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1. 发明授权

US08476409B2 Bispecific anti-IGF-1R and anti-ErbB3 antibodies 有权
标题翻译：双特异性抗IGF-1R和抗ErbB3抗体
公开(公告)号：US08476409B2
公开(公告)日：2013-07-02
申请号：US13451135
申请日：2012-04-19
申请人： Jason Baum , Bryan Johnson , Alexey Alexandrovich Lugovskoy , Lihui Xu , Neeraj Kohli , Jonathan Basil Fitzgerald , Sharlene Adams
发明人： Jason Baum , Bryan Johnson , Alexey Alexandrovich Lugovskoy , Lihui Xu , Neeraj Kohli , Jonathan Basil Fitzgerald , Sharlene Adams
IPC分类号： C07K16/30 , C07H21/04 , A61K39/00
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K16/30 , C07K16/32 , C07K16/40 , C07K16/468 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/565 , C07K2317/60 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Provided are bispecific antibodies that are useful as anti-neoplastic agents and that bind specifically to human IGF-1R and human ErbB3. Exemplary antibodies inhibit signal transduction through either or both of IGF-1R and ErbB3.
摘要翻译：提供可用作抗肿瘤剂并且特异性结合人IGF-1R和人ErbB3的双特异性抗体。示例性的抗体通过IGF-1R和ErbB3之一或两者抑制信号转导。

2. 发明申请

US20050084490A1 Boroproline compound combination therapy 审中-公开
标题翻译：波罗宁复合联合治疗
公开(公告)号：US20050084490A1
公开(公告)日：2005-04-21
申请号：US10616409
申请日：2003-07-09
申请人： Sharlene Adams , Glenn Miller , Michael Jesson , Barry Jones
发明人： Sharlene Adams , Glenn Miller , Michael Jesson , Barry Jones
IPC分类号： A61K31/69 , A61K38/05 , A61K38/06 , A61K38/17 , A61K38/21 , A61K39/395 , A61K45/06
CPC分类号： A61K45/06 , A61K31/69 , A61K38/05 , A61K38/1709 , A61K38/21 , A61K39/395 , A61K39/39558 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/422 , Y02A50/423 , Y02A50/478 , Y02A50/487 , A61K2300/00
摘要： A method is provided for treating subjects with combination therapy including compounds of Formula I. It was surprisingly discovered that this combination enhanced the efficacy of both agents, and that administration of Formula I compounds induced cytokine and chemokine production in vivo. The combinations can be used to enhance ADCC, stimulate immune responses and/or patient and treat certain disorders. The invention also relates to kits and compositions relating to such combinations.
摘要翻译：提供了一种用于联合治疗包括式I化合物治疗受试者的方法。令人惊奇地发现，这种组合增强了两种药物的功效，并且使用式I化合物在体内诱导细胞因子和趋化因子产生。这些组合可用于增强ADCC，刺激免疫反应和/或患者并治疗某些疾病。本发明还涉及与这种组合有关的试剂盒和组合物。

3. 发明授权

US07205274B2 Hybrid peptides modulate the immune response 有权
公开(公告)号：US07205274B2
公开(公告)日：2007-04-17
申请号：US10197000
申请日：2002-07-17
申请人： Robert E. Humphreys , Sharlene Adams , Minzhen Xu
发明人： Robert E. Humphreys , Sharlene Adams , Minzhen Xu
IPC分类号： A61K38/00 , A61K39/385
CPC分类号： C07K19/00 , A61K38/00 , C07K14/70539 , G01N33/505
摘要： The present invention provides an MHC class II antigen presentation enhancing hybrid polypeptide. The hybrid has an N-terminus comprising the mammalian Ii key peptide LRMKLPKPPKPVSKMR (SEQ ID NO: 1) and modifications thereof which retain antigen presentation enhancing activity, a C-terminus comprising an antigenic epitope in the form of a polypeptide or peptidomimetic structure which binds to the antigenic peptide binding site of an MHC class II molecule, and an intervening chemical structure covalently linking the N-terminal and C-terminal components.

4. 发明授权

US06432409B1 Hybrid peptides modulate the immune response 有权
标题翻译：杂交肽调节免疫反应
公开(公告)号：US06432409B1
公开(公告)日：2002-08-13
申请号：US09396813
申请日：1999-09-14
申请人： Robert E. Humphreys , Sharlene Adams , Minzhen Xu
发明人： Robert E. Humphreys , Sharlene Adams , Minzhen Xu
IPC分类号： A61K3900
CPC分类号： C07K19/00 , A61K38/00 , C07K14/70539 , G01N33/505
摘要： The present invention provides an MHC class II antigen presentation enhancing hybrid polypeptide. The hybrid has an N-terminus comprising the mammalian Ii key peptide LRMKLPKPPKPVSKMR (SEQ ID NO: 1) and modifications thereof which retain antigen presentation enhancing activity, a C-terminus comprising an antigenic epitope in the form of a polypeptide or peptidomimetic structure which binds to the antigenic peptide binding site of an MHC class II molecule, and an intervening chemical structure covalently linking the N-terminal and C-terminal components.
摘要翻译：本发明提供了增强MHC II类抗原呈递的杂交多肽。杂合体具有包含哺乳动物Ii关键肽LRMKLPKPPKPVSKMR（SEQ ID NO：1）的N末端及其保留抗原呈递增强活性的修饰，C末端包含多肽形式的抗原表位或肽模拟结构，其结合涉及MHC II类分子的抗原肽结合位点，以及共价连接N-末端和C-末端组分的中间化学结构。

5. 发明申请

US20070178094A1 Hybrid peptides modulate the immune response 失效
标题翻译：杂交肽调节免疫反应
公开(公告)号：US20070178094A1
公开(公告)日：2007-08-02
申请号：US11732639
申请日：2007-04-04
申请人： Robert Humphreys , Sharlene Adams , Minzhen Xu
发明人： Robert Humphreys , Sharlene Adams , Minzhen Xu
IPC分类号： A61K39/395 , G01N33/53 , C07K16/28 , C07K7/64 , C40B30/06 , C40B40/10
CPC分类号： C07K19/00 , A61K38/00 , C07K14/70539 , G01N33/505
摘要： The present invention provides an MHC class II antigen presentation enhancing hybrid polypeptide. The hybrid has an N-terminus comprising the mammalian Ii key peptide LRMKLPKPPKPVSKMR (SEQ ID NO: 1) and modifications thereof which retain antigen presentation enhancing activity, a C-terminus comprising an antigenic epitope in the form of a polypeptide or peptidomimetic structure which binds to the antigenic peptide binding site of an MHC class II molecule, and an intervening chemical structure covalently linking the N-terminal and C-terminal components.
摘要翻译：本发明提供了增强MHC II类抗原呈递的杂交多肽。杂合体具有包含哺乳动物Ii关键肽LRMKLPKPPKPVSKMR（SEQ ID NO：1）的N末端及其保留抗原呈递增强活性的修饰，C末端包含多肽形式的抗原表位或肽模拟结构，其结合涉及MHC II类分子的抗原肽结合位点，以及共价连接N-末端和C-末端组分的中间化学结构。

6. 发明申请

US20070135354A1 Hematopoietic stimulation 审中-公开
标题翻译：造血刺激
公开(公告)号：US20070135354A1
公开(公告)日：2007-06-14
申请号：US11474929
申请日：2006-06-26
申请人： Barbara Wallner , Barry Jones , Glenn Miller , Sharlene Adams
发明人： Barbara Wallner , Barry Jones , Glenn Miller , Sharlene Adams
IPC分类号： A61K38/04 , A61K31/69
CPC分类号： A61K31/69 , A61K35/12 , A61K38/05 , A61K38/55 , A61K45/06
摘要： Methods and products for stimulating hematopoietic, preventing low levels of hematopoietic cells and producing increased numbers of hematopoietic and, mature blood cells are provided. The methods and products can be used both in vivo and in vitro.
摘要翻译：提供了用于刺激造血，预防低水平造血细胞并产生增加的造血和成熟血细胞数量的方法和产品。方法和产品可以在体内和体外使用。

7. 发明申请

US20050037976A1 Hematopoietic stimulation 失效
标题翻译：造血刺激
公开(公告)号：US20050037976A1
公开(公告)日：2005-02-17
申请号：US10879479
申请日：2004-06-28
申请人： Barbara Wallner , Barry Jones , Glenn Miller , Sharlene Adams
发明人： Barbara Wallner , Barry Jones , Glenn Miller , Sharlene Adams
IPC分类号： A61K31/69 , A61K35/12 , A61K38/05 , A61K38/55 , A61K45/06 , A61P7/00 , A61P43/00 , A61K38/06 , A61K31/4025 , A61K38/04 , C07K5/06 , C07K5/04
CPC分类号： A61K31/69 , A61K35/12 , A61K38/05 , A61K38/55 , A61K45/06
摘要： Methods and products for stimulating hematopoietic, preventing low levels of hematopoietic cells and producing increased numbers of hematopoietic and, mature blood cells are provided. The methods and products can be used both in vivo and in vitro.
摘要翻译：提供了用于刺激造血，预防低水平造血细胞并产生增加的造血和成熟血细胞数量的方法和产品。方法和产品可以在体内和体外使用。

8. 发明授权

US06835382B2 Ii peptide therapeutics to enhance antigen presentation 失效
标题翻译： Ii肽治疗剂以增强抗原呈递
公开(公告)号：US06835382B2
公开(公告)日：2004-12-28
申请号：US09261894
申请日：1999-03-03
申请人： Robert E. Humphreys , Sharlene Adams , Minzhen Xu
发明人： Robert E. Humphreys , Sharlene Adams , Minzhen Xu
IPC分类号： A61K3900
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/1016 , C07K7/08 , C07K14/70539
摘要： Disclosed is a class of compounds referred to herein as effector compounds. Effector compounds are useful in connection with the modulation of an immune response. Modulation refers to the ability of the effector compounds of the present invention to either enhance (antigen supercharging) or inhibit (immunosuppressant activities) antigen presentation, depending upon the nature of the particular effector compound and the therapeutic context. Effector compounds include peptides, modified peptides and peptidomimetics. Also disclosed are methods for modulating presentation of an MHC class II restricted antigenic peptide to a T cell. Also disclosed are effector compounds demonstrated to act specifically on a human MHC class II allele. Also disclosed is a second class of compounds, referred to herein as immunomodulatory organic compounds. Such compounds are identified by a method which includes the following steps: providing a first complex comprising an MHC class II molecule to which an antigenic peptide has been bound; contacting the first complex with mammalian Ii key peptide LRMKLPKPPKPVSKMR (SEQ ID NO:1) (or modifications thereof including peptidomimetics), thereby forming a second complex; and screening organic molecules for compounds which bind to the second complex but not to the first complex, and which exhibit immunomodulatory activity. Compounds identified in this manner can be used to modulate an immune response in a mammal.

9. 发明授权

US06770628B2 Hematopoietic stimulation 失效
标题翻译：造血刺激
公开(公告)号：US06770628B2
公开(公告)日：2004-08-03
申请号：US09878792
申请日：2001-06-11
申请人： Barbara P. Wallner , Barry Jones , Glenn T. Miller , Sharlene Adams
发明人： Barbara P. Wallner , Barry Jones , Glenn T. Miller , Sharlene Adams
IPC分类号： A61K3804
CPC分类号： A61K31/69 , A61K35/12 , A61K38/05 , A61K38/55 , A61K45/06
摘要： Methods and products for stimulating hematopoiesis, preventing low levels of hematopoietic cells and producing increased numbers of hematopoietic and mature blood cells are provided. The methods and products can be used both in vivo and in vitro. The methods involve administering an agent of Formula I: wherein m is an integer between 0 and 10, inclusive; A and A1 are L-amino acid residues such that the A in each repeating bracketed unit can be the same or a different amino acid residue; the C bonded to B is in the L-configuration; the bonds between A and N, A1 and C, and between A1 and N are peptide bonds; and each X1 and X2 is, independently, a hydroxyl group or a group capable of being hydrolyzed to a hydroxyl group in aqueous solution at physiological pH. A particularly preferred agent that is useful in practicing the invention is a ValBoroPro.
摘要翻译：提供了刺激造血作用的方法和产品，防止造血细胞水平降低并造成造血和成熟血细胞数量增加。方法和产品可以在体内和体外使用。所述方法包括施用式I的试剂：其中m为0至10的整数，包括端值; A和A1是L-氨基酸残基，使得每个重复括号中的A可以相同或不同的氨基酸残基; 与B结合的C处于L构型; A和N，A1和C之间以及A1和N之间的键是肽键; 并且每个X1和X2独立地是在生理pH下能够在水溶液中水解成羟基的羟基或基团。可用于实施本发明的特别优选的试剂是ValBoroPro。

10. 发明授权

US06300314B1 Hematopoietic stimulation 失效
标题翻译：造血刺激
公开(公告)号：US06300314B1
公开(公告)日：2001-10-09
申请号：US09304199
申请日：1999-05-03
申请人： Barbara P. Wallner , Barry Jones , Glenn T. Miller , Sharlene Adams
发明人： Barbara P. Wallner , Barry Jones , Glenn T. Miller , Sharlene Adams
IPC分类号： A61K3804
CPC分类号： A61K31/69 , A61K35/12 , A61K38/05 , A61K38/55 , A61K45/06
摘要： Methods and products for stimulating hematopoiesis, preventing low levels of hematopoietic cells and producing increased numbers of hematopoietic and mature blood cells are provided. The methods and products can be used both in vivo and in vitro. The methods involve administering an agent of Formula I: wherein m is an integer between 0 and 10, inclusive; A and A1 are L-amino acid residues such that the A in each repeating bracketed unit can be the same or a different amino acid residue; the C bonded to B is in the L-configuration; the bonds between A and N, A1 and C, and between A1 and N are peptide bonds; and each X1 and X2 is, independently, a hydroxyl group or a group capable of being hydrolyzed to a hydroxyl group in aqueous solution at physiological pH. A particularly preferred agent that is useful in practicing the invention is a ValBoroPro.
摘要翻译：提供了刺激造血作用的方法和产品，防止造血细胞水平降低并造成造血和成熟血细胞数量增加。方法和产品可以在体内和体外使用。所述方法包括施用式I的试剂：其中m为0至10的整数，包括端值; A和A1是L-氨基酸残基，使得每个重复括号中的A可以相同或不同的氨基酸残基; 与B结合的C处于L构型; A和N，A1和C之间以及A1和N之间的键是肽键; 并且每个X1和X2独立地是在生理pH下能够在水溶液中水解成羟基的羟基或基团。可用于实施本发明的特别优选的试剂是ValBoroPro。

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