2007-05-16
申请人： Yukio Iijima , Nobuaki Minakuchi , Hidemi Takahashi , Yasushi Ueda , Makoto Okazaki
发明人： Yukio Iijima , Nobuaki Minakuchi , Hidemi Takahashi , Yasushi Ueda , Makoto Okazaki
IPC分类号： G11B7/00
CPC分类号： G11B19/04 , G11B7/0037 , G11B7/0053 , G11B7/00745 , G11B19/122 , G11B20/10 , G11B20/10009 , G11B20/10222 , G11B20/1403 , G11B20/1426 , G11B27/19 , G11B27/24 , G11B27/3027 , G11B2020/10888 , G11B2020/1269 , G11B2020/1274 , G11B2220/20 , G11B2220/2537
摘要： An optical disc recording and reproducing apparatus for recording and reproducing data in and from an optical disc by the use of the optical disc as a recording medium, comprises analog processing means including a binarization unit for subjecting a signal read from the optical disc to binarization and a servo unit for controlling recording and reproducing a signal in and from the optical disc; synchronous clock generating means for generating a synchronous clock signal which is synchronized with the signal read from the optical disc; address detecting means for detecting address information indicating a physical position on the optical disc based on the signal read from the optical disc, and outputting a signal indicating the address information and a signal indicating that the address has been detected when the address information has been detected; a sector counter for holding a sector count value of a sector as a recording unit on the optical disc, and updating the sector count value according to the synchronous clock signal and the signal output from the address detecting means; and gate signal generation switching means for generating gate a signal which controls the analog processing means, based on one of the sector count value held in the sector counter and information obtained from the analog processing means, according to the signal indicating that the address has been detected, which is output from the address detecting means.
摘要翻译：一种用于通过使用光盘作为记录介质来记录和从光盘再现数据的光盘记录和再现装置，包括模拟处理装置，包括用于对从光盘读取的信号进行二值化的二值化单元，以及用于控制在光盘中记录和再现信号的伺服单元; 同步时钟发生装置，用于产生与从光盘读取的信号同步的同步时钟信号; 地址检测装置，用于基于从光盘读取的信号检测表示光盘上的物理位置的地址信息，并且当检测到地址信息时，输出指示地址信息的信号和指示已经检测到地址的信号 ; 用于将光盘的扇区计数值保持为记录单位的扇区计数器，并根据同步时钟信号和从地址检测装置输出的信号来更新扇区计数值; 以及门信号产生切换装置，用于根据表示地址已经被信号的信号，基于扇区计数器中保存的扇区计数值和从模拟处理装置获得的信息，产生控制模拟处理装置的信号从地址检测装置输出。

5. 发明授权

US07292510B2 Optical disc recording and reproduction apparatus having automatic gate signal generation modes 失效
公开(公告)号：US07292510B2
公开(公告)日：2007-11-06
申请号：US11035272
申请日：2005-01-14
申请人： Yukio Iijima , Nobuaki Minakuchi , Hidemi Takahashi , Yasushi Ueda , Makoto Okazaki
发明人： Yukio Iijima , Nobuaki Minakuchi , Hidemi Takahashi , Yasushi Ueda , Makoto Okazaki
IPC分类号： G11B7/00
CPC分类号： G11B19/04 , G11B7/0037 , G11B7/0053 , G11B7/00745 , G11B19/122 , G11B20/10 , G11B20/10009 , G11B20/10222 , G11B20/1403 , G11B20/1426 , G11B27/19 , G11B27/24 , G11B27/3027 , G11B2020/10888 , G11B2020/1269 , G11B2020/1274 , G11B2220/20 , G11B2220/2537
摘要： An optical disc recording and reproducing apparatus for recording and reproducing data in and from an optical disc by the use of the optical disc as a recording medium, comprises analog processing means including a binarization unit for subjecting a signal read from the optical disc to binarization and a servo unit for controlling recording and reproducing a signal in and from the optical disc; synchronous clock generating means for generating a synchronous clock signal which is synchronized with the signal read from the optical disc; address detecting means for detecting address information indicating a physical position on the optical disc based on the signal read from the optical disc, and outputting a signal indicating the address information and a signal indicating that the address has been detected when the address information has been detected; a sector counter for holding a sector count value of a sector as a recording unit on the optical disc, and updating the sector count value according to the synchronous clock signal and the signal output from the address detecting means; and gate signal generation switching means for generating gate a signal which controls the analog processing means, based on one of the sector count value held in the sector counter and information obtained from the analog processing means, according to the signal indicating that the address has been detected, which is output from the address detecting means.

6. 发明授权

US07768891B2 Optical disc recording and reproduction apparatus having automatic gate signal generation modes 有权
标题翻译：具有自动门信号生成模式的光盘记录和再现装置
公开(公告)号：US07768891B2
公开(公告)日：2010-08-03
申请号：US11798713
申请日：2007-05-16
申请人： Yukio Iijima , Nobuaki Minakuchi , Hidemi Takahashi , Yasushi Ueda , Makoto Okazaki
发明人： Yukio Iijima , Nobuaki Minakuchi , Hidemi Takahashi , Yasushi Ueda , Makoto Okazaki
IPC分类号： G11B11/00
CPC分类号： G11B19/04 , G11B7/0037 , G11B7/0053 , G11B7/00745 , G11B19/122 , G11B20/10 , G11B20/10009 , G11B20/10222 , G11B20/1403 , G11B20/1426 , G11B27/19 , G11B27/24 , G11B27/3027 , G11B2020/10888 , G11B2020/1269 , G11B2020/1274 , G11B2220/20 , G11B2220/2537
摘要： An optical disc recording and reproducing apparatus for recording and reproducing data in and from an optical disc by the use of the optical disc as a recording medium, comprises analog processing means including a binarization unit for subjecting a signal read from the optical disc to binarization and a servo unit for controlling recording and reproducing a signal in and from the optical disc; synchronous clock generating means for generating a synchronous clock signal which is synchronized with the signal read from the optical disc; address detecting means for detecting address information indicating a physical position on the optical disc based on the signal read from the optical disc, and outputting a signal indicating the address information and a signal indicating that the address has been detected when the address information has been detected; a sector counter for holding a sector count value of a sector as a recording unit on the optical disc, and updating the sector count value according to the synchronous clock signal and the signal output from the address detecting means; and gate signal generation switching means for generating gate a signal which controls the analog processing means, based on one of the sector count value held in the sector counter and information obtained from the analog processing means, according to the signal indicating that the address has been detected, which is output from the address detecting means.
摘要翻译：一种用于通过使用光盘作为记录介质来记录和从光盘再现数据的光盘记录和再现装置，包括模拟处理装置，包括用于对从光盘读取的信号进行二值化的二值化单元，以及用于控制在光盘中记录和再现信号的伺服单元; 同步时钟发生装置，用于产生与从光盘读取的信号同步的同步时钟信号; 地址检测装置，用于基于从光盘读取的信号检测表示光盘上的物理位置的地址信息，并且当检测到地址信息时，输出指示地址信息的信号和指示已经检测到地址的信号 ; 用于将光盘的扇区计数值保持为记录单位的扇区计数器，并根据同步时钟信号和从地址检测装置输出的信号来更新扇区计数值; 以及门信号产生切换装置，用于根据表示地址已经被信号的信号，基于扇区计数器中保存的扇区计数值和从模拟处理装置获得的信息，产生控制模拟处理装置的信号从地址检测装置输出。

7. 发明授权

US06511830B1 Killer T cell receptor recognizing human immunodeficiency virus 有权
标题翻译：杀伤T细胞受体识别人类免疫缺陷病毒
公开(公告)号：US06511830B1
公开(公告)日：2003-01-28
申请号：US09509347
申请日：2000-03-27
申请人： Hidemi Takahashi , Takashi Saito
发明人： Hidemi Takahashi , Takashi Saito
IPC分类号： G01N3353
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0337 , A61K38/00 , C07K14/7051 , C07K2319/00
摘要： The present invention relates to a polypeptide which is a constituent of a killer T cell receptor and is capable of injuring human immunodeficiency virus-infected cells; a DNA encoding this polypeptide; a recombinant vector comprising this DNA and a vector; a transformant obtained by transferring this recombinant vector into a host cell; a process for producing the above polypeptide characterized by culturing the above transformant in a medium, thus forming and accumulating the polypeptide in the culture and then recovering the polypeptide from the culture; an antibody reacting specifically with the above polypeptide; human-mouse type killer T cell receptor &agr;chain and &bgr;chain in each of which the variable region site of the above polypeptide is sustained while the constant region site thereof has been replaced by that of the human type; transgenic animals having the above polypeptide expressed therein; and anti-HIV agents containing the above polypeptide.
摘要翻译：本发明涉及作为杀伤T细胞受体的成分并能够损伤人免疫缺陷病毒感染细胞的多肽; 编码该多肽的DNA; 包含该DNA和载体的重组载体; 通过将该重组载体转移到宿主细胞中获得的转化体; 制备上述多肽的方法，其特征在于在培养基中培养上述转化体，从而在培养物中形成和积累多肽，然后从培养物中回收多肽; 与上述多肽特异性反应的抗体; 人类 - 小鼠型杀伤T细胞受体alphachain和betachain，其中上述多肽的可变区位点在其恒定区位点被人类替代时被维持; 在其中表达上述多肽的转基因动物; 和含有上述多肽的抗HIV剂。

8. 发明授权

US4791299A Infrared ray sensing device 失效
标题翻译：红外线感测装置
公开(公告)号：US4791299A
公开(公告)日：1988-12-13
申请号：US20732
申请日：1987-03-02
申请人： Hiroshi Naito , Hidemi Takahashi , Minoru Kimura , Reiji Sano
发明人： Hiroshi Naito , Hidemi Takahashi , Minoru Kimura , Reiji Sano
IPC分类号： G01S7/02 , G01J5/02 , G01J5/06 , G01J5/60 , G01S7/03 , G01S7/48 , G01S17/02 , G01V8/12 , G01J3/00
CPC分类号： G01J5/06 , G01J2005/604
摘要： A thermally insulating casing accommodates an infrared ray sensing element. The casing has a window which conducts infrared ray to the sensing element. The window is covered with heat absorption gas. An infrared ray emitting element may be accommodated within the casing. The casing may have a second window which passes infrared ray generated by the emitting element. The second window may be covered with the heat absorption gas.
摘要翻译：绝热壳体容纳红外线传感元件。壳体具有向感测元件传导红外线的窗口。窗户被吸热气体覆盖。红外线发射元件可以容纳在壳体内。壳体可以具有通过由发射元件产生的红外线的第二窗口。第二窗口可以被吸热气体覆盖。

9. 发明授权

US4672621A Laser resonator having an improved gas-introducing portion 失效
标题翻译：激光谐振器具有改进的气体导入部分
公开(公告)号：US4672621A
公开(公告)日：1987-06-09
申请号：US484740
申请日：1983-04-13
申请人： Yasuyuki Morita , Hidemi Takahashi , Reiji Sano
发明人： Yasuyuki Morita , Hidemi Takahashi , Reiji Sano
IPC分类号： H01S3/03 , H01S3/036 , H01S3/07 , H01S3/22 , H01S3/223
CPC分类号： H01S3/036 , H01S3/0305 , H01S3/073
摘要： In a laser resonator having a gas-introducing portion at one end of a laser tube, where the gas introducing portion comprises an inner tube communicating with the laser tube and an outer tube covering the inner tube. The inner tube has a plurality of circumferentially spaced apart flow passages so that a gas mixture fed from a gas source to an annular chamber defined between the inner surface of the outer tube and the outer surface of the inner tube, is led into the inside of the inner tube via the flow passages. As a result, turbulence occurs within the inner tube so that radial distribution of gas flow speed in the laser tube is made uniform, thereby increasing the maximum output and stability. The flow passages may be slits, oval or circular openings, triangular openings or the like. The flow passages may be skewed relative to both the radial and tangential lines passing therethrough or relative to the axis of the inner tube so that the gas introduced inside the inner tube spirals, and therefore the gas travels along the laser tube with a spiral movement.
摘要翻译：在具有在激光管的一端具有气体导入部分的激光谐振器中，气体导入部分包括与激光管连通的内管和覆盖内管的外管。内管具有多个周向间隔开的流动通道，使得从气体源到限定在外管的内表面和内管的外表面之间的环形室供给的气体混合物被引入到内管经由流路。结果，在内管内发生湍流，使得激光管中的气体流速的径向分布均匀，从而增加最大输出和稳定性。流动通道可以是狭缝，椭圆形或圆形开口，三角形开口等。流动通道可以相对于穿过其中或相对于内管的轴线的径向和切线两者倾斜，使得引入内管内的气体螺旋，因此气体以螺旋运动沿着激光管行进。

10. 发明授权

US09230595B2 Error correction method and data reproduction device 有权
标题翻译：误差校正方法和数据再现装置
公开(公告)号：US09230595B2
公开(公告)日：2016-01-05
申请号：US13314971
申请日：2011-12-08
申请人： Yuka Hasegawa , Hidemi Takahashi , Yukio Sugimura
发明人： Yuka Hasegawa , Hidemi Takahashi , Yukio Sugimura
IPC分类号： G11C29/00 , G11B20/18 , H03M13/29 , H03M13/37 , G11B20/12 , G11B20/14
CPC分类号： G11B20/1833 , G11B2020/1287 , G11B2020/1476 , G11B2020/1836 , G11B2020/1853 , G11B2220/215 , G11B2220/2562 , H03M13/2909 , H03M13/293 , H03M13/3707
摘要： The error correction processing includes: data reproduction processing of reproducing recording data, constituted by a plurality of data units each made of a plurality of bits, from a recording medium sequentially; error correction processing of performing error correction in the row direction and error correction in the column direction at least once for an error correction code block that has the reproduced recording data arranged in the row direction over a plurality of rows; determination processing of determining whether uncorrectable data is left behind after execution of the error correction processing; and erasure correction processing of performing, when it is determined that uncorrectable data is left behind, column-direction error correction considering data constituting at least one row of the error correction code block as erasure data, even in cases where uncorrectable data in the error correction in the row direction is not left behind.
摘要翻译：纠错处理包括：依次从记录介质再现记录数据的数据再现处理，由由多个位组成的多个数据单元构成; 对于具有排列在多行上的行方向上的重放记录数据的纠错码块，对行方向进行行方向的纠错和列方向的纠错至少一次的纠错处理; 确定在执行纠错处理之后是否留下不可校正数据的确定处理; 以及擦除校正处理，当确定留下不可校正数据时，即使在构成至少一行纠错码块的数据作为擦除数据的列方向误差校正中，即使在错误校正中的不可校正数据的情况下在行方向不留下。

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